Recent advances in the optimization and functionalization of upconversion nanomaterials for in vivo bioapplications

Nd3+-Sensitized Upconversion Nanophosphors: Efficient In Vivo Bioimaging Probes with Minimized Heating Effect

(2013) Ye-Fu Wang et al.   ACS Nano

Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light

(2013) Chao Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Upconversion-Nanophosphor-Based Functional Nanocomposites

(2013) Wei Feng et al.   ADVANCED MATERIALS

Photon-Upconverting Nanoparticles for Optical Encoding and Multiplexing of Cells, Biomolecules, and Microspheres

(2013) Hans H. Gorris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica

(2013) Jianan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General Strategy for Biocompatible, High-Effective Upconversion Nanocapsules Based on Triplet–Triplet Annihilation

(2013) Qian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cyanine-Modified Nanosystem for in Vivo Upconversion Luminescence Bioimaging of Methylmercury

(2013) Yi Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging

(2013) Wenpei Fan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of Photon Upconversion in Nd3+-Sensitized Core–Shell Nanoparticles

(2013) Xiaoji Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Upconverting nanoparticles for pre-clinical diffuse optical imaging, microscopy and sensing: Current trends and future challenges

(2013) Can T. Xu et al.   Laser & Photonics Reviews

Upconversion luminescence imaging of cells and small animals

(2013) Qian Liu et al.   Nature Protocols

Stem Cell Labeling using Polyethylenimine Conjugated (α-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles

(2013) Liang Zhao et al.   Theranostics

Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800 nm

(2013) Jie Shen et al.   Advanced Optical Materials

(α-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging

(2012) Guanying Chen et al.   ACS Nano

Gd3+-Ion-Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization

(2012) Feng Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Multifunctional Upconversion Nanoparticles for Dual-Modal Imaging-Guided Stem Cell Therapy under Remote Magnetic Control

(2012) Liang Cheng et al.   ADVANCED FUNCTIONAL MATERIALS

Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

(2012) Yong Il Park et al.   ADVANCED MATERIALS

In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

(2012) Yanmei Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging

(2012) Qingfeng Xiao et al.   BIOMATERIALS

Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance

(2012) Ao Xia et al.   BIOMATERIALS

Cubic sub-20 nm NaLuF4-based upconversion nanophosphors for high-contrast bioimaging in different animal species

(2012) Tianshe Yang et al.   BIOMATERIALS

Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging

(2012) Yang Yang et al.   BIOMATERIALS

Radioisotope post-labeling upconversion nanophosphors for in vivo quantitative tracking

(2012) Yun Sun et al.   BIOMATERIALS

Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage

(2012) Ye-Fu Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Multifunctional Core-Shell Upconverting Nanoparticles for Imaging and Photodynamic Therapy of Liver Cancer Cells

(2012) Zengxia Zhao et al.   Chemistry-An Asian Journal

Upconversion Luminescence of Er and Yb Codoped NaYF4 Nanoparticles with Metal Shells

(2012) Minoru Fujii et al.   Journal of Physical Chemistry C

Self-Focusing by Ostwald Ripening: A Strategy for Layer-by-Layer Epitaxial Growth on Upconverting Nanocrystals

(2012) Noah J. J. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blue-Emissive Upconversion Nanoparticles for Low-Power-Excited Bioimaging in Vivo

(2012) Qian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Imaging the Upconversion Nanocrystal Core/Shell Structure at the Subnanometer Level: Shell Thickness Dependence in Upconverting Optical Properties

(2012) Fan Zhang et al.   NANO LETTERS

Lanthanide-doped up-converting nanoparticles: Merits and challenges

(2012) Anna Gnach et al.   Nano Today

Triple-functional core–shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro

(2012) Xiao-Fei Qiao et al.   Nanoscale

Plasmon enhanced upconversion luminescence of NaYF4:Yb,Er@SiO2@Ag core–shell nanocomposites for cell imaging

(2012) Peiyan Yuan et al.   Nanoscale

NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles

(2012) Yanmei Yang et al.   Nanoscale

In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers

(2012) Niagara Muhammad Idris et al.   NATURE MEDICINE

Broadband dye-sensitized upconversion of near-infrared light

(2012) Wenqiang Zou et al.   Nature Photonics

Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers

(2012) M. K. G. Jayakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lanthanide-Doped Nanocrystals: Synthesis, Optical-Magnetic Properties, and Applications

(2011) Guofeng Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

18F-Labeled Magnetic-Upconversion Nanophosphors via Rare-Earth Cation-Assisted Ligand Assembly

(2011) Qian Liu et al.   ACS Nano

Using 915 nm Laser Excited Tm3+/Er3+/Ho3+-Doped NaYbF4 Upconversion Nanoparticles for in Vitro and Deeper in Vivo Bioimaging without Overheating Irradiation

(2011) Qiuqiang Zhan et al.   ACS Nano

Upconverting Nanoparticles

(2011) Markus Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging

(2011) Yanlan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Core–shell NaYF4:Yb3+,Tm3+@FexOy nanocrystals for dual-modality T2-enhanced magnetic resonance and NIR-to-NIR upconversion luminescent imaging of small-animal lymphatic node

(2011) Ao Xia et al.   BIOMATERIALS

High-quality water-soluble and surface-functionalized upconversion nanocrystals as luminescent probes for bioimaging

(2011) Tianye Cao et al.   BIOMATERIALS

Near-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticles

(2011) Chao Wang et al.   BIOMATERIALS

Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy

(2011) Liang Cheng et al.   BIOMATERIALS

Highly plasmon-enhanced upconversion emissions from Au@β-NaYF4:Yb,Tm hybrid nanostructures

(2011) Ning Liu et al.   CHEMICAL COMMUNICATIONS

Breakthrough in concentration quenching threshold of upconversion luminescence via spatial separation of the emitter doping area for bio-applications

(2011) Xiaomin Liu et al.   CHEMICAL COMMUNICATIONS

Upconversion nanophosphors for small-animal imaging

(2011) Jing Zhou et al.   CHEMICAL SOCIETY REVIEWS

Strong Red-Emitting near-Infrared-to-Visible Upconversion Fluorescent Nanoparticles

(2011) Guangshun Yi et al.   CHEMISTRY OF MATERIALS

Colloidal synthesis and remarkable enhancement of the upconversion luminescence of BaGdF5:Yb3+/Er3+ nanoparticles by active-shell modification

(2011) Dongmei Yang et al.   JOURNAL OF MATERIALS CHEMISTRY

Multifunctional NaYF4 : Yb3+,Er3+@Ag core/shell nanocomposites: integration of upconversion imaging and photothermal therapy

(2011) Biao Dong et al.   JOURNAL OF MATERIALS CHEMISTRY

Core–Shell Structured Up-Conversion Luminescent and Mesoporous NaYF4:Yb3+/Er3+@nSiO2@mSiO2 Nanospheres as Carriers for Drug Delivery

(2011) Xiaojiao Kang et al.   Journal of Physical Chemistry C

Two-Photon Upconversion Laser (Scanning and Wide-Field) Microscopy Using Ln3+-Doped NaYF4 Upconverting Nanocrystals: A Critical Evaluation of their Performance and Potential in Bioimaging

(2011) Jothirmayanantham Pichaandi et al.   Journal of Physical Chemistry C

Sub-10 nm Hexagonal Lanthanide-Doped NaLuF4Upconversion Nanocrystals for Sensitive Bioimaging in Vivo

(2011) Qian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-Infrared Light-Triggered Dissociation of Block Copolymer Micelles Using Upconverting Nanoparticles

(2011) Bin Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Ligand-Free Colloidally Stable Water Dispersible Brightly Luminescent Lanthanide-Doped Upconverting Nanoparticles

(2011) Nicoleta Bogdan et al.   NANO LETTERS

In vivopharmacokinetics, long-term biodistribution and toxicology study of functionalized upconversion nanoparticles in mice

(2011) Liang Cheng et al.   Nanomedicine

Rare-Earth Upconverting Nanobarcodes for Multiplexed Biological Detection

(2011) Fan Zhang et al.   Small

Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers

(2010) Shili Gai et al.   ADVANCED FUNCTIONAL MATERIALS

Upconversion nanoparticles in biological labeling, imaging, and therapy

(2010) Feng Wang et al.   ANALYST

Direct Evidence of a Surface Quenching Effect on Size-Dependent Luminescence of Upconversion Nanoparticles

(2010) Feng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plasmonic Modulation of the Upconversion Fluorescence in NaYF4:Yb/Tm Hexaplate Nanocrystals Using Gold Nanoparticles or Nanoshells

(2010) Hua Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Neck-Formation” Strategy for an Antiquenching Magnetic/Upconversion Fluorescent Bimodal Cancer Probe

(2010) Feng Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photon upconversion based on sensitized triplet–triplet annihilation

(2010) Tanya N. Singh-Rachford et al.   COORDINATION CHEMISTRY REVIEWS

Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging

(2010) Heike S Mader et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Kinetic Analysis of Photochemical Upconversion by Triplet−Triplet Annihilation: Beyond Any Spin Statistical Limit

(2010) Yuen Yap Cheng et al.   Journal of Physical Chemistry Letters

Rate equation model analysis on the infrared and upconversion emission of Er/Yb co-doped borate-silicate glass

(2010) Shanfeng LI et al.   JOURNAL OF RARE EARTHS

Fabrication of Ag@SiO2@Y2O3:Er Nanostructures for Bioimaging: Tuning of the Upconversion Fluorescence with Silver Nanoparticles

(2010) Fan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Generalized Ligand-Exchange Strategy Enabling Sequential Surface Functionalization of Colloidal Nanocrystals

(2010) Angang Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly-sensitive multiplexed in vivo imaging using pegylated upconversion nanoparticles

(2010) Liang Cheng et al.   Nano Research

Absolute quantum yield measurements of colloidal NaYF4: Er3+, Yb3+ upconverting nanoparticles

(2010) John-Christopher Boyer et al.   Nanoscale

Small Upconverting Fluorescent Nanoparticles for Biomedical Applications

(2010) Dev K. Chatterjee et al.   Small

Immunolabeling and NIR-Excited Fluorescent Imaging of HeLa Cells by Using NaYF4:Yb,Er Upconversion Nanoparticles

(2009) Meng Wang et al.   ACS Nano

The Active-Core/Active-Shell Approach: A Strategy to Enhance the Upconversion Luminescence in Lanthanide-Doped Nanoparticles

(2009) Fiorenzo Vetrone et al.   ADVANCED FUNCTIONAL MATERIALS

High Contrast Upconversion Luminescence Targeted Imaging in Vivo Using Peptide-Labeled Nanophosphors

(2009) Liqin Xiong et al.   ANALYTICAL CHEMISTRY

Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors

(2009) Li-Qin Xiong et al.   BIOMATERIALS

Ag nanowires enhanced upconversion emission of NaYF4:Yb,Er nanocrystals via a direct assembly method

(2009) Wei Feng et al.   CHEMICAL COMMUNICATIONS

Near-infrared fluorescence: application to in vivo molecular imaging

(2009) Scott A Hilderbrand et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In vivo multiple color lymphatic imaging using upconverting nanocrystals

(2009) Hisataka Kobayashi et al.   JOURNAL OF MATERIALS CHEMISTRY

Upconversion Luminescence of β-NaYF4: Yb3+, Er3+@β-NaYF4 Core/Shell Nanoparticles: Excitation Power Density and Surface Dependence

(2009) Yu Wang et al.   Journal of Physical Chemistry C

Plasmon-Enhanced Upconversion in Single NaYF4:Yb3+/Er3+Codoped Nanocrystals

(2009) Stefan Schietinger et al.   NANO LETTERS

Mesoporous-Silica-Coated Up-Conversion Fluorescent Nanoparticles for Photodynamic Therapy

(2009) Hai Sheng Qian et al.   Small

A Four-Color Colloidal Multiplexing Nanoparticle System

(2008) Oliver Ehlert et al.   ACS Nano

Nanoparticles in photodynamic therapy: An emerging paradigm

(2008) Dev Kumar Chatterjee et al.   ADVANCED DRUG DELIVERY REVIEWS

Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

(2008) Rufaihah Abdul Jalil et al.   BIOMATERIALS

High Contrast in Vitro and in Vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+and Yb3+Doped Fluoride Nanophosphors

(2008) Marcin Nyk et al.   NANO LETTERS