Review
Cell Biology
Mei Huang, Shaozhe Xu, Lifei Liu, Miao Zhang, Jianmin Guo, Yu Yuan, Jiake Xu, Xi Chen, Jun Zou
Summary: Osteoporosis is a common bone disease in the elderly, characterized by decreased bone mass due to bone metabolism imbalance. The m6A modification, through epigenetic regulation, affects the biological processes of bone-related cells and related signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Samuel Herberg, Daniel Varghai, Daniel S. Alt, Phuong N. Dang, Honghyun Park, Yuxuan Cheng, Jung-Youn Shin, Anna D. Dikina, Joel D. Boerckel, Marsha W. Rolle, Eben Alsberg
Summary: This study demonstrates the potential of localized morphogen presentation to stimulate chondrogenic priming/endochondral differentiation in engineered hMSC tubes compared to loosely packed hMSC sheets for defect healing. hMSC tubes, unlike hMSC sheets, induced regenerate tissue partially resembling normal growth plate in long bone regeneration.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Huan Zhou, Lei Zhang, Yue Chen, Chun-Hui Zhu, Fa-Ming Chen, Ang Li
Summary: Bone formation is a complex regeneration process regulated by multiple signaling pathways, with the Hedgehog (Hh) pathway playing a crucial role. Dysregulation of the Hh pathway in adults is associated with bone-related diseases, while during repair processes, it can be reactivated to modulate bone formation. Current therapeutic strategies targeting the Hh cascade for osteogenesis coordination have been reviewed.
CELL PROLIFERATION
(2022)
Article
Chemistry, Multidisciplinary
Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, Yaoting Ji, Yufeng Zhang
Summary: Mitochondrial transfer from macrophages to mesenchymal stem cells regulates bone homeostasis, and abnormal transfer under osteoporotic conditions leads to metabolic remodeling in stem cells.
Article
Dentistry, Oral Surgery & Medicine
Y. Li, J. Zhang, W. Cai, C. Wang, Z. Yu, Z. Jiang, K. Lai, Y. Wang, G. Yang
Summary: The long-term success rate of dental implants can be improved by establishing a favorable biological sealing with a high-quality epithelial attachment. The application of mesenchymal stem cells (MSCs) holds promise for facilitating the soft tissue integration around implants, but the molecular mechanism is still unclear and the general application of MSC sheet for soft tissue integration is also relatively unexplored.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jaime Freitas, Sara Reis Moura, Mario Adolfo Barbosa, Susana G. Santos, Maria Ines Almeida
Summary: Long non-coding RNAs (lncRNAs) play a crucial role in regulating gene expression and have the potential to be therapeutic targets. In this study, the lncRNA CASC2 was found to be involved in the regulation of osteogenic differentiation and mineralization. Knockdown of CASC2 resulted in increased expression of the late osteogenic marker BSP and enhanced mineralization of human bone marrow-derived MSCs. Proteomic analysis revealed that CASC2 regulates the expression of several proteins associated with bone diseases and musculoskeletal traits, including COMP. This study suggests that targeting CASC2 could be a potential approach for modulating bone mineralization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Hanwen Gu, Jian Wei
Summary: This study found that peiminine can regulate osteogenesis and adipogenesis in ovariectomized rats, and prevent ovariectomy-induced osteoporosis by activating the Wnt/β-catenin pathway. These findings suggest that peiminine has the potential to be a preventive treatment for osteoporosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Yang Yu, Meng Chen, Shiyao Yang, Bingyi Shao, Liang Chen, Lei Dou, Jing Gao, Deqin Yang
Summary: Autologous bone marrow-derived mesenchymal stem cells (BMSCs) have promising potential for immunosuppressive therapy, but their immunomodulatory properties are often impaired in patients. Osthole has gained clinical attention for its biological activities, and in this study, it successfully restored the immunosuppressive ability of osteoporotic BMSCs in treating inflammatory colitis and osteoporosis. Enhancing the immune regulatory performance of BMSCs through pharmacological modification, such as osthole, may significantly improve targeted strategies for immunosuppressive therapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Xiaoyun Li, Rumeng Chen, Xiaotong Lei, Panpan Wang, Xiaofeng Zhu, Ronghua Zhang, Li Yang
Summary: The study found that ERα and QUE regulate the differentiation of rBMSCs through the circRNA-miR-326-5p-mRNA axis, with miR-326-5p playing a key role in osteogenic and adipogenic differentiation.
Article
Biotechnology & Applied Microbiology
Chi Zhang, Dongdong Xia, Jiajing Li, Yanan Zheng, Bowen Weng, Haijiao Mao, Jing Mei, Tao Wu, Mei Li, Jiyuan Zhao
Summary: This study evaluated the effects of BMSCs combined with cell-engineered ECM scaffolds on osteogenesis and angiogenesis in vivo. The results showed that Ca/Ic-SIS scaffolds promoted both bone and blood vessel formation, while reducing immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
He-xiang Zong, Ya-qian Liu, Xi-le Wang, Jie-yu Miao, Li-ping Luo, Jian-xiong Wang, Yi-ran Chu, Wan-qiu Tong, Xu Zhao, Sheng-qian Xu
Summary: This study reveals that RNA-binding protein RIOK3 may participate in the pathogenesis of ankylosing spondylitis by affecting the differentiation of mBMSCs and pathological bone formation.
Article
Cell Biology
Zheng-Zhao Liu, Chun-Gu Hong, Wen-Bao Hu, Meng-Lu Chen, Ran Duan, Hong-Ming Li, Tao Yue, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Lang Xu, Si-Yuan Tang, Rong-Gui Hu, Hui Xie
Summary: Senile osteoporosis (OP) is associated with decreased autophagic activity, with OPTN playing a crucial role in bone metabolism through selective autophagy. Reduced expression of OPTN during aging may lead to OP due to impaired degradation of FABP3 via selective autophagy, which impairs osteogenesis of MSCs and contributes to bone loss. Reactivating OPTN or inhibiting FABP3 could be a potential treatment strategy for senile OP.
Article
Chemistry, Medicinal
Yanran Yang, Daiyun Chen, Yilin Li, Jinghua Zou, Ruiqi Han, Hongkun Li, Jun Zhang
Summary: Puerarin has a positive impact on the proliferation and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells, and promotes new bone formation. In a rat RME model, puerarin solution enhances osteogenesis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ting-Wei Kao, Arthur Chiou, Keng-Hui Lin, Yi-Shiuan Liu, Oscar Kuang-Sheng Lee
Summary: Research shows that mechanical stimulation affects the intracellular viscoelasticity of human mesenchymal stem cells, with cells cultured in rigid matrix displaying higher elastic and viscous moduli. This effect remains consistent throughout the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)