Journal
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
Volume 5, Issue 5, Pages 283-287Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpgasthep1119
Keywords
anal fissure; Crohn's disease; disseminated histoplasmosis; immunosuppression; infliximab
Categories
Ask authors/readers for more resources
Background A 56-year-old female with a 30-year history of ileocolic Crohn's disease presented with a 1-month history of bloody diarrhea and decreased caliber of stools; physical examination revealed a broad indurated anal fissure. The patient had been receiving antimetabolite therapy with 6-mercaptopurine and maintenance therapy with infliximab for over a year. Investigations Physical examination; proctoscopy; perianal and anal canal biopsy; chest CT; blood and stool analysis, measurement of serum histoplasmosis antibodies and urine histoplasmosis antigen levels; fungal culture and Gomori's methenamine silver staining of resected tissue specimens. Diagnosis Disseminated histoplasmosis. Management Proctocolectomy and end ileostomy followed by treatment with liposomal amphotericin and then oral itraconazole. A palmar space abscess required multiple debridements, and a muscle flap to cover the defect.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available