Review
Pharmacology & Pharmacy
Huijie Zhao, Yiming Zhang, Yanting Zhang, Chaoran Chen, Huiyang Liu, Yihan Yang, Honggang Wang
Summary: Inflammasomes are important in innate immunity, dealing with pathogens and cellular products related to stress and injury. The NLRP3 inflammasome, consisting of NLRP3, ASC, and procaspase-1, is the best studied and most characteristic inflammasome. Activation of the NLRP3 inflammasome leads to caspase-1 activation, interleukin (IL)-1 beta and IL-18 maturation, and pyroptosis. While the NLRP3 inflammasome is involved in tumorigenesis, it also plays a protective role in some cancers. This article focuses on the role of the NLRP3 inflammasome in hepatocellular carcinoma (HCC) and analyzes the underlying mechanisms, aiming to provide insights for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rongze Wang, Yexuan Zhu, Jingyi Chen, Yiliang Wang, Xiaowei Song, Yanting Wu, Fujun Jin, Yifei Wang
Summary: The novel quinazoline derivative 04NB-03 exhibits potent anti-HCC activities by inducing cell cycle arrest and apoptosis in an ROS-dependent manner, making it a potential candidate for the development of antitumor drugs targeting HCC.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Chou-Yuan Ko, Po-Chang Shih, Po-Wei Huang, Yi-Hsin Lee, Yen-Fu Chen, Ming-Hong Tai, Chi-Hao Liu, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Sinularin was found to effectively inhibit the growth of hepatocellular carcinoma SK-HEP-1 cells at a concentration of 10 μM, inducing DNA fragmentation and apoptosis, as well as affecting cell migration and colony formation. Additionally, it altered the expression levels of various proteins related to cell signaling and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jiajie Tan, Yuling Xiang, Yuanguo Xiong, Yaoyuan Zhang, Boyang Qiao, Hong Zhang
Summary: In this study, crebanine, a bioactive compound derived from Stephania, was found to effectively inhibit the growth and migration capacity of hepatocellular carcinoma cells. It induces apoptosis through increasing reactive oxygen species levels and disrupting mitochondrial membrane potential. Additionally, crebanine affects the biological function of hepatocellular carcinoma cells through the ROS-AKT-FoxO3a signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yizhi Zhan, Zhanqiao Zhang, Yuechen Liu, Yuan Fang, Yuwen Xie, Yilin Zheng, Guoxin Li, Li Liang, Yi Ding
Summary: This study reveals the role of NUPR1 in regulating ROS homeostasis and oxidative stress through the AhR/CYP signal axis in hepatocellular carcinoma (HCC). Targeting the NUPR1/AhR/CYP pathway may have important clinical applications for improving the radiotherapeutic efficacy of HCC.
Article
Oncology
Isabel C. Lopez-Mejia, Jordi Pijuan, Raul Navaridas, Maria Santacana, Sonia Gatius, Ana Velasco, Gerard Castella, Anais Panosa, Elisa Cabiscol, Miquel Pinyol, Laura Coll, Nuria Bonifaci, Laura Plata Pena, August Vidal, Alberto Villanueva, Eloi Gari, David Llobet-Navas, Lluis Fajas, Xavier Matias-Guiu, Andree Yeramian
Summary: Uterine serous carcinoma (USC) is a highly metastatic and fatal form of endometrial cancer (EC). This study identified focal adhesion kinase (FAK) as a highly activated tyrosine kinase in USC and showed that targeting FAK can inhibit cell growth and reduce migration in USC cell lines. The study also revealed that oxidative stress is increased in USC tumors compared to endometrioid endometrial carcinoma (EEC), and ROS-mediated FAK activation plays a role in cell migration and poor prognosis in USC.
MOLECULAR ONCOLOGY
(2023)
Article
Anatomy & Morphology
Ming Yan, Yun Zhang, Wanting Niu, Kezhou Liu, Lingyun Xue, Kexin Zhou
Summary: During orthodontic tooth movement, the most mechanosensitive cells in alveolar bone, osteocytes, suffer from compressive force and lead to alveolar bone resorption on the compression side. The mechanisms of compressive force-induced osteocyte death remain unclear. This study establishes an OTM model and examines the involvement of reactive oxygen species (ROS)-mediated endoplasmic reticulum stress (ERS) pathway in compressive force-induced osteocyte death.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Oncology
Giuseppa Augello, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Lucia Condorelli, Antonella Cusimano, Lydia Giannitrapani, James A. McCubrey, Juan Lucio Iovanna, Melchiorre Cervello
Summary: The study revealed that NUPR1 knock-down impaired autophagic flux, increasing cell sensitivity to sorafenib, and activated the p73 signaling pathway, enhancing the anti-tumor effects of the drug. Combined therapy with the p73 activator NSC59984 and sorafenib showed synergistic suppression of tumor growth, suggesting a novel approach for HCC treatment.
Article
Biochemistry & Molecular Biology
Yixin Mao, Yang Chen, Wenjin Cai, Wanying Jiang, Xiaoyu Sun, Jun Zeng, Hongning Wang, Xia Wang, Wenmei Dong, Jianfeng Ma, Richard T. Jaspers, Shengbin Huang, Gang Wu
Summary: Titanium ions stimulate osteoblast apoptosis and have a negative effect on implant failure. Mitochondrial abnormalities are related to osteoblast dysfunction. This study found that mitochondrial oxidative stress and dysfunction play a role in titanium ion-induced apoptosis of osteoblastic cells. Mitochondrial-targeted antioxidants can alleviate the cytotoxic effects of titanium ions on osteoblasts. The primary regulator of mitochondrial permeability transition pore, cyclophilin D, is involved in mitochondrial dysfunction and osteoblast cell apoptosis induced by titanium ions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Han Ki Lee, Subin Bae, Jongsung Lee, Hyo Sun Cha, Myeong Jin Nam, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, Kwang-Hyeon Liu, See-Hyoung Park
Summary: The aim of this study was to investigate the apoptotic effects and anticancer mechanism of the biflavonoid bilobetin against human hepatocellular carcinoma (HCC) cells. The results showed that bilobetin inhibited cell proliferation, induced apoptosis and DNA fragmentation, elevated ROS levels, and caused DNA damage in HCC cells. It also regulated the expression of apoptotic signaling pathway proteins.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jingjing Wang, Qi Su, Qing Wu, Kun Chen, Asmat Ullah, Mohsin Ahmad Ghauri, Yanmin Zhang
Summary: This study investigated the antitumor effects of sanguinarine (Sang) on hepatocellular carcinoma (HCC) and found that Sang impairs lysosomal function, induces ROS-dependent mitophagy and apoptosis in HCC cells. The findings suggest that Sang could be a potential therapeutic option for treating HCC by targeting these mechanisms.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jianrong Zheng, Liao Zeng, Mingqing Tang, Hongjun Lin, Chao Pi, Ruian Xu, Xiuling Cui
Summary: Compound 1 exhibited potent anti-HCC activity by inducing cell cycle arrest and apoptosis through mitochondrial pathway, suggesting it as a promising candidate for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ming-Feng Tsai, Shih-Ming Chen, Ann-Zhi Ong, Yi-Hsuan Chung, Pei-Ni Chen, Yi-Hsien Hsieh, Yu-Ting Kang, Li-Sung Hsu
Summary: The study found that shikonin induced programmed cell death in renal cancer cells by increasing ROS levels and p38 activity, while also promoting autophagy. N-acetyl cysteine can alleviate shikonin-induced cell death and ROS generation.
Article
Biochemistry & Molecular Biology
Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang
Summary: The study confirmed that mitochondria are the main source of ROS induced by 6c, leading to mitochondrial dysfunction and lysosomal destabilization. Moreover, ROS regulated the expression of 6c-mediated proteins, promoted the formation of autophagosomes, and caused DNA damage, ultimately resulting in cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu
Summary: In this study, we found that alternol sensitized renal carcinoma cells to TRAIL-induced apoptosis by inhibiting antiapoptotic proteins, upregulating DR5 levels, ROS generation, and the CHOP pathway, thus enhancing TRAIL-mediated apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)