Review
Oncology
Christian Maihoefner, Ingo Diel, Hans Tesch, Tamara Quandel, Ralf Baron
Summary: Cancer diagnosis and treatment are significant events with potential severe side effects, including chemotherapy-induced peripheral neuropathy (CIPN). Some patients may face chronic symptoms, highlighting the importance of prevention and treatment strategies. Improved survival rates for cancer patients may lead to an increased incidence of CIPN in the future.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Medicine, Research & Experimental
Phiwayinkosi V. Dludla, Bongani B. Nkambule, Ilenia Cirilli, Fabio Marcheggiani, Sihle E. Mabhida, Khanyisani Ziqubu, Yonela Ntamo, Babalwa Jack, Tawanda M. Nyambuya, Sidney Hanser, Sithandiwe E. Mazibuko-Mbeje
Summary: Diabetic neuropathy is a serious condition that can lead to various complications and severely impact a patient's quality of life. The use of topical capsaicin cream has shown promising results in reducing pain symptoms and improving walking, working, and sleeping in patients with painful diabetic neuropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ariana Hudita, Bianca Galateanu, Marieta Costache, Carolina Negrei, Rodica-Mariana Ion, Lorena Iancu, Octav Ginghina
Summary: This study investigated the therapeutic effects of alginate-microencapsulated capsaicin on neuropathic pain, revealing that this new formulation has lower cytotoxic effects, significant improvements in cell morphology and oxidative stress status, and can alter the expression profile of inflammatory cytokines compared to the control group.
Review
Pharmacology & Pharmacy
Magdalena Kocot-Kepska, Renata Zajaczkowska, Joanna Mika, David J. Kopsky, Jerzy Wordliczek, Jan Dobrogowski, Anna Przeklasa-Muszynska
Summary: Neuropathic pain in humans results from injuries or diseases of the somatosensory nervous system, and despite advancements in pain management, topical treatments are gaining popularity for their safety and targeted mechanisms. Active compounds in topical treatments exert multiple mechanisms of action on neuronal and non-neuronal cells, contributing to pain relief, but the specific impact in humans remains unclear. Evidence from clinical studies supports certain topical treatments as effective options for managing neuropathic pain.
Article
Immunology
Emily Pickering, Elizabeth L. Steels, Kathryn J. Steadman, Amanda Rao, Luis Vitetta
Summary: This study demonstrated that a palmitoylethanolamide (PEA) formulation can reduce diabetic peripheral neuropathic pain and inflammation, while improving mood and sleep. Further research is needed to investigate the effectiveness of PEA as an adjunct medicine or monotherapy pain analgesic.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J. Boenhof, Dan Ziegler, Rayaz A. Malik, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: Neuropathic pain is common in diabetic peripheral neuropathy (DN), and it may be caused by pathogenic ion channel gene variants. Variants in ion channel genes were found in DN patients with and without pain, suggesting their role in pain generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Pall Karlsson, Sandra S. Gylfadottir, Alexander G. Kristensen, Juan D. Ramirez, Pedro Cruz, Nhu Le, Pallai R. Shillo, Solomon Tesfaye, Andrew S. C. Rice, Hatice Tankisi, Nanna B. Finnerup, Jens R. Nyengaard, Troels S. Jensen, David L. H. Bennett, Andreas C. Themistocleous
Summary: In individuals with type 2 diabetes where IENFD is >1.0 fibre/mm, axonal swelling ratio is related to type 2 diabetes but is not related to DSP or painful DSP. Axonal swellings may be an early marker of sensory nerve injury in type 2 diabetes.
Article
Clinical Neurology
Praveen Anand, Rosario Privitera, Philippe Donatien, Hassan Fadavi, Solomon Tesfaye, Vassiliki Bravis, V. Peter Misra
Summary: The study evaluated the effects of 8% capsaicin patch treatment on pain relief and nerve regeneration in painful and non-painful diabetic peripheral neuropathy, indicating that capsaicin 8% patch treatment can provide pain relief and restore nerve density and function through nerve regeneration.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Rory M. C. Abrams, Elizabeth J. Pedowitz, David M. Simpson
Summary: The high-concentration capsaicin 8% patch is an effective and well-tolerated treatment option for diabetic peripheral nerve pain, providing rapid and sustained pain relief following a single application. It can be used alone or in combination with other therapies, and is safe and effective for long-term use.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md Shahin Alam, Bairong Shen
Summary: Neuropathic pain is a worldwide problem, and capsaicin as a topical analgesic has been shown to effectively improve pain symptoms without significant side effects. Studies over the past decade suggest that capsaicin may be a potential drug for neuropathic pain treatment.
CURRENT DRUG METABOLISM
(2021)
Article
Anesthesiology
Emmanuel Backryd, Andreas Themistocleous, Anders Larsson, Torsten Gordh, Andrew S. C. Rice, Solomon Tesfaye, David L. Bennett, Bjorn Gerdle
Summary: This study aims to explore the pathophysiological mechanisms underlying neuropathic pain in patients with diabetic DSP. It suggests that low-grade systemic inflammation is related to the severity of neuropathy and neuropathic pain, and identifies specific inflammation-related proteins such as hepatocyte growth factor, colony-stimulating factor 1, and CD40 that may play a crucial role in neuropathic pain.
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Jackie Elliott, Gordon Sloan, Lynda Stevens, Dinesh Selvarajah, Giorgio Cruccu, Rajiv A. Gandhi, Peter Kempler, John H. Fuller, Nishi Chaturvedi, Solomon Tesfaye
Summary: This study analyzed the EURODIAB Prospective Complications Study data to investigate the incidence and risk factors of painful DPN. It found that female sex was a risk factor for painful DPN and there was less evidence of diabetic nephropathy in painful DPN cases.
Article
Biology
Alessio Bellelli, Daniele Santi, Manuela Simoni, Carla Greco
Summary: A 46-year-old man with perforated duodenal ulcer and type 2 diabetes presented with depressed mood, weight loss, lower limb weakness, and bilateral foot pain. Diagnosis of diabetic cachectic neuropathy was made based on the clinical presentation and nerve conduction study. Treatment with pregabalin and duloxetine had limited effect, but the patient experienced relief of neuropathic pain and weight gain over time, confirming the diagnosis.
Article
Endocrinology & Metabolism
Zeynep Unluturk, Saadet Nur Sena Oztekin, Hakan Alkan, Hande Senol, Selin Betas, Cagdas Erdogan
Summary: LANSS, sLANSS, DN4, and PainDETECT are all useful tools for diagnosing diabetic neuropathic pain, with DN4 showing the highest specificity and sensitivity, and PainDETECT performing well with a cut off value set above 12.
BMC ENDOCRINE DISORDERS
(2022)
Article
Clinical Neurology
Praween Lolekha, Piyanat Wongwan, Kongkiat Kulkantrakorn
JOURNAL OF CLINICAL NEUROSCIENCE
(2015)
Review
Rheumatology
Ratchaya Lertnawapan, Kongkiat Kulkantrakorn
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Article
Immunology
Pongsatorn Meesawatsom, James Burston, Gareth Hathway, Andrew Bennett, Victoria Chapman
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Orthopedics
L. Xu, L. N. Nwosu, J. J. Burston, P. J. Millns, D. R. Sagar, P. I. Mapp, P. Meesawatsom, L. Li, A. J. Bennett, D. A. Walsh, V. Chapman
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Clinical Neurology
Lulin Choubtum, Pirada Witoonpanich, Kongkiat Kulkantrakorn, Suchat Hanchaiphiboolkul, Sunsanee Pongpakdee, Somsak Tiamkao, Teeratorn Pulkes
PARKINSONISM & RELATED DISORDERS
(2016)
Article
Biotechnology & Applied Microbiology
Wichittra Tassaneeyakul, Napat Prabmeechai, Chonlaphat Sukasem, Thachanan Kongpan, Parinya Konyoung, Pansu Chumworathayi, Somsak Tiamkao, Usanee Khunarkornsiri, Kongkiat Kulkantrakorn, Niwat Saksit, Nontaya Nakkam, Patompong Satapornpong, Suda Vannaprasaht, Alisara Sangviroon, Surakameth Mahasirimongkol, Nuanjun Wichukchinda, Ticha Rerkpattanapipat, Wongwiwat Tassaneeyakul
PHARMACOGENETICS AND GENOMICS
(2016)
Editorial Material
Clinical Neurology
Pompatr A. Dharmasaroja, Praween Lolekha, Kongkiat Kulkantrakorn, Thammanard Charernboon, Arvemas Watcharakorn, Pritsana Piyabhan
JOURNAL OF CLINICAL NEUROSCIENCE
(2017)
Article
Clinical Neurology
Kongkiat Kulkantrakorn, Dararat Suksasunee
JOURNAL OF CLINICAL NEUROSCIENCE
(2017)
Letter
Clinical Neurology
Kongkiat Kulkantrakorn, Tumtip Sangruchi
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Praween Lolekha, Arthita Choolam, Kongkiat Kulkantrakorn
NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Kongkiat Kulkantrakorn
NEUROLOGICAL SCIENCES
(2014)
Article
Clinical Neurology
Kongkiat Kulkantrakorn, Assawin Chomjit, Pasiri Sithinamsuwan, Thipaporn Tharavanij, Juthamas Suwankanoknark, Phunyada Napunnaphat
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Immunology
Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu, Victoria Chapman
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Kongkiat Kulkantrakorn, Weraphan Moonman
Article
Clinical Neurology
Praween Lolekha, Kongkiat Kulkantrakorn