Article
Pharmacology & Pharmacy
Dan Huang, Xindong Wang, Yunhong Zhu, Juexiao Gong, Junqing Liang, Yanfei Song, Yiyan Zhang, Linsheng Liu, Cong Wei
Summary: The study demonstrated the anti-atherosclerotic effect of Bazi Bushen capsule through experiments with Ovx/ApoE(-/-) mice and human umbilical vein endothelial cells, indicating a potential mechanism involving GPER1-dependent anti-inflammatory and anti-apoptotic actions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Young-Sun Lee, Deepak Prasad Gupta, Sung Hee Park, Hyun-Jeong Yang, Gyun Jee Song
Summary: The study found that DMF can inhibit nitric oxide and proinflammatory cytokine production in microglia, induce microglial switching to the M2 state, increase the expression levels of autophagy markers such as LC3 and ATG7, and promote the formation of autophagosomes. These results suggest that DMF induces autophagy in microglia and its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Chae Young Lee, Sang Hee Park, Hye Yeon Lim, Seok Gu Jang, Kyung Ja Park, Dong Sam Kim, Ji Hye Kim, Jae Youl Cho
Summary: The study demonstrated the therapeutic effects of Prasiola japonica ethanol extract (Pj-EE) in various mouse inflammation models, including reducing edema, decreasing inflammatory gene expressions, and ameliorating gastrointestinal disorders. These findings suggest the potential of Pj-EE as a promising anti-inflammatory functional food.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Immunology
Wenji Zhang, Hui Lin, Mingmin Zou, Qinghua Yuan, Zhenrui Huang, Xiaoying Pan, Wenjuan Zhang
Summary: Nicotine, as an anti-inflammatory alkaloid, has dual roles in treating diseases. It predominantly exhibits anti-inflammatory effects, especially in ulcerative colitis, arthritis, sepsis, and endotoxemia, but may promote and aggravate certain diseases such as periodontitis and gingivitis in oral inflammation. The molecular mechanism of nicotine in these inflammatory diseases involves regulating immune cells, immune factors, and the vagus and acetylcholinergic anti-inflammatory pathways, offering potential value for remedying acute and chronic inflammation in humans.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Jong Yeon Park, Bich Hang Do, Ju-Seung Lee, Hyun Cheol Yang, Anh Ngoc Nguyen, Martin Krupa, Chong Jai Kim, Yeon Jin Jang, Han Choe
Summary: The study found that recombinant crotamine has significant antinociceptive and anti-inflammatory effects, which are not related to the opioid receptor. Additionally, the effects of intraperitoneal or intraplantar recombinant crotamine are related to TNF-alpha.
Article
Immunology
Supender Kaur, Nathan R. Selden, Alejandro Aballay
Summary: The neural control of the immune system is crucial for maintaining immune homeostasis, and disruption of this control may lead to various diseases. In this study, the impact of vagus nerve stimulation (VNS) on gene expression in peripheral blood mononuclear cells (PBMCs) was investigated. The results showed that VNS downregulated genes related to stress, inflammatory response, and immunity, suggesting its anti-inflammatory effect.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Yongli Shi, Xiaofei Pan, Suyue Xu, Huiqing Zhu, Bingqian Zhao, Zeyu Sun, Ruoyi Dong, Na Li, Xueyan Hou, Xue Yang
Summary: This study synthesized DHPD polymers and fabricated pH-responsive DHPD nanoparticles for investigation of their biosecurity and in vivo anti-tumor activity. The results showed that the DHPD NPs could release doxorubicin in tumor cells, reduce its toxicity, and enhance its anti-tumor effects. Furthermore, the DHPD NPs improved the anti-4T1 tumor effect of doxorubicin, suggesting their potential application in the treatment of breast cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Article
Oncology
Zhaoxia Chang, Ying Zhang, Jue Fan, Lixing Zhang, Suling Liu, Guangyu Liu, Juchuanli Tu
Summary: Breast cancer is the most common cancer in women and the leading cause of cancer death for women. The mechanisms by which inflammation affects the initiation and progression of breast cancer are poorly understood. By analyzing the transcriptome, this study identified key regulatory factors and interface genes between inflammation and ER-negative breast cancer, providing a basis for early detection and treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shaun C. Moore, Pedro A. S. Vaz de Castro, Daniel Yaqub, Pedro A. Jose, Ines Armando
Summary: This article focuses on the synthesis of dopamine in the nervous system as a neurotransmitter, its synthesis in peripheral organs and cells, and its role in regulating the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Ohnishi, Zhongying Zhang, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Ryu Tsujimoto, Kunihiko Miyazaki, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani
Summary: This study investigated the effects of AdipoRon on human intervertebral disc (IVD) nucleus pulposus (NP) cells using a three-dimensional in vitro culturing system, and also examined the effects of AdipoRon on rat tail IVD tissues using an in vivo puncture-induced IVD degeneration model. The results demonstrated that AdipoRon suppressed the gene expression of proinflammatory factors and phosphorylation of p65 via the AMPK pathway, thereby alleviating IVD degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Orthopedics
Kaihu Li, Yong Zhu, Penghui Zhang, Mauro Alini, Sibylle Grad, Zhen Li
Summary: The study demonstrates the anti-inflammatory and protective effects of 5-ASA on human chondrocyte and osteochondral inflammatory OA models. These findings highlight the translational potential of 5-ASA for the treatment of OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Oncology
Chuan Jin, Arwa Ali, Alexandros Iskantar, Grammatiki Fotaki, Hai Wang, Magnus Essand, Alex Karlsson-Parra, Di Yu
Summary: This study demonstrates that a combination treatment involving intratumoral administration of pro-inflammatory allogeneic dendritic cells (AlloDCs) and systemic treatment with alpha CTLA-4 can significantly enhance the anti-tumor efficacy compared to alpha CTLA-4 monotherapy. The combination treatment leads to an immune-inflamed tumor microenvironment characterized by increased infiltration of activated endogenous antigen-presenting dendritic cells and CD8(+) T cells with a tissue-resident memory phenotype. This study highlights the potential of this combination therapy for improving the response to immune checkpoint inhibitors.
Article
Cell Biology
Qiang Fu, Qian Shen, Jin Tong, Liu Huang, Yi Cheng, Wei Zhong
Summary: Our study demonstrates that TNFR2 antagonist can inhibit Tregs function and suppress breast tumor cell proliferation, suggesting it as a potential therapeutic strategy for breast cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
