Article
Medicine, General & Internal
Qiannan Chai, Yimin Yao, Congrong Guo, Hong Lu, Jingxue Ma
Summary: This study aimed to analyze changes in the structure and function of the fundus in diabetic patients without diabetic retinopathy (NDR). The results showed that diabetic patients in the early stages of the disease already exhibit decreased retinal sensitivity and changes in vessel density and perfusion density. This suggests that the structure and function of the retina in diabetic patients can change even before the onset of diabetic retinopathy.
ANNALS OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mitsuru Arima, Shintaro Nakao, Yoshihiro Kaizu, Iori Wada, Muneo Yamaguchi, Kohta Fujiwara, Masato Akiyama, Alan W. Stitt, Koh-Hei Sonoda
Summary: Our study found that vascular permeability influences vascular flow density (FD)-correlated retinal sensitivity (RS) in diabetic retinopathy, suggesting that vascular hyperpermeability may inhibit RS reduction in the non-edematous ischemic diabetic retina.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Alvaro Santos-Ortega, Carmen Alba-Linero, Facundo Urbinati, Carlos Rocha-de-Lossada, Rafael Orti, Jose Antonio Reyes-Bueno, Francisco Javier Garzon-Maldonado, Vicente Serrano, Carmen de Rojas-Leal, Carlos de la Cruz-Cosme, Manuela Espana-Contreras, Marina Rodriguez-Calvo-de-Mora, Natalia Garcia-Casares
Summary: This study analyzed retinal changes in patients with mild cognitive impairment (MCI) using optical coherence tomography angiography (OCT-A) and found that diabetes may exacerbate retinal vascular changes when combined with MCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Dhanashree Ratra, Rajesh Nagarajan, Daleena Dalan, Nandini Prakash, Kaviarasan Kuppan, Sadagopan Thanikachalam, Undurti Das, Angayarkanni Narayansamy
Summary: The study found that prediabetic individuals exhibit early changes in neuronal function in the retina, preceding structural and vascular changes. Central foveal thickness and subfoveal choroidal thickness were significantly reduced in prediabetics.
Article
Ophthalmology
Matteo Menean, Riccardo Sacconi, Beatrice Tombolini, Federico Fantaguzzi, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to detect retinal neovascularization elsewhere (NVE), of the optic disc (NVD) and intraretinal microvascular abnormalities (IRMA) in treatment naive diabetic retinopathy (DR) using wide-field colour fundus photography (WF CFP), wide-field spectral-domain optical coherence tomography angiography (OCTA) and the combination of WF CFP and OCTA through overlay software. The results showed that OCTA had high levels of agreement in detecting NVE, NVD and IRMA, and combining WF CFP and OCTA further improved the detection of NVE and NVD.
Article
Medicine, General & Internal
Marie Elise Wistrup Torm, Birgit Sander, Mads Hornum, Paul Krohn, Henrik Birn, Michael Larsen
Summary: This study analyzed the characteristics and perfusion status of hyperreflective dots using OCT scans and developed a method to differentiate between perfused and occluded capillaries. It has the potential to non-invasively identify capillary non-perfusion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Andrew S. H. Tsai, Janice Marie Jordan-Yu, Alfred T. L. Gan, Kelvin Y. C. Teo, Gavin S. W. Tan, Shu Yen Lee, Victor Chong, Chui Ming Gemmy Cheung
Summary: This study found that changes in parafoveal microvasculature over one year in diabetic patients can be detected using OCTA. A larger baseline foveal avascular zone area in the deep vascular plexus predicted worsening visual outcomes, while larger decreases in superficial vascular plexus vessel density were associated with worsening retinal sensitivity over the course of one year.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Aldo Vagge, Paolo Corazza, Lorenzo Ferro Desideri, Paola Camicione, Giulia Agosto, Roberta Vagge, Calevo Maria Grazia, Adriano Carnevali, Giuseppe Giannaccare, Massimo Nicolo, Carlo Enrico Traverso
Summary: Patients with NF1 exhibit lower macular RNFL and retinal thickness, along with higher vascular flow area in the SCP. Compared to control subjects, the flow area in the second choroidal layer is also lower in NF1 patients. OCTA is a potentially valuable tool for detecting early ocular abnormalities in NF1.
Article
Multidisciplinary Sciences
Dulce Milagros Razo Blanco-Hernandez, Selma Alin Somilleda-Ventura, Rebeca Chavez-Herrera, Maria Guadalupe Colas-Calvere, Virgilio Lima-Gomez
Summary: This study found that vessel and perfusion densities may decrease before the appearance of diabetic retinopathy, and larger retinal vessels may contribute more to perfusion density in patients without retinopathy.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Valentin Hacker, Gregor Sebastian Reiter, Markus Schranz, Reinhard Told, Adrian Reumueller, Dominik Hofer, Irene Steiner, Ursula Schmidt-Erfurth, Stefan Sacu
Summary: This study found that large choroidal vessels (LCV) have a significant impact on the Choriocapillaris (CC) flow deficit (FD) analyses of swept-source optical coherence tomography angiography (SS-OCTA) images, with their visibility negatively associated with choroidal thickness (CT). In patients with intermediate age-related macular degeneration, areas containing LCV showed significantly lower FD%.
Article
Immunology
Yanlin Lang, William Robert Kwapong, Lingyao Kong, Ziyan Shi, Xiaofei Wang, Qin Du, Bo Wu, Hongyu Zhou
Summary: Optical coherence tomography (OCT)/OCT angiography (OCTA) measures were compared between patients with neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD), showing distinct structural and microvascular changes, indicating different pathological mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Philipp Matten, Julius Scherer, Thomas Schlegl, Jonas Nienhaus, Heiko Stino, Michael Niederleithner, Ursula M. Schmidt-Erfurth, Rainer A. Leitgeb, Wolfgang Drexler, Andreas Pollreisz, Tilman Schmoll
Summary: Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults with diabetes mellitus, and optical coherence tomography angiography (OCTA) has shown potential as a tool for early diagnosis. We propose a multiple instance learning-based network, MIL-ResNet, capable of detecting biomarkers in OCTA images with high accuracy without pixel-level annotations. Our method outperforms previous state-of-the-art networks and is robust against adversarial attacks, making it a powerful diagnostic decision support tool for clinical ophthalmic screening.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Nikitha Gurram Reddy, Ram Snehith, Jophy Philip Cherry, Arpitha Pereira, Akhila Sridharan, B. Poornachandra, Rohit Shetty, Naresh Kumar Yadav, Jay Chhablani
Summary: The study aimed to assess the structural-functional relationship in choroideremia (CHM) patients using optical coherence tomography (OCT) and autofluorescence (AF) images. RPE thinning was found to contribute to poor visual acuity in patients with advanced CHM. Further studies are needed to evaluate the role of retinal thickness and SFCT in relation to visual acuity.
Article
Medicine, General & Internal
Huiping Yao, Zijian Yang, Yu Cheng, Xi Shen
Summary: This study investigated the changes in macular status and choroidal thickness following phacoemulsification in patients with mild to moderate nonproliferative diabetic retinopathy. The results showed that the increase in SCP-VD, MT, and CT after surgery was significantly greater in diabetic retinopathy patients compared to the control group.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Tian Huang, Xiaoli Li, Jie Xie, Liang Zhang, Guanrong Zhang, Aiping Zhang, Xiangting Chen, Ying Cui, Qianli Meng
Summary: The study assessed long-term retinal microvascular, neural, and choroidal changes following panretinal photocoagulation in patients with severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy. The findings showed no significant differences in visual acuity, vessel density, and choroidal thickness post-PRP, but indicated increased macular thickness and changes in RNFL and GCC thickness. The results suggest that PRP may help prevent retinal neurovascular and choroidal damage in diabetic retinopathy patients.
FRONTIERS IN MEDICINE
(2021)