Journal
ONCOTARGET
Volume 5, Issue 19, Pages 9472-9483Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.2418
Keywords
miR-382; osteosarcoma growth; chemoresistance
Categories
Funding
- China International Medical Foundation [CIMF-F-H001-240]
- National Natural Science Foundation of China [81402216]
- Beijing Nova Program [Z141107001814097]
- Military youth support program of China [13QNP173]
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Dysregulation of miRNAs is involved in osteosarcoma (OS). Here, we demonstrate that miR-382 is decreased in specimens of OS patients with a poor chemoresponse compared to those with a good chemoresponse. In addition, our clinical data show that decreased miR-382 was associated with poor survival in OS patients. Overexpression of miR-382 inhibited cell growth and chemoresistance by targeting KLF12 and HIPK3, respectively. In contrast, inhibition of miR-382 or overexpression of target genes stimulated OS cell growth and chemoresistance both in vitro and in vivo. Taken together, these findings suggest that miR-382 is a tumor suppressor miRNA and induction of miR-382 is a potential strategy to inhibit OS progression.
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