Article
Medicine, General & Internal
Vipin Thampi, Roopa Hariprasad, Amrita John, Suzanne Nethan, Kavitha Dhanasekaran, Vipin Kumar, Praveen Birur, J. S. Thakur, Richard Lilford, Nasir M. Rajpoot, Paramjit Gill
Summary: Visual screening for oral cancer showed a substantial reduction in mortality in a trial in Kerala, India, while utilizing community health workers has been proposed as a strategy to address the shortage of medical personnel in resource-deficient regions. A cross-sectional study in Uttar Pradesh, India, found that trained community health workers, after initial supervision by qualified dentists, were able to perform oral cancer screening programs effectively, suggesting their feasibility in resource-constrained settings.
Article
Oncology
Xinyi Zhang, Frederico O. Gleber-Netto, Shidan Wang, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez, Nadarajah Vigneswaran, Arunangshu Sarkar, William N. N. William Jr, Vassiliki Papadimitrakopoulou, Michelle Williams, Diana Bell, Doreen Palsgrove, Justin Bishop, John V. V. Heymach, Ann M. M. Gillenwater, Jeffrey N. N. Myers, Renata Ferrarotto, Scott M. M. Lippman, Curtis Rg Pickering, Guanghua Xiao
Summary: Convolutional neural networks-based histology image analysis can accelerate the discovery of better oral cancer progression risk models by predicting the development of oral leukoplakia. This can contribute to early intervention and decrease morbidity and mortality of oral cancer.
Article
Biology
Milind Vaidya, Crismita Dmello, Saie Mogre
Summary: Human oral cancer is a major malignancy in the Indian subcontinent and worldwide. Squamous cell carcinomas (SCC) are the most common type of oral cancer, with over 90% of cases being SCC. The survival rate for oral squamous cell carcinoma is relatively low, and late diagnosis, recurrence, and metastasis are the main causes of high mortality rates. Biomarkers, particularly keratins, may have value in predicting the development and progression of oral precancerous lesions and cancers. However, further research is needed in this area.
Review
Oncology
Ahmet Hazini, Kerry Fisher, Len Seymour
Summary: Tumors undergo clonal selection, leading to the expression of tumor antigens in a subset of tumor cells. Immunosurveillance exerts selective pressure by eliminating tumor cells expressing recognized antigens by T cells, and may also select for tumor cells that evade immune detection by acquiring deficiencies in their HLA presentation pathways.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Cherine Abou-Faycal, Claire Deligne, Ines Velazquez-Quesada, William Erne, Marine Nascimento, Matthias Morgelin, Gerard Cremel, Nicodeme Paul, Raphael Carapito, Romain Veber, Helene Dumortier, Jingping Yuan, Kim S. Midwood, Thomas Loustau, Gertraud Orend
Summary: The study found that tenascin-C inhibits CD8 T cell infiltration by inducing CXCL12, which may contribute to the low response rates of immune checkpoint therapy in cancer treatment. Blocking the CXCR4 receptor of CXCL12 enhances macrophage and CD8 T cell infiltration, reducing tumor growth and metastasis.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Jonah Musa, Mamoudou Maiga, Stefan J. Green, Francis A. Magaji, Ali J. Maryam, Mark Okolo, Chuwang J. Nyam, Nanma T. Cosmas, Olugbenga A. Silas, Godwin E. Imade, Yinan Zheng, Brian T. Joyce, Brehima Diakite, Imran Morhason-Bello, Chad J. Achenbach, Atiene S. Sagay, Innocent A. O. Ujah, Robert L. Murphy, Lifang Hou, Supriya Dinesh Mehta
Summary: Vaginal microbiome community state types (CSTs) are not significantly associated with high-grade precancer and/or invasive cervical cancer (HSIL/ICC). However, CST could be helpful in identifying women with HSIL/ICC who have HR-HPV infection. Characterizing CSTs using point-of-care molecular testing in women with HR-HPV should be studied as an approach to improve early detection and prevention of cervical cancer.
Article
Oncology
Sudhansubala Lenka, Sanat Kumar Bhuyan, Ruchi Bhuyan
Summary: Neutrophils, the most prevalent form of leukocytes in human blood, are considered an essential part of the innate immune system and the body's first line of defense against foreign invaders. However, their role in cancer is debated due to the existence of various neutrophil subsets. Factors in the tumor microenvironment can alter the phenotype and function of neutrophils, leading to immune suppression.
Article
Oncology
Yan Qin, Fang Wang, Hengli Ni, Yao Liu, Yuan Yin, Xinyi Zhou, Guihua Gao, Qing Li, Xiaowei Qi, Jianming Li
Summary: This study found that high expression of CXCL12 in CAFs in the gastric cancer TME can enhance the migration, invasion, and EMT of GC cells, leading to poor prognosis in patients with GC.
Article
Oncology
Tomokatsu Kato, Yoichi Matsuo, Goro Ueda, Hiromichi Murase, Yoshinaga Aoyama, Kan Omi, Yuichi Hayashi, Hiroyuki Imafuji, Kenta Saito, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi
Summary: The study found that CXCR4 is highly expressed in radiation-resistant PaCa cells, and the CXCL12/CXCR4 axis may be involved in the radiation resistance of PaCa. Treatment with a CXCR4 antagonist can suppress the invasion ability of radiation-resistant PaCa cells, aiding in the inhibition of cell colonization.
Review
Biochemistry & Molecular Biology
Erika B. Danella, Marcell Costa de Medeiros, Nisha J. D'Silva
Summary: The oral mucosa plays a crucial role in protecting against physical, microbial, and chemical damage. When compromised, the wound healing response is activated, which involves processes such as immune infiltration, re-epithelialization, and stroma remodeling, all controlled by cytokines that promote cellular migration, invasion, and proliferation. These same cytokines are also implicated in cancer dissemination. Therefore, studying the cytokines involved in oral wound healing can provide insights into the cytokines exploited by oral squamous cell carcinoma (SCC) to promote tumor development and progression.
Review
Immunology
Partha Jyoti Saikia, Lekhika Pathak, Shirsajit Mitra, Bikul Das
Summary: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. Recent studies have shown that oral microbiota play a critical role in the initiation and progression of OSCC by activating inflammatory pathways and stemness pathways in cancer cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Giulia Cantini, Laura Fei, Letizia Canu, Elena Lazzeri, Mariangela Sottili, Michela Francalanci, Maria Lucia Angelotti, Giuseppina De Filpo, Tonino Ercolino, Stefania Gelmini, Monica Mangoni, Gabriella Nesi, Constanze Hantel, Massimo Mannelli, Mario Maggi, Michaela Luconi
Summary: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis, and the chemokine CXCL12/CXCR4 axis plays an important role in ACC development. Treatment with the PPAR gamma-ligand rosiglitazone (RGZ) effectively inhibits tumor growth in ACC and is associated with the modulation of the CXCL12/CXCR4/CXCR7 axis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
YiHeng Du, Jin Cao, Xiang Jiang, XiaoWei Cai, Bo Wang, Yi Wang, XiZhi Wang, BoXin Xue
Summary: This study revealed the significantly reduced expression of CXCL12 in BLCA compared with normal tissue, along with the reduced expression of various iCAFs marker genes in BLCA tissues. CXCL12 and iCAFs were associated with pathological features, TME remodeling, and aging in BLCA patients. iCAFs played dual roles in the carcinogenesis and progression of BLCA, impacting the prognosis and immunotherapy responsiveness for BLCA patients.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Jieheng Wu, Xinlei Liu, Jiangwei Wu, Chunju Lou, Qiaoling Zhang, Huiping Chen, Zeyang Yang, Shiqi Long, Yun Wang, Zhenling Shang, Zuquan Hu, Rui Zhang, Jian Zhang, Zhu Zeng
Summary: This study found that CD248-positive cancer-associated fibroblasts (CAFs) promote the progression of nonsmall cell lung cancer (NSCLC) by mediating M2-polarized macrophages. The expression of CD248 is associated with poor patient prognosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Katsunori Tozuka, Pattama Wongsirisin, Shigenori E. Nagai, Yasuhito Kobayashi, Miki Kanno, Kazuyuki Kubo, Ken Takai, Kenichi Inoue, Hiroshi Matsumoto, Yoshihito Shimizu, Masami Suganuma
Summary: Through studying breast cancer patients, it was found that SET plays a role in the development of breast cancer and can act as a potential biomarker for CTCs.
SCIENTIFIC REPORTS
(2021)
Article
Otorhinolaryngology
J. J. E. Sargunaraj, R. R. Paul, S. S. Mathews, R. R. A. Albert
Summary: For airway surgeons, radiological assessment of vascular structures in relation to the trachea prior to surgery is as important as the endoluminal airway assessment for the best outcome.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2021)
Article
Computer Science, Information Systems
Debaleena Nawn, Sawon Pratiher, Subhankar Chattoraj, Debjani Chakraborty, Mousumi Pal, Ranjan Rashmi Paul, Srimonti Dutta, Jyotirmoy Chatterjee
Summary: The research focused on the sub-epithelium region of the oral mucosa, utilizing tissue characteristics for analysis. Tissue-index transmission patches were cropped and characterized for multi-scale spatial-deformation dynamics and local contour connectivity. The 2D multifractal detrended fluctuation analysis (2D-MFDFA) was used to explore discriminative multifractal signatures for healthy, oral potentially malignant disorders, and oral cancer tissue samples.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Letter
Oncology
Biswajoy Ghosh, Avishek Bhandari, Mousumi Mandal, Ranjan Rashmi Paul, Mousumi Pal, Pabitra Mitra, Jyotirmoy Chatterjee
Article
Cell Biology
Monalisa Das, Ankita Das, Ananya Barui, Ranjan Rashmi Paul
Summary: MSCs are potential sources for tissue regeneration and cell-based therapy, and can be isolated from various body tissues and biological waste sources. The source of MSCs influences their proliferation capacity and replicative senescence, urging the need for comparative studies to select appropriate stem cell sources for regenerative medicine applications in the future.
CELL AND TISSUE BANKING
(2022)
Article
Engineering, Electrical & Electronic
Neha Sharma, Debaleena Nawn, Sawon Pratiher, Sayani Shome, Ritam Chatterjee, Karabi Biswas, Mousumi Pal, Ranjan Rashmi Paul, Srimonti Dutta, Jyotirmoy Chatterjee
Summary: This study proposed a multifractal based methodology to quantitatively study the alteration of salivary fern pattern in different oral potentially malignant disorders and oral cancer. By elucidating the complexity and heterogeneity of these micro-structured patterns, the study demonstrated the potential discriminatory nature of the features extracted from multi-scale self-similarity of irregular patterns in different study groups for fast and cost effective screening of various oral lesions.
IEEE SENSORS JOURNAL
(2021)
Meeting Abstract
Oncology
Michael Thomas Schweizer, Smruthy Sivakumar, Hanna Tukachinsky, Ilsa Coleman, Navonil De Sarkar, Evan Y. Yu, Eric Quentin Konnick, Peter Nelson, Colin C. Pritchard, Robert B. Montgomery
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Alexandra O. Sokolova, Catherine H. Marshall, Rebeca Lozano, Roman Gulati, Elisa M. Ledet, Navonil De Sarkar, Petros Grivas, Celestia S. Higano, Bruce Montgomery, Peter S. Nelson, David Olmos, Vadim Sokolov, Michael T. Schweizer, Todd A. Yezefski, Evan Y. Yu, Channing J. Paller, Oliver Sartor, Elena Castro, Emmanuel S. Antonarakis, Heather H. Cheng
Summary: The study found that prostate cancer patients with ATM and BRCA2 mutations have similar response to conventional therapies but significant differences in response to PARPi, indicating the need for different treatment strategies for these two genetic mutation groups.
Article
Oncology
Michael T. Schweizer, Smruthy Sivakumar, Hanna Tukachinsky, Ilsa Coleman, Navonil De Sarkar, Evan Y. Yu, Eric Q. Konnick, Peter S. Nelson, Colin C. Pritchard, Bruce Montgomery
Summary: DDR gene mutations are key actionable alterations for precision medicine strategies in advanced prostate cancer. Primary prostate tissue accurately reflects the mutational status of DDR genes in metastatic tissue, with potential mechanisms of resistance detected in ctDNA profiling.
Article
Biochemistry & Molecular Biology
Pooja Lahiri, Suranjana Mukherjee, Biswajoy Ghosh, Debnath Das, Basudev Lahiri, Shailendra Kumar Varshney, Mousumi Pal, Ranjan Rashmi Paul, Jyotirmoy Chatterjee
Summary: This study evaluated the application of the PAXgene tissue fixation system on oral tissues and found that PAXgene-fixed tissues showed significantly less tissue fall-off from slides, comparable morphology with formalin-fixed tissues, and slightly superior immunostaining for cancer-associated proteins without antigen retrieval. FTIR measurements revealed superior preservation of biomolecules in PAXgene-fixed tissues.
Article
Medicine, Research & Experimental
Navonil De Sarkar, Sayan Dasgupta, Payel Chatterjee, Ilsa Coleman, Gavin Ha, Lisa S. Ang, Emily A. Kohlbrenner, Sander B. Frank, Talina A. Nunez, Stephen J. Salipante, Eva Corey, Colm Morrissey, Eliezer Van Allen, Michael T. Schweizer, Michael C. Haffner, Radhika Patel, Brian Hanratty, Jared M. Lucas, Ruth F. Dumpit, Colin C. Pritchard, Robert B. Montgomery, Peter S. Nelson
Summary: The study identified genomic characteristics of HRR deficiency in a subset of metastatic prostate cancers, even in the absence of biallelic loss of core genes like BRCA2. These aberrations were strongly correlated with responses to PARPi and platinum chemotherapy, highlighting the importance of evaluating functional HRRd biomarkers for treatment allocation.
Article
Oncology
Ilsa M. Coleman, Navonil DeSarkar, Colm Morrissey, Li Xin, Martine P. Roudier, Erolcan Sayar, Dapei Li, Eva Corey, Michael C. Haffner, Peter S. Nelson
Summary: This study classified metastatic castration-resistant prostate cancers (mCRPC) into LumA, LumB, and Basal subtypes using the PAM50 breast cancer classification algorithm and investigated their association with treatment outcomes. The study found that the LumA subtype was enriched in TGFss and... pathways.
CLINICAL CANCER RESEARCH
(2022)
Letter
Clinical Neurology
Anindita Ray, Paolo Reho, Zalak Shah, Sonja W. Scholz
MOVEMENT DISORDERS
(2022)
Article
Medicine, Research & Experimental
Michael D. Nyquist, Lisa S. Ang, Alexandra Corella, Ilsa M. Coleman, Michael P. Meers, Anthony J. Christiani, Cordell Pierce, Derek H. Janssens, Hannah E. Meade, Arnab Bose, Lauren Brady, Timothy Howard, Navonil De Sarkar, Sander B. Frank, Ruth F. Dumpit, James T. Dalton, Eva Corey, Stephen R. Plymate, Michael C. Haffner, Elahe A. Mostaghel, Peter S. Nelson
Summary: Prostate cancer is driven by androgen receptor activity, which can be targeted by selective androgen receptor modulators (SARMs) to inhibit tumor growth. SARMs have shown to activate AR program, repress MYC oncoprotein expression, and inhibit the growth of both castration-sensitive and castration-resistant prostate cancer. Further clinical investigation of SARMs for treating advanced prostate cancer is supported by these promising results.
JOURNAL OF CLINICAL INVESTIGATION
(2021)