Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9

Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype

(2016) Joana Capote et al.   JOURNAL OF CELL BIOLOGY

Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis–like disease

(2016) Elaheh Ekhtiari Bidhendi et al.   JOURNAL OF CLINICAL INVESTIGATION

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

(2015) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

(2015) Xin Duan et al.   NEURON

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS

(2015) L. Comley et al.   NEUROSCIENCE

Novel Roles for Osteopontin and Clusterin in Peripheral Motor and Sensory Axon Regeneration

(2014) M. C. Wright et al.   JOURNAL OF NEUROSCIENCE

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

(2014) Artem Kaplan et al.   NEURON

Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy

(2014) Constanza J. Cortes et al.   NEURON

Selective degeneration of a physiological subtype of spinal motor neuron in mice with SOD1-linked ALS

(2014) Muhamed Hadzipasic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

(2014) Florian Kahles et al.   Molecular Metabolism

α-Synuclein coaggregation in familial amyotrophic lateral sclerosis with SOD1 gene mutation

(2013) Yo-ichi Takei et al.   HUMAN PATHOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival

(2013) Smita Saxena et al.   NEURON

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

(2013) Mariana C. Rocha et al.   PLoS One

Marked intrafamilial phenotypic variation in a family with SOD1 C111Y mutation

(2012) Akinori Nakamura et al.   Amyotrophic Lateral Sclerosis

Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles

(2012) Gregorio Valdez et al.   PLoS One

Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic

(2012) Nils von Neuhoff et al.   PLoS One

GDNF-induced osteopontin from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration

(2011) Patricia Del Río et al.   GLIA

Osteopontin-Stimulated Expression of Matrix Metalloproteinase-9 Causes Cardiomyopathy in the mdx Model of Duchenne Muscular Dystrophy

(2011) S. Dahiya et al.   JOURNAL OF IMMUNOLOGY

Osteopontin is an alpha motor neuron marker in the mouse spinal cord

(2011) Hidemi Misawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases

(2011) Toshimitsu Uede   PATHOLOGY INTERNATIONAL

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells

(2010) Hao Liu et al.   CANCER LETTERS

Osteopontin: An Effector and an Effect of Tumor Metastasis

(2010) L. Shevde et al.   CURRENT MOLECULAR MEDICINE

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

(2010) J. V. Chakkalakal et al.   DEVELOPMENT

Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells

(2010) Anders Enjin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

(2010) Melissa Lazar et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Osteopontin Enhances Phagocytosis through a Novel Osteopontin Receptor, the  X 2 Integrin

(2009) L. Schack et al.   JOURNAL OF IMMUNOLOGY

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival

(2009) Neil A Shneider et al.   Neural Development

Gamma and alpha motor neurons distinguished by expression of transcription factor Err3

(2009) A. Friese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Osteopontin functions as an opsonin and facilitates phagocytosis by macrophages of hydroxyapatite-coated microspheres: Implications for bone wound healing

(2008) Claudio E. Pedraza et al.   BONE

Preferential motor unit loss in the SOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis

(2008) J. Hegedus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY