Article
Biochemical Research Methods
Xiongfeng Zhu, Tianxing Man, Xing Haw Marvin Tan, Pei-Shan Chung, Michael A. Teitell, Pei-Yu Chiou
Summary: A novel platform for mapping pressure distribution in complex microfluidics networks with high spatial resolution has been demonstrated. By using colorimetric interferometers, real-time monitoring of local pressures within fluid networks is achieved. Machine-learning-assisted sensor calibration enables adjustments to the dynamic measurement range for timely detection of anomalies in flow conditions.
Article
Electrochemistry
Yingchao Liu, Yuanyu Huang, Mengxi Wu, Siyuan Kong, Weiqian Cao, Shunxiang Li, Guoquan Yan, Baohong Liu, Pengyuan Yang, Quanqing Zhang, Liang Qiao, Huali Shen
Summary: In this study, a novel microfluidic free-flow paper electrochromatography (mu-FFPE) method was developed by combining mu-FFE with filter paper-based chromatography, enabling continuous separation of charged analytes. The addition of filter paper as the stationary phase improved the stability of the separation system. The mu-FFPE showed great potential in the separation and analysis of various biological molecules.
Article
Biochemical Research Methods
Miroslava Stastna, Karel Slais
Summary: A preparative instrumentation based on bidirectional isotachophoresis/electrophoresis in continuous divergent flow was developed for efficient separation of samples. The instrument can be easily optimized and tailored for various types of samples, providing fast and effective separation without the need for intermediate steps.
Article
Chemistry, Analytical
Congrui Tan, Jie Hong, Wei Xu
Summary: In this study, ion bunching in a liquid channel was achieved by replacing the DC voltage with square waves. The ions were concentrated and grouped in the positive and negative half cycles of the square wave, leading to increased ion signal intensities. This research has great significance for ion separation and measurement.
ANALYTICAL CHEMISTRY
(2022)
Article
Physics, Multidisciplinary
Ahmer Mehmood, Babar Hussain Shah, Muhammad Usman, Iqrar Raza
Summary: Theoretical investigations of fundamental boundary-layer flows are always given prime importance. Flows due to moving continuous surfaces offer richer physics and more technological applications compared to flows over surfaces of finite length, and are more useful in delaying flow separation.
Article
Chemistry, Analytical
Aodong Zhang, Jian Xu, Xiaolong Li, Zijie Lin, Yunpeng Song, Xin Li, Zhenhua Wang, Ya Cheng
Summary: This study proposes a method for the design and fabrication of a high-throughput micro free-flow electrophoresis (mu FFE) chip using laser-assisted chemical etching, electrode integration, and low-temperature bonding. The careful design of the height ratio of the separation chamber and electrode channels combined with a high flow rate of buffer solution allows for efficient removal of electrolysis-generated bubbles and enhances separation stability.
Article
Mechanics
Shuai Yuan, Mingyong Zhou, Xijiang Liu, Qiang Li, Dietmar Drummer, Bingyan Jiang
Summary: With the recent interest in microfluidic devices, this study focuses on preconcentration technology using field-amplified sample stacking (FASS) in microchannels. Numerical investigations reveal that reducing microchannel width is an effective way to improve enrichment quality. In addition, the study proposes a high-conductance gradient boundary to further enhance the performance of traditional FASS.
Article
Chemistry, Multidisciplinary
Marton Korosi, Petra Kantor, Peter Bana, Edit Szekely
Summary: This article presents a new continuous solvent removal process based on the use of dense carbon dioxide for efficient concentration of diluted solutions. The method involves the formation of homogeneous mixtures of dilute organic solutions with excess carbon dioxide, followed by pressure reduction to release the carbon dioxide and vaporize the organic solvent. The concentration of the solute in the resulting liquid phase can be significantly enhanced. The process parameters, such as the mass-flow rate ratio and the temperature of the phase separator, can be carefully controlled to achieve the desired concentration enhancement. This method offers a continuous and efficient alternative to thermal concentration methods.
Article
Biochemical Research Methods
Kunpeng Cai, Shruti Mankar, Taiga Ajiri, Kentaro Shirai, Tasuku Yotoriyama
Summary: The study introduces a fully integrated high-throughput microfluidic circulatory fluorescence-activated cell sorting system capable of significantly increasing the purity of rare cells in a short period of time and effectively enriching different types of cells. Through a sequential sorting process and efficient contamination-free design, effective enrichment of clinical rare cells has been achieved.
Article
Thermodynamics
Shuai Yuan, Mingyong Zhou, Xijiang Liu, Bingyan Jiang
Summary: The coupling effect of pressure-driven flow (PDF) and electroosmotic flow (EOF) was studied in microfluidics. Numerical simulations were conducted to explore the interaction between these two flows under different Reynolds numbers (Re) to understand the pressure effect on mass species transport and sample separation. It was found that the pressure induced by PDF reduced separation quality and caused sample deformation. However, a novel porous polymer plug was introduced in the EOF channel to neutralize the outlet pressure and improve the separation effect.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Engineering, Chemical
Amna Khatoon, Nadir H. Khand, Arfana Mallah, Amber R. Solangi, Saima Q. Memon, Almas F. Memon, Ceren Karaman, Fatemeh Karimi, Onur Karaman
Summary: This study demonstrates the potential and utility of capillary electrophoresis for rapid size-based characterization of Ag NPs. By using specific buffer and voltage conditions, the size of Ag NPs can be analyzed based on electrophoretic mobility, providing comparable results with conventional techniques at a lower cost.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Analytical
Sangwoo Kim, Minseok Kim, Suhyeon Kim, Bumjoo Kim, Geunbae Lim
Summary: This study reported a method for continuous and filterless separation of submicron-scale oil droplets using a three-dimensional printed microfluidic free-flow electrophoresis device. By controlling parameters such as applied voltage, recovery ratio, flow velocity, solution concentration, and flow-channel dimension, successful separation of various submicron-scale oil droplets was achieved, with examination of separation performance and surface charge status. The future scale-up of the proposed microfluidic electrodialysis system holds promise for treating industrial oily wastewater and relevant applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Mechanics
Xiaojing Ma, Chaoqiang Wang, Jinliang Xu
Summary: Inspired by the light-diverging effect of convex mirrors, a novel droplet actuator was proposed to enhance mixing/reaction in this study. The actuator utilizes a rectangle formed by an open tunnel and two convex surfaces. When a droplet contacts a convex surface, contact-induced explosive boiling generates a large thrust force, resulting in self-sustained droplet oscillation. The convex surface enhances droplet motion in the width direction. The study also introduces a thermal insulation technique to achieve hotter convex surfaces and a colder tunnel. The collision frequency and droplet velocity were found to be significantly enhanced when using the convex side surface. Additionally, the range of reflection angles becomes larger, which is the key mechanism for enhancing motion and forming fold line trajectories.
Article
Chemistry, Analytical
Mojgan Sadat Shushtarian, Mohammad Hadi Givianrad, Mohammad Saber Tehrani, Parviz Aberoomand-Azar
Summary: This study developed an efficient strategy utilizing ion imprinted polymer (IIP) based mu-TLC-LA-ICP-MS for speciation analysis of inorganic arsenic. The IIP was characterized using FTIR and FESEM, and a TLC plate was successfully prepared. Under optimized conditions, the method demonstrated a low detection limit and wide linear dynamic range, with good performance in wastewater and human blood plasma samples.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Farhad Shiri, Bruce K. Gale, Himanshu Sant, Brody King, Gina T. Bardi, Joshua L. Hood, Kevin E. Petersen
Summary: A new high-volume, continuous particle separation device based on size and charge has been developed, showing improved particle separations over traditional devices. This new technique combines electrical and flow fields into a single device, streamlining high-throughput continuous separations based upon electrophoretic mobility.
ANALYTICAL CHEMISTRY
(2021)
Correction
Multidisciplinary Sciences
Jung Hwal Shin, Geon Hwee Kim, Intae Kim, Hyungkook Jeon, Taechang An, Geunbae Lim
SCIENTIFIC REPORTS
(2015)
Article
Chemistry, Analytical
Hyungkook Jeon, Seong Kyung Hong, Seong J. Cho, Geunbae Lim
Article
Chemistry, Analytical
Seong Kyung Hong, Seongjin Yang, Seong J. Cho, Hyungkook Jeon, Geunbae Lim
Article
Chemistry, Analytical
Hyungkook Jeon, Min Seo Kim, Seong Kyung Hong, Seong J. Cho, Geunbae Lim
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Chemistry, Multidisciplinary
Hyungkook Jeon, Do-Hyun Lee, Bakr Jundi, Mayra Pinilla-Vera, Rebecca M. Baron, Bruce D. Levy, Joel Voldman, Jongyoon Han
Summary: This study presents a fully automated platform for monitoring immune responses in sepsis, allowing rapid diagnosis and differentiation. The integrated platform shows promising potential as a critical tool for daily monitoring of host leukocyte function in critically ill patients.
Article
Medicine, Research & Experimental
Bakr Jundi, Do-Hyun Lee, Hyungkook Jeon, Melody G. Duvall, Julie Nijmeh, Raja-Elie E. Abdulnour, Mayra Pinilla-Vera, Rebecca M. Baron, Jongyoon Han, Joel Voldman, Bruce D. Levy
Summary: The study found that specialized proresolving mediators resolvin D1 and resolvin D2 play a role in regulating leukocyte activation and function in patients with sepsis through anti-inflammatory mechanisms, and are associated with sepsis severity.
Article
Biochemical Research Methods
Hyungkook Jeon, Taehong Kwon, Junghyo Yoon, Jongyoon Han
Summary: This paper presents a deformation-free and mass-producible plastic spiral inertial microfluidic device for high-throughput cell separation applications. The plastic spiral device shows similar performance to PDMS devices in blood separation and CHO cell retention. Furthermore, a multiplexed plastic spiral unit achieves ultra-high-throughput cell clarification with high efficiency, which could have a significant impact on biomanufacturing.
Article
Chemistry, Analytical
Hyungkook Jeon, Maoyu Wei, Xiwei Huang, Jiangfan Yao, Wentao Han, Renjie Wang, Xuefeng Xu, Jin Chen, Lingling Sun, Jongyoon Han
Summary: This study demonstrates a fully automated and label-free sample-to-answer platform for rapid immune state monitoring using white blood cells (WBCs). The platform integrates WBC separation and image processing to classify WBCs into their subtypes and detect activation-induced morphological changes for functional immune assessment, potentially enabling early detection of diseases.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Seongjin Yang, Minjae Kim, Seong Kyung Hong, Suhyeon Kim, Wan Kyun Chung, Geunbae Lim, Hyungkook Jeon
Summary: In this study, a novel three-dimensional (3D) controller design incorporating a versatile stretchable strain sensor (OPSS sensor) is introduced. The OPSS sensor exhibits high sensitivity with a gauge factor of approximately 30 and a wide working range accommodating strain up to 150%, enabling precise 3D motion sensing. By quantifying the deformation of the controller through multiple OPSS sensors, the triaxial motion along the X, Y, and Z axes can be discerned independently. A machine learning-based data analysis technique was implemented for accurate and real-time interpretation of the sensor signals. The results demonstrate that resistance-based sensors successfully track the 3D controller's motion. This innovative design has the potential to enhance the performance of 3D motion sensing devices in various applications including gaming, virtual reality, and robotics.
Article
Chemistry, Analytical
Zhumei Rohskopf, Taehong Kwon, Sung Hee Ko, Dragana Bozinovski, Hyungkook Jeon, Naresh Mohan, Stacy L. Springs, Jongyoon Han
Summary: This study developed a novel nanofluidic system for continuous direct measurement of IgG titers, enabling online monitoring and showing good correlation with biolayer interferometry assays.
ANALYTICAL CHEMISTRY
(2023)
Article
Polymer Science
Taegyun Kim, Man Gyu Song, Kanghyun Kim, Hyungkook Jeon, Geon Hwee Kim
Summary: In this study, a superhydrophobic surface was prepared using recycled PET through electrospinning and electrospraying processes. The optimized hierarchical structure showed a high water contact angle. The study also demonstrated the self-cleaning functionality and solar panel efficiency of the fabricated surface, highlighting its potential applications.
Article
Biochemical Research Methods
Hyungkook Jeon, Bakr Jundi, Kyungyong Choi, Hyunryul Ryu, Bruce D. Levy, Geunbae Lim, Jongyoon Han
Article
Chemistry, Analytical
Eunji Lee, Iljeok Kim, Hyoryung Nam, Hyungkook Jeon, Geunbae Lim
Article
Chemistry, Multidisciplinary
Hyungkook Jeon, Jong Hyun Kim, Geunbae Lim
