Article
Oncology
Chia-Hao Tung, Jia-En Wu, Meng-Fan Huang, Wen-Lung Wang, Yi-Ying Wu, Yao-Tsung Tsai, Xiu-Rui Hsu, Sheng-Hsiang Lin, Yuh-Ling Chen, Tse-Ming Hong
Summary: This study reveals clinical evidence for USP5-enhanced Wnt/β-catenin signaling in promoting lung cancer stemness and metastasis, suggesting that targeting USP5 could provide beneficial effects for improving lung cancer therapeutics.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Yang Chen, Hongfei Yan, Lirong Yan, Ximing Wang, Xiaofang Che, Kezuo Hou, Yi Yang, Xuena Li, Yaming Li, Ye Zhang, Xuejun Hu
Summary: ALDH3A1 is highly expressed in non-small-cell lung cancer (NSCLC) and is associated with poor prognosis. It enhances glycolysis and suppresses oxidative phosphorylation (OXPHOS) by activating the HIF-1 alpha/LDHA pathway, promoting cell proliferation in NSCLC. Additionally, β-elemene can downregulate ALDH3A1, inhibiting glycolysis and enhancing OXPHOS, thereby suppressing NSCLC proliferation.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Xueke Shi, Jingjing Luo, Kelsey J. Weigel, Spencer C. Hall, Danfeng Du, Fanglong Wu, Michael C. Rudolph, Hongmei Zhou, Christian D. Young, Xiao-Jing Wang
Summary: The study demonstrates that TGF beta-enriched CAFs play a critical role in promoting SCC lung metastasis by facilitating tumor cell seeding and growth in the lung. Experimental results show that CAFs enhance tumor volume, inhibit apoptosis, and stimulate cell proliferation and angiogenesis in the lung. The findings suggest that CAFs could serve as a prognostic marker and therapeutic target for SCC lung metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weiyu Wang, Shengyao Ma, Zhenyu Ding, Yang Yang, Huaijie Wang, Kunning Yang, Xiaoshan Cai, Hanyue Li, Zhiqin Gao, Meihua Qu
Summary: XPC expression levels in lung adenocarcinoma have been found to influence patients' prognosis and inhibit tumor invasion and metastasis by regulating the stemness of lung cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Summary: Research has shown that inhibiting EGFR can block the circulating cancer stem cell (cCSC) clustering and lung metastasis of triple-negative breast cancer (TNBC). In addition to CD44, microRNA-30c also plays a negative regulatory role in cCSC clustering and lung metastasis.
Article
Cell Biology
Zhe Liu, Liang Ma, Yiming Sun, Wenying Yu, Xue Wang
Summary: The study demonstrated that the STAT3/ZEB1 axis is critical in gefitinib resistance in lung cancer, and a new potential therapeutic strategy targeting STAT3 has been identified with the inhibitor LL1. LL1 was shown to sensitize resistant cells to gefitinib by depleting STAT3 activity and blocking its signaling pathways, with little observed toxicity in animal models, indicating it could be a chemotherapeutic adjuvant for gefitinib resistance in NSCLC.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Junyi Pan, Yueguang Xue, Shilin Li, Liuxiang Wang, Jie Mei, Dongqi Ni, Jipeng Jiang, Meng Zhang, Shaoqiong Yi, Rong Zhang, Yongfu Ma, Yang Liu, Ying Liu
Summary: This study focuses on the impact of PM2.5 on lung adenocarcinoma and finds that chronic exposure to PM2.5 promotes tumor occurrence and metastasis, with more severe effects in Shijiazhuang. The underlying mechanisms involve the stem cell properties of cancer cells, the epithelial-mesenchymal transition process, and related miRNAs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Julie Ko, Monte M. Winslow, Julien Sage
Summary: Metastasis is a major cause of morbidity and mortality in cancer patients, especially with small cell lung cancer (SCLC) known for its remarkable metastatic proclivity. Recent advances in research, such as using circulating tumor cells and genetically engineered mouse models, are helping to overcome limitations in studying SCLC metastasis. New insights into cellular mechanisms associated with increased metastatic ability offer promise for future therapeutic options.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Haitao Wang, Sen Guo, Seung-Jin Kim, Fangyuan Shao, Joshua Wing Kei Ho, Kuan Un Wong, Zhengqiang Miao, Dapeng Hao, Ming Zhao, Jun Xu, Jianming Zeng, Koon Ho Wong, Lijun Di, Ada Hang-Heng Wong, Xiaoling Xu, Chu-Xia Deng
Summary: Cisplatin at different doses has varying effects on breast cancer growth and metastasis, with higher doses inhibiting both growth and metastasis but causing severe side effects, and lower doses only blocking metastasis. Cisplatin prevents breast cancer metastasis by blocking early EMT steps.
Editorial Material
Oncology
Jihan K. Osborne, John D. Minna
Summary: In this study, Yin and colleagues utilized Gprc5a knockout genetically engineered mouse models to investigate the cell(s) of origin for lung adenocarcinoma, and suggested that the bronchioalveolar stem cell is the cancer-initiating cell in this model.
Article
Nanoscience & Nanotechnology
Z. Fereshteh, M. N. Dang, C. Wenck, E. S. Day, J. H. Slater
Summary: This study investigated the efficacy of inhibiting cancer cell binding to human lung microvascular endothelial cells (HMVEC-Ls) via antibody blocking of E-selectin using antibody-functionalized gold nanoshells (NS). The results demonstrated that E-selectin-targeted NS reduced the binding of MDA-MB-231 cancer cells to HMVEC-Ls by up to 41%, suggesting the potential of these conjugates in inhibiting cancer cell extravasation during metastasis.
ACS APPLIED NANO MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Jia-Qi Xu, Yan-Li Fu, Jing Zhang, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Zhi-Wei Zhang, Zhong-Yan Zhou
Summary: Metabolic disturbance, particularly of glucose metabolism, is a hallmark of tumors such as non-small cell lung cancer (NSCLC). This review focuses on research advances in glycolysis in NSCLC and systematically provides an overview of the key enzymes, biomarkers, non-coding RNAs, and signaling pathways that modulate the glycolysis process and, consequently, tumor growth and metastasis in NSCLC. Current medications, therapeutic approaches, and natural products that affect glycolysis in NSCLC are also summarized. The development of metabolic intervention that targets glycolysis, alone or in combination with current therapy, is a potential therapeutic approach in NSCLC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Mao, Jin Chen, Xue Lu, Canlin Yang, Yi Ding, Mingming Wang, Yunpeng Zhang, Yuying Tian, Xing Li, Yunyun Fu, Yueying Yang, Yunyun Gu, Fei Gao, Junxing Huang, Lujian Liao
Summary: It was found that BCAT1 plays a crucial role in promoting lung cancer cell metastasis, with its overexpression related to tumor metastasis and prognosis. Knocking down BCAT1 expression can reduce the migration of metastatic cells and their ability to metastasize to distant organs.
Review
Cell Biology
Bin Wang, Hanfei Guo, Haiyang Xu, Hongquan Yu, Yong Chen, Gang Zhao
Summary: CNS metastasis in NSCLC is a common complication that seriously affects patients' quality of life, and current treatment methods do not meet patients' needs, with many issues still needing to be addressed.