Article
Anesthesiology
Ria E. Hopkins, Gabrielle Campbell, Louisa Degenhardt, Suzanne Nielsen, Fiona Blyth, Milton Cohen, Natasa Gisev
Summary: Although multimodal management is recommended for chronic noncancer pain (CNCP), little is known about the long-term treatment utilization patterns among individuals using opioids. This study conducted in Australia found that many Australians using opioids for CNCP also used nonopioid pharmacological and nonpharmacological treatments. However, some treatment use was inconsistent with guidelines and the use of nonpharmacological treatments was associated with having private health insurance.
Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Article
Health Care Sciences & Services
Tsung-Che Wu, Chih-Hung Hsu, Wei-Zen Sun, Ho-Min Chen, Chih-Peng Lin, Yu-Yun Shao
Summary: The introduction of new strong opioids in Taiwan led to changes in opioid prescription patterns for cancer pain management, aligning more with international guidelines. While the use of strong opioids increased, the use of weak opioids decreased.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Anesthesiology
Josh Bleicher, Benjamin Sands Brooke, Kimberlee Bayless, Zachary Anderson, Julie Beckstrom, Chong Zhang, Angela P. Presson, Lyen C. Huang, Michael Jacob Buys
Summary: Understanding the patterns of postoperative opioid use among different populations is important for developing opioid stewardship programs. This retrospective study investigated opioid prescribing, use, and pain after general surgery procedures for patients at a veterans administration hospital. The results showed that both non-opioid users and chronic opioid users required very few opioids after surgery, and chronic opioid users quickly returned to their baseline opioid use. There was no difference in pain recovery between the two groups. The study suggests that opioid prescribing guidelines should consider including chronic opioid therapy patients and recommend a more conservative approach.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Urology & Nephrology
Jeffrey Villanueva, Valentina Grajales, Marc Colaco, Omar Ayyash, Rajeev Chaudhry, Francis Schneck, Glenn Cannon, Janelle Fox
Summary: The study found that a state-mandated opioid consent for minors significantly reduced post-urological surgery opioid prescription rates, without increasing rates of readmission or delayed prescriptions.
JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Connie H. Yan, Todd A. Lee, Lisa K. Sharp, Colin C. Hubbard, Charlesnika T. Evans, Gregory S. Calip, Susan A. Rowan, Jessina C. McGregor, Walid F. Gellad, Katie J. Suda
Summary: The study found that the prescribing rates of opioid medications by dentists in the United States have declined over the past few years, following national trends and the implementation of strategies to regulate opioid prescribing.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Medicine, General & Internal
Deanne E. Jenkin, Justine M. Naylor, Joseph Descallar, Ian A. Harris
Summary: This study found that treatment with strong opioid medication subacutely was not superior to treatment with milder medication for the management of pain in surgically managed orthopedic fracture patients. Therefore, ongoing first-line strong opioid use after discharge from the hospital should not be supported.
Article
Anesthesiology
Mark C. Bicket, Vidhya Gunaseelan, Pooja Lagisetty, Anne C. Fernandez, Amy Bohnert, Elizabeth Assenmacher, Melwyn Sequeira, Michael J. Englesbe, Chad M. Brummett, Jennifer F. Waljee
Summary: This study aimed to determine the effect of prescription opioid use in the year before surgery on opioid consumption after surgery. The results showed that preoperative opioid use is associated with small increases in patient-reported opioid consumption after surgery for most patients, though greater differences exist for patients with chronic use. Existing guidelines may meet the postoperative needs of most patients with preoperative opioid exposure, but may need tailoring for patients with chronic use.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Chemistry, Medicinal
Boshi Huang, Mengchu Li, Pornprom Klongkumnuankarn, Rolando E. Mendez, James C. Gillespie, David L. Stevens, William L. Dewey, Dana E. Selley, Yan Zhang
Summary: Opioid-induced constipation (OIC) is a common side effect of opioid analgesics. Peripherally acting mu opioid receptor antagonists (PAMORAs) can effectively treat OIC without affecting the analgesic effects. A new compound has shown promising results in improving intestinal motility and may be developed as an oral treatment for constipation.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Magdalena Cerda, Katherine Wheeler-Martin, Emilie Bruzelius, William Ponicki, Paul Gruenewald, Christine Mauro, Stephen Crystal, Corey S. Davis, Katherine Keyes, Deborah Hasin, Kara E. Rudolph, Silvia S. Martins
Summary: The study found that pain management clinic laws with criminal penalties were associated with reduced high-dose opioid prescriptions and overdose deaths, but also raised concerns regarding heroin/synthetic overdose deaths.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Anesthesiology
Karim S. Ladha, Kathak Vachhani, Gretchen Gabriel, Rasheeda Darville, Karl Everett, Jodi M. Gatley, Refik Saskin, Dorothy Wong, Praveen Ganty, Rita Katznelson, Alexander Huang, Joseph Fiorellino, Diana Tamir, Maxwell Slepian, Joel Katz, Hance Clarke
Summary: Patients who received Transitional Pain Service showed a faster reduction in opioid use compared to the control group. The difficulty in finding an appropriate control group highlights the need for future randomized controlled trials to determine efficacy.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Health Care Sciences & Services
Patrice Forget, Champika Patullo, Duncan Hill, Atul Ambekar, Alex Baldacchino, Juan Cata, Sean Chetty, Felicia J. Cox, Hans D. de Boer, Kieran Dinwoodie, Geert Dom, Christopher Eccleston, Brona Fullen, Liisa Jutila, Roger D. Knaggs, Patricia Lavand'homme, Nicholas Levy, Dileep N. Lobo, Esther Pogatzki-Zahn, Norbert Scherbaum, Blair H. Smith, Joop van Griensven, Steve Gilbert
Summary: This study presents a consensus statement on the appropriate use of opioids for acute pain management. Through a modified Delphi methodology, the research panel developed consensus statements focusing on system-level policies to improve the safety and quality of opioid prescribing. The results show agreement among a multidisciplinary panel, including patient representation, on the prioritization of system-level interventions.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Anesthesiology
Nafisseh S. Warner, Michelle Mielke, Brandon P. Verdoorn, David S. Knopman, William M. Hooten, Elizabeth B. Habermann, David O. Warner
Summary: This manuscript summarizes the evidence and critical knowledge gaps regarding the relationships between pain, opioid analgesics, and cognition in older adults. It provides a conceptual framework to guide future research in optimizing analgesic outcomes in older adults while minimizing deleterious effects on cognition.
Review
Medicine, General & Internal
Yan Li, Jun Ma, Guijun Lu, Zhi Dou, Roger Knaggs, Jun Xia, Sai Zhao, Sitong Dong, Liqiang Yang
Summary: The benefits and harms of hydromorphone compared with other analgesics remain uncertain, as there is insufficient evidence to support or refute its use for cancer pain. Further research with larger sample sizes and more comprehensive outcome data collection is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Christian Rhudy, Courtney L. Perry, Michael Singleton, Jeffery Talbert, Terrence A. Barrett
Summary: Chronic opioid use is associated with higher risk of early discontinuation of biologic therapy in patients with inflammatory bowel disease. Patients with chronic opioid use tend to utilize a greater number of different biologic agents and have lower persistence with biologic therapies. Symptoms of opioid withdrawal may lead to inappropriate switching of biologic therapies and compromise disease control.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Health Care Sciences & Services
Jan Gaertner, Ulrike M. Stamer, Constanze Remi, Raymond Voltz, Claudia Bausewein, Rainer Sabatowski, Stefan Wirz, Gabriele Mueller-Mundt, Steffen T. Simon, Anne Pralong, Friedemann Nauck, Markus Follmann, Lukas Radbruch, Winfried Meissner
PALLIATIVE MEDICINE
(2017)
Article
Anesthesiology
K. Neustadt, S. Deckert, R. Heineck, C. Kopkow, A. Preissler, R. Sabatowski, J. Schmitt, U. Kaiser
Review
Anesthesiology
Ulrike Kaiser, Rolf-Detlef Treede, Rainer Sabatowski
Article
Anesthesiology
B. Arnold, J. Lutz, P. Nilges, M. Pfingsten, Winfried Rief, A. Boeger, T. Brinkschmidt, H. -R. Casser, D. Irnich, U. Kaiser, K. Klimczyk, R. Sabatowski, M. Schiltenwolf, W. Soellner
Article
Anesthesiology
K. Neustadt, S. Deckert, C. Kopkow, A. Preissler, B. Bosse, C. Funke, L. Jacobi, P. Mattenklodt, B. Nagel, P. Seidel, R. Sittl, E. Steffen, R. Sabatowski, J. Schmitt, U. Kaiser
Article
Anesthesiology
M. Richter, E. Gruhl, E. Lautenschlaeger, T. Mueller, F. Schumann, D. Skiera, A. Theisinger, U. Zimmer, R. Berner, M. von der Hagen, R. Sabatowski, A. Haehner, G. Gossrau
Article
Oncology
Sigridur Gunnarsdottir, Valgerdur Sigurdardottir, Marianne Kloke, Lukas Radbruch, Rainer Sabatowski, Stein Kaasa, Pal Klepstad
SUPPORTIVE CARE IN CANCER
(2017)
Article
Orthopedics
Jochen Schmitt, Toni Lange, Klaus-Peter Guenther, Christian Kopkow, Elisabeth Rataj, Christian Apfelbacher, Martin Aringer, Eckhardt Boehle, Hartmut Bork, Karsten Dreinhoefer, Niklaus Friederich, Karl-Heinz Frosch, Sascha Gravius, Erika Gromnica-Ihle, Karl-Dieter Heller, Stephan Kirschner, Bernd Kladny, Hendrik Kohlhof, Michael Kremer, Nicolai Leuchten, Maike Lippmann, Juergen Malzahn, Heiko Meyer, Rainer Sabatowski, Hanns-Peter Scharf, Johannes Stoeve, Richard Wagner, Joerg Luetzner
ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE
(2017)
Article
Anesthesiology
A. Haehner, T. Hummel, W. Heinritz, S. Krueger, M. Meinhardt, K. L. Whitcroft, R. Sabatowski, G. Gossrau
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Anesthesiology
B. Arnold, A. Boeger, T. Brinkschmidt, H. -R. Casser, D. Irnich, U. Kaiser, K. Klimczyk, J. Lutz, M. Pfingsten, R. Sabatowski, M. Schiltenwolf, W. Soellner
Article
Orthopedics
J. Luetzner, T. Lange, J. Schmitt, C. Kopkow, M. Aringer, E. Boehle, H. Bork, K. Dreinhoefer, N. Friederich, S. Gravius, K. -D. Heller, R. Hube, E. Gromnica-Ihle, S. Kirschner, B. Kladny, M. Kremer, M. Linke, J. Malzahn, R. Sabatowski, H. -P. Scharf, J. Stoeve, R. Wagner, K. -P. Guenther
Article
Health Policy & Services
Ulrike Kaiser, Rainer Sabatowski, Friedrich Balck
ZEITSCHRIFT FUR EVIDENZ FORTBILDUNG UND QUALITAET IM GESUNDHEITSWESEN
(2017)
Article
Medicine, General & Internal
Rainer Sabatowski, Irmgard Boesl, Simone Koenig, Bettina Buchheister, Torsten Meier, Ralf Baron
CURRENT MEDICAL RESEARCH AND OPINION
(2017)
Meeting Abstract
Clinical Neurology
V. Assmann, R. Berner, M. von der Hagen, R. Sabatowski, M. Richter, G. Gossrau
Review
Health Care Sciences & Services
Ulrike Kaiser, Katrin Neustadt, Christian Kopkow, Jochen Schmitt, Rainer Sabatowski