Review
Engineering, Biomedical
Wenying Wei, Honglian Dai
Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Wen-Jin Fan, Di Liu, Lin-Yuan Pan, Wei-Yang Wang, Yi-Lan Ding, Yue-Yao Zhang, Rui-Xi Ye, Yang Zhou, Sen-Bo An, Wen-Feng Xiao
Summary: Osteoarthritis (OA) is a prevalent public health problem worldwide, with no effective disease-modifying drugs available. Exosomes, which contain various important components, play a role in the pathophysiological processes of OA and can potentially serve as diagnostic biomarkers for the disease. Additionally, exosomes derived from different cells have therapeutic potential in restoring OA cartilage and attenuating inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olimpia Ortiz-Arrabal, Ramon Carmona, Oscar-Dario Garcia-Garcia, Jesus Chato-Astrain, David Sanchez-Porras, Alberto Domezain, Roke-Inaki Oruezabal, Victor Carriel, Antonio Campos, Miguel Alaminos
Summary: Research on a novel decellularized sturgeon cartilage scaffold showed promising results in terms of biocompatibility and sustainability for chondrocytes, as well as triggering a pro-regenerative reaction. This suggests potential for further development of these cartilage substitutes for clinical translation.
Article
Chemistry, Medicinal
Jiaxiang Gu, Bin Wang, Tianliang Wang, Naichen Zhang, Hongjun Liu, Jianchao Gui, Yiming Lu
Summary: In this study, the effects of cartilage progenitor cells (CPCs), bone marrow mesenchymal stem cells (BMSCs), and chondrocytes (CCs) on cartilage repair were investigated. The results showed that CPCs had higher proliferation ability compared to CCs and BMSCs. Moreover, CPCs seeded in agarose gel exhibited significantly higher levels of collagen, glycosaminoglycan, DNA content, and chondrocyte-related gene expression. Integration strength in the CPCs seeded gel was also higher than the other two gels. These findings suggest that CPCs have advantages over CCs and BMSCs as seed cells in tissue engineering for cartilage repair.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Wenguang Wang, Yanbin Shi, Guimei Lin, Bingtao Tang, Xuelin Li, Jing Zhang, Xinbing Ding, Guangzhen Zhou
Summary: This paper discusses the application of hydrogels in cartilage repair, including their mechanical properties and materials used. The challenges faced by hydrogels and future research directions are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Hamidreza Tolabi, Niyousha Davari, Mehran Khajehmohammadi, Haniyeh Malektaj, Katayoun Nazemi, Samaneh Vahedi, Behafarid Ghalandari, Rui L. Reis, Farnaz Ghorbani, Joaquim Miguel Oliveira
Summary: Cartilage degeneration is a major cause of disability and pain worldwide, but current treatments have limited success in the long term. The convergence of tissue engineering and microfabrication principles offers advanced microfluidic technologies as alternatives. This review summarizes the developments in microfluidic hydrogel-based scaffolds for cartilage regeneration and discusses the advantages over traditional hydrogels. It also presents the technologies for fabricating microfluidic scaffolds and chips, and highlights the preclinical and clinical applications and challenges in developing microfluidic systems for cartilage repair.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shenqiang Wang, Sheng Zhao, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: 3D printing technology has great potential in the field of tissue engineering, allowing the fabrication of biomimetic tissue structures for personalized therapy of various diseases. This review introduces the recently developed 3D printing techniques and summarizes their applications in cartilage, bone, and osteochondral tissue regeneration.
Article
Engineering, Biomedical
Sheng-Long Ding, Xin Liu, Xi-Yuan Zhao, Ke-Tao Wang, Wei Xiong, Zi-Li Gao, Cheng-Yi Sun, Min-Xuan Jia, Cheng Li, Qi Gu, Ming-Zhu Zhang
Summary: The successful regeneration of cartilage tissue at a clinical scale has been a significant challenge. Microcarrier systems offer an attractive approach to regulate cell phenotype and tissue maturation, and have shown promise in cartilage regeneration. This review provides comprehensive guidelines for the rational design and applications of microcarriers in cartilage tissue engineering.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Angela Bonato, Philipp Fisch, Simone Ponta, David Fercher, Mikko Manninen, Daniel Weber, Kari K. Eklund, Goncalo Barreto, Marcy Zenobi-Wong
Summary: Articular cartilage defects from traumatic injuries are difficult to heal naturally, leading to post-traumatic osteoarthritis. Current cell-based treatments are hindered by limited regenerative capacity and inflammation. Researchers developed a tissue-engineered cartilage that is more resistant to inflammation by using CRISPR-Cas9 to knock out the TAK1 gene in chondrocytes. The engineered cartilage shows successful integration and produces less inflammation-related macrophages, suggesting a promising option for regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Benjamin J. Bielajew, Ryan P. Donahue, Elliott K. Lamkin, Jerry C. Hu, Vincent C. Hascall, Kyriacos A. Athanasiou
Summary: In this study, proteomics, mechanical, and biochemical analyses were used to quantitatively investigate self-assembled neocartilage development from passaged, rejuvenated costal chondrocytes. The results showed that the temporal trends in neocartilage formation are similar to those seen in native hyaline articular cartilage development. Importantly, self-assembled neocartilage derived from costal chondrocytes is suitable for a non-homologous approach in the knee.
BIOMATERIALS RESEARCH
(2022)
Article
Engineering, Biomedical
Mingjing Zhu, Wenchao Zhong, Wei Cao, Qingbin Zhang, Gang Wu
Summary: This review summarizes the current knowledge on the design, molecular mechanisms, and applications of peptides in cartilage tissue engineering. Peptides, which can be chemically synthesized and mimic the functions of cartilaginous extracellular matrix and growth factors, show better stability and modifiability compared to natural biomaterials and recombinant growth factors. Studies have shown that peptides have a good efficacy in inducing chondrogenesis.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Wei Wei, Yuanzhu Ma, Xianzhu Zhang, Wenyan Zhou, Hongwei Wu, Jingwei Zhang, Junxin Lin, Chenqi Tang, Youguo Liao, Chenglin Li, Xiaozhao Wang, Xudong Yao, Yi Wen Koh, Wenwen Huang, Hongwei Ouyang
Summary: A biomimetic joint paint was designed for repairing intractable partial-thickness cartilage defects, showing restoration of smooth cartilage surface and preservation of normal glycosaminoglycan content in rabbit and pig models. The treatment functions by prohibiting chondrocyte apoptosis, maintaining chondrocyte phenotype, and preserving glycosaminoglycan content in the defects, illustrating its effectiveness as a revolutionary therapeutics for noncurable partial-thickness cartilage defects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Yang, Jianwei Li, Haoyuan Deng, Hao Li, Tianyuan Zhao, Tianze Gao, Dan Xing, Jianhao Lin
Summary: 3D printing technology offers hope for the repair and regeneration of cartilage defects, but research in this area is still limited. Through bibliometric analysis, we summarized the research status of 3D printing technology and cartilage repair and regeneration from 2002 to 2022. Based on the analysis, we discussed the current advantages, limitations, and future development prospects in this field, aiming to guide researchers and promote clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
