Significance of p53 dynamics in regulating apoptosis in response to ionizing radiation and polypharmacological strategies

Activation and control of p53 tetramerization in individual living cells

(2013) G. Gaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor Oscillations Induce Differential Gene Expressions

(2012) Keng Boon Wee et al.   BIOPHYSICAL JOURNAL

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Traveling Bax and Forth from Mitochondria to Control Apoptosis

(2011) Maria Eugenia Soriano et al.   CELL

Stimulus-dependent dynamics of p53 in single cells

(2011) E. Batchelor et al.   Molecular Systems Biology

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

(2011) Jeffrey Atkinson et al.   Nature Communications

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death

(2010) Joanna Skommer et al.   APOPTOSIS

Nuclear proteins acting on mitochondria

(2010) Liora Lindenboim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coordination of the Nuclear and Cytoplasmic Activities of p53 in Response to DNA Damage

(2010) Tian Pu et al.   BIOPHYSICAL JOURNAL

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

(2010) M M Cleland et al.   CELL DEATH AND DIFFERENTIATION

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death

(2010) Gabriela Mustata et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Decision making of the p53 network: Death by integration

(2010) Zhiyuan Li et al.   JOURNAL OF THEORETICAL BIOLOGY

Fourier analysis and systems identification of the p53 feedback loop

(2010) N. Geva-Zatorsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML

(2009) B. Z. Carter et al.   BLOOD

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

(2009) N D Marchenko et al.   CELL DEATH AND DIFFERENTIATION

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Cell fate decision mediated by p53 pulses

(2009) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Explaining oscillations and variability in the p53-Mdm2 system

(2008) Carole J Proctor et al.   BMC Systems Biology

Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA Damage

(2008) Eric Batchelor et al.   MOLECULAR CELL

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

(2008) John G Albeck et al.   PLOS BIOLOGY