Article
Oncology
John M. Fenimore, Danielle A. Springer, Maria E. Romero, Elijah F. Edmondson, Dan W. McVicar, Sudhirkumar Yanpallewar, Michael Sanford, Thea Spindel, Elizabeth Engle, Thomas J. Meyer, Julio C. Valencia, Howard A. Young
Summary: The effect of cytokines on non-traditional immunological targets under conditions of chronic inflammation is explored. Fatigue is associated with autoimmune diseases, and immune dysfunction-driven changes in myocyte mitochondria are hypothesized to play a critical role in fatigue-related pathogenesis. The study shows that persistent low-level expression of IFN-gamma results in mitochondrial and metabolic deficiencies in myocytes, particularly affecting heart function under stress. These findings highlight the actions of IFN-gamma in fatigue, energy metabolism, and autoimmunity.
JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Xiao-Xi Pan, Kang-Li Yao, Yong-Feng Yang, Qian Ge, Run Zhang, Ping-Jin Gao, Cheng-Chao Ruan, Fang Wu
Summary: Aging-associated chronic inflammation is a key factor contributing to chronic metabolic disorders. Research shows an accumulation of T cells in adipose tissue in old mice, with a cross talk between T cells and preadipocytes contributing to tissue remodeling. Senescent T cells were found to inhibit brown adipocyte differentiation in adipose tissue, with increased production of IFN-gamma identified as a critical mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Zhiqiang Zhu, Yuanyuan Qin, Qi Liang, Wei Xia, Tong Zhang, Wen Wang, Mengmeng Zhang, Taiyi Jiang, Hao Wu, Ye Tian
Summary: The coinfection rate of HBV in HIV patients increases as HIV disease progresses, possibly due to the reduced numbers of HBV-specific IFN-gamma-producing CD8+ T cells. Close monitoring of HBV serum markers from the early stage of HIV infection is necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Fengyang Li, Xiuhong Hu, Zengshuai Wu, Qiulei Yang, Qila Sa, Wenbo Ren, Tingting Wang, Zhengchao Ji, Na Li, Jing Huang, Liancheng Lei
Summary: This study investigated the metabolic alterations in bovine mammary epithelial cells (BMECs) upon IFN-gamma induction using metabolomic analysis. The results revealed significant differences in the content of lipids and lipid-like molecules, organic acids and derivatives, organ heterocyclic compounds, and benzenoids. Pathway analysis showed that the differentially expressed metabolites were enriched in various metabolic pathways, including fructose and mannose metabolism, phosphotransferase system, beta-alanine metabolism, arginine and proline metabolism, methane metabolism, phenylalanine metabolism, and glycolysis/gluconeogenesis. Targeted metabolomics further confirmed the changes in selected key metabolites.
BMC VETERINARY RESEARCH
(2023)
Article
Immunology
Emma L. Lewis, Natalia Tulina, Lauren Anton, Amy G. Brown, Paige M. Porrett, Michal A. Elovitz
Summary: The study found that intrauterine inflammation can lead to long-term changes in cellular immune mechanisms, particularly in the fetal brain, which may cause neuronal injury, especially by Gr-1+γ/δ T cells. In addition, in a study of term infants, it was found that IFN gamma levels were elevated in infants exposed to intrauterine inflammation compared to those who were not exposed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Katsunori Endo, Toko Sawa, Hidemitsu Kitamura, Koji Umezawa, Hidefumi Makabe, Sachi Tanaka
Summary: This study investigated the inhibitory effect of PCB2DG on IFN-gamma production through regulation of glutamine metabolism. The researchers found that PCB2DG reduced intracellular glutamine levels in CD4+ T cells, leading to the upregulation of activating transcription factor 4. They also identified ASCT2 as a target protein of PCB2DG, suggesting that it directly interacts with this glutamine transporter to inhibit glutamine influx. These findings provide new insights into the immunomodulatory effects of dietary polyphenols.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Fisheries
Julia Lagler, Selma Schmidt, Taniya Mitra, Maria Stadler, Patricia Wernsdorf, Beatrice Grafl, Tamas Hatfaludi, Michael Hess, Wilhelm Gerner, Dieter Liebhart
Summary: In infected chickens, re-stimulated splenocytes showed a significant increase of IFN-gamma(+)CD4(+) T cells. Contrariwise, significant increments of IFN-gamma-producing cells within all major T-cell subsets of the spleen and liver were found for vaccinated/infected turkeys. This indicates that the vaccine in turkeys causes more intense systemic immune responses whereas in chickens protection might be mainly driven by local immunity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Microbiology
Julio Flores-Gonzalez, Lucero A. A. Ramon-Luing, Jesus Romero-Tendilla, Alexia Urban-Solano, Alfredo Cruz-Lagunas, Leslie Chavez-Galan
Summary: This study aimed to identify the frequency and function of B1 and immature/transitional B cells in patients with active and latent TB. The results showed that latent TB patients have an increased frequency of CD5+ B cells and decreased CD10+ B cells. Furthermore, latent TB patients stimulated with mycobacteria's antigens increase the frequency of IFN-?-producing B cells, whereas cells from active TB do not respond. The importance of better understanding the immune response in TB is highlighted.
Article
Immunology
Shi-Lin Qiu, Qi-Xiang Sun, Jian-Peng Zhou, Hai-Juan Tang, Yan-Qiong Chen, Fu-Shou Chen, Tao Feng, Zai-Qing He, Hua-Jiao Qin, Min-Chao Duan
Summary: The research reveals that IL-27 plays a negative regulatory role in chronic inflammation induced by smoking, preventing CD8(+)T cells from producing excessive inflammatory responses. This study provides a new therapeutic strategy for smoking-related COPD/emphysema by targeting the IL-27 pathway.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Jong Kyu Woo, Tae-Geuk Kim, Na Yeon Im, Ka-Yeon Son, Minhyeon Cho, Yeo Jin Jeong, Jeong-Im Hong, BoRim Kang, Gansukh Enkhtaivan, Nam-Hyuk Cho, Tommy Alain, Dong Guk Park, Yeon-Sook Lee
Summary: Myxoma virus is a safe and effective anticancer therapy that selectively targets tumor cells. Engineered MyxV_CD47/IFN-gamma enhances tumor suppression and activates host immune anticancer responses. Further combination with anti-PD-L1 antibodies improves treatment outcomes in the melanoma model.
Article
Biochemistry & Molecular Biology
Yunyan Sun, Bing Wang, Qianwen Hu, Haixiao Zhang, Xun Lai, Tier Wang, Chunxiao Zhao, Jiali Wang, Xi Zhang, Qing Niu, Baolin He, Erlie Jiang, Mingxia Shi, Xiaoming Feng, Yuechen Luo
Summary: Adipose tissue CD11c(+) myeloid cell is an independent risk factor for obesity and metabolic disorders. In this study, it was found that liver kinase B1 (Lkb1) plays a role in CD11c(+) cell-mediated immune responses in diet-induced obesity. Loss of Lkb1 in CD11c(+) cells leads to obesity resistance but lower glucose tolerance, accompanied by immune abnormalities. The imbalance of IL-17A and IFN-gamma is observed in fat T cells and CD11c(-) macrophages, contributing to the resistance to weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Chemistry, Medicinal
Laureni Ferrer-Lino, Blanca Marina Vera-Ku, Miriam Rubi Gamboa-Leon, Sergio Ruben Peraza-Sanchez, Jose Leonardo Guillermo-Cordero, Karina Beatriz Lopez-Avila, Erika Ivett Sosa-Bibiano, Elsy Nalleli Loria-Cervera
Summary: The study evaluated the oral effect of Tridax procumbens L. and (3S)-16,17-didehydrofalcarinol on Leishmania mexicana infection in mice. Results showed that Tridax procumbens significantly reduced ulcer size and induced interferon gamma expression, while the combination with Allium sativum had no effect on lesion reduction.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Cell & Tissue Engineering
Yixin Ye, Xiaomei Zhang, Dongsheng Su, Yushuang Ren, Fuyi Cheng, Yunqi Yao, Gang Shi, Yanhong Ji, Shuang Chen, Pengyi Shi, Lei Dai, Xiaolan Su, Hongxin Deng
Summary: In this study, the researchers used IFN-γ and KYNA to treat hADSCs and successfully alleviated CD-like colitis injury and fibrosis in a mouse model. The therapeutic ability of hADSCs pretreated with IFN-γ and KYNA was significantly impaired when the IDO-1 gene was knocked out.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Hiroshi Kato, Andras Perl
Summary: IL-2 treatment can expand Treg cell population while also potentially increasing pro-inflammatory cells, showing varying effects on SLE patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Jasiecka-Mikolajczyk, Jerzy J. Jaroszewski, Tomasz Maslanka
Summary: The study found that OCL has beneficial effects on treating skin allergies by inhibiting IL-4 production and suppressing CD8(+) T cell proliferation, without affecting other cell types or cytokines.
Article
Immunology
Vania Gaio, Tania Lima, Manuel Vilanova, Nuno Cerca, Angela Franca
Summary: The mazEF homologue does not play a role in VBNC cell formation, antimicrobial susceptibility, virulence factor expression, or immune cell response in S. epidermidis strain 1457.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Mariem Hamed, Elisabete Coelho, Rita Bastos, Dmitry Evtuguin, Sonia S. Ferreira, Tania Lima, Manuel Vilanova, Assaad Sila, Manuel A. Coimbra, Ali Bougatef
Summary: This study successfully extracted and purified a novel arabinogalactan from pistachio external hull, which showed potential immunostimulatory activity and could be used in nutraceutical and biomedical applications.
Article
Chemistry, Multidisciplinary
Tania Lima, Stefan B. Gunnarsson, Elisabete Coelho, Dmitry Evtuguin, Alexandra Correia, Manuel A. Coimbra, Tommy Cedervall, Manuel Vilanova
Summary: This study developed a method using nanoparticles to modulate the deleterious inflammatory response caused by fungal infection. The results showed that β-Glc-PS nanoparticles can reduce the inflammatory response caused by C. albicans cells and decrease the production of reactive oxygen species. This provides a theoretical basis for the development of targeted therapy for fungal infections.
Article
Immunology
Catarina M. Ferreira, Consuelo Micheli, Palmira Barreira-Silva, Ana Margarida Barbosa, Mariana Resende, Manuel Vilanova, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Margarida Correia-Neves, Antonio Gil Castro, Egidio Torrado
Summary: The control of tuberculosis relies on the rapid activation of protective CD4(+) T-cell responses in the lungs. The immunomodulatory cytokine IL-10 hinders this response by impairing the migratory capacity of CD4(+) T cells. However, BCG vaccination can prevent the immunosuppressive effects of IL-10 and accelerate the CD4(+) T-cell response, leading to better control of tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alexandra Correia, Pedro Alves, Ricardo Frois-Martins, Luzia Teixeira, Manuel Vilanova
Summary: Neospora caninum is a protozoan that causes abortion and still-births in cattle. In this study, we extended a mucosal vaccination approach using N. caninum membrane proteins and CpG adjuvant by incorporating the carbomer-based adjuvant Carbigen (TM). Immunized mice showed increased proportions and numbers of memory CD4(+) and CD8(+) T cells. When infected with N. caninum, the immunized mice had lower parasite burdens and produced higher levels of IL-17A.
Article
Food Science & Technology
Sofia F. Reis, Vitor J. Martins, Rita Bastos, Tania Lima, Viviana G. Correia, Benedita A. Pinheiro, Lisete M. Silva, Angelina S. Palma, Paula Ferreira, Manuel Vilanova, Manuel A. Coimbra, Elisabete Coelho
Summary: This study aims to investigate the feasibility of brewer's spent yeast (BSY) microcapsules as oral carriers for food and biomedical applications. The results demonstrate that BSY microcapsules have strong resistance to digestion and are rich in (beta 1 -> 3)-glucans, which can be recognized by the human Dectin-1 immune receptor. Additionally, the digested material is recognized by various lectins related to (beta 1 -> 3)-glucans, glycogen, and mannans.
Article
Chemistry, Applied
Sonia S. Ferreira, Alexandra Correia, Artur M. S. Silva, Dulcineia Ferreira Wessel, Susana M. Cardoso, Manuel Vilanova, Manuel A. Coimbra
Summary: Broccoli by-products were used to study the structure-function relationships and immunostimulatory activity of pectic polysaccharides. Pectic polysaccharides extracted by hot water showed high immunostimulatory activity, which was further enhanced by treatment with 80% ethanol. The action of pectin methylesterase and endo-polygalacturonase on the polysaccharides resulted in a fraction with high immunostimulatory activity. Therefore, agri-food by-products are an important source of pectic polysaccharide functional food ingredients.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Medicinal
Ana S. P. Moreira, Diana Gaspar, Sonia S. Ferreira, Alexandra Correia, Manuel Vilanova, Marie-Mathilde Perrineau, Philip D. Kerrison, Claire M. M. Gachon, Maria Rosario Domingues, Manuel A. Coimbra, Filipe M. Coreta-Gomes, Claudia Nunes
Summary: This study aimed to characterize the chemical structure of water-soluble polysaccharides from Saccharina latissima and evaluate their immunostimulatory and hypocholesterolemic activities. It was found that laminarans and two fractions of fucose-containing sulphated polysaccharides showed immunostimulatory activity on B lymphocytes, and one of the fractions exhibited a significant effect in reducing cholesterol bioaccessibility.
Review
Veterinary Sciences
Catarina Sofia Aluai-Cunha, Catarina Alves Pinto, Isabel Alexandra Duarte Ferreira Lopes Correia, Claudia Alexandra dos Reis Serra, Andreia Alexandra Ferreira Santos
Summary: Cancer is a major global health problem with increasing mortality and incidence rate. The commensal microbiota plays a role in regulating physiological and pathological processes, including cancer. Recent studies have found similarities between the gut microbiota of humans and companion animals. This study reviews the relationship between microbiota and cancer in humans and animals and compares their resemblance in various types of tumors.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Immunology
Amparo Martinez-Perez, Lara Diego-Gonzalez, Manuel Vilanova, Alexandra Correia, Rosana Simon-Vazquez, Africa Gonzalez-Fernandez
Summary: In this study, we developed new vaccines for pancreatic cancer using chitosan nanocapsules (CS NCs) containing IMQ as adjuvant, targeting the K-Ras mutation G12V. However, our results suggest that the different combinations of our CS NCs vaccines may enhance tumor growth and reduce survival rate, possibly due to an inadequate immune response and the induction of a regulatory tolerogenic response.
FRONTIERS IN IMMUNOLOGY
(2023)
News Item
Immunology
Iris Caramalho, Maria Strecht Almeida, Manuel Vilanova, Carlos Penha-Goncalves
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Microbiology
Fernando Oliveira, Tania Lima, Alexandra Correia, Ana Margarida Silva, Cristina Soares, Simone Morais, Samira Weisselberg, Manuel Vilanova, Holger Rohde, Nuno Cerca
Summary: This study reveals the pivotal role of the iron-regulated loci hts and fhuC in biofilm formation and survival of Staphylococcus epidermidis within the host, providing important insights for future therapeutic strategies against infections caused by this pathogen.
MICROBIOLOGY SPECTRUM
(2022)