Article
Chemistry, Physical
Pavel O. Maksimchuk, Kateryna O. Hubenko, Ganna Grygorova, Vladimir K. Klochkov, Alexander Sorokin, Svetlana L. Yefimova
Summary: This paper analyzes the impact of doping of GdYVO4 and LaVO4 nanoparticles with Eu3+ ions on their dark reactive oxygen species (ROS) generation efficiency. It was found that UV light pretreatment can enhance the dark ROS generation efficiency in small GdYVO4:Eu3+ nanoparticles through Eu3+ reduction to Eu2+. However, in larger LaVO4:Eu3+ nanoparticles, the process of Eu3+ reduction is not as effective due to the energy required to stabilize the reduced Eu2+ ion.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Biochemistry & Molecular Biology
Dannah R. Miller, Matthew A. Ingersoll, Yu -Wei Chou, Elizabeth A. Kosmacek, Rebecca E. Oberley-Deegan, Ming-Fong Lin
Summary: This study investigates the role of the reactive oxygen species (ROS) signaling pathway in the progression of castration-resistant prostate cancer (CR PCa). The elevated levels of HO-1 and p66Shc proteins in AI PCa cells suggest their involvement in the development of the CR phenotype. Knockdown or inhibition of HO-1 or p66Shc leads to reduced tumorigenicity and the corresponding protein levels. Knockdown of HO-1 alone increases ROS levels, nucleotide and protein oxidation, and induces cell death. These findings suggest that HO-1 and p66Shc can be potential targets for treating CR PCa.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Idolo Tedesco, Carmela Spagnuolo, Gian Luigi Russo, Maria Russo, Carmen Cervellera, Stefania Moccia
Summary: Research has shown that red wine polyphenols (RWp) have a modulating effect on the antioxidant potential of human erythrocytes, increasing intracellular glutathione levels and enhancing their antioxidant defense. Additionally, the pro-oxidant effect of RWp triggers an adaptive stress response in erythrocytes.
Article
Chemistry, Applied
Dilini Bopitiya, Sixuan Guo, Milton T. W. Hearn, Jie Zhang, Louise E. Bennett
Summary: Recently, it has been discovered that autoxidation mediated by ascorbic acid (AA) and other ingredients in energy beverages can generate hydrogen peroxide (H2O2). In this study, cyclic voltammetry and the FOX assay were used to monitor the production and stability of H2O2 generated by AA and redox-active ingredients at short and long incubation times, respectively. The levels of H2O2 in energy drinks were found to be stable or increased upon vessel opening. A predictive model showed that H2O2 peaked after 1 day and declined over time. This research highlights the importance of monitoring H2O2 levels and modifying formulations to avoid AA autoxidation in beverages.
Article
Engineering, Chemical
Jaehyun Ju, Yongjun Choi, Sangho Lee, Namjo Jeong
Summary: This study compared the power density and fouling potential of reverse electrodialysis (RED) and pressure retarded osmosis (PRO) processes using various low salinity (LS) solutions and high salinity (HS) solutions. Results showed that PRO had higher power density than RED under non-fouling conditions, but the loss of power density due to fouling was smaller in RED.
Article
Chemistry, Applied
Mohamed A. Farag, Zeinab T. Abdel Shakour, Moamen M. Elmassry, Mohamed S. Donia
Summary: The gut microbiome plays a role in host nutrition metabolism, and investigating the interactions between dietary components, toxicants, and gut microbiota is important. This study used LC/ESI-MS/MS to identify metabolites produced during the interaction of diet-derived toxicants with green tea polyphenols, revealing a potential protective role of gut microbiome against negative interactions between food-derived toxicants and dietary polyphenols.
Article
Biochemistry & Molecular Biology
Enrico Falcone, Francesco Stellato, Bertrand Vileno, Merwan Bouraguba, Vincent Lebrun, Marianne Ilbert, Silvia Morante, Peter Faller
Summary: Copper is essential for most organisms, but excess copper can be toxic through various mechanisms. In this study, the reactivity of copper with a mixture of physiological reducing agents was investigated. The results showed that copper preferentially reacts with glutathione (GSH) and cysteine (Cys), halting the oxidation of ascorbate (AscH) and the release of reactive oxygen species (ROS). The formation of copper-thiolate clusters with GSH and Cys was observed, and a synergistic effect of Cys on copper toxicity was identified.
Article
Chemistry, Inorganic & Nuclear
M. M. Sozarukova, E. V. Proskurnina, I. V. Mikheev, L. A. Polevoy, A. E. Baranchikov, V. K. Ivanov
Summary: Cerium oxide sols functionalized with gallic acid were synthesized, and it was found that these composites possess antioxidant and pro-oxidant properties. The immobilization of gallic acid on the surface of cerium dioxide nanoparticles leads to a decrease in its antioxidant and pro-oxidant activities, especially in the 2:1 ratio.
RUSSIAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Maria Laura Alfieri, Lucia Panzella, Orlando Crescenzi, Marco d'Ischia, Alessandra Napolitano
Summary: The study reports the synthesis of a symmetric homolog of the bibenzothiazine system, showing excellent photochromic, solvatochromic, and acidichromic properties. The cyanine structure exhibited intense absorption peaks at different wavelengths under varying pH conditions, along with a marked color change from red to deep blue in response to acid exposure. The acidichromic behavior of the cyanine was reversible and showed potential applications as pH sensors for monitoring food freshness.
Article
Agriculture, Multidisciplinary
Lucia Panzella, Alessandra Napolitano
Summary: This article provides an overview of the structural features, accessible sources, methods of analysis, and functional properties of condensed tannins (CT), highlighting the opportunities offered by these natural phenolic compounds for the rational design of multifunctional and sustainable food packaging materials.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Hiba N. Rajha, Armelle Paule, Gerard Aragones, Mariana Barbosa, Carla Caddeo, Esperance Debs, Rada Dinkova, Gunter P. Eckert, Ariel Fontana, Prisca Gebrayel, Richard G. Maroun, Alessandra Napolitano, Lucia Panzella, Giulio Maria Pasinetti, Jan F. Stevens, Andreas Schieber, Marvin Edeas
Summary: Polyphenols have attracted researchers from various disciplines due to their diverse biological activities. The latest scientific research has focused on polyphenol interactions with the microbiome and mitochondria, as well as their potential applications in cosmetics, dietary supplements, and functional foods. Polyphenols may play a key role in disease prevention and have promising prospects in future food and nutrition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Maria Laura Alfieri, Lucia Panzella, Riccardo Amorati, Alice Cariola, Luca Valgimigli, Alessandra Napolitano
Summary: The activity of natural phenols is primarily associated with their antioxidant potential and is expressed in various biological effects. Molecular scaffold manipulation of these compounds is a sought-after approach to enhance or modulate their properties. The insertion of S/Se/Te containing substituents on phenols can increase/decrease their H-donor/acceptor ability through electronic and stereo-electronic effects. Some phenols with chalcogen substitutions exhibit better antioxidant activity than their natural counterparts.
Article
Chemistry, Applied
Lucia Panzella, Kenneth Benning, Darren N. Nesbeth, Brunella Setaro, Gerardino D'Errico, Alessandra Napolitano, Marco D'Ischia
Summary: This study purified the pigment of black sturgeon caviar and identified it as a typical black pigment through chemical degradation and electron paramagnetic resonance (EPR) evidence. Analysis of oxidative degradation mixtures revealed the formation of a specific marker of eumelanin pigments, providing a novel molecular basis for the valorization of black caviar and production wastes in food chemistry and diet.
Article
Chemistry, Organic
Maria L. Alfieri, Alice Cariola, Lucia Panzella, Alessandra Napolitano, Marco d'Ischia, Luca Valgimigli, Orlando Crescenzi
Summary: This study provides evidence for the addition mechanism of thiol compounds to quinones and discovers an anomalous 1,6-type regiochemistry compared to the usual 1,4-nucleophilic addition. These findings would prompt a revision of the commonly accepted mechanisms for thiol-quinone conjugation and stimulate further research in this field.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rita Argenziano, Marina Della Greca, Lucia Panzella, Alessandra Napolitano
Summary: In this study, an optimized procedure was developed to prepare carboxamides of DHICA for obtaining pigments with improved solubility properties. The protection of the catechol function and the use of a coupling agent allowed for efficient synthesis of these amides, which, upon oxidative polymerization, resulted in melanin-like pigmented materials with good solubility in alcoholic solvents.
Article
Multidisciplinary Sciences
Jinyang Li, Zhiling Zhao, Eunkyoung Kim, John R. Rzasa, Guanghui Zong, Lai-Xi Wang, William E. Bentley, Gregory F. Payne
Summary: Recent observations suggest that abiotic materials can engage in interactive communication through redox reactions. In this study, a hydrogel made from four-armed thiolated polyethylene glycol (PEG-SH) and the bacterial metabolite pyocyanin (PYO) was fabricated and shown to exhibit reversible redox activity. The study also highlighted the significance of the redox network's topology in controlling molecular switching and electron flow within the hydrogel.
Article
Biochemistry & Molecular Biology
Federica Moccia, Davide Liberti, Samuele Giovando, Carla Caddeo, Daria Maria Monti, Lucia Panzella, Alessandra Napolitano
Summary: Ellagic acid (EA) is well-known for its strong antioxidant, anti-inflammatory, and antimicrobial properties, but its low bioavailability limits its applications in health-related fields. In this study, a phospholipid vesicle-based controlled release system for EA was developed using chestnut wood mud (CWM) as a low-cost and easily available source. The CWM-incorporated transfersomes showed enhanced antioxidant properties compared to CWM alone, and the release of EA from CWM-B transfersomes exhibited a gradual and sustained pattern. Cell-based experiments confirmed the effectiveness of CWM-B transfersomes as antioxidant agents against photodamage.
Article
Biochemistry & Molecular Biology
Rita Argenziano, Federica Moccia, Rodolfo Esposito, Gerardino D'Errico, Lucia Panzella, Alessandra Napolitano
Summary: This study reports an efficient strategy for the recovery of antioxidant lignins from edible nut shells using ball milling and deep eutectic solvent treatment. The recovered lignins exhibited promising antioxidant properties, opening new perspectives for their application in various fields.
Article
Biochemistry & Molecular Biology
Sara Viggiano, Lucia Panzella, Maria Reichenbach, Joachim Hans, Alessandra Napolitano
Summary: Immediate pigment darkening, the rapid onset of melanin pigmentation resulting from oxidation, can lead to irregular pigmentation and dark spots. Phenolic cosmetic ingredients (CIs) such as paradol-6 and phenylethyl resorcinol can decrease the oxidation and melanin formation of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA). CIs also show photoprotective effects in model systems, reducing peroxidation and generation of reactive oxygen species. These findings have potential implications for the development of skincare formulations to improve skin spots and counteract aging processes associated with sun exposure.
Article
Biochemistry & Molecular Biology
Rita Argenziano, Maria Laura Alfieri, Noemi Gallucci, Gerardino D'Errico, Lucia Panzella, Alessandra Napolitano
Summary: The search for new synthetic melanin-related pigments with antioxidant and photoprotective properties is important for dermo-cosmetic purposes. In this study, a melanin derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) was synthesized and found to have similar structural properties to DHICA melanin. The synthesized pigment demonstrated stronger UV-visible absorption and improved solubility compared to DHICA melanin. Furthermore, the pigment exhibited marked antioxidant properties and enhanced inhibitory action against lipid peroxidation. These findings suggest that the melanin derived from DHICA has potential as a functional ingredient in dermo-cosmetic formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carmela Spagnuolo, Federica Moccia, Idolo Tedesco, Eva Adabbo, Lucia Panzella, Gian Luigi Russo, Alessandra Napolitano
Summary: The extract obtained from the waste of fermented strawberry distillate production exhibited high antioxidant and antiproliferative properties, mainly attributed to the presence of ellagic acid and p-coumaric acid. It showed strong antiproliferative effects on human cancer cell lines, especially on HL-60 cells, through rapid apoptosis induction. The extract also exhibited antioxidant activity and modulation of cellular oxidative stress and signaling pathways.
Article
Engineering, Electrical & Electronic
Zhiling Zhao, Si Wu, Eunkyoung Kim, Chen-yu Chen, John R. Rzasa, Xiaowen Shi, William E. Bentley, Gregory F. Payne
Summary: This study fabricated a catechol-containing hydrogel film and characterized its properties through experimental and modeling approaches. The results showed that catechols can provide redox activity without conductivity, and the flow of electrons through the catechol film is controlled by diffusible electron carriers and synchronized with electron transfer at the electrode.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhiling Zhao, Eunkyoung Kim, Chen-Yu Chen, John R. Rzasa, Qian Zhang, Jinyang Li, Yang Tao, William E. Bentley, Jean-Philip Lumb, Bern Kohler, Gregory F. Payne
Summary: Catechol-based materials in redox-based bioelectronics possess diverse properties and can transduce near infrared (NIR) radiation into heat. The study shows that catechol-chitosan films can reversibly respond to both NIR and redox inputs, suggesting the independent flow of energy through catechol-based materials via redox and electromagnetic modalities. These findings highlight the potential of catecholic materials for bio-device communication, offering both short-range redox communication and long-range electromagnetic communication.
MATERIALS CHEMISTRY FRONTIERS
(2022)