Restoring Mitochondrial Function: A Small Molecule-mediated Approach to Enhance Glucose Stimulated Insulin Secretion in Cholesterol Accumulated Pancreatic beta cells

3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol

(2015) Catalina Carrasco-Pozo et al.   EXPERIMENTAL CELL RESEARCH

Relationship Between Insulin Resistance and β-Cell Dysfunction in Subphenotypes of Prediabetes and Type 2 Diabetes

(2015) Kristine Færch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypercholesterolemic diet induces hepatic steatosis and alterations in mRNA expression of NADPH oxidase in rat livers

(2014) Isabel Cristina Mallosto Emerich de Abreu et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke

(2014) Alex Dregan et al.   CIRCULATION

Myokines in insulin resistance and type 2 diabetes

(2014) Kristin Eckardt et al.   DIABETOLOGIA

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

(2014) David J. Hodson et al.   MOLECULAR ENDOCRINOLOGY

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells

(2013) Ramya S. Kuna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

(2012) Danling Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

(2012) Jakob D. Wikstrom et al.   PLoS One

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway

(2011) Xiuli Lu et al.   CELL STRESS & CHAPERONES

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

(2011) J. K. Kruit et al.   DIABETES

Effect of exposure to non-esterified fatty acid on progressive deterioration of insulin secretion in patients with Type 2 diabetes: a long-term follow-up study

(2011) S. Morita et al.   DIABETIC MEDICINE

Palmitoylated TMX and calnexin target to the mitochondria-associated membrane

(2011) Emily M Lynes et al.   EMBO JOURNAL

Mitochondrial Cholesterol: A Connection Between Caveolin, Metabolism, and Disease

(2011) Marta Bosch et al.   TRAFFIC

Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes

(2010) Wei Yu et al.   BMC Medical Informatics and Decision Making

An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells

(2010) Jeffrey M. Sturek et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased HDL Cholesterol and ApoA-I in Humans and Mice Treated With a Novel SR-BI Inhibitor

(2009) David Masson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

(2009) Nigel Irwin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological Characterization of Human Incretin Receptor Missense Variants

(2009) J.-P. Fortin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: The role of Ras

(2009) Olga Martins de Brito et al.   MITOCHONDRION

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY