Journal
SCIENTIFIC REPORTS
Volume 2, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep00936
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Funding
- National Basic Research Program of China [2012CB316504]
- NSFC [81225025, 90709013, 61021063, 60928007]
- TNLIST
- NSF [1043075]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1043075] Funding Source: National Science Foundation
- Directorate For Geosciences
- Division Of Ocean Sciences [1136818] Funding Source: National Science Foundation
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Tongue diagnosis is a unique method in traditional Chinese medicine (TCM). This is the first investigation on the association between traditional tongue diagnosis and the tongue coating microbiome using next-generation sequencing. The study included 19 gastritis patients with a typical white-greasy or yellow-dense tongue coating corresponding to TCM Cold or Hot Syndrome respectively, as well as eight healthy volunteers. An Illumina paired-end, double-barcode 16S rRNA sequencing protocol was designed to profile the tongue-coating microbiome, from which approximately 3.7 million V6 tags for each sample were obtained. We identified 123 and 258 species-level OTUs that were enriched in patients with Cold/Hot Syndromes, respectively, representing Cold Microbiota and Hot Microbiota. We further constructed the tongue microbiota-imbalanced networks associated with Cold/Hot Syndromes. The results reveal an important connection between the tongue-coating microbiome and traditional tongue diagnosis, and illustrate the potential of the tongue-coating microbiome as a novel holistic biomarker for characterizing patient subtypes.
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