Article
Medicine, Research & Experimental
Hanju Yoo, Ha-Ri Lee, Ki-Hyun Kim, Min-Ah Kim, Seunghyun Bang, Young-Ho Kang, Woo-hyung Kim, Youngsup Song, Sung Eun Chang
Summary: CRTC3 plays a crucial role in melanogenesis by directly targeting MITF and regulating the expression of most key melanogenesis-related genes. The absence of CRTC3 results in a reduction in melanin deposition, while its introduction can increase epidermal melanocytes. Additionally, altiratinib shows potential as a therapeutic agent for inhibiting melanogenesis effectively and safely.
Article
Plant Sciences
Jianzeng Liu, Xiaohao Xu, Jingyuan Zhou, Guang Sun, Zhenzhuo Li, Lu Zhai, Jing Wang, Rui Ma, Daqing Zhao, Rui Jiang, Liwei Sun
Summary: This study investigated the regulatory effects of phenolic acid monomers from Panax ginseng Meyer on melanin production. It found that SA, PA, p-CA, and VA inhibited melanin production, while CA had the opposite effects. Furthermore, the phenolic acid monomers reduced the expression of melanin synthesis-related proteins through multiple signaling pathways and affected MITF protein levels through phosphorylation and post-translational modification processes.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kyu-Ree In, Mi Ae Kang, Su Dong Kim, Jinho Shin, Sung Un Kang, Tae Jun Park, Seung-Joo Kim, Jong-Soo Lee
Summary: This study demonstrates that anhydrous alum can inhibit melanin synthesis by downregulating the expression of MITF. The mechanism of action of anhydrous alum involves attenuating phosphorylation of the co-activator of MITF gene transcription, cAMP response element-binding protein, and promoting phosphorylation of extracellular signal-regulated kinase to impair the nuclear localization of MITF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Feifei Yu, Zexin Du, Zhiming Zhong, Xiangyong Yu, Jiayu Chen, Yishan Lu, Jinji Lin
Summary: This study identified the role of PpCreb2 in melanogenesis and innate immunity in P. penguin. It was found that PpCreb2 played an important role in melanin production and immune response. The regulatory mechanism of PpCreb2 in innate immunity was also analyzed.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Jing-Hua Wang, Seung-Ju Hwang, Sam-Keun Lee, Yujin Choi, Chang Kyu Byun, Chang-Gue Son
Summary: CAFB has been found to inhibit UVB-induced skin hyperpigmentation and decrease melanin production. The mechanism of action involves the modulation of tyrosinase activity through the regulation of the cAMP cascade and MITF pathway, suggesting its potential for treating skin disorders caused by overproduction of melanin.
Article
Biochemistry & Molecular Biology
Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Jiho Yang, Hyunjung Lee, Chang-Suk Kong
Summary: The current study investigated the anti-melanogenic effect of Quercetin 3-O-galactoside (Q3G) and revealed its underlying mechanism of action in B16F10 melanoma cells. Q3G treatment downregulated melanogenesis-related enzymes and transcription factor MITF, inhibited cAMP/PKA and MAPK signaling pathways, and reduced melanin production. These findings suggest that Q3G has potential as a cosmetic ingredient for treating hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ji Hye Yoon, Won Young Jang, Sang Hee Park, Han Gyung Kim, Youn Young Shim, Martin J. T. Reaney, Jae Youl Cho
Summary: This study investigated the inhibitory effects of cyclic peptides Linosorbs (Los) from flaxseed oil on melanogenesis, and found that LOMIX and LO could suppress melanin synthesis by downregulating the CREB-dependent signaling pathways, suggesting their potential application in treating hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Siang-Jyun Chen, You-Cheng Hseu, Yugandhar Vudhya Gowrisankar, Yi-Ting Chung, Yan-Zhen Zhang, Tzong-Der Way, Hsin-Ling Yang
Summary: 3-O-ethyl ascorbic acid exhibits anti-melanogenic activity through a variety of mechanisms, including inhibition of melanin synthesis, antioxidative effects, and promotion of autophagy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hyungyeong Choi, Jeong-Hyun Yoon, Kumju Youn, Mira Jun
Summary: This study investigated the anti-melanogenic effects of decursin and its underlying mechanism. Decursin was found to inhibit melanin synthesis and exert its effects through the regulation of MITF and multiple signaling pathways. The anti-melanogenic effects of decursin were confirmed in ex vivo 3D human skin models, suggesting its potential as a protective agent against hyperpigmentation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Silvia Yunmam, Hae Ran Lee, Seong Min Hong, Ji-Young Kim, Tong Ho Kang, Ai Young Lee, Dae Sik Jang, Sun Yeou Kim
Summary: This study demonstrates that Aspacochioside C (ACC) inhibits melanogenesis by targeting the TRP2 protein, reducing eumelanin production in cells and zebrafish embryos. ACC could be potentially used as an anti-melanogenic agent in both aesthetic and pharmaceutical applications.
SCIENTIFIC REPORTS
(2023)
Article
Developmental Biology
Ravi Das, Shatabdi Bhattacharjee, Jamin M. Letcher, Jenna M. Harris, Sumit Nanda, Istvan Foldi, Erin N. Lottes, Hansley M. Bobo, Benjamin D. Grantier, Jozsef Mihaly, Giorgio A. Ascoli, Daniel N. Cox
Summary: Dendrite shape is influenced by cytoskeletal fiber organization and dynamics, impacting functional connectivity. Formin 3 is identified as a key regulator of cytoskeletal architecture in nociceptive sensory neurons, playing a crucial role in dendritic arbor complexity. Mutations in the human ortholog of Formin 3 have been linked to Charcot-Marie-Tooth disease, highlighting the importance of understanding cytoskeletal regulation in neuronal function and related neuropathies.
Review
Biochemistry & Molecular Biology
Aparna Chauhan, Norbert Gretz
Summary: Recent research has shown that visible light can have both beneficial and detrimental effects on skin, especially in terms of skin pigmentation. Various wavelengths within the visible spectrum have been reported to alter skin pigmentation, though the underlying mechanisms are still not fully understood.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Sic Eom, Dongho Jeong, A-Reum Ryu, Keon-Hyoung Song, Dai Sig Im, Mi-Young Lee
Summary: The study found that Daphne odora extract can inhibit melanogenesis signaling pathways by activating ERK and AKT signaling pathways, thus having the potential for depigmentation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hyun Jeong Lee, Sungkwan An, Seunghee Bae, Jae Ho Lee
Summary: DPN inhibits melanogenesis through downregulation of the PKA/CREB/MITF signaling pathway, and its suppression of melanin production is not related to the estrogen signaling pathway.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chaiwat Monmai, Jin-Suk Kim, Joong Hyoun Chin, Sanghyun Lee, So-Hyeon Baek
Summary: This study investigated the antioxidative and anti-melanogenic activities of polyphenol- and flavonoid-enriched rice seed extracts in melan-a cells. SB extract showed higher polyphenol and flavonoid content and increased antioxidative activity compared to HP extract. At a concentration of 100µg/mL, both extracts showed no significant cytotoxicity, and SB extract exhibited inhibition of p-38 MAPK phosphorylation/activation, increased expression of phosphorylated ERK 1/2 and Akt, and downregulation of MITF, resulting in decreased levels of tyrosinase and tyrosinase-related protein-1 and -2. These findings suggest the potential of polyphenol- and flavonoid-enriched rice seed extract as a treatment for hyperpigmentation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Gyeong-Hun Park, Sung Eun Chang, Seunghyun Bang, Kwang Hee Won, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Kee Chan Moon
ANNALS OF DERMATOLOGY
(2015)
Article
Dermatology
Myoung Shin Kim, Seung Hyun Bang, Jeong-Hwan Kim, Hong-Ju Shin, Jee-Ho Choi, Sung Eun Chang
ANNALS OF DERMATOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Woo Jin Lee, Do Young Rhee, Seung Hyun Bang, Su Yeon Kim, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Woo Jin Lee, Seunghyun Bang, Bo Young Chung, Hyejung Jung, Eok Soo Oh, Sung Eun Chang
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2016)
Article
Dermatology
Jeong Eun Kim, Seung Hyun Bang, Jee Ho Choi, Chang Deok Kim, Chong Hyun Won, Mi Woo Lee, Sung Eun Chang
ANNALS OF DERMATOLOGY
(2016)
Article
Dermatology
Yong Hyun Kim, Jong Il Park, Cheol Hwan Myung, Ji Eun Lee, Seunghyun Bang, Sung Eun Chang, Jae Sung Hwang
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2016)
Article
Oncology
Seunghyun Bang, Kwang Hee Won, Hye-Rim Moon, Hanju Yoo, Areum Hong, Youngsup Song, Sung Eun Chang
PIGMENT CELL & MELANOMA RESEARCH
(2017)
Article
Multidisciplinary Sciences
Jisu Park, Heesung Chung, Seung Hyun Bang, Ah-Reum Han, Eun-Kyoung Seo, Sung Eun Chang, Duk-Hee Kang, Eok-Soo Oh
Article
Biochemistry & Molecular Biology
Tai Kyung Noh, Seung Hyun Bang, Ye Jin Lee, Hong Il Cho, Mi Young Jung, Inki Kim, Chae Hun Leem, Sung Eun Chang
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Jinhwan Kim, Yo-Han Kim, Seunghyun Bang, Hanju Yoo, InKi Kim, Sung Eun Chang, Youngsup Song
Letter
Dermatology
Ik Jun Moon, Seung Hyun Bang, Youngsup Song, Sung Eun Chang
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Nutrition & Dietetics
Ik Jun Moon, WooHyeong Kim, Su Yeon Kim, JeongHyeon Lee, Hanju Yoo, Seunghyun Bang, Youngsup Song, Sung Eun Chang
Summary: This study investigated whether saponins of Korean red ginseng can protect the skin from the harmful effects of airborne particulate matter (PM). The results showed that saponins can reduce levels of reactive oxygen species (ROS), leptin, inflammatory cytokines, and melanin, thereby protecting the skin from the detrimental effects of PM exposure.
Article
Medicine, General & Internal
Chang-Jin Jung, Hee-Joo Yang, Seung-Hyun Bang, Woo-Jin Lee, Chong-Hyun Won, Mi-Woo Lee, Youngsup Song, Sung-Eun Chang
Summary: The study found that high epidermal PD-1 expression in patients with chronic plaque psoriasia (CPP) was associated with longer disease duration and higher severity index scores, while low dermal PD-1 expression in patients with guttate psoriasis (GP) was associated with higher relapse rate and lower relapse-free survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hanju Yoo, Ha-Ri Lee, Ki-Hyun Kim, Min-Ah Kim, Seunghyun Bang, Young-Ho Kang, Woo-hyung Kim, Youngsup Song, Sung Eun Chang
Summary: CRTC3 plays a crucial role in melanogenesis by directly targeting MITF and regulating the expression of most key melanogenesis-related genes. The absence of CRTC3 results in a reduction in melanin deposition, while its introduction can increase epidermal melanocytes. Additionally, altiratinib shows potential as a therapeutic agent for inhibiting melanogenesis effectively and safely.