Article
Anesthesiology
Huan Yan, Wannan Chen, Youwen Chen, Huayuan Gao, Yu Fan, Mingxiang Feng, Xiaoming Wang, Han Tang, Jiacheng Yin, Yunjia Qian, Ming Ding, Jing Cang, Changhong Miao, Hao Wang
Summary: This study investigated the impact of opioid-free anesthesia on chronic postoperative pain in patients undergoing video-assisted thoracoscopic surgery. The results showed that using opioid-free anesthesia can reduce the occurrence of chronic pain and side effects in patients after surgery.
ANESTHESIA AND ANALGESIA
(2023)
Article
Cardiac & Cardiovascular Systems
Zixiang Wu, Qi Wang, Cong Wu, Chuanqiang Wu, Huan Yu, Congcong Chen, Hong He, Ming Wu
Summary: This study found that there was no significant difference in pain relief between paravertebral block (PVB) and thoracic epidural analgesia (TEA) in patients experiencing moderate to severe pain after thoracoscopic surgery. However, PVB had a shorter catheter placement time and lower incidence of side effects compared to TEA.
ANNALS OF THORACIC SURGERY
(2023)
Review
Anesthesiology
Chengluan Xuan, Wen Yan, Dan Wang, Cong Li, Haichun Ma, Ariel Mueller, Vanessa Chin, Timothy T. Houle, Jingping Wang
Summary: Preemptive analgesia reduces postoperative pain, opioid consumption, and postoperative nausea or vomiting, and delays rescue analgesia.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Surgery
Ju Tang, Zhiguo Zheng, Qijun Ran, Feng Zhao, Yao Wang, Feng Hu, Chao Yang, Xiaoyong Tan
Summary: The aim of this study was to examine whether the addition of esketamine to morphine could improve postoperative analgesia after cesarean section. The results showed that patients who received 0.25 mg/kg esketamine plus 2 mg morphine through the epidural catheters had significantly lower pain scores at rest and with movement compared to the other groups, and they also required fewer rescue analgesics. Additionally, the addition of esketamine did not increase the incidence of adverse events.
FRONTIERS IN SURGERY
(2023)
Review
Chemistry, Medicinal
Panu Piirainen, Hannu Kokki, Merja Kokki
Summary: Epidural administration of oxycodone has advantageous pharmacokinetics and higher efficacy compared to intravenous administration, making it a potential option for epidural analgesia.
Article
Clinical Neurology
Erin Isaza, Jesse Santos, Greg J. Haro, Joy Chen, Daniel J. Weber, Tobias Deuse, Jonathan P. Singer, Jeffrey A. Golden, Steven Hays, Binh N. Trinh, Marek Brzezinski, Jasleen Kukreja
Summary: This study compared the analgesic outcomes of cryoanalgesia and thoracic epidural analgesia (TEA) in lung transplant patients and found that cryoanalgesia is as effective as TEA in pain management with lower opioid use and fewer complications.
Article
Medicine, General & Internal
Su-Sung Lee, Ji-Hye Baek, Soon-Ji Park, Hye-Jin Kim, Hee-Young Kim, Gyeong-Jo Byeon
Summary: This study investigated the effects of programmed intermittent epidural bolus injection versus continuous epidural injection on controlling nighttime pain and improving sleep quality after thoracotomy. The results showed that the programmed intermittent epidural bolus technique reduced postoperative nighttime pain, increased total sleep time, and improved satisfaction with sleep quality.
Article
Anesthesiology
Xiu-Liang Li, Jie Zhang, Lei Wan, Jing Wang
Summary: In a randomized controlled study of 96 patients undergoing thoracotomy, continuous thoracic epidural analgesia (TEA) significantly reduced the incidence of chronic pain at rest at 3 months and 12 months post-operation and provided better acute pain relief up to 24 hours post-operation compared with single-shot thoracic paravertebral block (TPVB) combined with intravenous analgesia.
Article
Medicine, General & Internal
Musa Zengin, Gulay Ulger, Ramazan Baldemir, Hilal Sazak, Ali Alagoz
Summary: The study investigated the impact of BMI on postoperative pain management in patients who underwent thoracotomy with TEA. Higher BMI values were associated with increased VAS scores and a greater need for rescue analgesics, indicating the importance of close monitoring and follow-up for patients with higher BMI values.
Article
Cardiac & Cardiovascular Systems
Jordan D. W. Ross, Christopher M. W. Cole, Wingchi Lo, Masashi Ura
Summary: This study identified that factors such as younger age, chronic opioid use, talc use, and multi-port VATS were associated with higher levels of acute postoperative pain. Furthermore, it found that a history of mental health condition, chronic use of opioids, urgent operations, and postoperative tramadol use were independently associated with a higher risk of chronic pain. It is important to consider modifying surgical practices associated with higher levels of pain and informing patients of non-modifiable risk factors for pain postoperatively.
HEART LUNG AND CIRCULATION
(2021)
Article
Anesthesiology
Holly B. Ende, Jeanette R. Bauchat, Laura L. Sorabella, Britany L. Raymond, Xiaoke Feng, Matthew S. Shotwell, Michael G. Richardson
Summary: The study aimed to investigate the impact of postoperative gabapentin administration on opioid consumption or pain scores in women undergoing cesarean delivery while on chronic buprenorphine. The results showed that including gabapentin in the analgesic regimen did not lead to lower opioid consumption or pain scores during the first 72 hours after cesarean delivery.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Anesthesiology
Carl Chauvin, Gregory Klar, Wilma M. Hopman, Leopoldo Muniz da Silva, Andrew G. Day, Rachel Phelan, Michael McMullen, Kai Chen, Rodrigo Moreira E. Lima, Glenio B. Mizubuti
Summary: The study showed that epidural waveform analysis (EWA) is useful in assessing the position of thoracic epidural catheters in the immediate postoperative period, with high sensitivity and specificity as well as robust inter-rater reliability. EWA may provide a useful adjunct for assessing epidural functionality in patients in whom sensory block to ice cannot be reliably assessed postoperatively.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Health Care Sciences & Services
Ioan Adrian Petrache, Cristian Oancea, Elisei Moise Hasan, Octavian Constantin Neagoe, Emanuela Tudorache, Mihaela Ionica, Ovidiu Nicolae Burlacu
Summary: The study suggests that using the extra-costal chest closure technique can significantly reduce post-operative pain levels compared to the traditional peri-costal closure technique, without increasing the complexity of the procedure.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Dmitriy Viderman, Karina Tapinova, Fatima Nabidollayeva, Ramil Tankacheev, Yerkin G. Abdildin
Summary: This study compares the use of intravenous and epidural routes for patient-controlled analgesia in abdominal surgery. The results show that there is no significant difference in pain control and side effects between the two methods. However, epidural analgesia is associated with a shorter length of hospital stay, while intravenous analgesia is associated with fewer episodes of hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ming Yan, Qiao Wang, Yufeng Zhang, Jing Zhou, Enhui Cui, Jian Sun
Summary: This study demonstrates that the dural puncture epidural technique combined with programmed intermittent epidural bolus mode for labor analgesia provides faster analgesia, reduces the consumption of ropivacaine, and decreases the incidence of incomplete analgesia and intrapartum fever compared to conventional methods.
Article
Public, Environmental & Occupational Health
Suzette J. Bielinski, Jennifer L. St Sauver, Janet E. Olson, Nicholas B. Larson, John L. Black, Steven E. Scherer, Matthew E. Bernard, Eric Boerwinkle, Bijan J. Borah, Pedro J. Caraballo, Timothy B. Curry, HarshaVardhan Doddapaneni, Christine M. Formea, Robert R. Freimuth, Richard A. Gibbs, Jyothsna Giri, Matthew A. Hathcock, Jianhong Hu, Debra J. Jacobson, Leila A. Jones, Sara Kalla, Tyler H. Koep, Viktoriya Korchina, Christie L. Kovar, Sandra Lee, Hongfang Liu, Eric T. Matey, Michaela E. McGree, Tammy M. McAllister, Ann M. Moyer, Donna M. Muzny, Wayne T. Nicholson, Lance J. Oyen, Xiang Qin, Ritika Raj, Veronique L. Roger, Carolyn R. Rohrer Vitek, Jason L. Ross, Richard R. Sharp, Paul Y. Takahashi, Eric Venner, Kimberly Walker, Liwei Wang, Qiaoyan Wang, Jessica A. Wright, Tsung-Jung Wu, Liewei Wang, Richard M. Weinshilboum
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Physiology
Jacqueline K. Limberg, Blair D. Johnson, Michael T. Mozer, Walter W. Holbein, Timothy B. Curry, Nanduri R. Prabhakar, Michael J. Joyner
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Neurosciences
Paolo B. Dominelli, Chad C. Wiggins, Sarah E. Baker, John R. A. Shepherd, Shelly K. Roberts, Tuhin K. Roy, Timothy B. Curry, James D. Hoyer, Jennifer L. Oliveira, Michael J. Joyner
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Cardiac & Cardiovascular Systems
Jacqueline K. Limberg, James A. Smith, Rogerio N. Soares, Jennifer L. Harper, Keeley N. Houghton, Dain W. Jacob, Michael T. Mozer, Zachary Grunewald, Blair D. Johnson, Timothy B. Curry, Tracy Baynard, Camila Manrique-Acevedo, Jaume Padilla
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Letter
Neurosciences
Paolo Dominelli, Chad Wiggins, Sarah E. Baker, John R. A. Shepherd, Shelly Roberts, Tuhin K. Roy, Timothy Curry, James Hoyer, Jennifer L. Oliveira, Michael J. Joyner
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Neurosciences
Joshua R. Smith, Michael J. Joyner, Timothy B. Curry, Barry A. Borlaug, Manda L. Keller-Ross, Erik H. Van Iterson, Thomas P. Olson
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Review
Medicine, General & Internal
Paolo B. Dominelli, Chad C. Wiggins, Tuhin K. Roy, Timothy W. Secomb, Timothy B. Curry, Michael J. Joyner
Summary: The oxygen transport cascade describes the physiological steps of bringing atmospheric oxygen into the body for consumption by metabolically active tissue, which is crucial for understanding exercise in health and disease. The review highlights each step of the oxygen transport cascade and draws parallels between elite athletes and clinical conditions in terms of oxygen transport cascade.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Pharmacology & Pharmacy
Carolyn R. Rohrer Vitek, Jyothsna Giri, Pedro J. Caraballo, Timothy B. Curry, Wayne T. Nicholson
Summary: The study found that internal medicine residents received more pharmacogenomics training compared to attending physicians, but there were no significant differences in self-reported knowledge, skills, and perceptions. Both groups expressed that pharmacogenomics was important in clinical practice, but lacked sufficient education to effectively utilize it.
Editorial Material
Medicine, Research & Experimental
Thomas P. Olson, Joshua R. Smith, Timothy B. Curry
Summary: Wahren and Jorfeldt's manuscript on leg blood flow during exercise, published over 50 years ago, utilized a novel approach to indicator dye dilution. Their study revealed the fundamental relationships between muscle blood flow, oxygen uptake, and exercise, and introduced the concept of mechanical efficiency, which is crucial in assessing muscle function. This manuscript laid the foundation for further research on muscle blood flow and exercise, and remains influential in modern research.
Article
Pharmacology & Pharmacy
Susanne B. Haga, Wendy K. Chung, Luis A. Cubano, Timothy B. Curry, Philip E. Empey, Geoffrey S. Ginsburg, Kara Mangold, Christina Y. Miyake, Siddharth K. Prakash, Laura B. Ramsey, Robb Rowley, Carolyn R. Rohrer Vitek, Todd C. Skaar, Julia Wynn, Teri A. Manolio
Summary: The fields of genetics and genomics have expanded in medicine, revealing genetic contributions to various traits and diseases. To ensure timely and appropriate utilization of this knowledge in patient care, accessible and sustainable online education resources are needed for healthcare providers. The National Human Genome Research Institute called for proposals in 2020 to develop such resources, and this paper describes the efforts of six awarded teams to meet this goal.
PERSONALIZED MEDICINE
(2023)
Article
Physiology
Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck
Summary: Type S and FR motor units, consisting of smaller phrenic motor neurons, are regularly recruited to meet indefatigable ventilatory requirements. In contrast, Type FF motor units, consisting of larger phrenic motor neurons, are infrequently recruited for expulsive straining and airway defense maneuvers. This difference in activation history is reflected in the mitochondrial volume density (MVD), with smaller PhMNs having higher MVD than larger PhMNs. In proximal dendrites, this trend is reversed, with larger PhMNs having higher MVD than smaller PhMNs, likely due to the maintenance requirements for the larger dendritic arbor of FF PhMNs.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Carlos B. Mantilla, Leonid G. Ermilov, Sarah M. Greising, Heather M. Gransee, Wen-Zhi Zhan, Gary C. Sieck
Summary: Our study found that the neurotrophin brain-derived neurotrophic factor (BDNF) can enhance neuromuscular transmission by activating the tropomyosin-related kinase receptor B (TrkB). BDNF not only increases quantal release in all fiber types, but also enhances synaptic vesicle replenishment. We concluded that BDNF/TrkB signaling can mitigate synaptic depression and maintain neuromuscular transmission.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Obaid U. Khurram, Carlos B. Mantilla, Gary C. Sieck
Summary: This study investigates the neuromotor control of the diaphragm muscle (DIAm) during spontaneous breathing in awake rats. The analysis of electromyography (EMG) data reveals differences in activity patterns during motor unit recruitment and derecruitment, providing insights into the temporal aspects of motor control.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Physiology
Joshua R. Smith, Jessica D. Berg, Timothy B. Curry, Michael J. Joyner, Thomas P. Olson
PHYSIOLOGICAL REPORTS
(2020)
Article
Peripheral Vascular Disease
Sarah E. Baker, Jacqueline K. Limberg, Zachariah M. Scruggs, Timothy B. Curry, Wayne T. Nicholson, Jill N. Barnes, Michael J. Joyner