Journal
SCIENTIFIC REPORTS
Volume 4, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep06423
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Funding
- National Natural Science Foundation [81030027, 91120305]
- National Key Technologies RD Program [2012BAI01B03]
- National High-Tech R&D Program of China (863 Program) [2012AA011601]
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Neurobiological markers of stress symptom progression for healthy survivors from a disaster (e. g., an earthquake) would greatly help with early intervention to prevent the development of stress-related disorders. However, the relationship between the neurobiological alterations and the symptom progression over time is unclear. Here, we examined 44 healthy survivors of the Wenchuan earthquake in China in a longitudinal resting-state fMRI study to observe the alterations of brain functions related to depressive or anxiety symptom progression. Using multi-variate pattern analysis to the fMRI data, we successfully predicted the depressive or anxiety symptom severity for these survivors in short-(25 days) and long-term (2 years) and the symptom severity changes over time. Several brain areas (e.g., the frontolimbic and striatal areas) and the functional connectivities located within the fronto-striato-thalamic and default-mode networks were found to be correlated with the symptom progression and might play important roles in the adaptation to trauma.
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