Article
Allergy
Cosby A. Stone, Jason A. Trubiano, Elizabeth J. Phillips
Summary: This study found that cross-reactivity of cephalosporins is based on shared R1 groupings, and increasing time since the original reaction and having a penicillin allergy label (PAL) with unknown cephalosporin tolerance predicted a lower likelihood of positive skin testing.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Sevgi Sipahi Cimen, Zeynep Hizli Demirkale, Esra Yucel, Deniz Ozceker, Ayse Suleyman, Ugurcan Sayili, Zeynep Tamay, Nermin Guler
Summary: This study aimed to determine the clinical characteristics and potential risk factors of true BL allergy in children with suspected mild cutaneous reactions to BLs. Results showed that 10.7% of patients were confirmed to have BL allergy, with the majority being immediate-type reactions and urticaria being the most common complaint. The negative predictive value of penicillin-G skin testing for immediate-type penicillin allergy and non-immediate reactions were 89.7% and 93.4% respectively. A history of proven drug allergy was found to be a risk factor for BL allergy.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Immunology
Shan Jiang, Bo Sun, Yan Zhang, Jiayin Han, Yanyan Zhou, Chen Pan, Hongjie Wang, Nan Si, Baolin Bian, Linna Wang, Lifang Wang, Xiaolu Wei, Haiyu Zhao
Summary: In this study, the mechanism of immediate adverse drug reactions induced by ShenMai injection (SMI) was investigated. It was found that the adverse reactions were mediated by thymus-derived T cells and involved imbalanced CD4(+) T cell subsets and increased cytokine levels. Metabolomics analysis highlighted the significant changes in the metabolic profile, particularly the notable increase in lysolecithin level. Furthermore, the activation of the RhoA/ROCK signaling pathway was suggested to be associated with the increased lysolecithin levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Edyta Jura-Szoltys, Lesia Rozlucka, Radoslaw Gawlik, Joanna Gluck
Summary: According to the analysis, the use of paraformaldehyde as a dental material can cause delayed hypersensitivity reactions, which can be life-threatening. Approximately 50% of patients treated with paraformaldehyde had positive specific IgE levels. Compared to the control group, the level of certainty of anaphylactic reaction after paraformaldehyde application was significantly higher in the PF-positive group according to the Brighton criteria.
Review
Immunology
Rakesh D. Bansie, A. Faiz Karim, Maurits S. van Maaren, Maud A. W. Hermans, Paul L. A. van Daele, Roy Gerth van Wijk, Saskia M. Rombach
Summary: Skin tests and provocation tests are recommended for evaluating hypersensitivity reactions to contrast agents, showing a high risk of immediate repeat hypersensitivity reactions for skin-test-positive patients. However, provocation tests are not common in clinical practice.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Immunology
Xin Rong Lim, Grace Yin Lai Chan, Justina Wei Lynn Tan, Carol Yee Leng Ng, Choon Guan Chua, Guat Bee Tan, Stephrene Seok Wei Chan, Kiat Hoe Ong, Ying Zhi Tan, Sarah Hui Zhen Tan, Claire Min Li Teo, Samuel Shang Ming Lee, Bernard Yu Hor Thong, Bernard Pui Lam Leung
Summary: The mechanisms of immediate-type hypersensitivity reactions to the Pfizer BNT162b2 vaccine and the response of antibodies to the polyethylene glycol (PEG)ylated lipid nanoparticle were investigated in this study. The study found that patients with immediate-type hypersensitivity reactions to the vaccine showed elevated levels of C5a and Th2-related cytokines, along with higher levels of IgM antibodies and ICAM-1. These findings suggest that acute hypersensitivity reactions to the BNT162b2 vaccine may be pseudo-allergic reactions mediated by the activation of C5a and are independent of IgE mechanisms.
Article
Allergy
Ellen Minaldi, Elizabeth J. Phillips, Allison Norton
Summary: Beta-lactam antibiotics are the most commonly reported drug allergy, but over 95% of reported allergies are not confirmed upon testing. Immediate and delayed hypersensitivity reactions are associated with beta-lactams, and risk stratification based on diagnosis and timing guides appropriate management. Different evaluation methods are used for immediate and delayed reactions, and cross-reactivity is commonly driven by shared R1 side-chains.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Knut Brockow
Summary: Diagnosing drug hypersensitivity reactions is complex, involving skin tests and in vitro tests to detect sensitization. Sensitivity of in vitro tests for specific IgE depends on the drug, and caution is advised in interpreting the results. Clear medical decisions and further research are needed.
JOURNAL OF IMMUNOLOGICAL METHODS
(2021)
Review
Allergy
Shawn J. R. Goh, Johanna E. E. Tuomisto, Anthony W. Purcell, Nicole A. Mifsud, Patricia T. Illing
Summary: Penicillin, as a first-line treatment for infections, can induce immune-mediated adverse reactions including IgE-mediated and non-IgE-mediated reactions, manifesting as skin eruptions and liver injury. Studies have shown that the infiltration of T cells at the site of inflammation is dependent on the nature of the reaction.
Review
Oncology
Sofie Seghers, Laure-Anne Teuwen, Michiel Beyens, Dennis De Blick, Vito Sabato, Didier G. Ebo, Hans Prenen
Summary: Immediate hypersensitivity reactions (IHRs) to antineoplastic agents are common and can significantly impact the treatment of cancer patients. However, clear guidelines for diagnosis and management are lacking, especially from an oncologic perspective. This review focuses on defining IHRs and discussing their underlying mechanisms, summarizing the epidemiology of common causative agents, and providing guidance on diagnosis and treatment to improve the care of cancer patients.
CANCER TREATMENT REVIEWS
(2023)
Article
Allergy
Michelle Dilley, Bob Geng
Summary: Hypersensitivity reactions to aminoglycosides, clindamycin, linezolid, and metronidazole are rare, with diverse manifestations. Clindamycin commonly causes delayed maculopapular exanthems, sometimes leading to severe systemic symptoms. Linezolid and metronidazole-induced hypersensitivity reactions are exceedingly rare, with cases including urticaria, angioedema, and anaphylaxis.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shuen-Iu Hung, Ivan Arni C. Preclaro, Wen-Hung Chung, Chuang-Wei Wang
Summary: As the world deals with the COVID-19 pandemic, vaccination remains crucial. However, vaccine hesitancy is partly caused by immediate hypersensitivity reactions induced by COVID-19 vaccines. Various strategies have been suggested to prevent hypersensitivity reactions.
Article
Immunology
Toon Ieven, Martijn Vandebotermet, Lisa Nuyttens, David Devolder, Peter Vandenberghe, Dominique Bullens, Rik Schrijvers
Summary: This study analyzed the tolerability of adenoviral vector and mRNA-based COVID-19 vaccines in high-risk patient groups. The results showed that these vaccines were safe and well-tolerated in patients with pMCD, HAE, and IA, with no cases of anaphylaxis observed. Some patients with pMCD may experience mild flare-ups of mast cell activation-like symptoms after vaccination.
Article
Surgery
Spencer Fosnot, Katelyn Currier, Jay Pendell, Meghan N. Jeffres
Summary: This study showed that hypersensitivity reactions are uncommon in patients labeled as penicillin allergic. The frequency of immediate hypersensitivity reactions did not differ significantly among patients receiving cefazolin, clindamycin, or vancomycin. Avoiding cefazolin in patients labeled as penicillin allergic may not be necessary.
Review
Pharmacology & Pharmacy
Mahalaxmi Iyer, Mohana Devi Subramaniam, Dhivya Venkatesan, Ssang-Goo Cho, Matias Ryding, Morten Meyer, Balachandar Vellingiri
Summary: Parkinson's disease is a complex neurodegenerative disease characterized by depletion of midbrain dopaminergic neurons. Current challenges in PD research include finding therapies to stop or reverse disease progression, identifying reliable biomarkers, and improving understanding of the pathophysiological mechanisms. The RhoA-ROCK signaling pathway shows promise in potentially addressing PD symptoms and pathogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
