Article
Biochemistry & Molecular Biology
Xiulei Zhao, Wei Chai, Tiegong Wang, Xiongfei Chen, Lei Zhang, Fengshan Li, Ruhai Liu
Summary: This study comprehensively analyzed the prognostic, diagnostic, and biological significance of miR-148a-3p and CTSA in hepatocellular carcinoma (HCC), indicating their potential as molecular targets to enhance the potency of immunotherapy in HCC.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Yong-Li Wang, Dan Ren, Jin-Long Lu, He Jiang, Jia-Zhang Wei, Jiao Lan, Fei Liu, Shen-Hong Qu
Summary: In nasopharyngeal carcinoma (NPC), CREB1 and SRGN are increased while miR-148a-5p is decreased. Silencing of SRGN and CREB1, and miR-148a-5p overexpression represses NPC tumor progression. The authors show that CREB1 promotes SRGN expression by targeting its promoter. In NPC, FoxO1 binds to miR-148a-5p, and miR-148a-5p targets CREB1. FoxO1 knockdown abolishes the downregulation of CREB1 and SRGN induced by STAT3 silencing. In summary, STAT3 regulates SRGN and promotes the growth and metastasis of NPC through the FoxO1-miR-148a-5p-CREB1 axis.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Zhuozhen Lyu, Mingyu Yang, Tan Yang, Mingze Ma, Zhen Yang
Summary: MTF-1 plays a regulatory role in the progression of HCC, and selectively targeting exosomal miR-148a-3p, which negatively regulates MTF-1, may have therapeutic benefits for patients with HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Zhang, Feiyu Chen, Peiran Huang, Xinyu Wang, Kaiqian Zhou, Cheng Zhou, Lei Yu, Yuanfei Peng, Jia Fan, Jian Zhou, Zuohua Lu, Jie Hu, Zheng Wang
Summary: MiR-148a-3p derived from activated HSCs accelerates HCC progression through ITGA5/PI3K/Akt signaling pathway. These findings contribute to a better understanding of the molecular mechanisms underlying the development of HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Yan Sun, Li Liu, Wanying Xing, Hai Sun
Summary: Sevoflurane inhibits proliferation, invasion, and migration while enhancing apoptosis of HCCLM3 and Huh7 cells by regulating miR-148a-3p. Up-regulation of miR-148a-3p or down-regulation of ROCK1 also inhibits cell progression in a similar manner.
CELLULAR SIGNALLING
(2021)
Article
Environmental Sciences
Mo Yi, Samei Lv, Yu He, Youwei Wu, Jian Zhang, Qian Chen
Summary: This study investigated the role of circKDM1B in hepatocellular carcinoma (HCC) and found that its overexpression was associated with tumor stage and poor prognosis in HCC patients. Knockdown of circKDM1B suppressed cell proliferation, migration, invasion, and promoted apoptosis in HCC cells. It was discovered that circKDM1B acted as a ceRNA of miR-1322 to upregulate PRC1 expression. Overexpression of miR-1322 inhibited cell proliferation, migration, invasion, and promoted apoptosis, which was partly reversed by PRC1 overexpression. CircKDM1B knockdown inhibited tumor growth in vivo.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Rong Li, Runze Shang, Shunle Li, Yifan Ren, Lin Shen, Longbao Yang, Shuo Chen, Xi Chen, Junhui Li, Meng Xu
Summary: The study found that high expression of LOXL3 in HCC was significantly correlated with tumor size and clinical stage, predicting a poor prognosis. Experimental results demonstrated that LOXL3 promoted HCC EMT process through the Snail1/USP4-mediated circulation loop and Wnt/β-catenin signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Boqiang Liu, Yuanshi Tian, Mingyu Chen, Hao Shen, Jiafeng Xia, Junjie Nan, Tingting Yan, Yifan Wang, Liang Shi, Bo Shen, Hong Yu, Xiujun Cai
Summary: This study identified a novel circRNA, circUBAP2, in hepatocellular carcinoma (HCC) through bioinformatics analysis. CircUBAP2 was significantly upregulated in HCC tissues and correlated with aggressive clinical characteristics and poor prognosis. Functionally, circUBAP2 promoted cell proliferation, colony formation, migration, and invasion in vitro, and enhanced tumor growth and pulmonary metastasis in vivo. Mechanistically, circUBAP2 acted as a competing endogenous RNA (ceRNA) for miR-194-3p, thereby regulating the expression of MMP9 and promoting HCC progression. CircUBAP2 could potentially serve as a prognostic biomarker and therapeutic target for HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiaoxi Fan, Zhongwei Zhao, Jingjing Song, Dengke Zhang, Fazong Wu, Jianfei Tu, Min Xu, Jiansong Ji
Summary: The study demonstrated that SNHG6 is highly expressed in HCC tissues and knocking down SNHG6 reduces proliferation, migration, and invasion abilities of cells in vitro. The research also revealed the direct binding of miR-6509-5p to SNHG6 and the regulation of HIF1A expression through the SNHG6/miR-6509-5p axis. Furthermore, down-regulation of SNHG6 significantly decreased tumor growth ability of Huh7 cells in vivo, suggesting the potential of SNHG6/miR-6509-5p/HIF1A axis as therapeutic targets for HCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Chunli OuYang, Guang Shu, Jiaxin Liu, Shumin Deng, Pengyan Lu, Yimin Li, Yaqi Gan, Bintao Xie, Junwen Liu, Gang Yin
Summary: HDAC5 overexpression is associated with tumor progression and cell migration in colon adenocarcinoma, which can be inhibited by miR-148a-3p.
Article
Medical Laboratory Technology
Guogang Li, Yang Tian, Zhenzhen Gao
Summary: This study revealed that AURKA is highly expressed in HCC and is associated with poor prognosis. There is a significant negative correlation between miR-199b-3p and AURKA. By inhibiting HCC cell proliferation, migration, and invasion while promoting apoptosis, miR-199b-3p affects tumor growth in HCC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cell Biology
Libing Wang, Mingxin Cui, Daming Cheng, Fengzhi Qu, Jingkun Yu, Yanbin Wei, Ling Cheng, Xiaotang Wu, Xiaogang Liu
Summary: The study revealed that miR-9-5p is highly expressed in HCC cells while ESR1 is poorly expressed; overexpression of miR-9-5p can enhance cell proliferation, invasion, and migration; ESR1 is identified as a downstream target of miR-9-5p in HCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Boan Li, Fan Feng, Hui Jia, Qiyu Jiang, Shuang Cao, Ling Wei, Yingshi Zhang, Jincai Lu
Summary: The study demonstrated that rhamnetin could decelerate the elimination of sorafenib in HCC cells through the miR-148a/PXR axis, thus enhancing the sensitivity of these cells to sorafenib.
Article
Oncology
Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Guodong Liu
Summary: The study revealed that androgen receptor can suppress HCC cells invasion and migration capacities via miR-122-5p/RABL6 signaling, providing a new potential therapeutic target for better treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lin Yang, Wan-li Deng, Bao-guo Zhao, Yao Xu, Xiao-wen Wang, Yu Fang, Hai-juan Xiao
Summary: LOC554202 is upregulated in HCC patients and can promote HCC progression by competitively binding to miR-485-5p. This suggests that targeting the FOXO3/LOC554202/miR-485-5p/BSG axis may be beneficial for HCC treatment.
CANCER GENE THERAPY
(2022)
Letter
Gastroenterology & Hepatology
Jihyun An, Ha Il Kim, Bora Oh, Yoo-Jin Oh, Ji-Hye Oh, Wonkyung Kim, Chang Ohk Sung, Ju Hyun Shim
Article
Gastroenterology & Hepatology
Jihyun An, Deokhoon Kim, Bora Oh, Yoo-Jin Oh, Jihyun Song, Naomi Park, Ha Il Kim, Hyo Jeong Kang, Ji-Hye Oh, Wonkyung Kim, Eunjung Lee, Chang Ohk Sung, Gi-Won Song, Dae-Ghon Kim, Eunsil Yu, Eric Letouze, Jessica Zucman-Rossi, Han Chu Lee, Ju Hyun Shim
Summary: This study identified the landscape and mechanisms of HBV integration in iCCA tumors, revealing recurrent viral integration breakpoints at multiple sites including TERT and FAT2, and oncogenic effects through intergenic insertions activating the mTOR pathway. The mutational profiles of HBV-iCCA were found to be more similar to nonviral conventional iCCA, rather than HBV-related liver cancers like HBV-HCC and HBV-cHCC/CCA.
Article
Biochemistry & Molecular Biology
Ayoung Kim, Ja Hyun Koo, Jung Min Lee, Min Sung Joo, Tae Hyun Kim, Hyunsung Kim, Dae Won Jun, Sang Geon Kim
Summary: This study investigated the role of NRF2-mediated SIRT3 activation in ER stress. The results showed that NRF2 induced SIRT3 through antioxidant responsive elements, protecting hepatocytes from ER stress-induced injury.
Review
Biochemistry & Molecular Biology
Yoon Mee Yang, Ye Eun Cho, Seonghwan Hwang
Summary: Alcoholic liver disease (ALD), caused by excessive alcohol consumption, results in liver damage. Studies have shown that there is a relationship between hepatic oxidative stress and inflammatory responses, which may be useful for developing therapeutic approaches for ALD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Chung-Feng Huang, Tyng-Yuan Jang, Dae Won Jun, Sang Bong Ahn, Jihyun An, Masaru Enomoto, Hirokazu Takahashi, Eiichi Ogawa, Eileen Yoon, Soung Won Jeong, Jae-Jun Shim, Jae Yoon Jeong, Sung Eun Kim, Hyunwoo Oh, Hyoung Su Kim, Yong Kyun Cho, Ritsuzo Kozuka, Kaori Inoue, Ka Shing Cheung, Lung Yi Mak, Jee-Fu Huang, Chia-Yen Dai, Man-Fung Yuen, Mindie H. Nguyen, Ming-Lung Yu
Summary: The study found that in CHB patients, measuring serum GGT levels during treatment, particularly in non-cirrhotic patients, can effectively predict the development of HCC. Factors strongly associated with increased risk of HCC included high M6-GGT levels, age, gender, and cirrhosis.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Jihyun An, Hyung-Don Kim, Seon-Ok Kim, Ha Il Kim, Gi-Won Song, Han Chu Lee, Ju Hyun Shim
Summary: Compared to the general population, patients with liver cirrhosis have a lower prevalence of intracranial atherosclerosis, while the prevalence of extracranial atherosclerosis is similar. Thrombocytopenia and high coronary artery calcium score may be associated with intracranial atherosclerosis.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Jihyun An, Ju Hyun Shim
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Jieun Lee, Sang Bong Ahn, Sun Young Yim, Jihyun An, Dae Won Jun, Min Jung Ko, Dong Ah Park, Jeong-Ju Yoo
Summary: This meta-analysis evaluated the efficacy and safety of direct-acting agents (DAAs) in elderly patients. The study found that DAAs had high efficacy in elderly patients, with a notable sustained virologic response (SVR) rate of 96%, although adverse event (AE) rates were comparatively higher in the elderly population.
JOURNAL OF VIRAL HEPATITIS
(2022)
Article
Gastroenterology & Hepatology
Jeong Won Jang, Jun Yong Park, Jung Hyun Kwon, Su Jong Yu, Wonseok Kang, Young Eun Chon, Tae Hyung Kim, Jonggi Choi, Jihyun An
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jihye Lim, Jung-Bok Lee, Jihyun An, Gi-Won Song, Kang Mo Kim, Han Chu Lee, Ju Hyun Shim
Summary: This study provides evidence that prolonged nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B patients may increase the risks of colorectal/anal cancers and lymphoma, but has a protective effect on breast and prostate cancers. The study also shows that NAs do not affect most extrahepatic organs.
JOURNAL OF VIRAL HEPATITIS
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hyun Yu, Eun-Yi Moon, Jiyoon Kim, Ja Hyun Koo
Summary: Multiple small GTPases have been found to promote IRF3 phosphorylation, suggesting their significant contribution in IRF3 signaling and providing a new therapeutic approach against diseases with GTPase overexpression or active mutations.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Jae-Wook Lee, Pham Xuan Thuy, Ja Hyun Koo, Eun-Yi Moon
Summary: The function of TB4 expression and PC formation in cervical cancer cell survival under conditions of serum deprivation was investigated. It was found that Nrf2 counter-regulates TB4 expression and PC formation, and that H2O2 treatment increases PC formation, which is attenuated in response to TB4 siRNA.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hyun Yu, Jeong Heon Kim, Nak-Kyun Soung, Eun-Yi Moon, Ja Hyun Koo
Summary: This study reveals the involvement of ciliary proteins in mitogen signaling and identifies the regulatory roles of IFT38 and IFT144 in serum-mediated Hippo pathway signaling and cellular growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jihyun An, Seungbong Han, Ha Il Kim, Ju Hyun Shim
Summary: This study compared different treatment options for advanced hepatocellular carcinoma and found that atezolizumab+bevacizumab was the best first-line systemic modality, especially for patients with portal invasion.
HEPATOLOGY COMMUNICATIONS
(2022)
