A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

SirT1 brings stemness closer to cancer and aging

(2016) Vincenzo Calvanese et al.   Aging-US

Safety, pharmacokinetics, pharmacogenomics and QT concentration−effect modelling of the SirT1 inhibitor selisistat in healthy volunteers

(2015) Goran Westerberg et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

Combining Suppression of Stemness with Lineage-Specific Induction Leads to Conversion of Pluripotent Cells into Functional Neurons

(2015) Debasish Halder et al.   CHEMISTRY & BIOLOGY

Modulation of Neurogenesis by Targeting Epigenetic Enzymes Using Small Molecules: An Overview

(2014) Amrutha Swaminathan et al.   ACS Chemical Neuroscience

Imidazole-Based Small Molecules that Promote Neurogenesis in Pluripotent Cells

(2014) Gun-Hee Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

(2014) D. Sasca et al.   BLOOD

Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations inXenopus laevisembryos

(2014) Yoshihisa Ohata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response

(2014) Diana J. Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small molecules, big roles - the chemical manipulation of stem cell fate and somatic cell reprogramming

(2013) Y. Zhang et al.   JOURNAL OF CELL SCIENCE

SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus

(2013) Sumiti Saharan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro

(2013) Síle M. Griffin et al.   NEUROREPORT

Signaling mechanisms regulating adult neural stem cells and neurogenesis

(2012) Roland Faigle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

(2012) V. Leko et al.   BLOOD

Chemical Strategies for Stem Cell Biology and Regenerative Medicine

(2011) Saiyong Zhu et al.   Annual Review of Biomedical Engineering

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Role of Pax3 acetylation in the regulation of Hes1 and Neurog2

(2010) Shunsuke Ichi et al.   MOLECULAR BIOLOGY OF THE CELL

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Sirtuin 1 regulation of developmental genes during differentiation of stem cells

(2010) V. Calvanese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells

(2009) Moo-Rim Kang et al.   NUCLEIC ACIDS RESEARCH

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Small-molecule activation of neuronal cell fate

(2008) Jay W Schneider et al.   Nature Chemical Biology

β-catenin–mediated Wnt signaling regulates neurogenesis in the ventral telencephalon

(2008) Alexandra A Gulacsi et al.   NATURE NEUROSCIENCE

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation

(2008) S. Hisahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA