Article
Multidisciplinary Sciences
Mengya He, Limin Yue, Haiyan Wang, Feiyan Yu, Mingyang Yu, Peng Ni, Ke Zhang, Shuaiyin Chen, Guangcai Duan, Rongguang Zhang
Summary: CBX1/2/3/4/5 were upregulated and CBX7 was downregulated in gastric cancer tissues. High mRNA expression levels of CBX3/8 were associated with prolonged overall survival in GC patients.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
He-Wei Zhang, Ying Guo, Lin-xiao Sun, Fu-biao Ni, Ke Xu
Summary: The study found that high expression of three members of SMADs (SMAD1, SMAD2, SMAD4) is associated with favorable overall survival of gastric cancer patients, while the expression level of SMAD3 indicates highly differentiated cancer. Surgical treatment is associated with high expression levels of SMAD1 and SMAD2, and the effect of Her2 on gastric cancer is not significant. Furthermore, inhibition of SMAD3 expression suppressed the proliferation and migration ability of gastric cancer cells through inducing apoptosis.
Article
Multidisciplinary Sciences
Peipei Wang, Ying Zhu, Xinru Jia, Xiangchang Ying, Leitao Sun, Shanming Ruan
Summary: This study investigated the promoting effect of OSGIN2 on gastric cancer through databases and in vitro experiments. The relationship between OSGIN2 expression, prognosis, functional enrichment of differential genes, immune infiltration, and mutational information in gastric cancer was comprehensively analyzed. Knockdown of OSGIN2 inhibited tumor cell proliferation and affected the immune function. OSING2 is a potential biomarker and target for gastric cancer treatment.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Dexin Chen, Meiting Fu, Liangjie Chi, Liyan Lin, Jiaxin Cheng, Weisong Xue, Chenyan Long, Wei Jiang, Xiaoyu Dong, Jian Sui, Dajia Lin, Jianping Lu, Shuangmu Zhuo, Side Liu, Guoxin Li, Gang Chen, Jun Yan
Summary: In this study, a pathomics signature (PSGC) derived from multiple features of haematoxylin and eosin-stained slides is proposed as an independent predictor of prognosis for gastric cancer patients. The PSGC, when combined with the TNM staging system, significantly improves the accuracy of predicting prognosis. Additionally, satisfactory chemotherapy benefits are observed in patients with a low PSGC, suggesting its potential usefulness as a predictive indicator for decision-making regarding adjuvant chemotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Chengcheng Hao, Yuxin Cui, Jane Lane, Shuqin Jia, Jiafu Ji, Wen G. Jiang
Summary: The study found that osteopontin (OPN) splice variants have distinct prognostic value in gastric cancer and exhibit unique functions in gastric cancer cells. Specifically, high levels of OPN-a and OPN-b were associated with short overall survival and disease-free survival in gastric cancer patients, while low expression of OPN-c was linked to poor prognosis.
Article
Surgery
Ho-Jung Shin, Chul-Kyu Roh, Sang-Yong Son, Hur Hoon, Sang-Uk Han
Summary: Low serum total cholesterol is associated with higher postoperative complication rate in gastric cancer patients, and decreasing total cholesterol is linked to poor prognosis. Therefore, preoperative total cholesterol can serve as a predictor for postoperative survival and complications in gastric cancer patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Junya Ning, Min Liu, Jing Shen, Deping Wang, Lijuan Gao, Huiyu Li, Jimin Cao
Summary: In this study, it was found that the expression levels of the CREC family were elevated in CRC tissues, and they were significantly correlated with advanced tumor stage and poor prognosis of CRC patients. The genes of the CREC family were also found to be associated with CRC metastasis and the infiltration of immune cells in the tumor microenvironment.
Article
Genetics & Heredity
Jiao Li, Shan Tian, Yingyun Guo, Weiguo Dong
Summary: AMAP1 mRNA and protein levels were found to be upregulated in gastric cancer specimens compared to normal tissues. High AMAP1 mRNA abundance was associated with poor overall survival and reduced progression-free survival in patients with gastric cancer. AMAP1 was negatively correlated with miR-192-3p and acted as a novel oncogene in gastric cancer, serving as a potential diagnostic and prognostic marker.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Li Chen, Ruihu Zhao, Hao Sun, Rong Huang, Hongming Pan, Yanjiao Zuo, Lele Zhang, Yingwei Xue, Xingrui Li, Hongjiang Song
Summary: This study aimed to investigate the prognostic value of the gastric immune prognostic index (GIPI) in gastric cancer patients treated with PD-1/PD-L1 inhibitors. The results showed that patients with GIPI intermediate/poor had shorter progression-free survival (PFS) and overall survival (OS) compared to those with GIPI good, especially in subgroups of patients receiving immune checkpoint inhibitor (ICI) treatment and patients with PD-1/PD-L1 positive status. Therefore, GIPI may be useful for identifying gastric cancer patients who are unlikely to benefit from PD-1/PD-L1 inhibitor treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ningxin Dong, Xiaolong Ma, Jing Shen, Yunlu Zheng, Guiyuan Li, Shaoqiang Zheng, Xiaoyi Huang
Summary: A four-gene prognostic model was constructed to stratify GC patients into different prognosis score groups, with high-prognosis score groups showing significantly poorer survival rates. MYL9 was found to be associated with migration and metastasis of GC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ping Wang, Yulan Gu, Jianke Yang, Jiamin Qiu, Yeqiong Xu, Zengxiang Xu, Jiguang Gao, Chuandan Wan
Summary: Inflammasomes play an important role in the development of gastric cancer and immune regulation. Elevated expression of NLRP1/NLRP3 is associated with poor prognosis and immune cell infiltration in gastric cancer. NLRP1 and NLRP3 may participate in the same immune-related pathways.
Article
Medicine, General & Internal
Sung Gon Kim, Bang Wool Eom, Hongman Yoon, Young-Woo Kim, Keun Won Ryu
Summary: This study evaluated the association between preoperative systemic inflammatory parameters and overall survival in patients with advanced gastric cancer. The results showed that the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were independent prognostic factors for overall survival in patients with advanced gastric cancer. Additionally, an elevated lymphocyte count was the only factor associated with a favorable prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Qing-Tai Dong, Dan-Dan Ma, Qi Gong, Zhen-Yu Lin, Zhong-Hu Li, Jia-Xin Ye, Chun-Hui Qin, Wei-Dong Jin, Jian-Xin Zhang, Zhi-Yong Zhang
Summary: FAM3 family genes show significant differential expression in multiple cancers and are closely associated with RNAss, immune subtype, tumor immune microenvironment, and drug sensitivity. In particular, high expression of FAM3C is associated with the malignancy of pancreatic cancer.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Xin-qiang Liang, Ke-zhi Li, Zhao Li, Ming-zhi Xie, Yan-pin Tang, Jiang-biao Du, Yi Huang, Ji-lin Li, Bang-li Hu
Summary: The study revealed that plasma Hsp90 alpha levels were significantly elevated in gastric cancer patients, correlated with tumor biomarkers and immune cells, but had no predictive value for patient survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)