Article
Medicine, General & Internal
Jin-Ju Kim, Judith M. David, Sydney S. Wilbon, Javier Santos, Devang M. Patel, Anis Ahmad, Alla Mitrofanova, Xiaochen Liu, Shamroop K. Mallela, Gloria M. Ducasa, Mengyuan Ge, Alexis J. Sloan, Hassan Al-Ali, Marcia Boulina, Armando J. Mendez, Gabriel N. Contreras, Marco Prunotto, Anjum Sohail, Rafael Fridman, Jeffrey H. Miner, Sandra Merscher, Alessia Fornoni
Summary: DDR1 activation mediated by Col I induces CD36-mediated podocyte lipotoxic injury in Alport Syndrome mice. Ezetimibe interferes with the CD36/DDR1 interaction, thus protecting renal function. Targeting the Col I/DDR1 pathway may represent a new therapeutic strategy for patients with AS and CKD associated with Col4 mutations.
Article
Immunology
Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Summary: Treatment with nilotinib in patients with mild-moderate Alzheimer's disease for 12 months can reduce amyloid plaque and cerebrospinal fluid amyloid levels, as well as attenuate hippocampal volume loss. This is achieved by inhibiting DDR-1 gene expression and activity, leading to a reduction in inflammation. Nilotinib may not only clear amyloid and tau but also reduce cerebrovascular fibrosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Oncology
Kaouther Ben Arfi, Christophe Schneider, Amar Bennasroune, Nicole Bouland, Aurore Wolak-Thierry, Guillaume Collin, Cuong Cao Le, Kevin Toussaint, Cathy Hachet, Veronique Lehrter, Stephane Dedieu, Olivier Bouche, Hamid Morjani, Camille Boulagnon-Rombi, Aline Appert-Collin
Summary: This study found that high expression of DDR1 is associated with worse event-free survival in CRC patients, and it may play a role in the invasive properties of colon adenocarcinoma.
Review
Cell Biology
Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang
Summary: Discoidin domain receptor tyrosine kinases (DDRs) are a type of receptor tyrosine kinases associated with various diseases, widely expressed in different cell types and involved in signaling pathways, closely related to the development and progression of solid tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Allen Sam Titus, Mereena George Ushakumary, Harikrishnan Venugopal, Mingyi Wang, Edward G. Lakatta, Shivakumar Kailasam
Summary: The molecular mechanisms underlying the therapeutic effects of metformin, a drug used to treat diabetes, beyond its anti-hyperglycemic effects are not well understood. Recent investigations have shown that a receptor called Discoidin Domain Receptor 2 (DDR2) plays a role in collagen type I gene expression in fibroblasts and may be involved in arterial fibrosis and metabolic syndrome. This study found that metformin targets DDR2 and inhibits the expression of fibronectin and collagen type I, providing insight into the molecular basis of its protective effects against vascular and cardiac fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bo Young Jeong, Kyung Hwa Cho, Se-Hee Yoon, Chang Gyo Park, Hwan-Woo Park, Hoi Young Lee
Summary: LPA induces DDR2 expression through the activation of the PI3K/Akt/mTOR/HIF-1α/Twist1 signaling axes, aggravating ovarian cancer cell invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Linghong Wu, Xinhua Zhao, Huan Ma, Lili Zhang, Xiaoan Li
Summary: Understanding the role of DDRs in HCC is critical for the development of new diagnostic/prognostic biomarkers and treatments.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Urology & Nephrology
Yuya Sannomiya, Shota Kaseda, Misato Kamura, Hiroshi Yamamoto, Hiroyuki Yamada, Masataka Inamoto, Jun Kuwazuru, Saki Niino, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai
Summary: This study investigated the involvement of DDR2 in Alport syndrome, finding that reducing Ddr2 expression with DDR2 ASO did not significantly improve proteinuria or BUN levels, nor did it ameliorate renal injury, inflammation and fibrosis in AS mice. This suggests that DDR2 may not play a critical role in the progression of Alport syndrome.
Article
Oncology
Shuai Wang, Yanping Xie, Aina Bao, Jing Li, Tingting Ye, Chu Yang, Shufang Yu
Summary: Nilotinib, a potent DDR1 inhibitor, demonstrated potential antitumor activity in the treatment of breast cancer by inducing apoptosis and blocking cell migration. Targeting DDR1 could potentially impact survival and metabolism in breast cancer, with nilotinib showing promise as a candidate for breast cancer treatment.
Article
Biology
Kieop Park, Ranjay Jayadev, Sara G. Payne, Isabel W. Kenny-Ganzert, Qiuyi Chi, Daniel S. Costa, William Ramos-Lewis, Siddharthan B. Thendral, David R. Sherwood
Summary: Separate tissues are connected through adjoining basement membranes to fulfill their barrier, exchange, and support functions. The robust and balanced cell adhesion at these connections is essential for withstanding tissue movement. However, the mechanism by which cells achieve synchronized adhesion to connect tissues remains unclear. This study reveals that type IV collagen both fastens the linkage and activates the collagen receptor DDR-2 in the utse and seam tissues, coordinating the strengthening of integrin adhesion through the LET-60/Ras signaling pathway.
Article
Biochemistry & Molecular Biology
Qingyun Liu, Xiaolong Wang, Yazhuo Chen, Xiao Ma, Xiaomin Kang, Fang He, Dongxu Feng, Yan Zhang
Summary: Chronic systemic inflammation causes severe disorders and diseases. Exploring a new target for effective treatment is crucial. This study showed that Ddr2 has a protective role against inflammation in myeloid lineage cells. Mechanistically, Ddr2 promotes macrophage repolarization and is critical in macrophage-mediated inflammation. This research provides a potential target for intervention in inflammation and related diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medical Laboratory Technology
Ali C. M. Johnson, Richard A. Zager
Summary: Cardiorenal syndrome I (CRS-1) is a state of acute kidney injury in acute heart failure (AHF), induced by isoproterenol (Iso) in mouse model showed iron-mediated cortical abnormalities with oxidative stress and pro-inflammatory reactions, despite no lasting renal injury. Iso affects both hemodynamics and tubular cell toxicity, potentially contributing to a systemic inflammatory state through renal cytokine production.
TRANSLATIONAL RESEARCH
(2021)
Article
Plant Sciences
Bingran Liu, Jiankun Deng, Xina Jie, Fuhua Lu, Xusheng Liu, Difei Zhang
Summary: In this study, we used network pharmacology analysis and experimental validation to demonstrate the protective effects of the Bupi Yishen Formula (BYF) against renal fibrosis. We identified the inhibition of the PI3K/AKT signaling pathway as a key mechanism for BYF's anti-fibrotic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qi Wang, Bixi Tang, Dandan Sun, Ying Dong, Yinchun Ji, Huanyu Shi, Liwei Zhou, Yueyue Yang, Menglan Luo, Qian Tan, Lin Chen, Yue Dong, Cong Li, Rongrong Xie, Yi Zang, Jingkang Shen, Bing Xiong, Jia Li, Danqi Chen
Summary: Idiopathic pulmonary fibrosis (IPF) is a serious chronic lung disease with inaccurate diagnosis, limited clinical therapy, and high mortality. The discoidin domain receptors (DDR) have been identified as promising drug targets for IPF treatment, and compound 47 shows potential as a candidate for further drug development.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Oncology
V. Mehta, H. Chander, A. Munshi
Summary: Discoidin domain receptors (DDRs) play a critical role in cancer development, where they can promote tumor progression and metastasis, but also have potential as a therapeutic target due to their ability to induce apoptosis and suppress tumor growth in various human cancers.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Francesca Marta Elli, Deborah Mattinzoli, Camilla Lucca, Matteo Piu, Maria A. Maffini, Jole Costanza, Laura Fontana, Carlo Santaniello, Concetta Forino, Donatella Milani, Maria Teresa Bonati, Andrea Secco, Roberto Gastaldi, Carlo Alfieri, Piergiorgio Messa, Monica Miozzo, Maura Arosio, Giovanna Mantovani
Summary: Skeletal disorders are caused by genetic defects that affect the pathways involved in skeletogenesis and growth-plate development. A study identified novel genetic variants associated with skeletal malformations similar to Albright's hereditary osteodystrophy and confirmed their pathogenic impact. The study highlights the importance of interdisciplinary collaboration in rare patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Anna Regalia, Matteo Benedetti, Silvia Malvica, Carlo Alfieri, Mariarosaria Campise, Donata Cresseri, Maria Teresa Gandolfo, Federica Tripodi, Giuseppe Castellano, Piergiorgio Messa
Summary: In kidney transplanted patients, those with SARS-CoV-2 infection had lower levels of 25(OH)D compared to controls, but there was no significant association between vitamin D status and severity or outcomes of the infection.
Article
Nutrition & Dietetics
Lara Caldiroli, Simone Vettoretti, Silvia Armelloni, Deborah Mattinzoli, Masami Ikehata, Paolo Molinari, Carlo Alfieri, Piergiorgio Messa, Giuseppe Castellano
Summary: This study compared the effects of low protein and normal protein diets on the nutritional status and metabolic complications related to the progression of kidney damage in older patients with advanced chronic kidney disease. The results showed that the low protein diet may have greater benefits on the progression of kidney disease and some of its metabolic complications.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
C. Crotti, F. Zucchi, C. Alfieri, R. Caporali, M. Varenna
Summary: This case report describes the long-term efficacy and safety profile of burosumab in a TIO patient who had three unsuccessful surgical attempts in tumor removal. Burosumab showed promising results in improving pain, physical performance, and normalizing serum phosphate levels in TIO patients refractory to surgery or not eligible for surgical treatment.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Aude Dorison, Irene Ghobrial, Alison Graham, Thanushi Peiris, Thomas A. A. Forbes, Michael See, Mithun Das, Moin A. A. Saleem, Catherine Quinlan, Kynan T. T. Lawlor, Mirana Ramialison, Sara E. E. Howden, Melissa H. H. Little
Summary: NPHS2 variants are the most common cause of steroid-resistant nephrotic syndrome in children. This study used induced pluripotent stem cell lines to investigate the effects of NPHS2 variants on the expression and subcellular localization of PODOCIN protein, and found that different variants resulted in distinct intracellular localization of PODOCIN, providing insight into the pathobiology of NPHS2 variants.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Endocrinology & Metabolism
Barbara Infante, Francesca Conserva, Paola Pontrelli, Serena Leo, Alessandra Stasi, Marco Fiorentino, Dario Troise, Andrea dello Strologo, Carlo Alfieri, Loreto Gesualdo, Giuseppe Castellano, Giovanni Stallone
Summary: Several insults, especially diabetes, can lead to acute kidney injury (AKI) in both native kidney and transplant patients. High glucose levels disrupt signaling pathways within the kidney, causing maladaptive repair and kidney dysfunction. Diabetic kidneys are often vulnerable to hypoxia due to reduced oxygenation, vascular damage, and increased inflammation. Patients with a history of AKI have a worse prognosis, highlighting the importance of monitoring diabetic patients for AKI. This review focuses on the molecular mechanisms underlying increased susceptibility to AKI in diabetes and the potential biomarkers for diagnosis and prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Adamasco Cupisti, Domenico Giannese, Claudia D'Alessandro, Alessia Benedetti, Vincenzo Panichi, Carlo Alfieri, Giuseppe Castellano, Piergiorgio Messa
Summary: Complementary and alternative medicine (CAM), including herbal remedies, probiotics, and vitamins, is often used in the treatment of kidney stone patients. However, most dietary supplements claiming to treat or prevent kidney stones lack scientific evidence. Clinicians should inform patients that the effects of these supplements are largely unknown and that absence of evidence does not mean lack of potential harm. Despite the popularity of CAM products among kidney stone patients, the lack of knowledge in this field prevents their recommendation in daily clinical practice, with only a weak suggestion for their use being reasonable.
Review
Nutrition & Dietetics
Jordi Bover, Elisabet Masso, Laia Gifre, Carlo Alfieri, Jordi Soler-Majoral, Maria Fusaro, Jordi Calabia, Rosely Rodriguez-Pena, Nestor Rodriguez-Chitiva, Victor Lopez-Baez, Maya Sanchez-Baya, Iara da Silva, Armando Aguilar, Misael C. Bustos, Natacha Rodrigues, Jonathan S. Chavez-Iniguez, Gregorio Romero-Gonzalez, Jose Manuel Valdivielso, Pablo Molina, Jose L. Gorriz
Summary: Chronic kidney disease (CKD) is a common condition that impairs kidney function and can lead to vitamin D (VD) deficiency. While studies have shown a link between low VD levels and negative outcomes, recent research has lowered expectations for the benefits of VD supplementation. However, guidelines still recommend VD supplementation for CKD patients. It is important to carefully balance the adverse effects of VD derivatives with the prevention of severe secondary hyperparathyroidism.
Review
Urology & Nephrology
Deborah Mattinzoli, Paolo Molinari, Gregorio Romero-Gonzalez, Jordi Bover, Elisa Cicero, Francesco Pesce, Matteo Abinti, Costanza Conti, Giuseppe Castellano, Carlo Alfieri
Summary: Cardio-renal syndrome is a well-defined clinical condition that involves interactions between the heart and kidney. Acute kidney injury can lead to chronic cardiovascular events and the progression of kidney disease. The role of bone in this relationship, as well as the impact on long-term outcomes, is an important topic of research.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Hematology
Rossana Franzin, Alessandra Stasi, Gianvito Caggiano, Elena Squiccimarro, Vincenzo Losappio, Marco Fiorentino, Carlo Alfieri, Giovanni Stallone, Loreto Gesualdo, Giuseppe Castellano
Summary: ESRD is associated with immune dysregulation caused by factors such as uremia and hemodialysis membrane biocompatibility. Understanding the molecules involved in altered immune response is important for therapeutic intervention. PMMA-based membranes have adsorptive properties for uremic toxins and can modulate adaptive immune response.
BLOOD PURIFICATION
(2023)
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
C. Alfieri, M. Gandolfo, D. Cresseri, M. Campise, A. Regalia, P. Messa, G. Castellano
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
C. Alfieri, F. Tripodi, D. Cresseri, M. Gandolfo, M. Campise, A. Regalia, P. Messa, G. Castellano
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Transplantation
Vincenzo Antonio Panuccio, Rocco Tripepi, Maria Carmela Versace, Domenico Russo, Luigi Francesco Pio Morrone, Maria Cristina Mereu, Giovanni Luigi Tripepi, Carlo Alfieri
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Alessandra Brescacin, Samuele Iesari, Sonia Guzzo, Carlo Maria Alfieri, Ruggero Darisi, Marta Perego, Carmelo Puliatti, Mariano Ferraresso, Evaldo Favi
Summary: Allograft vesicoureteral reflux (VUR) is a common complication of kidney transplantation, but there is still debate over the risk factors, impact on renal function, and treatment options. Clinical manifestations vary, and treatment should be tailored based on patient characteristics and the severity of VUR. Current evidence supporting surgical referral is weak, and more research is needed to address these issues.
MEDICINA-LITHUANIA
(2022)
