Article
Medicine, General & Internal
Jin Yao, Zheyi Dong, Qian Wang, Zhe Li, Weiguang Zhang, Wenwen Lin, Yayong Luo, Hangtian Li, Xinru Guo, Li Zhang, Guangyan Cai, Wanjun Shen, Shuwei Duan, Xiangmei Chen
Summary: This study found that in patients with chronic kidney disease (CKD), factors such as female sex, age, smoking, mean arterial pressure (MAP), glomerular filtration rate (eGFR), cause of disease, ACEI/ARB, and glucocorticoid were associated with arterial stiffness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Environmental Sciences
Aleeta Maria Jolly, Jaya Thomas
Summary: This article reviews CKDu in India and compares it with that in Mesoamerica and Sri Lanka. Risk factors for CKDu vary by region, and it is important to categorize the CKDu population based on these factors to avoid misinterpretation and further complications. Further research is needed to reveal the detailed pathophysiological mechanisms and their relation to the irrational exploitation of environmental resources.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Environmental
Jake C. Ulrich, Kate Hoffman, T. D. K. S. C. Gunasekara, P. M. M. A. Sandamini, Brian P. Jackson, P. Mangala C. S. De Silva, Nishad Jayasundara, P. Lee Ferguson
Summary: Chronic kidney disease of uncertain etiology (CKDu) is a serious public health concern in farming communities, particularly in Sri Lanka. This study found that glyphosate, water hardness, and trace elements, including fluoride, in drinking water were associated with CKDu prevalence. The presence of elevated levels of glyphosate, fluoride, hardness, and vanadium in wells was positively correlated with CKDu incidence.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Multidisciplinary Sciences
Saba Alvand, Sudabeh Alatab, Sahar Dalvand, Fariba Shahraki-Sanavi, Mahmoud Ali Kaykhaei, Elham Shahraki, Erfaneh Barar, Sadaf G. Sepanlou, Alireza Ansari-Moghaddam
Summary: This study investigated the association between indoor pesticide use and chronic kidney disease (CKD) and found a positive correlation. The results highlight the need for further longitudinal studies to confirm these findings.
Article
Transplantation
Natasha J. McIntyre, Adam Shardlow, Richard J. Fluck, Christopher W. McIntyre, Maarten W. Taal
Summary: This study observed a clinically significant increase in PWV over 5 years in a cohort of elderly patients with early CKD, despite well-controlled hypertension. Blood pressure measurements were identified as the most important modifiable determinant of Delta PWV, suggesting interventions for preventing arterial disease should mainly focus on improving blood pressure control.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Chaojie Ye, Lijie Kong, Zhiyun Zhao, Mian Li, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Yuhong Chen, Yiping Xu, Weiqing Wang, Guang Ning, Yufang Bi, Min Xu, Tiange Wang
Summary: This study, using mendelian randomization analysis, found causal relations between obesity and chronic kidney disease (CKD) and arterial stiffness. The findings highlight the importance of weight management for the prevention and control of subclinical vascular diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Karolis Azukaitis, Marietta Kirchner, Anke Doyon, Mieczyslaw Litwin, Aysun Bayazit, Ali Duzova, Nur Canpolat, Augustina Jankauskiene, Rukshana Shroff, Anette Melk, Uwe Querfeld, Franz Schaefer
Summary: This study investigated the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression. The results showed that pulse wave velocity increased in children with CKD but did not associate with eGFR or CKD progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Josipa Radic, Ela Kolak, Marijana Vuckovic, Andrea Gelemanovic, Hana Dogas, Dora Bucan Nenadic, Mislav Radic
Summary: The aim of this study was to determine body fluid volume in patients with chronic kidney disease (CKD) and arterial hypertension (AH), and to investigate the relationship between fluid overload, nutritional status, and arterial stiffness. Data on various parameters were collected from 169 participants with CKD and AH. The results showed that factors such as diuretic and oral hypoglycemic agent use, sex, body mass index, and antihypertensive medication use influenced hydration status. Differences in blood pressure and arterial stiffness parameters were observed based on volume status and the presence of diabetes mellitus. These findings highlight the importance of considering volume status in the care of CKD patients with AH, especially those with diabetes mellitus.
Article
Environmental Sciences
Pavithra N. Kulasooriya, Kithsiri B. Jayasekara, Thilini Nisansala, Sajani Kannangara, Ranawaka Karunarathna, Chaminda Karunarathne, Mahinda Wikramarathne, Steven M. Albert
Summary: Heat stress symptoms and NGAL values were higher among agricultural workers in endemic CKDu regions in Sri Lanka, with higher correlations between NGAL and serum microalbumin in this group, suggesting a link between acute kidney injury and chronic kidney disease.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Physiology
Ravindra K. Sharma, Shyam H. Kamble, Suraj Krishnan, Joshua Gomes, Brandon To, Shiyu Li, I. -Chia Liu, Michelle L. Gumz, Rajesh Mohandas
Summary: Patients with chronic kidney disease (CKD) have an increased risk of adverse cardiovascular events. This study aimed to evaluate the role of increased LOX activity in inducing aortic stiffness in CKD and whether a LOX inhibitor could prevent aortic stiffness by reducing collagen cross linking. The results indicated that LOX might be an early and key mediator of aortic stiffness in CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Xinru Guo, Yisha Li, Ying Yang, Wenling Wang, Shuang Liang, Ying Zheng, Xiangmei Chen, Guangyan Cai
Summary: Our study revealed strong correlations between 24-hour pulse pressure, baPWV, and AIx@75, suggesting arterial stiffness as a potential target for delaying the decline in kidney function. The use of 24-hour pulse pressure as an arterial stiffness marker should be valued in clinical practice for chronic kidney disease.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
S. A. Gunawardena, M. Ranasinghe, T. Ranchamali, P. Dileka, J. W. Gunawardana
Summary: A study in Sri Lanka found that there is no high exposure risk to environmental cadmium contamination based on the analysis of cadmium bioaccumulation in kidneys of deceased individuals who underwent forensic autopsies in Colombo.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Pediatrics
Karolis Azukaitis, Augustina Jankauskiene, Franz Schaefer, Rukshana Shroff
Summary: Changes in arterial structure and function in the early stages of chronic kidney disease are linked to cardiovascular morbidity. Arterial stiffening, induced by various risk factors, can lead to increased risk of mortality, cardiovascular events, and cognitive decline. Assessing arterial stiffness in children with CKD presents technical challenges but is crucial for understanding the long-term cardiovascular implications.
PEDIATRIC NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
Chung-Jen Lee, Yi-Jen Hsieh, Yu-Li Lin, Chih-Hsien Wang, Bang-Gee Hsu, Jen-Pi Tsai
Summary: This study found that lower serum 25-hydroxyvitamin D levels and older age were associated with peripheral arterial stiffness in patients with stage 3-5 chronic kidney disease.
Article
Immunology
Dhanushka Dasanayake, Jacinta Bustamante, Stephanie Boisson-Dupuis, Chandima Karunatilleke, James Thambyrajah, Anne Puel, Koon Wing Chan, Rainer Doffinger, Yu-Lung Lau, Jean-Laurent Casanova, Dinakantha Kumararatne, Rajiva de Silva
Summary: This study evaluated inborn errors of immunity (IEI) diagnosed in Sri Lanka. Out of 206 patients, 84.9% had disease onset below 12 years and the male to female ratio was 1.78:1. Predominantly antibody deficiencies were the most common category, followed by combined immune deficiencies with syndromic features. The study also found high mortality rates in some IEI cases, indicating the need for transplant services.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muditha S. Bandara, Buddika Gurunayaka, Gamage Lakraj, Aruna Pallewatte, Sisira Siribaddana, Janaka Wansapura
Summary: This study utilized Radiomics features derived from ultrasound images to differentiate chronic kidney disease (CKD) and healthy kidneys, with wavelet transformed Gray Level Run Length Matrix identified as the most significant feature. The study demonstrated that Radiomics features based on wavelet transformation can successfully differentiate CKD and healthy kidneys based on ultrasound images.
ACADEMIC RADIOLOGY
(2022)
Article
Clinical Neurology
Helena M. S. Zavos, Patricia A. Zunszain, Kaushalya Jayaweera, Timothy R. Powell, Maria Chatzivasileiadou, Lisa Harber-Aschan, Anushka Adikari, Gayani Pannala, Sisira Siribaddana, Isabella Badini, Carmine M. Pariante, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk
Summary: This study examined the relationship between CRP levels and depression in a Sri Lankan population and found that CRP was significantly associated with BMI but not with depression. The variance in CRP levels was influenced by shared environment and non-shared environment in males, while it was influenced by genetic factors and non-shared environment in females. The lack of association between depression and CRP suggests that inflammation may play a role in the development of certain types of depression, and interventions to reduce CRP levels and inflammation risk may be particularly effective in males.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Panagiota Triantafyllou, Zeynep Nas, Helena M. S. Zavos, Athula Sumathipala, Kaushalya Jayaweera, Sisira H. Siribaddana, Matthew Hotopf, Stuart J. Ritchie, Fruhling Rijsdijk
Summary: This study explored the relationship between depressive symptoms and health-related quality of life (HRQL) in a low-middle-income Sri Lankan population, as well as possible sex differences. The results showed a negative association between depressive symptoms and HRQL, with the correlation mostly explained by overlapping nonshared environmental effects. The study highlights the importance of cross-cultural research in understanding the association between psychological well-being and HRQL.
Article
Multidisciplinary Sciences
Suneth Agampodi, Janith Warnasekara, Sisira Siribaddana, S. A. M. Kularatna, Chandika Gamage, Dinesha Jayasundara, Indika Senevirathna, Shalka Srimantha, Chamila Kappagoda, Prasanna Weerawansa, Senaka Pilapitiya, Niroshan Lokunarangoda, Chamara Sarathchandra, Hemal Senanayake, Michael Matthias, Joseph Vinetz
Summary: This dataset includes data from febrile patients recruited for a large hospital-based study in Sri Lanka from 2016 to 2019. The variables include primary socio-demographic data, exposure data, clinical data, biochemical and investigation data. Patients with leptospirosis were diagnosed through a series of tests.
Article
Public, Environmental & Occupational Health
R. Senarathne, U. Hettiaratchi, L. Athiththan, H. Peiris, C. Sarathchandra, H. Senanayake, P. Weerawansa, S. Siribaddana
Summary: This study aimed to assess the severity of acute OP and carbamate poisoning by measuring liver transaminases and bilirubin levels. The results showed that liver transaminases were significantly correlated with the severity of poisoning, and treatment outcomes were also associated with the severity of poisoning and liver function.
JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
(2022)
Article
Toxicology
Supun Wedasingha, Anjana Silva, Sisira Siribaddana, Kanishka Seneviratne, Geoffrey K. Isbister
Summary: This study investigated the diagnostic accuracy of whole blood clotting test and capillary blood clotting test for detecting VICC in viper envenoming in Sri Lanka. WBCT-15 had the best sensitivity for detecting VICC and complete VICC, while CBCT-t had an excellent sensitivity for detecting VICC but poor specificity. The study found higher sensitivity in detecting VICC in Russell's viper bites.
CLINICAL TOXICOLOGY
(2022)
Article
Infectious Diseases
Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K. Isbister
Summary: The study aimed to describe the long-term health effects perceived by snakebite patients after confirmed snakebites. Based on two groups of patients reviewed one and four years post-bite, the research found that long-term musculoskeletal disabilities are uncommon and not severe in snakebite survivors in rural Sri Lanka. However, a large portion of patients complain of various non-specific general and oral symptoms, not explainable based on the known pathophysiology of snakebite.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Toxicology
Subodha Waiddyanatha, Anjana Silva, Kosala Weerakoon, Sisira Siribaddana, Geoffrey K. Isbister
Summary: There is no significant association between snakebite-associated acute kidney injury (AKI) and chronic kidney disease (CKD) in rural Sri Lankan snakebite patients. However, microalbuminuria is common and it is likely associated with hypertension, diabetes mellitus, and chronic interstitial nephritis in this population.
CLINICAL TOXICOLOGY
(2023)
Article
Economics
Nathan Kettlewell, Fruhling Rijsdijk, Sisira Siribaddana, Athula Sumathipala, Agnieszka Tymula, Helena Zavos, Nicholas Glozier
Summary: We use a unique survey of Sri Lankan twins to estimate the impact of traumatic events on risk preferences. The survey includes information on individual's exposure to the 2004 Indian Ocean Tsunami, validated measures of mental health and risk preferences, and a rich set of control variables. Our findings suggest that exposure to the tsunami leads to decreased risk aversion, and this effect is not explained by changes in mental health.
Article
Environmental Sciences
T. D. K. S. C. Gunasekara, P. Mangala C. S. De Silva, E. P. S. Chandana, Sudheera Jayasinghe, Chula Herath, Sisira Siribaddana, Nishad Jayasundara
Summary: Prolonged heat exposure during outdoor physical exertion may have negative effects on renal health, but its association with chronic kidney disease in tropical regions is uncertain. This study investigated the likelihood of pediatric renal injury in Sri Lankan school students in dry climatic zones with high prevalence of CKDu, and found no strong evidence for an association between heat exposure and renal injury.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Melissa Pearson, Andrew Dawson, Jacques Raubenheimer, Lalith Senerathna, Katherine Conigrave, K. S. Kylie Lee, Thilini Rajapakse, Pahala Hangidi Gedara Janaka Pushpakumara, Sisira Siribaddana, Jane Brandt Soerensen, Flemming Konradsen, Stephen Jan, Angela J. Dawson, Nicholas Buckley, Ranil Abeysinghe, Prabash Siriwardhana, Chamil Priyadarshana, Paul S. Haber, Monika Dzidowska, Palitha Abeykoon, Nick Glozier
Summary: This article describes a complex alcohol intervention program in Sri Lanka and the modifications made due to COVID-19. The study faced disruptions from various events and was adapted with hybrid delivery and a rolling pre-post study design. The aim of the research is to evaluate the effects of the intervention on alcohol use, mental health, social capital, and financial stress. The modifications have received ethical approval and will be disseminated in collaboration with the community and stakeholders.
Article
Toxicology
Subodha Waiddyanatha, Anjana Silva, Supun Wedasingha, Sisira Siribaddana, Geoffrey K. Isbister
Summary: This study aimed to assess the frequency of serum sickness following the administration of Indian polyvalent antivenom in Sri Lanka. The results showed that only a small proportion of patients developed serum sickness, in contrast to other antivenom studies.
CLINICAL TOXICOLOGY
(2023)
Article
Pediatrics
T. D. K. S. C. Gunasekara, P. Mangala C. S. De Silva, E. P. S. Chandana, Sudheera Jayasinghe, Chula Herath, Sisira Siribaddana, Nishad Jayasundara
Summary: This study evaluated the association between body mass index (BMI) and kidney health in Sri Lankan students. The results showed that there is no clear association between BMI and kidney function, but severely malnourished girls may have abnormal kidney health outcomes.
PEDIATRIC NEPHROLOGY
(2023)
Article
Pediatrics
T. D. K. S. C. Gunasekara, P. Mangala C. S. De Silva, E. P. S. Chandana, Sudheera Jayasinghe, Chula Herath, Sisira Siribaddana, Nishad Jayasundara
Summary: This study investigated the association between fluoride exposure and pediatric kidney health in different regions of Sri Lanka with varying fluoride levels. The results showed significantly high fluoride levels in CKDu-endemic dry zones, but a strong link between fluoride exposure and kidney health was not clearly evident based on the observed exposure levels and kidney injury biomarkers.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Sisira Siribaddana, Arjuna Medagama, Nadeesha Wickramasinghe, Nipuna M. Siribaddana, Suneth Agampodi, Devaka Fernando
Summary: This study investigated the effect of a KH biscuit, made from Salacia reticulata plant extracts, on glycemic control in patients with type 2 diabetes. The results showed that the KH biscuit, taken as a snack, reduced HbA1c levels compared to placebo without adverse effects on the kidneys or liver. It can be safely recommended as a snack for patients with type 2 diabetes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)