USP8 modulates ubiquitination of LRIG1 for Met degradation

USP8 Is a Novel Target for Overcoming Gefitinib Resistance in Lung Cancer

(2013) S. Byun et al.   CLINICAL CANCER RESEARCH

Lrig1: a new master regulator of epithelial stem cells

(2012) Paloma Ordóñez-Morán et al.   EMBO JOURNAL

A new anti-c-met antibody selected by a mechanism-based dual-screening method: Therapeutic potential in cancer

(2012) Young Mi Oh et al.   MOLECULES AND CELLS

Cbl-independent degradation of Met: ways to avoid agonism of bivalent Met-targeting antibody

(2012) J M Lee et al.   ONCOGENE

GGA3 Functions as a Switch to Promote Met Receptor Recycling, Essential for Sustained ERK and Cell Migration

(2011) Christine Anna Parachoniak et al.   DEVELOPMENTAL CELL

A direct role for Met endocytosis in tumorigenesis

(2011) Carine Joffre et al.   NATURE CELL BIOLOGY

ERBB2 is a target for USP8-mediated deubiquitination

(2010) Inez M.J. Meijer et al.   CELLULAR SIGNALLING

Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex

(2010) Ilana Berlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease

(2010) Shan Qin et al.   JOURNAL OF CLINICAL INVESTIGATION

MET signalling: principles and functions in development, organ regeneration and cancer

(2010) Livio Trusolino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

(2009) Masashi Sanada et al.   NATURE

MET receptor tyrosine kinase as a therapeutic anticancer target

(2008) Christine M. Stellrecht et al.   CANCER LETTERS

"Active" Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

(2008) E. Vigna et al.   CANCER RESEARCH

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting ubiquitin specific proteases for drug discovery

(2007) Laurent Daviet et al.   BIOCHIMIE