Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Article
Chemistry, Medicinal
Nikita Lomis, Ziyab K. Sarfaraz, Aiman Alruwaih, Susan Westfall, Dominique Shum-Tim, Satya Prakash
Summary: A novel protein nanoparticle formulation designed for heart-targeted delivery of milrinone demonstrated improved pharmacokinetics and cardiac function parameters compared to the non-targeted drug, effectively enhancing treatment for congestive heart failure.
Review
Biotechnology & Applied Microbiology
Haoyue Song, Xiaohang Chen, Yujia Hao, Jia Wang, Qingpeng Xie, Xing Wang
Summary: This review comprehensively summarizes the potential and challenges of natural endogenous extracellular vesicles (EVs) in precision medicine drug delivery systems. The strategies to improve targeting specificity, such as nanoengineering techniques to modify source cells and EVs surfaces, as well as auxiliary strategies to change the external environment, are discussed. The lack of a gold standard for assessing targeting efficiency in contemporary issues is also highlighted.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Bianka Golba, Edmondo M. Benetti, Bruno G. De Geest
Summary: Cyclic polymers, lacking chain ends, possess unique architecture and properties that make them suitable for various applications in nano-, micro-, and macro-scale materials. In the biomedical field, biomaterials based on cyclic polymers demonstrate distinct properties in terms of drug delivery efficiency and surface activity. Future challenges in utilizing cyclic polymers in biomedical applications are also discussed in this review.
Article
Engineering, Biomedical
Simone Capuani, Nathanael Hernandez, Jesus Paez-Mayorga, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Corrine Ying Xuan Chua, Joan E. Nichols, Alessandro Grattoni
Summary: Local immunomodulation has been shown to be effective in controlling immune response for wound healing, cancer, allergy, and cell transplantation, without the adverse effects associated with systemic administration of immunotherapeutics. A 3D-printed subcutaneous implant called 'NICHE' was developed to provide a bioengineered vascularized microenvironment that enables sustained drug delivery. The study investigated the pharmacokinetics and biodistribution of different immunomodulatory agents delivered locally via NICHE, and developed a physiologically-based pharmacokinetic (PBPK) model that accurately predicted the distribution of the drugs.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Olga Pelikh, Ralph W. Eckert, Shashank Reddy Pinnapireddy, Cornelia M. Keck
Summary: Nanocrystals are a promising formulation for improved drug delivery, targeting the hair follicles and providing long-lasting and efficient dermal drug delivery. Different types of vehicles do not significantly affect the efficacy of nanocrystals' penetration into hair follicles, but they do impact passive dermal penetration. Gels containing humectants can enhance passive penetration effectiveness.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu, Alda L. Tam
Summary: A novel nanoemulsion combining irinotecan with lipiodol showed higher irinotecan deposition in the liver via TACE and more irinotecan distribution in the tumor via PVCE compared to traditional delivery methods, demonstrating promising potential for the treatment of metastatic colorectal cancer.
Article
Chemistry, Multidisciplinary
Vincent Mittelheisser, Pierre Coliat, Eric Moeglin, Lilian Goepp, Jacky G. Goetz, Loic J. Charbonniere, Xavier Pivot, Alexandre Detappe
Summary: Tumor-targeted antibody/fragment-conjugated nanoparticles show promise in improving local delivery of small molecules. A meta-analysis of 161 studies confirmed that targeted nanoparticles had significantly higher tumor uptake compared to naked nanoparticles. The study also found that the choice of nanoparticle type, size, and antibody moiety affected tumor uptake.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Elahehnaz Parhizkar, Soliman Mohammadi Samani, Amirhossein Sakhteman, Saeid Daneshamouz, Golnaz Parhizkar, Fatemeh Ahmadi
Summary: Prodrugs, especially folate conjugates, demonstrate higher cytotoxicity and longer serum residence time compared to free CTX. Tissue accumulation data shows liver as the major organ for CTX. Data modeling analysis reveals significant differences in pharmacokinetics properties between CTX and prodrugs, suggesting promise as a potential CTX delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Jia Nong, Patrick M. M. Glassman, Jacob W. W. Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia, Alvin Mukalel, Serena Omo-Lamai, Landis R. R. Walsh, Marco E. E. Zamora, Xijing Gong, Zhicheng Wang, Kartik Bhamidipati, Raisa Y. Y. Kiseleva, Carlos H. H. Villa, Colin Fred Greineder, Scott E. E. Kasner, Drew Weissman, Michael J. J. Mitchell, Silvia Muro, Yuri Persidsky, Jacob Samuel Brenner, Vladimir R. R. Muzykantov, Oscar A. A. Marcos-Contreras
Summary: The study investigated the loading of nanoparticles targeted to intercellular adhesion molecule 1 (anti-ICAM/NP) into white blood cells (WBC) in vivo, bypassing the ex vivo manipulation. The results showed successful transport of anti-ICAM/NP to pathological foci in the central nervous system (CNS) through the migration of WBCs from the lungs. This method could be clinically significant in the treatment of acute brain inflammation and reduction of brain edema.
Review
Pharmacology & Pharmacy
Jia Nong, Patrick M. Glassman, Vladimir R. Muzykantov
Summary: Acute inflammation is a common component of many prevalent conditions, and targeting endothelial cells for therapeutic intervention shows promise in correcting the damaging effects of inflammation. However, current drugs and drug delivery systems lack precision and effectiveness.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Polymer Science
Hassaan Umar, Habibah A. Wahab, Amirah Mohd Gazzali, Hafsa Tahir, Waqas Ahmad
Summary: Thanks to advancements in biomedical nanotechnology, traditional drug delivery systems have evolved into smart systems that respond to stimuli. Cubosomes, a lipid-based nano system, can be utilized in various drug delivery applications.
Article
Chemistry, Multidisciplinary
Syed Muhammad Usama, Sierra C. Marker, Donald R. Caldwell, Nimit L. Patel, Yang Feng, Joseph D. Kalen, Brad St Croix, Martin J. Schnermann
Summary: ADCs are an important therapeutic platform, where the linker between antibodies and drug payloads greatly affects efficacy and tolerability. A new NIR imaging method has been developed to quantitatively assess linker cleavage efficiency, enabled by an improved variant of the CyBam platform. Furthermore, different linkers were compared across antibodies and tumor models, revealing that cathepsin-cleavable linkers show higher tumor activation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Baode Shen, Chengying Shen, Weifeng Zhu, Hailong Yuan
Summary: The study revealed that the size of the nanoparticles affects the absorption and biodistribution of the drug, with smaller particles being more easily absorbed but dissolving faster in vivo, leading to higher drug distribution but lower accumulation of integral nanocrystals in the liver. Larger particles, on the other hand, show slower dissolution and higher liver distribution due to enhanced recognition by RES. The absolute exposure of integral nanocrystals to oral bioavailability enhancement was unexpectedly high, indicating a significant difference in absorption and biodistribution between integral nanocrystals and overall drugs following oral and intravenous administration.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Biagio Todaro, Elisa Ottalagana, Stefano Luin, Melissa Santi
Summary: Peptides, similar to oligonucleotide aptamers and antibodies, can be used as targeting molecules. They have high production efficiency and stability in physiological environments. In recent years, they have been extensively studied for targeting various diseases, including tumors and central nervous system disorders, due to their ability to cross the blood-brain barrier. This review discusses the techniques for designing peptides experimentally and in silico, as well as their potential applications. It also explores advancements in their formulation and chemical modifications to enhance their stability and effectiveness. Furthermore, the review explores how peptides could be effectively utilized to overcome physiological challenges and improve existing treatments.
Article
Materials Science, Multidisciplinary
L. M. Carter, J. D. Brockman, S. K. Loyalka, J. D. Robertson
JOURNAL OF NUCLEAR MATERIALS
(2015)
Article
Materials Science, Multidisciplinary
L. M. Carter, J. D. Brockman, J. D. Robertson, S. K. Loyalka
JOURNAL OF NUCLEAR MATERIALS
(2015)
Article
Multidisciplinary Sciences
David Rotsch, Tom Brossard, Saadia Bihmidine, Weijiang Ying, Vikram Gaddam, Michael Harmata, J. David Robertson, Michael Swyers, Silvia S. Jurisson, David M. Braun
Article
Materials Science, Multidisciplinary
L. M. Carter, J. D. Brockman, J. D. Robertson, S. K. Loyalka
JOURNAL OF NUCLEAR MATERIALS
(2016)
Article
Plant Sciences
Thu M. Tran, Carissa S. Hampton, Tom W. Brossard, Michael Harmata, J. David Robertson, Silvia S. Jurisson, David M. Braun
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Materials Science, Multidisciplinary
L. M. Carter, J. D. Seelig, J. D. Brockman, J. D. Robertson, S. K. Loyalka
JOURNAL OF NUCLEAR MATERIALS
(2018)
Article
Engineering, Electrical & Electronic
Tongtawee Wacharasindhu, Bradley R. Nullmeyer, Jae W. Kwon, J. David Robertson, Alexander Y. Garnov
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
(2014)
Article
Toxicology
Jian You, Jialin Zhou, Min Zhou, Yang Liu, J. David Robertson, Dong Liang, Carolyn Van Pelt, Chun Li
PARTICLE AND FIBRE TOXICOLOGY
(2014)
Article
Nanoscience & Nanotechnology
Md. Nazir Hossen, Geeta Rao, Anindya Dey, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Multidisciplinary Sciences
Md Nazir Hossen, Lin Wang, Harisha R. Chinthalapally, Joe D. Robertson, Kar-Ming Fung, Stefan Wilhelm, Magdalena Bieniasz, Resham Bhattacharya, Priyabrata Mukherjee
Article
Nanoscience & Nanotechnology
Benjamin Kogos, Leona Cohen-Gould, Cristina Rodriguez-Rodriguez, Vesna Sossi, Nicholas Sobol, Richard Johnson, Douglas C. Miller, J. David Robertson, Paul H. Pevsner
Summary: The study identified the ultrastructural loci of nanoparticles containing lutetium-177 conjugated to an anti-thrombomodulin antibody following murine injection. Results confirmed prior work on localizing nanoparticles using Single Photon Emission Computed Tomography (SPECT) scans and identified the in vivo pharmacokinetics of these nanoparticles. This study serves as proof that nanoparticles conjugated with appropriate antibodies can target specific antigens in vivo, suggesting potential for targeted cancer therapy with minimal harm to healthy cells.
Article
Engineering, Biomedical
Nicholas Sobol, Logan Sutherlin, Edyta Cedrowska, Joshua Schorp, Cristina Rodriguez-Rodriguez, Vesna Sossi, Jimmy Lattimer, Douglas C. Miller, Paul Pevsner, J. David Robertson
APL BIOENGINEERING
(2018)
Meeting Abstract
Chemistry, Multidisciplinary
John W. Brown, John D. Brockman, J. David Robertson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Meeting Abstract
Chemistry, Multidisciplinary
Xingyao Wang, John D. Brockman, James M. Guthrie, Amanda Durbak, Ryan T. Ladd, J. D. Robertson, Paula C. McSteen, Susan Z. Lever
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Meeting Abstract
Chemistry, Multidisciplinary
John D. Robertson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)