Review
Polymer Science
Shuo Chen, Yihan Wang, Lei Yang, Chengzhen Chu, Shichun Cao, Zhao Wang, Jiajia Xue, Zhengwei You
Summary: In this review, the recent progress in synthesis, process technologies, and biomedical applications of biodegradable elastomers is summarized. The emphasis is on the molecular design and processing strategies of biodegradable polyesters and polyurethanes, as well as the newly developed functionalities in biomedical applications. Future research directions, challenges, and potential solutions are discussed.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jianmei Chen, Yurui Xu, Xinghai Ning
Summary: Cellular therapy holds enormous promise, but reliable cell sources are scarce. This study introduces a 3D bioinspired scaffold that improves cell production and cryopreservation efficiency. The scaffold mimics the structure of silkworm cocoons and maintains cell viability and biofunctions, providing high cryopreservation efficacy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Ceramics
Patricia Ros-Tarraga, Carlos M. Martinez, Miguel A. Rodriguez, Piedad N. De Aza
Summary: The elderly population is increasing, leading to an increase in bone and joint problems. Scaffold for bone tissue regeneration can solve these problems, and material selection is crucial for satisfactory results. This study designed a three-dimensional porous ceramic scaffold and analyzed its biocompatibility and osteoinductive capacity. The results suggest that it has potential applications as bone substitutes.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Applied
Tomasz Machalowski, Joanna Idaszek, Adrian Chlanda, Marcin Heljak, Adam Piasecki, Wojciech Swieszkowski, Teofil Jesionowski
Summary: The study developed chitin-based biocomposites through biomimetic ex vivo deposition of calcium carbonate particles in the hemolymph from the cultivated mollusk Cornu aspersum and chitinous matrix from the marine demosponge Aplysina fistularis. The results showed that the biofunctionalized scaffold had about 4 times higher mechanical resistance and exhibited significant topographical changes, indicating its potential for modifying cell delivery systems in future biomedical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Zhou Jian, Tian Zhuang, Tian Qinyu, Peng Liqing, Li Kun, Luo Xujiang, Wang Diaodiao, Yang Zhen, Jiang Shuangpeng, Sui Xiang, Huang Jingxiang, Liu Shuyun, Hao Libo, Tang Peifu, Yao Qi, Guo Quany
Summary: By optimizing the preparation of meniscus-derived bioink and utilizing a custom 3D bioprinting system, a biomimetic meniscal scaffold with optimal features in terms of morphology and components was successfully created. Comprehensive evaluations were conducted on cell viability, mechanics, biodegradation, and tissue formation to ensure the scaffold's feasibility and functionality for application in tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Jae Seo Lee, Haram Nah, Donghyun Lee, Sang-Hyun An, Wan-Kyu Ko, Sang Jin Lee, Seung Yeon Lee, Kyung Min Park, Jung Bok Lee, Hyeong-joong Yi, Il Keun Kwon, Kyu-Sun Choi, Dong Nyoung Heo
Summary: Reconstructing patient-specific scaffolds for repairing uniquely shaped bone defects is a major challenge in tissue engineering. 3D printed scaffolds have gained attention as a promising technology for rapid generation of custom shapes. However, commonly used synthetic polymers lack the biological capacity to mimic native extracellular matrix functions. This study describes the preparation and characterization of a 3D hybrid model for bone tissue engineering that incorporates an extracellular matrix-enriched hydrogel in a synthetic polymer scaffold, showing excellent biocompatibility and osteogenic activity.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Sangil Min, David Cleveland, In Kap Ko, Ji Hyun Kim, Hee Jo Yang, Anthony Atala, James J. Yoo
Summary: By incorporating vascular endothelial growth factor (VEGF) into the vascular scaffold, improved angiogenic capability was achieved, promoting vascularization, reducing apoptosis of implanted cells, and forming hybrid renal tubule-like structures.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Multidisciplinary
Yuzhang Du, Meng Yu, Wenxuan Lu, Jie Kong
Summary: This study developed 3D macroporously elastic biodegradable nanocomposite bone scaffolds with multiple cues, which promote bone regeneration both in vitro and in vivo, showing potential clinical applications in the field of large bone defect repair.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
A. Dadashzadeh, S. Moghassemi, C. A. Amorim
Summary: This study demonstrated that PEGylated fibrin hydrogels enhanced scaffold stability, supported cell viability and proliferation. PEG:Fib 5:1 T50 showed a significantly higher cell density dynamic and a lower expression of caspase-3. In contrast, PEG:Fib 10:1 T50 hydrogels had uniform cell distribution and a higher rate of Ki67-positive cells.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Engineering, Manufacturing
Mehdi Atari, Sheyda Labbaf, Shaghayegh Haghjooy Javanmard
Summary: Heart valve disease is a leading cause of cardiovascular complications and mortalities worldwide. This study successfully improves the durability and hemodynamic function of heart valves through the manufacturing strategy of a 3D biofunctional elastomeric biomimetic material. The crosslinked scaffold shows improved cellular response and hemo-compatibility.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Biophysics
Jian He, Zhidong Lin, Xulin Hu, Luyao Xing, Gaofeng Lian, Dongliang Chen, Junling An, Chengdong Xiong, Xiangchun Zhang, Lifang Zhang
Summary: The study developed bioactive scaffolds with favorable mechanical properties and osteogenesis promotion, which could be a promising alternative to bone cement in bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biotechnology & Applied Microbiology
Zimu Mao, Baoshi Fan, Xinjie Wang, Ximeng Huang, Jian Guan, Zewen Sun, Bingbing Xu, Meng Yang, Zeyi Chen, Dong Jiang, Jiakuo Yu
Summary: The use of tissue engineering scaffold, especially biomaterials, has shown significant effectiveness in tendon-bone healing and can be enhanced by biological interventions. Current research is mainly focused on animal models, calling for further clinical trials to explore the full potential of these approaches in clinical practice.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Multidisciplinary
Lin Zou, Le Hu, Panpan Pan, Solaiman Tarafder, Mingzu Du, Yusheng Geng, Gan Xu, Li Chen, Jingdi Chen, Chang H. Lee
Summary: The polycaprolactone and nano-hydroxyapatite composite is a promising material for bone scaffolds with excellent mechanical properties. In this study, a 3D printed scaffold embedded with poly (lactic-co-glycolic acid) microspheres was developed for controlled delivery of Icariin to promote bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Jiawei Sun, Lei Jiang, Yi Lin, Ethan Michael Gerhard, Xuehua Jiang, Li Li, Jian Yang, Zhongwei Gu
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Review
Chemistry, Multidisciplinary
Chuying Ma, Michelle L. Kuzma, Xidochun Bai, Jian Yang
Article
Multidisciplinary Sciences
Qiong Wei, Xuechen Shi, Tiankai Zhao, Pingqiang Cai, Tianwu Chen, Yao Zhang, Changjin Huang, Jian Yang, Xiaodong Chen, Sulin Zhang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Materials Science, Multidisciplinary
Jia Zhu, Zhihui Hu, Chaoyun Song, Ning Yi, Zhaozheng Yu, Zhendong Liu, Shangbin Liu, Mengjun Wang, Michael Gregory Dexheimer, Jian Yang, Huanyu Cheng
Summary: The ultimate application of bio-integrated, stretchable electronics relies on the crucial modules of stretchable wireless data transmission and power supplies, with the introduction of stretchable wideband antennas and rectennas robustly operating and combining received RF power over their wideband upon mechanical deformations, creating application opportunities such as self-powered systems, remote monitoring of the environment, and clean energy.
MATERIALS TODAY PHYSICS
(2021)
Article
Biophysics
Jia Zhu, Shangbin Liu, Zhihui Hu, Xianzhe Zhang, Ning Yi, Kairui Tang, Michael Gregory Dexheimer, Xiaojun Lian, Qing Wang, Jian Yang, Jennifer Gray, Huanyu Cheng
Summary: The study highlights the superiority of non-enzymatic glucose sensors in terms of sensitivity and linear range, as well as their potential practical applications in sweat sampling and glucose sensing.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Engineering, Biomedical
Keke Wu, Meimei Fu, Yitao Zhao, Ethan Gerhard, Yue Li, Jian Yang, Jinshan Guo
Summary: This study developed a multifunctional bioadhesive made from the natural polyphenolic compound tannic acid, which possesses antioxidant, anti-inflammatory, and antimicrobial properties. The bioadhesive showed favorable biocompatibility and mechanical strength, and it promoted wound closure and scarless healing.
BIOACTIVE MATERIALS
(2023)
Review
Engineering, Biomedical
Jia Zhu, Honglei Zhou, Ethan Michael Gerhard, Senhao Zhang, Flor Itzel Parra Rodriguez, Taisong Pan, Hongbo Yang, Yuan Lin, Jian Yang, Huanyu Cheng
Summary: The high demand for rapid wound healing has led to the development of multifunctional and smart bioadhesives that can promote accelerated wound healing through real-time sensing and on-demand treatment. However, challenges in designing and fabricating integrated systems remain, presenting opportunities for future development.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Yunyun Cheng, Li Li, Caleb H. Meredith, Rebecca V. Balaj, Dingbowen Wang, Meng Pan, Ting Han, Jian Yang, Qing Wang, Lijie Dong, Lauren D. Zarzar
Summary: Photoluminescence (PL)-type humidity sensing materials with high sensitivity, stretchability, and healability are developed using poly(vinyl alcohol)(PVA) composite gels with Cd x Se1-x Zn y S1-y quantum dots (QDs). A droplet-assisted strategy is employed to improve moisture adsorption by achieving a uniform distribution of QDs and forming micropores in the polymer matrix. The PVA/QD composite gels exhibit excellent humidity sensing performance with high linearity, wide sensing range, fast response/recovery time, and good stability.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Huifeng Wang, Samantha Huddleston, Jian Yang, Guillermo A. Ameer
Summary: Regenerative medicine aims to restore tissue and organ function, but faces barriers such as the lack of proregenerative biomaterials, a complex regulatory process, and user adoption challenges. Biodegradable polymers, although important in regenerative medicine, have limitations in their mechanical and degradation properties. Despite these limitations, a small number of biodegradable polymers have dominated the market for the past 50 years.
ADVANCED MATERIALS
(2023)
Article
Biophysics
Chenji Zhang, Jimin P. Kim, Michael Creer, Jian Yang, Zhiwen Liu
BIOSENSORS & BIOELECTRONICS
(2017)
Article
Chemistry, Multidisciplinary
Jian Zhang, Jinpeng Jia, Jimin P. Kim, Hong Shen, Fei Yang, Qiang Zhang, Meng Xu, Wenzhi Bi, Xing Wang, Jian Yang, Decheng Wu
ADVANCED MATERIALS
(2017)
Review
Engineering, Biomedical
Ethan Michael Gerhard, Wei Wang, Caiyan Li, Jinshan Guo, Ibrahim Tarik Ozbolat, Kevin Michael Rahn, April Dawn Armstrong, Jingfen Xia, Guoying Qian, Jian Yang
ACTA BIOMATERIALIA
(2017)
Article
Chemistry, Physical
Gong Cheng, Si-Jie Hao, Yuan Wan, Ding-Ying Shan, Jian Yang, Si-Yang Zheng
CHEMISTRY OF MATERIALS
(2017)
Article
Engineering, Biomedical
Zhiwei Xie, Jimin P. Kim, Qing Cai, Yi Zhang, Jinshan Guo, Ranjodh S. Dhami, Li Li, Bin Kong, Yixue Su, Kevin A. Schug, Jian Yang
ACTA BIOMATERIALIA
(2017)
Article
Engineering, Biomedical
Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu