Article
Oncology
Yi Liu, Zhongjun Li, Maolei Zhang, Huangkai Zhou, Xujia Wu, Jian Zhong, Feizhe Xiao, Nunu Huang, Xuesong Yang, Rong Zeng, Lixuan Yang, Zhibo Xia, Nu Zhang
Summary: The study identified a novel EGFR variant, rtEGFR, encoded by circEGFR, which promotes GBM development by maintaining EGFR activation and inhibiting EGFR degradation, showing significant correlation with patient prognosis. Targeting rtEGFR could potentially enhance the efficacy of EGFR-targeting therapies in GBM treatment.
Article
Oncology
Hai Song, Yanpei Wang, Chaojia Shi, Jianxiang Lu, Tian Yuan, Xiangpeng Wang
Summary: This study reveals that SH3KBP1 is highly expressed in GBM and associated with worse survival outcomes, potentially serving as a marker for GSCs. Silencing SH3KBP1 can significantly impair GBM cell proliferation, migration, and GSCs self-renewal, likely acting as an adaptor protein for EGFR signaling.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Stefanie Moritz, Matthias Krause, Jessica Schlatter, Nils Cordes, Anne Vehlow
Summary: Glioblastoma patients face poor prognosis due to aggressive invasion and therapy resistance, with Lamellipodin playing a key role in mediating these processes. The study highlights a novel Lamellipodin-RICTOR-EGFR signaling axis contributing to glioblastoma radiation survival, adding a critical facet to the complex resistance network in glioblastoma.
Article
Neurosciences
Antoni Andreu Martija, Alexandra Krauss, Natalie Baechle, Laura Doth, Arne Christians, Damir Krunic, Martin Schneider, Dominic Helm, Rainer Will, Christian Hartmann, Christel Herold-Mende, Andreas von Deimling, Stefan Pusch
Summary: This study reveals that epithelial membrane protein 3 (EMP3) promotes EGFR/CDK2 signaling in glioblastoma (GBM) by regulating the trafficking and stability of EGFR. EMP3 knockout reduces cell proliferation, weakens mitogenic response to EGF, and increases sensitivity to kinase inhibitors. These findings provide insights into the EMP3-dependent mechanism sustaining EGFR/CDK2 activity in GBM, and highlight EMP3 as a potential target for overcoming tumor cell resistance against kinase inhibition.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Oncology
Ling He, Kruttika Bhat, Angeliki Ioannidis, Le Zhang, Nhan T. Nguyen, Joshua E. Allen, Phioanh Leia Nghiemphu, Timothy F. Cloughesy, Linda M. Liau, Harley I. Kornblum, Frank Pajonk
Summary: The study suggests that combined treatment with the DRD2/3 antagonist ONC201 and radiation improves the efficacy of radiation against GBM by targeting GICs, reducing tumor recurrence, and prolonging survival in mouse models. Transcriptome analysis show shifts in gene expression signatures related to quiescent GBM populations, GBM plasticity, and GBM stem cells after combined treatment.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Pathology
Xinyu Yang, Qingge Jia, Zheng Zou, Xuantong Liu, Xinning Li, He Chen, Hongxin Ma, Ligang Chen
Summary: This study identified INHBB as an upregulated gene in GBM that predicts poor prognosis. INHBB promotes tumor growth, invasion, and stemness in GBM and is correlated with the expression levels of EGFR and downstream AKT and ERK. The tumor progression induced by INHBB can be inhibited by afatinib.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Neera Yadav, Deepak Babu, Sailaja Madigubba, Manas Panigrahi, Prakash Babu Phanithi
Summary: This study found that increased expression of oncogenes aggravates the malignancy of astrocytoma and is associated with poor prognosis. Laboratory and animal experiments have shown that the drug TYR A9 can reduce the growth and migration of glioblastoma cells, induce apoptosis, and improve animal survival by suppressing the PYK2/EGFR-ERK signaling pathway.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Huijuan Liu, Jiahuan Yang, Yang Zhang, Jingxia Han, Yuyan Yang, Zihan Zhao, Xintong Dai, Hongqi Wang, Xiujuan Ding, Yanrong Liu, Weilong Zhong, Wenqing Gao, Tao Sun
Summary: This study confirmed the impact of psychological stress on tumor progression and identified DRD2 as a potential mediator of stress-induced malignant tumor progression. The results suggest that DRD2 regulation of HIF1 alpha may play a key role in this process, and DRD2 inhibition with TFP could be a promising therapeutic strategy for managing stress in cancer patients.
Article
Cell Biology
Rajappa S. Kenchappa, Athanassios Dovas, Michael G. Argenziano, Christian T. Meyer, Lauren E. Stopfer, Matei A. Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Peter Sims, Vito Quaranta, Peter Sims, Peter Canoll, Steven S. Rosenfeld
Summary: This study reveals a mechanism of resistance to Kif11 inhibitors in glioblastoma, where suppression of apoptosis driven by activation of STAT3 plays a crucial role. Simultaneous inhibition of SRC and EGFR can reverse this resistance and significantly prolong survival in mice. These findings provide a translational actionable approach to overcome Kif11 inhibitor resistance.
Article
Oncology
B. Kasenda, D. Koenig, M. Manni, R. Ritschard, U. Duthaler, E. Bartoszek, A. Baerenwaldt, S. Deuster, G. Hutter, D. Cordier, L. Mariani, J. Hench, S. Frank, S. Kraehenbuehl, A. Zippelius, C. Rochlitz, C. Mamot, A. Wicki, H. Laeubli
Summary: This study evaluated the tolerability and effectiveness of anti-EGFR immunoliposomes in treating patients with relapsed glioblastoma harboring an EGFR amplification. The results showed that these immunoliposomes were unable to cross the blood-brain barrier, but could deliver drugs to glioblastoma tissue. In terms of efficacy, the median progression-free survival was 1.5 months and the median overall survival was 8 months.
Article
Cell Biology
Chao Qu, Cui Wang, Hongyan Li, Ying Li, Chao Han, Xiaofeng Tao, Xin Guan, Yejun Zhang, Meng Chen, Jing Liu, Wei Zou
Summary: This study investigates the cross talk between ER-alpha 36 and EGFR in estrogen-mediated GBM cell proliferation. The results demonstrate that ER-alpha 36 promotes non-genomic estrogen signaling via the EGFR/SRC/MAPK pathway in GBM.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Sicheng Wan, Chaolong Liu, Chongyang Li, Zhi Wang, Gaichao Zhao, Jingui Li, Wenhao Ran, Xi Zhong, Yongsen Li, Li Zhang, Hongjuan Cui
Summary: A protein called AKIP1 was found to be overexpressed in various human cancers and linked to worse prognosis. It has been shown to play a role in tumor metastasis, angiogenesis, and resistance to chemotherapy and radiotherapy. However, its specific mechanism in accelerating the progression of glioblastoma (GBM) remains unknown.
Article
Cell Biology
Jianbing Hou, Minghao Xu, Hongyu Gu, Dakun Pei, Yudong Liu, Pan Huang, Hongbo Chang, Hongjuan Cui
Summary: ZC3H15, an overexpressed protein in GBM, promotes the proliferation, migration, invasion, and tumorigenesis of GBM cells by activating the EGFR signaling pathway. High expression of ZC3H15 is associated with poor patient survival.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Nomi Zalcman, Mijal Gutreiman, Tal Shahar, Michael Weller, Iris Lavon
Summary: The study demonstrates the involvement of EGFR signaling in AR activation in glioblastoma, showing that inhibiting EGFR signaling can reduce AR nuclear translocation. Combination therapy of EGFR and AR antagonists has synergistic therapeutic efficacy in cells overexpressing EGFR and EGFRvIII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kunlin Zeng, Yu Zeng, Hongchao Zhan, Ziling Zhan, Li Wang, Yuxin Xie, Yanqing Tang, Cuiying Li, Yanwen Chen, Shangbiao Li, Ming Liu, Xiaoxia Chen, Li Liang, Fan Deng, Ye Song, Aidong Zhou
Summary: This study identifies SEC61G as a critical regulator facilitating GBM immune evasion and tumor growth, and provides a compelling rationale for combination therapy of EGFR-amplified GBMs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Clinical Neurology
Bob S. Carter, Fred G. Barker
JOURNAL OF NEUROSURGERY
(2020)
Article
Biochemistry & Molecular Biology
Franz L. Ricklefs, Cecile L. Maire, Jakob Matschke, Lasse Duehrsen, Thomas Sauvigny, Mareike Holz, Katharina Kolbe, Sven Peine, Christel Herold-Mende, Bob Carter, E. Antonio Chiocca, Sean E. Lawler, Manfred Westphal, Katrin Lamszus
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Clinical Neurology
Bob S. Carter, E. Antonio Chiocca
JOURNAL OF NEUROSURGERY
(2020)
Editorial Material
Clinical Neurology
Sepideh Amin-Hanjani, Nicholas C. Bambakidis, Fred G. Barker, Bob S. Carter, Kevin M. Cockroft, Rose Du, Justin F. Fraser, Mark G. Hamilton, Judy Huang, John A. Jane, Randy L. Jensen, Michael G. Kaplitt, Anthony M. Kaufmann, Julie G. Pilitsis, Howard A. Riina, Michael Schulder, Michael A. Vogelbaum, Lynda J. S. Yang, Gabriel Zada
JOURNAL OF NEUROSURGERY
(2020)
Article
Medicine, General & Internal
Valya Ramakrishnan, Beibei Xu, Johnny Akers, Thien Nguyen, Jun Ma, Sanjay Dhawan, Jianfang Ning, Ying Mao, Wei Hua, Efrosini Kokkoli, Frank Furnari, Bob S. Carter, Clark C. Chen
Article
Cell Biology
Alison D. Parisian, Tomoyuki Koga, Shunichiro Miki, Pascal D. Johann, Marcel Kool, John R. Crawford, Frank B. Furnari
GENES & DEVELOPMENT
(2020)
Article
Cell Biology
Afsheen Banisadr, Mariam Eick, Pranjali Beri, Alison D. Parisian, Benjamin Yeoman, Jesse K. Placone, Adam J. Engler, Frank Furnari
JOURNAL OF CELL SCIENCE
(2020)
Article
Multidisciplinary Sciences
Jie Li, Megan M. Kaneda, Jun Ma, Ming Li, Ryan M. Shepard, Kunal Patel, Tomoyuki Koga, Aaron Sarver, Frank Furnari, Beibei Xu, Sanjay Dhawan, Jianfang Ning, Hua Zhu, Anhua Wu, Gan You, Tao Jiang, Andrew S. Venteicher, Jeremy N. Rich, Christopher K. Glass, Judith A. Varner, Clark C. Chen
Summary: Precision medicine in oncology is leveraging clinical observations to identify molecular features that define exceptional responses. In a study on glioblastoma, it was found that exceptional responders show decreased accumulation of microglia/macrophages in the tumor microenvironment. Inhibition of PI3K gamma disrupted signaling pathways involving IL11 secretion, enhancing the therapeutic effects in glioblastoma models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Julia M. T. Ledderose, Jorge A. Benitez, Amanda J. Roberts, Rachel Reed, Willem Bintig, Matthew E. Larkum, Robert N. S. Sachdev, Frank Furnari, Britta J. Eickholt
Summary: PTEN mutations are associated with autism spectrum disorders and regulate neuron size and connectivity in brain circuits involved in sensory processing. Knock-in mice with PTEN T366 substitution exhibit cognitive deficits and selective sensory impairments. Differences in connectivity to the primary somatosensory cortex are observed in Pten(T366A/T366A) brains.
Article
Biology
Jacqueline S. Gerritsen, Joseph S. Faraguna, Rudy Bonavia, Frank B. Furnari, Forest M. White
Summary: This study investigated the relationship between specific EGFR phosphorylation sites and the signaling network as well as cell response. The results showed that the EGFR network remains resilient even with multiple Y-to-F mutations in the C-terminal tail. Additionally, the study revealed previously unidentified network nodes associated with EGFR signaling. The data-driven model highlighted the signaling network nodes associated with distinct EGF-driven cell responses.
LIFE SCIENCE ALLIANCE
(2023)
Meeting Abstract
Oncology
Valya Ramakrishnan, Beibei Xu, Johnny Akers, Thien Nguyen, Jun Ma, Sanjay Dhawan, Jianfang Ning, Ying Mao, Wei Hua, Efrosini Kokkoli, Frank Furnari, Bob Carter, Clark Chen
Meeting Abstract
Oncology
Debraj Mukherjee, Maureen Rakovec, Chetan Bettegowda, Christopher Jackson, Gary Gallia, Michael Lim, Jon Weingart, Yoshua Esquenazi, Brad Zacharia, Ezequiel Goldschmidt, Mateo Ziu, Michael Ivan, Andrew Venteicher, Edjah Nduom, Adam Mamelak, Ray Chu, John Yu, Jason Sheehan, Brian Nahed, Bob Carter, Mitchel Berger, Raymond Sawaya, Adham Khalafallah
Review
Materials Science, Biomaterials
Anudeep Yekula, Koushik Muralidharan, Zachary S. Rosh, Anna E. Youngkin, Keiko M. Kang, Leonora Balaj, Bob S. Carter
ADVANCED BIOSYSTEMS
(2020)
Meeting Abstract
Clinical Neurology
Anudeep Yekula, Sudipto Chakrabortty, Robert Kitchen, Bob Carter, Xandra Breakefield, Johan Skog, Balaj Leonora
JOURNAL OF NEUROSURGERY
(2020)
Meeting Abstract
Clinical Neurology
Bryan Choi, Xiaoling Yu, Anna Castano, Amanda Bouffard, Matthew Frigault, Andrea Schmidts, William Curry, Bob Carter, Marcela Maus
JOURNAL OF NEUROSURGERY
(2020)