Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1

(2014) Robert Wagner et al.   Molecular Metabolism

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

(2013) Q. Huang et al.   CANCER RESEARCH

TCF7L2 and Diabetes: A Tale of Two Tissues, and of Two Species

(2013) Mark I. McCarthy et al.   Cell Metabolism

TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas

(2013) M. A. Nobrega   DIABETES

Serum Levels of Acylcarnitines Are Altered in Prediabetic Conditions

(2013) Manuel Mai et al.   PLoS One

Plasma Metabolomics Reveal Alterations of Sphingo- and Glycerophospholipid Levels in Non-Diabetic Carriers of the Transcription Factor 7-Like 2 Polymorphism rs7903146

(2013) Cornelia Then et al.   PLoS One

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

Understanding the Elusive Mechanism of Action of TCF7L2 in Metabolism

(2012) S. F. A. Grant   DIABETES

Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)

(2012) P. Spegel et al.   DIABETES

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis

(2012) W. Shao et al.   DIABETES

Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men

(2012) E. Renström   DIABETOLOGIA

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

(2012) O. Le Bacquer et al.   DIABETOLOGIA

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Allele Summation of Diabetes Risk Genes Predicts Impaired Glucose Tolerance in Female and Obese Individuals

(2012) Katarzyna Linder et al.   PLoS One

Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers

(2012) Anna L. Gloyn et al.   PLoS One

New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms

(2011) Silke A. Schäfer et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

(2011) D. Savic et al.   GENOME RESEARCH

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion

(2010) M. Heni et al.   DIABETES

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test

(2010) A. P. Gjesing et al.   DIABETOLOGIA

Metabolomics Applied to Diabetes Research: Moving From Information to Knowledge

(2009) J. R. Bain et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES