Feeding critically ill patients the right ‘whey’: thinking outside of the box. A personal view

Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial

(2014) Eric J Charles et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A high whey protein–, leucine-, and vitamin D–enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial

(2014) Amely M Verreijen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit–acquired Weakness in Adults

(2014) Eddy Fan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans

(2014) Sharmila C. Subaran et al.   CLINICAL SCIENCE

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness

(2014) Tobias Wollersheim et al.   INTENSIVE CARE MEDICINE

A Dose- rather than Delivery Profile–Dependent Mechanism Regulates the “Muscle-Full” Effect in Response to Oral Essential Amino Acid Intake in Young Men

(2014) William Kyle Mitchell et al.   JOURNAL OF NUTRITION

ICU-Acquired Weakness and Recovery from Critical Illness

(2014) John P. Kress et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise

(2013) Oliver C Witard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Physical and Cognitive Performance of Patients with Acute Lung Injury 1 Year after Initial Trophic versus Full Enteral Feeding. EDEN Trial Follow-up

(2013) Dale M. Needham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Physical Therapy for the Critically Ill in the ICU

(2013) Geetha Kayambu et al.   CRITICAL CARE MEDICINE

Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol in Critically Ill Patients

(2013) Daren K. Heyland et al.   CRITICAL CARE MEDICINE

Incretin actions beyond the pancreas: lessons from knockout mice

(2013) Daisuke Yabe et al.   CURRENT OPINION IN PHARMACOLOGY

Muscle Injury During Critical Illness

(2013) Jane Batt et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Acute Skeletal Muscle Wasting in Critical Illness

(2013) Zudin A. Puthucheary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly

(2013) Leigh Breen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Is There an Optimal Time for Warfighters to Supplement with Protein?

(2013) Philip James Atherton   JOURNAL OF NUTRITION

One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial

(2013) D. M. Needham et al.   BMJ-British Medical Journal

Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial

(2012) Michael P. Casaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Update on incretin hormones

(2012) Liza K. Phillips et al.   Annals of the New York Academy of Sciences

Hypoxia, MTOR and autophagy

(2012) Mikhail V. Blagosklonny   Autophagy

Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men

(2012) Yifan Yang et al.   BRITISH JOURNAL OF NUTRITION

Greater stimulation of myofibrillar protein synthesis with ingestion of whey protein isolate v. micellar casein at rest and after resistance exercise in elderly men

(2012) Nicholas A. Burd et al.   BRITISH JOURNAL OF NUTRITION

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide-Dependent Mechanism

(2012) W. Chai et al.   DIABETES

Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial

(2012) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes

(2012) Daniela Jakubowicz et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Continuous Parenteral and Enteral Nutrition Induces Metabolic Dysfunction in Neonatal Pigs

(2012) Barbara Stoll et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Sparing of muscle mass and function by passive loading in an experimental intensive care unit model

(2012) Guillaume Renaud et al.   JOURNAL OF PHYSIOLOGY-LONDON

Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial

(2011) Y. M. Arabi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise

(2011) D. W. West et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men

(2011) Bart Pennings et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women

(2011) Gordon I. Smith et al.   CLINICAL SCIENCE

Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis

(2011) Maria Klaude et al.   CLINICAL SCIENCE

Regulation of muscle protein synthesis in humans

(2011) Bethan E. Phillips et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Intermittent Bolus Feeding Has a Greater Stimulatory Effect on Protein Synthesis in Skeletal Muscle Than Continuous Feeding in Neonatal Pigs

(2011) María C. Gazzaneo et al.   JOURNAL OF NUTRITION

Mammalian Target of Rapamycin Complex 1 Activation Is Required for the Stimulation of Human Skeletal Muscle Protein Synthesis by Essential Amino Acids

(2011) Jared M. Dickinson et al.   JOURNAL OF NUTRITION

Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms

(2011) Julien Ochala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Novel events in the molecular regulation of muscle mass in critically ill patients

(2011) Despina Constantin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Early versus Late Parenteral Nutrition in Critically Ill Adults

(2011) Michael P. Casaer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

(2010) Philip J Atherton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial

(2010) Gordon I Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

(2010) Sanford Levine et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute Acalculous Cholecystitis

(2010) Philip S. Barie et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism

(2010) Ira J. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling

(2010) Kyle L. Timmerman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Carbohydrate Does Not Augment Exercise-Induced Protein Accretion versus Protein Alone

(2010) AARON W. STAPLES et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Early intensive care unit mobility therapy in the treatment of acute respiratory failure*

(2009) Peter E. Morris et al.   CRITICAL CARE MEDICINE

Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men

(2009) Jason E. Tang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Feeding Rapidly Stimulates Protein Synthesis in Skeletal Muscle of Neonatal Pigs by Enhancing Translation Initiation

(2009) Fiona A. Wilson et al.   JOURNAL OF NUTRITION

The Leucine Content of a Complete Meal Directs Peak Activation but Not Duration of Skeletal Muscle Protein Synthesis and Mammalian Target of Rapamycin Signaling in Rats

(2009) Layne E. Norton et al.   JOURNAL OF NUTRITION

Presence of low-grade inflammation impaired postprandial stimulation of muscle protein synthesis in old rats

(2009) Michèle Balage et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient:

(2009) Stephen A. McClave et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Whey Protein Ingestion Activates mTOR-dependent Signalling after Resistance Exercise in Young Men: A Double-Blinded Randomized Controlled Trial

(2009) Michelle Farnfield et al.   Nutrients

Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men

(2008) Daniel R Moore et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs

(2008) Agus Suryawan et al.   AMINO ACIDS

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

(2008) Elisa I. Glover et al.   JOURNAL OF PHYSIOLOGY-LONDON

Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men

(2008) Vinod Kumar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content

(2008) Christos S. Katsanos et al.   NUTRITION RESEARCH