Article
Oncology
Agnieszka Pikula, Magdalena Skorzewska, Zuzanna Pelc, Radoslaw Mlak, Katarzyna Geca, Katarzyna Sedlak, Bogumila Cisel, Magdalena Kwietniewska, Karol Rawicz-Pruszynski, Wojciech P. Polkowski
Summary: The study confirmed the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in advanced gastric cancer patients, serving as significant prognostic factors.
Article
Oncology
Kaustav P. Shah, Haocan Song, Fei Ye, Douglas B. Johnson
Summary: In patients with BRAF(V600)-mutated melanoma, the number of distinct tumor sites at the initiation of targeted therapy is associated with survival, while serum lactate dehydrogenase values and the absolute lymphocyte count to absolute neutrophil count ratio are strong predictors of prognosis. Using both of these markers can help stratify prognosis for patients with metastatic melanoma receiving targeted therapy.
Article
Oncology
Chian-Wei Chen, Chien-Yu Lin, Jeng-Shiuan Tsai, Chia-Yin Lin, Chao-Chun Chang, Yi-Ting Yen, Yau-Lin Tseng, Po-Lan Su, Chien-Chung Lin
Summary: Combination therapy with chemotherapy and immune checkpoint inhibitors (ICIs) has been shown to improve overall survival (OS) in patients with non-small-cell lung cancer (NSCLC). However, there is a higher incidence of adverse events and treatment discontinuation. We investigate the neutrophil-to-lymphocyte ratio (NLR) as a predictive biomarker, especially in patients with low PD-L1 expression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maurizio A. Leone, Jessica Mandrioli, Sergio Russo, Aliona Cucovici, Giulia Gianferrari, Vitalie Lisnic, Dafin Fior Muresanu, Francesco Giuliani, Massimiliano Copetti, Andrea Fontana
Summary: This study suggests that the neutrophil-to-lymphocyte ratio (NLR) could be a potential marker for disease progression and survival in ALS, possibly associated with low-grade inflammation. Further prospective studies are needed to validate these findings.
Article
Virology
Jing Zeng, Xiuqun Zhang, Lin Jia, Yongfeng Wu, Yakun Tian, Yulin Zhang
Summary: Both LMR (lymphocyte-to-monocyte ratio) and PLR (platelet-to-lymphocyte ratio) have been found to be prognostic indicators in patients with AR-DLBCL (AIDS-related diffuse large B-cell lymphoma). Lower LMR is independently associated with poorer overall survival in these patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Nobuhiro Nakazawa, Makoto Sohda, Yasunari Ubukata, Kengo Kuriyama, Akiharu Kimura, Norimichi Kogure, Hisashi Hosaka, Atsushi Naganuma, Masanori Sekiguchi, Kana Saito, Kyoichi Ogata, Akihiko Sano, Makoto Sakai, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki
Summary: This study aimed to analyze the association between Gustave Roussy Immune Score (GRIm-s) and the therapeutic sensitivity of nivolumab in patients with advanced gastric cancer (AGC). The study found that after two courses of nivolumab, GRIm-s significantly increased and there were more PD cases in the high-risk group, with significantly worse overall survival and progression-free survival. Evaluation of GRIm-s and its changes can be beneficial in predicting nivolumab sensitivity.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Dermatology
Kentaro Awaji, Takuya Miyagawa, Jun Omatsu, Hiroko Numajiri, Toru Kawai, Kaoru Funamizu, Ryosuke Saigusa, Daisuke Yamada, Yoshihide Asano, Shinichi Sato
Summary: This study found that systemic inflammatory response markers are predictive factors for primary cutaneous angiosarcoma, with high neutrophil count and high neutrophil-to-lymphocyte ratio identified as independent poor prognostic factors for overall survival.
ACTA DERMATO-VENEREOLOGICA
(2021)
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Huan Yang, Yuan Xu, Zhijie Li, Ling Yan, Jing Wang, Pu Liao
Summary: This study analyzed the clinical characteristics of COVID-19 patients in Chongqing, identifying differences in lymphocyte and neutrophil levels between severe and non-severe groups. The study also found dynamic changes in blood routine analyzing items at different stages of illness, with potential for distinguishing severe cases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Eriko Tokunaga, Yasuo Miyoshi, Koji Dozono, Tsutomu Kawaguchi, Masakazu Toi
Summary: This study investigated the relationship between pretreatment neutrophil-to-lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) with the outcomes of abemaciclib treatment for breast cancer. The results showed that baseline NLR and ALC were predictive of progression-free survival (PFS) and overall survival (OS). Low baseline NLR was associated with better efficacy outcomes, but the addition of abemaciclib to fulvestrant had a similar treatment effect regardless of baseline NLR status.
Article
Medicine, General & Internal
Yerim Cho, Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
Summary: This study aimed to investigate the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in stage II to III colorectal cancer (CRC) patients who underwent surgery. The results showed that NLR was significantly associated with overall survival (OS) and could be used as a simple and useful parameter for predicting OS in these patients.
Article
Oncology
M. Nakano, R. Kuromatsu, T. Niizeki, S. Okamura, H. Iwamoto, S. Shimose, T. Shirono, Y. Noda, N. Kamachi, H. Koga, T. Torimura
Summary: The neutrophil-to-lymphocyte ratio is an independent prognostic factor for patients with advanced hepatocellular carcinoma receiving molecular-targeted agents as primary treatment, affecting survival significantly. Decreases in the neutrophil-to-lymphocyte ratio after one month of treatment are associated with longer survival among these patients.
Article
Otorhinolaryngology
Hong Chen, Shenghua Song, Ao Li, Dengbin Ma, Chuanyao Lin, Xiaoyun Qian, Xia Gao, Xiaohui Shen
Summary: This study retrospectively assessed the effects of platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and overall survival (OS) in patients undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC). Elevated PLR was found to be associated with an increased risk of recurrence and reduced survival in these cases. Further multi-institutional prospective studies are needed to better understand the prognostic value of pre-operative blood PLR in HSCC.
ACTA OTO-LARYNGOLOGICA
(2021)
Article
Gastroenterology & Hepatology
Elena Daveri, Luca Sorrentino, Luca Lalli, Marcello Guaglio, Luigi Battaglia, Laura Cattaneo, Giovanna Sabella, Massimo Milione, Licia Rivoltini, Maurizio Cosimelli, Filiberto Belli
Summary: This study evaluated the prognostic role of peripheral immune estimators (NLR and PLR) in survival outcomes of locally recurrent rectal cancer patients. The study found that NLR and PLR were associated with worse 5-year overall survival rate and could serve as prognostic markers. However, NLR and PLR were irrelevant in cases of R0 surgery.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Jeong Won Lee, Ki Ho Seol
Summary: The study found that high NLR-PLR is associated with poor clinical outcomes, while increases in both NLR and PLR are correlated with lower survival rates for patients. Elevation in both NLR and PLR before initiation of CCRT may be a useful biomarker for predicting clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
