Article
Clinical Neurology
John Conklin, Matthew P. Frosch, Shibani S. Mukerji, Otto Rapalino, Mary D. Maher, Pamela W. Schaefer, Michael H. Lev, R. G. Gonzalez, Sudeshna Das, Samantha N. Champion, Colin Magdamo, Pritha Sen, G. Kyle Harrold, Haitham Alabsi, Erica Normandin, Bennett Shaw, Jacob E. Lemieux, Pardis C. Sabeti, John A. Branda, Emery N. Brown, M. Brandon Westover, Susie Y. Huang, Brian L. Edlow
Summary: In patients with severe COVID-19, microvascular brain lesions, characterized by punctate SWI lesions, are commonly found in the subcortical and deep white matter. These lesions are associated with widespread microvascular injury, indicating a risk for hemorrhagic and ischemic lesions in the brain.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Xianwen Zhang, Liaoyuan Zheng, Jinfeng Duan, Shunyuan Zhang, Ying Zhou, Yufeng Tang
Summary: This article evaluates the value of susceptibility-weighted imaging (SWI) in the diagnosis of cerebral fat embolism (CFE), and demonstrates the characteristics of CFE on SWI through a patient case report.
Article
Multidisciplinary Sciences
Hai-Ling Wang, Donglin Liu, Jian-Hua Jia, Jun-Liang Liu, Ze-Yu Ruan, Wei Deng, Shiping Yang, Si-Guo Wu, Ming-Liang Tong
Summary: Researchers have successfully synthesized two highly stable high-nuclear lanthanide clusters (Ho-32 and Gd-32) that show excellent imaging effects in MRI. These clusters can replace traditional gadolinium chelates as contrast agents, avoiding the use of high doses of gadolinium contrast agents.
NATIONAL SCIENCE REVIEW
(2023)
Article
Clinical Neurology
Maarten Lequin, Floris Groenendaal, Jeroen Dudink, Paul Govaert
Summary: Diagnosing kernicterus in the acute phase is challenging, as the conventional T1w sequence may show high signal intensity due to early myelination. However, the SWI sequence appears to be more sensitive and reliable for detecting damage in the globus pallidum area.
Review
Neurosciences
Yin Liu, Liyan Lu, Fengfang Li, Yu-Chen Chen
Summary: This review summarizes the application of multimodal MRI techniques in mild traumatic brain injury (mTBI), as well as its benefits and drawbacks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Jung Bae, Yoo Sung Song, Byung Se Choi, Jong-Min Kim, Yoonho Nam, Jae Hyoung Kim
Summary: SMWI showed higher inter-observer agreement for nigral hyperintensity and a higher concordance rate with I-123-FP-CIT SPECT results compared to SWI. SMWI provided significantly higher diagnostic performance for PD than SWI.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liyun Zheng, Chun Yang, Liang Liang, Shengxiang Rao, Yongming Dai, Mengsu Zeng
Summary: This study aimed to explore the feasibility of pancreatic imaging at 5 T and evaluate the practical improvement of T2-weighted MRI and diffusion-weighted imaging (DWI) at 5 T as compared with 3 T. The results showed that imaging at 5 T provided higher image quality ratings and SNR compared to 3 T for both T2-weighted and DWI images. However, there were no significant differences in the mean ADC values and CV of ADC between 3 T and 5 T measurements.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiaen Liu, Erin S. Beck, Stefano Filippini, Peter van Gelderen, Jacco A. de Zwart, Gina Norato, Pascal Sati, Omar Al-Louzi, Hadar Kolb, Maxime Donadieu, Mark Morrison, Jeff H. Duyn, Daniel S. Reich
Summary: This study investigated the impact of navigator-guided motion and B-0 correction on cortical lesion detection in T-2*w magnetic resonance imaging at 7 T. Results showed that correction significantly improved image quality, particularly for images with severe motion artifacts, leading to enhanced detection of cortical lesions.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengxing Wei, Lulu Wang, Yanfang Wang, Tong Zhang, Chenchen Wang, Chengfan Wu, Changlin Tian, Gaolin Liang, Yue Yuan
Summary: Magnetic resonance imaging (MRI) is an excellent imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution. However, the use of intracellular self-assembled Gd-containing nanoparticles to enhance T-2-weighted MR contrast in vivo for precise tumor MRI is rarely reported. This study developed a CTSB-responsive small molecular contrast agent VC-Gd-CBT, which can self-assemble into large intracellular Gd-containing nanoparticles, and it has the potential to be used as a T-2 contrast agent for early-stage cancer diagnosis.
Article
Chemistry, Multidisciplinary
Hai-Dong Xu, Xiaotong Cheng, Xianbao Sun, Peiyao Chen, Wenjun Zhan, Xiaoyang Liu, Xinliang Wang, Bing Hu, Gaolin Liang
Summary: A self-assembling probe for apoptosis imaging was designed, which underwent a Caspase-3 cleavage and CBT-Cys click reaction to form Gd nanoparticles. This probe achieved enhanced MR imaging of apoptosis in vitro, in apoptotic cells, and in zebrafish.
Article
Clinical Neurology
Monica Margoni, Elisabetta Pagani, Paolo Preziosa, Mor Gueye, Matteo Azzimonti, Maria A. Rocca, Massimo Filippi
Summary: This study used multimodal MRI to investigate the regional distribution of different pathological processes in the brain white and gray matter of relapse-onset multiple sclerosis (MS) patients. The results showed that compared to healthy controls, relapsing-remitting MS (RRMS) patients exhibited white matter, deep gray matter, and cortical atrophy, as well as significantly lower MTR and T1w/T2w ratio in periventricular and infratentorial white matter, deep gray matter, and several cortical areas. Secondary progressive MS (SPMS) patients showed more severe deep gray matter and widespread cortical atrophy, lower MTR of periventricular white matter, deep gray matter, and cerebellum, lower T1w/T2w ratio of fronto-temporal white matter regions, lower ICV_f of some fronto-tempo-occipital white matter and cortical areas, and increased QSM and T1w/T2w ratio in the pallidum.
JOURNAL OF NEUROLOGY
(2023)
Article
Biophysics
Qiang Liu, Zhongbiao Xu, Kaixuan Zhao, W. Scott Hoge, Xinyuan Zhang, Yingjie Mei, Qiqi Lu, Thoralf Niendorf, Yanqiu Feng
Summary: This study aimed to enhance kidney DWI in rats using 2D navigated, interleaved multishot EPI, which successfully differentiated differences in MD and FA between renal cortex and medulla while reducing image distortion.
NMR IN BIOMEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daiki Tamada, Aaron S. Field, Scott B. Reeder
Summary: This study introduces a novel method for simultaneous T1w and T2w imaging using RF phase-modulated 3D gradient-echo imaging. Theoretical basis derived equations using configuration theory and practical validation through simulation and phantom experiments were conducted. Results show promising outcomes in both model and volunteer imaging, indicating the feasibility and potential of this alternative imaging approach.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liyun Zheng, Chun Yang, Ruofan Sheng, Yongming Dai, Mengsu Zeng
Summary: This study evaluates the feasibility of renal imaging at 5 T MRI and compares it with 3 T MRI. The results show that 5 T MRI provides improved image quality and anatomical imaging compared to 3 T MRI, with higher signal-to-noise ratio and contrast ratio for abdomen organ tissues. However, there are still some artifacts in image quality. Moreover, 5 T MRI performs better in functional imaging compared to 3 T MRI.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woojin Jung, Eu Hyun Kim, Jingyu Ko, Geunu Jeong, Moon Hyung Choi
Summary: This study developed a deep neural network (DNN)-based method for highly accelerated 2D TSE data reconstruction in prostate MRI, which showed comparable quality to conventional scans. The DNN reconstructions demonstrated better quantitative error metrics, visual appropriateness, and lesion detection compared to TSE scans.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Takeya Tsutsumi, Makoto Saito, Hiroyuki Nagai, Shinya Yamamoto, Kazuhiko Ikeuchi, Lay Ahyoung Lim, Eisuke Adachi, Michiko Koga, Kazuya Okushin, Hiroyuki Akai, Akira Kunimatsu, Hiroshi Yotsuyanagi
Summary: This study examined 60 COVID-19 patients and found that 52% of patients had high ALT levels, with these patients being obese and having significantly higher levels of D-dimer and fibrin/fibrinogen degradation products. Multivariable analysis showed D-dimer and white blood cells as independent factors.
HEPATOLOGY RESEARCH
(2021)
Article
Clinical Neurology
Koichiro Yasaka, Koji Kamagata, Takashi Ogawa, Taku Hatano, Haruka Takeshige-Amano, Kotaro Ogaki, Christina Andica, Hiroyuki Akai, Akira Kunimatsu, Wataru Uchida, Nobutaka Hattori, Shigeki Aoki, Osamu Abe
Summary: Deep learning techniques applied to parameter-weighted structural matrices can differentiate patients with Parkinson's disease from healthy controls. Neural circuit disorders, such as alterations in connections between the basal ganglia and cerebellum, can be visualized using gradient-weighted class activation mapping.
Article
Clinical Neurology
Pin Fee Chong, Ryutaro Kira, Hiroyuki Torisu, Sawa Yasumoto, Akihisa Okumura, Harushi Mori, Keiko Tanaka-Taya
Summary: This study summarizes the long-term motor outcome and disability level in pediatric patients with acute flaccid myelitis (AFM) associated with the enterovirus D68 outbreak in 2015. Results showed that some patients demonstrated improvement at the recovery-to-chronic period, and the disability level generally improved at the three-year time point.
PEDIATRIC NEUROLOGY
(2021)
Editorial Material
Medicine, General & Internal
A. Mitsutake, Y. Nagashima, H. Mori, H. Sawamura, T. Toda
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Clinical Neurology
Shinichi Cho, Ryo Kurokawa, Akifumi Hagiwara, Wataru Gonoi, Harushi Mori, Takuya Kawahara, Moto Nakaya, Naoya Sakamoto, Nana Fujita, Satoru Kamio, Hiroaki Koyama, Osamu Abe
Summary: The study aimed to investigate the distinctive signal of the paracentral lobule (PL) on T1-weighted images and evaluate its utility in identifying the central sulcus. The results showed that the PL cortex had higher signal intensity compared to the superior frontal cortex and could accurately identify the central sulcus in 94.3% of cases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haruto Sugawara, Hirokazu Watanabe, Akira Kunimatsu, Osamu Abe, Yasushi Yatabe, Shun-ichi Watanabe, Masahiko Kusumoto
Summary: Tumor diameter measured on preoperative CT images is significantly smaller in patients with severe emphysema compared to those without emphysema, especially for large tumors. Multiplanar reconstruction measurement using the widest of three dimensions should be utilized for T-stage determination in emphysema patients.
EUROPEAN RADIOLOGY
(2022)
Article
Pediatrics
Kenichi Maeda, Pin Fee Chong, Satoshi Akamine, Fumiya Yamashita, Yuya Morooka, Harushi Mori, Sooyoung Lee, Yumi Mizuno, Ryutaro Kira
Summary: This study reports a case of acute fulminant cerebral edema in a patient with Kawasaki disease, which represents an extreme manifestation of complications. The study suggests that vasogenic edema with perivascular abnormalities on MRI may serve as an alert for potentially fatal cerebral edema.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Masashi Endo, Yukiko Fukuda, Kazunari Ogawa, Satoru Takahashi, Michiko Nakamura, Masahiro Kawahara, Keiko Akahane, Yoshitaka Yamanouchi, Koichi Hagiwara, Harushi Mori, Katsuyuki Shirai
Summary: Adrenal metastases from lung cancer often have few symptoms, but palliative radiotherapy can effectively relieve pain and reduce the need for opioids.
CASE REPORTS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wataru Ueno, Naoto Sato, Kouichi Miura, Naoki Morimoto, Shunji Watanabe, Hiroaki Nomoto, Norio Isoda, Shigeyoshi Kijima, Tomohiro Kikuchi, Saki Manaka, Harushi Mori, Hironori Yamamoto
Summary: This case report highlights successful management of a patient with alcoholic liver cirrhosis and multiple large spontaneous portosystemic shunts (SPSS) through two embolization procedures within 6 months. The patient's hepatic encephalopathy and hepatic function were significantly improved after embolization for the SPSS, leading to freedom from hepatic encephalopathy.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Surgery
Atsushi Ugajin, Shinichi Iwakoshi, Shigeo Ichihashi, Takashi Inoue, Takahiro Nakai, Hayato Kishida, Yuto Chanoki, Toshihiro Tanaka, Harushi Mori, Kimihiko Kichikawa
Summary: Measuring baPWV before EVAR in patients with abdominal aortic aneurysm can predict significant sac growth after EVAR, with patients having higher baPWV values at increased risk for growth.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Clinical Neurology
Pin Fee Chong, Hiroyuki Torisu, Sawa Yasumoto, Akihisa Okumura, Harushi Mori, Tatsuharu Sato, Jun Kimura, Shouichi Ohga, Keiko Tanaka-Taya, Ryutaro Kira
Summary: Acute flaccid myelitis (AFM) typically exhibits neurophysiological features of neuronopathy, and nerve conduction studies (NCS) may be useful for diagnosis and evaluation. Abnormalities in compound muscle action potentials (CMAPs) are correlated with muscle strength reduction.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Oncology
Yukiko Fukuda, Satoru Takahashi, Michiko Nakamura, Masashi Endo, Kazunari Ogawa, Masahiro Kawahara, Keiko Akahane, Shoko Ito, Yoshinobu Kanda, Harushi Mori, Katsuyuki Shirai
Summary: This case report presents a rare case of irreversible paraplegia caused by combined treatment of intrathecal methotrexate and palliative radiation therapy. The findings serve as a reminder for caution when using low-dose palliative radiation therapy in combination with intrathecal methotrexate.
CASE REPORTS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Akihiko Mitsutake, Takashi Matsukawa, Atsushi Iwata, Hiroyuki Ishiura, Jun Mitsui, Harushi Mori, Takashi Toya, Akira Honda, Mineo Kurokawa, Norio Sakai, Shoji Tsuji, Tatsushi Toda
Summary: This article presents a case of late-onset Krabbe disease treated with hematopoietic stem cell transplantation. The treatment resulted in improved symptoms and no severe adverse events occurred.
BRAIN & DEVELOPMENT
(2023)
Article
Endocrinology & Metabolism
Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Ashraful Alam, Harushi Mori, Naoto Hayashi
Summary: This study aimed to determine a standardized cut-off value for abnormal FDG accumulation in the thyroid gland. By analyzing 7013 FDG-PET/CT scans, the study found that a mean SUV greater than or equal to 2 was strongly associated with abnormal thyroid function. Therefore, mean SUV can be used as a criterion for thyroid evaluation.
EUROPEAN THYROID JOURNAL
(2023)
Article
Genetics & Heredity
Toshiyuki Itai, Satoko Miyatake, Taku Hatano, Nobutaka Hattori, Atsuko Ohno, Yusuke Aoki, Kazuya Itomi, Harushi Mori, Hirotomo Saitsu, Naomichi Matsumoto
Summary: Two patients with NSD1 deletion presented with early-onset or recurrent cerebrovascular diseases. One female patient showed developmental delay and movement disorders, with brain imaging suggesting parenchymal hemorrhages; while a male patient had tremor as a neonate, with brain imaging revealing subdural hematoma and brain contusion.
HUMAN GENOME VARIATION
(2021)
