Article
Biochemistry & Molecular Biology
Tong Cao, Yue Cui, Yingying Wang, Linhui Wu, Ke Yu, Kai Chen, Jun Xia, Yuyun Li, Zhiwei Peter Wang, Jia Ma
Summary: In this study, researchers discovered an antisense lncRNA, CACNA1C-AS2, that inhibits the growth, migration, and invasion of glioma cells, functioning as a tumor suppressor. They also found that CACNA1C-AS2 negatively regulates Fbxo45 protein expression in glioma cells. These findings reveal the critical role of the CACNA1C-AS2/Fbxo45/mTOR axis in glioma tumorigenesis and progression.
Article
Multidisciplinary Sciences
Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song
Summary: eEF-2K plays a critical role in regulating the fate and function of CD8(+) T cells. Loss of eEF-2K leads to increased proliferation but decreased survival of CD8(+) T cells, along with premature senescence and exhaustion. eEF-2K deficiency also affects the metabolic activity of CD8(+) T cells and the effectiveness of CAR-T therapy against cancer.
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Jennifer L. Cotton, Kyvan Dang, Lu Hu, Yang Sun, Alka Singh, Mihir S. Rajurkar, Qi Li, Xu Wu, Junhao Mao
Summary: PTEN and LKB1 deficiency in Gli1-expressing gut mesenchymal cells, but not intestinal epithelium, drives polyp formation resembling human polyposis. Additionally, the study reveals the differential roles of PTEN and LKB1 in regulating the mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Xiang Gao, Wenqu Jiang, Zunliang Ke, Qiwei Huang, Liang Chen, Guobin Zhang, Chao Li, Xiaojun Yu
Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Jing Ren, Shijun Zheng, Lei Zhang, Jia Liu, Haowei Cao, Sicheng Wu, Yixin Xu, Jinmin Sun
Summary: MAPK4 is overexpressed in glioma and associated with poor prognosis. It promotes the proliferation and migration of glioblastoma multiforme (GBM) cells through the AKT/mTOR pathway. Furthermore, MAPK4 is involved in immune infiltration and the expression of immune checkpoints in the glioma microenvironment.
Article
Oncology
Esraa Mohamed, Anupam Kumar, Yalan Zhang, Albert S. Wang, Katharine Chen, Yunita Lim, Anny Shai, Jennie W. Taylor, Jennifer Clarke, Stephanie Hilz, Mitchel S. Berger, David A. Solomon, Joseph F. Costello, Annette M. Molinaro, Joanna J. Phillips
Summary: The study highlights the value of proteomic assessment of signaling pathway activity in tumors as a means to identify relevant oncogenic pathways and potentially as a biomarker for identifying aggressive disease.
Article
Chemistry, Multidisciplinary
Jinbiao Xiong, Gaochao Guo, Lianmei Guo, Zengguang Wang, Zhijuan Chen, Yang Nan, Yiyao Cao, Ruilong Li, Xuejun Yang, Jun Dong, Xun Jin, Weidong Yang, Qiang Huang
Summary: The combined treatment with TMZ and amlexanox showed significant efficacy in inducing apoptosis and inhibiting cell viability, migration, and invasion in GBM cells. It also reversed the activation of Akt induced by TMZ and inhibited mTOR phosphorylation, potentially improving the prognosis of glioblastoma patients.
Article
Cell Biology
Young Mi Kim, Sung-Hwa Ko, Yong-Il Shin, Yeonye Kim, Taehyung Kim, Jaehoon Jung, Sang-Yull Lee, Nam Gyun Kim, Kyoung-Jun Park, Ji Hyeon Ryu
Summary: The study demonstrated that blue LED irradiation suppressed pancreatic cancer cell and tumor growth by regulating the AKT/mTOR signaling pathway, while also increasing the expression of apoptosis-related proteins. These findings suggest that blue LEDs could be utilized as a nonpharmacological treatment for pancreatic cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Mikkel G. Terp, Kirstine Jacobsen, Miguel Angel Molina, Niki Karachaliou, Hans C. Beck, Jordi Bertran-Alamillo, Ana Gimenez-Capitan, Andres F. Cardona, Rafael Rosell, Henrik J. Ditzel
Summary: Resistance to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC patients is often associated with increased FGFR1 expression and Akt activation, leading to the development of targeted therapy strategies for overcoming resistance. Combination therapy targeting both FGFR and Akt has shown superior growth inhibition of resistant cells in vitro and in vivo, providing a promising rationale for future clinical trials in NSCLC patients.
NPJ PRECISION ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
William P. Miller, Allyson L. Toro, Siddharth Sunilkumar, Shaunaci A. Stevens, Ashley M. VanCleave, David L. Williamson, Alistair J. Barber, Michael D. Dennis
Summary: Clinical studies support the role of REDD1 protein in ischemic retinal complications caused by diabetes. The study found that REDD1 expression specifically in Muller glia contributes to diabetes-induced retinal pathology, including gliosis, neurodegeneration, and impaired vision.
Article
Biochemistry & Molecular Biology
Dominik C. Fuhrmann, Bernhard Bruene
Summary: Human macrophages undergoing hypoxia alter their metabolism, increasing glycolysis as an adaptation. MiR-193a-3p enhances Akt phosphorylation, which is regulated by PPTC7 protein abundance. This leads to increased glycolysis under hypoxia. MiR-193a-3p also affects PFKFB3 phosphorylation, further regulating glycolysis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Guifang Zhao, Lijuan Ding, Hongquan Yu, Weiyao Wang, Huan Wang, Yao Hu, Lingsha Qin, Guangce Deng, Buqing Xie, Guofeng Li, Ling Qi
Summary: This study found that M2 tumor-associated macrophage-derived exosomal miR-27b-3p enhances the tumorigenicity of glioblastoma stem cells (GSCs) through the MLL4/PRDM1/IL-33 axis.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Xia Li, Cui Sun, Jing Chen, Ji-Fen Ma, Yi-Heng Pan
Summary: FAM83D is upregulated in glioma and its overexpression activates the AKT/mTOR pathway, leading to increased proliferation, invasion, and migration of glioma cells. Silencing FAM83D, on the other hand, inhibits these processes.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Developmental Biology
Jose Esteban-Collado, Montserrat Corominas, Florenci Serras
Summary: The study showed that in Drosophila wing, PI3K Akt signaling is crucial for Ask1 to activate p38, but not JNK. Nutrient restriction or mutations targeting specific residues of Drosophila Ask1 protein can block regeneration, which can be reversed by ectopic activation of p38.