Article
Medicine, Research & Experimental
Feng Bai, Chenglong Zheng, Xiong Liu, Ho Lam Chan, Shiqin Liu, Jinshan Ma, Sijia Ren, Wei-Guo Zhu, Xin-Hai Pei
Summary: This study provides the first genetic evidence demonstrating that loss-of-function of GATA3 directly induces basal-like breast cancer, suggesting that basal-like breast cancer may also originate from other types of cancer.
Article
Pathology
Priscilla A. Furth, Weisheng Wang, Keunsoo Kang, Brendan L. Rooney, Grace Keegan, Vinona Muralidaran, Xiaojun Zou, Jodi A. Flaws
Summary: Genetically engineered mouse models with overexpression of Esr1 and CYP19A1 revealed divergent disease processes in mammary glands due to distinct molecular pathophysiological intrusions into estrogen signaling during reproductive senescence. Esr1 overexpression led to higher rates of preneoplasia and cancer compared to CYP19A1 overexpression. Tamoxifen and letrozole exposure down-regulated cell proliferation genes and resolved differences between the two models.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Michalis Petropoulos, Spyridon Champeris Tsaniras, Sofia Nikou, Styliani Maxouri, Vasilis S. Dionellis, Argyro Kalogeropoulou, Angeliki Karamichali, Konstantinos Ioannidis, Iosif-Rodolfos Danalatos, Mandy Obst, Ronald Naumann, George J. Delinasios, Vassilis G. Gorgoulis, Vassilis Roukos, Konstantinos Anastassiadis, Thanos D. Halazonetis, Vasiliki Bravou, Zoi Lygerou, Stavros Taraviras
Summary: Overexpression of CDT1 enhances tumorigenesis and increases genomic and chromosomal instability. High-level expression of CDT1 is correlated with increased origin licensing, activation of the DNA damage response, and microsatellite instability in human colorectal cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maite Garcia-Guasch, Lourdes Navarro, Vanessa Rivero, Irmgard Costa, Eduard Escrich, Raquel Moral
Summary: Breast cancer is the most common malignancy in women worldwide, with dietary and environmental factors playing a role in its etiology. The study found that high fat diets have different effects on tumor progression, and metabolic changes play a role in the molecular modulation of different signaling pathways in the context of tumor malignancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Agriculture, Dairy & Animal Science
Guilherme Henrique Tamarindo, Adriana Alonso Novais, Luiz Gustavo Almeida Chuffa, Debora Aparecida Pires Campos Zuccari
Summary: Metabolic reprogramming in canine mammary tumors presents a therapeutic opportunity. Alterations in carbohydrate metabolism, amino acid metabolism, lipid metabolism, and mitochondrial functions have been observed in these tumors. Targeting metabolic vulnerabilities may improve the outcome of canine mammary tumors.
Editorial Material
Biochemistry & Molecular Biology
Gergely Rona, Michele Pagano
Summary: Cells prevent rereplication by avoiding licensing of neosynthesized DNA. In this study published in Molecular Cell, Ratnayeke et al. (2022)(1) demonstrate that the licensing factor CDT1 inhibits CMG helicase progression at replication forks by suppressing DNA elongation before its degradation.
Article
Veterinary Sciences
L. Muscatello, F. Gobbo, E. Di Oto, G. Sarli, R. De Maria, A. De Leo, G. Tallini, B. Brunetti
Summary: HER2 amplification was found in a subgroup of canine mammary carcinomas, with the HER2 gene copy number correlated with HER2 protein overexpression but not with tumor behavior. Additionally, a possible translocation of HER2/CRYBA1 was discovered. This study highlights the potential for different amplification patterns in studying HER2 in canine mammary tumors.
VETERINARY SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhi Pang, Xinran Dong, Huayun Deng, Chengzhi Wang, Xiaodong Liao, Chunhua Liao, Yahui Liao, Weidong Tian, Jinke Cheng, Guoqiang Chen, Haiying Yi, Lei Huang
Summary: Aberrant overexpression of MUC1 and HER2 is associated with breast cancer, and their concomitant expression leads to worse clinical outcome. In a mouse model, coexpression of Her2 and MUC1-CD promotes mammary tumor development and induces changes in tumor lineage plasticity and downregulation of tricarboxylic acid cycle genes. Furthermore, MUC1 enhances the Her2 signaling pathway by inducing Her2/Egfr dimerization.
Article
Multidisciplinary Sciences
Maja Louise Arendt, Sharadha Sakthikumar, Malin Melin, Ingegerd Elvers, Patricio Rivera, Majbritt Larsen, Sara Saellstrom, Frode Lingaas, Henrik Roennberg, Kerstin Lindblad-Toh
Summary: Biological features of neoplastic disease affecting mammary gland tissue are shared between canines and humans. Research performed in either species has translational value and early phase clinical trials performed in canines with spontaneous disease could be informative for human trials. This study identified PIK3CA as the most commonly mutated gene in canine mammary tumors, with mutations similar to human breast neoplasia. Other mutations in KRAS and PTEN were also identified. This data supports the validity of studying cancer in non-human species.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng, Yaowu Zheng
Summary: The study using a transgenic mouse model of OXTR overexpression found that OXTR can promote mammary hyperplasia and tumorigenesis, as well as creating a microenvironment that promotes tumor growth, providing potential for targeted therapy in HER2-type breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, Takuro Sunada, Shusuke Akamatsu, Gang He, Junji Itou, Masakazu Toi, Mary Miyaji, Kimiko M. Tsutsui, Scott Keeney, Shintaro Yamada
Summary: ATM gene mutation carriers have a higher risk of developing estrogen-receptor-positive breast cancer (BC). ATM is involved in the early transcriptional response to estrogens through its interaction with topoisomerase II (TOP2) and helps in the repair of TOP2-DNA double-strand breaks (DSBs). Defective repair of TOP2-dependent DSBs after estrogen exposure leads to changes in enhancer activation and overexpression of genes, including the c-MYC oncogene.
Article
Biochemistry & Molecular Biology
Kiley Graim, Dmitriy Gorenshteyn, David G. Robinson, Nicholas J. Carriero, James A. Cahill, Rumela Chakrabarti, Michael H. Goldschmidt, Amy C. Durham, Julie Funk, John D. Storey, Vessela N. Kristensen, Chandra L. Theesfeld, Karin U. Sorenmo, Olga G. Troyanskaya
Summary: Studying canine mammary tumors can model molecular changes in human breast cancer, improving diagnostics and treatments. Utilizing multiple canine tumor samples reveals specific biological pathways of malignant tumors compared to benign and normal tissues. Research indicates that multiple histological samples per patient are crucial for capturing disease progression-related features in human breast cancer.
Article
Plant Sciences
Stephen P. Slocombe, Tatiana Zuniga-Burgos, Lili Chu, Payam Mehrshahi, Matthew P. Davey, Alison G. Smith, Miller Alonso Camargo-Valero, Alison Baker
Summary: Remediation of phosphate pollution using micro-algae can be enhanced by pre-conditioning the algae to induce luxury phosphorus uptake. Over-expression of the global regulator PSR1 in algae led to increased P levels and accelerated removal of phosphate from the medium. The study also revealed a feed-forward mechanism involving P-transporter genes for hyper-accumulation of P even in the presence of excess external phosphate. These findings support a bio-circular approach of nutrient recycling from wastewater back to agriculture.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Medicine, Research & Experimental
Prathibha R. Gajjala, Rajesh K. Kasam, Divyalakshmi Soundararajan, Debora Sinner, Steven K. Huang, Anil G. Jegga, Satish K. Madala
Summary: IPF is a fatal fibrotic lung disease characterized by unremitting fibroblast activation, and Sox9 is identified as a profibrotic transcription factor that promotes FMT, migration, survival, and ECM production in distal lung-resident fibroblasts. Targeting Sox9 could be a potential therapeutic approach for treating IPF.
Article
Multidisciplinary Sciences
Songyeon Lee, Byung-Joon Seung, In Seok Yang, Jueun Lee, Taewoong Ha, Hee-Myung Park, Jae-Ho Cheong, Sangwoo Kim, Jung-Hyang Sur, Geum-Sook Hwang, Hojung Nam
Summary: Metabolomics is used to identify biomarkers for canine mammary tumors, providing insights into cancer-specific metabolic alterations.
