Article
Biochemistry & Molecular Biology
Wanlin Xu, Zhen Zhang, Hao Lu, Yifan Wu, Jia Liu, Shengwen Liu, Wenjun Yang
Summary: The study created a PU/Gel/VEGF conduit which promotes proliferation, migration, and expression of neural markers in nerve cells, aiding in functional recovery of the injured side.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Neurosciences
Yi-jun Liu, Xiao-feng Chen, Li-ping Zhou, Feng Rao, Dian-ying Zhang, Yan-hua Wang
Summary: This study aimed to analyze the effect and mechanism of Wnt5a-loaded fibrin hydrogel on a 10-mm rat sciatic nerve defect. Results showed that Wnt5a could promote Schwann cell proliferation and the expression of various neurotrophic factors, and the Wnt5a/Fn group outperformed the control groups in terms of nerve regeneration and functional recovery 12 weeks after the operation. The Wnt5a/Fn nerve conduit may promote peripheral nerve defect regeneration by facilitating multiple neurotrophin secretion, combining vascularization and neurotrophic growth cues.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Review
Chemistry, Multidisciplinary
Faranak Mankavi, Rana Ibrahim, Hongjun Wang
Summary: This article summarizes the recent advances in nerve guidance conduits (NGCs) for peripheral nerve regeneration and repair, including biomaterial innovations, structural design, advanced fabrication technologies, and cellular responses to biomimetic cues.
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wanlin Xu, Yifan Wu, Hao Lu, Yun Zhu, Jinhai Ye, Wenjun Yang
Summary: This study successfully achieved controlled release of vascular endothelial growth factor using a modified gelatin hydrogel, leading to improved nerve regeneration and repair.
NEURAL REGENERATION RESEARCH
(2022)
Article
Acoustics
Arzu Hizay, Umut Ozsoy, Kamil Savas, Sezin Yakut-Uzuner, Ozlem Ozbey, Simla Su Akkan, Pinar Bahsi
Summary: This study aimed to investigate the effect of ultrasound treatment on the expression of vascular endothelial growth factor (VEGF), its receptors, and new vessel formation after facial nerve injury. The results showed that ultrasound treatment significantly increased the levels of VEGF, VEGFR1, VEGFR2, and CD31, promoting facial nerve regeneration and functional improvement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: This scoping review summarizes the adequate quantitative/morphometric parameters of polymeric nerve guide conduits (NGCs) that provide a supportive environment for nerve regeneration. Optimal morphometric characteristics, such as wall thickness, fiber size, pore size, and porosity, are identified to enhance nerve regeneration and reduce the need for experimental studies.
Review
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Alex Lopez Marquez, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: The study summarizes the main morphological characteristics of nerve guide conduits (NGC) that influence nerve regeneration, including diameter, wall thickness, porosity, pore size, fiber alignment, and thickness.
Article
Engineering, Biomedical
Yuting Cai, Qun Huang, Penghui Wang, Kaichuang Ye, Zhen Zhao, Haomin Chen, Zhenjing Liu, Hongwei Liu, Hoilun Wong, Mohsen Tamtaji, Kenan Zhang, Feng Xu, Guorui Jin, Lun Zeng, Jianbo Xie, Yucong Du, Zhigang Hu, Dazhi Sun, Jinbao Qin, Xinwu Lu, Zhengtang Luo
Summary: This study develops a graphene-based nerve guidance conduit for diabetic patients with peripheral nerve injury. The conduit incorporates a natural double network hydrogel and a neurotrophic concentration gradient, providing good biocompatibility and sustained growth factor release. The graphene mesh improves the toughness and conductivity of the conduit, promoting regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Haixing Xu, Yi Yu, Lingxi Zhang, Furong Zheng, Yixia Yin, Yuxiang Gao, Kebi Li, Jingyi Xu, Jing Wen, Hui Chen, Zhixin Lei, Zhijun Huang, Dan Yu, Nan Jiang, Peihu Xu
Summary: The study investigates the repair of injured peripheral nerves in rats using PDLLA/beta-TCP nerve conduits laden with CS-HA/NGF hydrogels, showing that the hydrogels promote adhesion, spreading, and differentiation of neuronal cells while sustaining NGF release. In vivo studies demonstrate a significant positive effect on axon regeneration and myelination compared to control groups, indicating the potential of CS-HA/NGF injectable hydrogel in promoting nerve regeneration in neural tissue engineering.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Review
Cell Biology
Kamilla Faritovna Idrisova, Alina Kazymovna Zeinalova, Galina Andreevna Masgutova, Alexey Andreevich Bogov, Cinzia Allegrucci, Valeriia Yurievna Syromiatnikova, Ilnur Ildusovich Salafutdinov, Ekaterna Evgenievna Garanina, Dina Ivanovna Andreeva, Adilet Abdullaatovich Kadyrov, Albert Anatolevich Rizvanov, Ruslan Faridovich Masgutov
Summary: The limited ability of peripheral nerves to regenerate after injury can lead to poor motor function and permanent disability. Gene therapy and cell therapy-based drugs that increase nerve growth factors can compensate for this limitation. Fibroblast growth factor 2 and vascular endothelial growth factor have positive effects on angiogenesis and neural cell growth, making them important for nerve regeneration.
NEURAL REGENERATION RESEARCH
(2022)