Article
Medicine, General & Internal
Yanjing Chen, Chengliang Cai, Fan Qiao, Bailing Li, Zhiyun Xu, Fanglin Lu, Zhao An
Summary: This study aimed to investigate the association between preoperative 6-minute walk test (6MWT) and prolonged postoperative hospitalization in high risk patients with severe tricuspid regurgitation (TR) after transcatheter tricuspid valve replacement (TTVR). The study found that preoperative decreased 6MWT distance was an independent risk factor for prolonged hospitalization in high risk TR patients after TTVR.
Article
Critical Care Medicine
Daniel Lachant, Ethan Kennedy, Blaise Derenze, Allison Light, Michael Lachant, R. James White
Summary: This study aimed to investigate whether a chest-based accelerometer can remotely estimate 6MWT distance and compare the reproducibility of remote cardiac effort and 6MWT distance with clinic assessment. The results showed that the estimated 6MWT distance using MC10 was strongly correlated with the directly measured distance. Remote 6MWT distances were shorter than clinic distances, but there was no difference in cardiac effort between remote and clinic assessments.
Article
Cardiac & Cardiovascular Systems
Kenji Matsumoto, Yi Xiao, Shunichi Homma, John L. P. Thompson, Richard Buchsbaum, Kazato Ito, Stefan D. Anker, Min Qian, Marco R. Di Tullio
Summary: This study found that in HFrEF, baseline 6 min walk test distance (6MWTD) is independently associated with all-cause death, cardiovascular death, and heart failure hospitalization. A 6MWTD of 200 m is the best cut-off point for predicting these adverse events. The prognostic impact of 6MWTD for heart failure hospitalization was only observed in older patients.
Article
Medicine, General & Internal
Kamila Mietkiewska-Szwacka, Tomasz Krauze, Katarzyna Barecka, Anna Rozanska-Kirschke, Dagmara Przymuszala-Staszak, Agata Schneider, Milosz Dziarmaga, Jacek Lech Tarchalski, Aneta Nowak, Mateusz Bryl, Jolanta Kaczmarek, Jaroslaw Piskorski, Andrzej Wykretowicz, Przemyslaw Guzik
Summary: Aldosterone concentration in systolic heart failure patients affects blood pressure during and after exercise, with higher concentrations leading to lower blood pressure. However, it does not have a specific effect on heart rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Christopher Gupta, Anjali Sachdeva, Jigish Khamar, Cecilia Bu, Jessica Bartoszko, Mark Loeb
Summary: Influenza vaccination appears to reduce adverse cardiovascular events in heart failure patients, although the certainty of the evidence is low or very low. Rigorous randomized controlled trial evidence is needed to further examine the protective effect of the influenza vaccine.
Article
Cardiac & Cardiovascular Systems
Remi Sabatier, Damien Legallois, Mouna Jodar, Laurene Courouve, Valerie Donio, Florence Boudevin, Thibault De Chalus, Karine Hauchard, Annette Belin, Paul Milliez
Summary: This study evaluated the impact of patient engagement in home-based telemonitoring for heart failure on rehospitalization and mortality rates. It found significant associations between the level of patient engagement and rehospitalization and mortality rates.
Article
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Stefan D. Anker, Tim Friede, Ewa A. Jankowska, Marco Metra, Ileana L. Pina, Andrew J. S. Coats, Giuseppe Rosano, Bernard Roubert, Udo-Michael Goehring, Fabio Dorigotti, Josep Comin-Colet, Dirk J. Van Veldhuisen, Gerasimos S. Filippatos, Piotr Ponikowski, Javed Butler
Summary: This study aims to calculate the minimal clinically important difference (MCID) for change in exercise capacity in the 6-minute walk test (6MWT) in iron-deficient populations with heart failure and reduced ejection fraction (HFrEF). Through secondary analysis of two trials, the MCIDs for improvement and deterioration in the 6MWT at 12 and 24 weeks were determined.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Marcelo C. Shibata, Jordan Curl-Roper, Dirk J. Van Veldhuisen, Michael Roughton, Andrew J. S. Coats, Marcus Flather
Summary: The 6-minute walk test (6MWT) has prognostic utility in elderly patients with heart failure, with those who walked less than 200 meters being at the highest risk. Nebivolol did not have any effect on 6MWT outcomes over a 6-month period according to the SENIORS trial data.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Rehabilitation
G. N. Andrade, T. Rodrigues, J. Y. Takada, L. M. Braga, I. I. K. Umeda, J. A. Nascimento, H. G. Pereira-Filho, C. J. Grupi, V. M. C. Salemi, W. Jacob-Filho, L. P. Cahalin, A. P. Mansur, E. A. Bocchi, N. K. Nakagawa
Summary: This study found that the time for peak exercise heart rate to return to resting heart rate after the 6MWT (>= 3 minutes) was an independent predictor of cardiac events in patients with HF.
Article
Cardiac & Cardiovascular Systems
Ambarish Pandey, Matthew W. Segar, Sumitabh Singh, Gordon Reeves, Christopher O'Connor, Ileana Pina, David Whellan, William Kraus, Robert Mentz, Dalane Kitzman
Summary: This study investigates the impact of baseline frailty on the efficacy of aerobic exercise training in patients with heart failure. The results show that aerobic exercise training significantly reduces the risk of all-cause hospitalization in frail patients, but the effect is not significant for non-frail patients.
Review
Medicine, General & Internal
Carlos Escobar, Domingo Pascual-Figal, Luis Manzano, Julio Nunez, Miguel Camafort
Summary: Based on recent evidence, SGLT2 inhibitors, specifically dapagliflozin, are recommended as first-line therapy for managing heart failure patients, irrespective of ejection fraction, to reduce the burden of heart failure. Studies have shown that dapagliflozin significantly reduces the risk of cardiovascular death, all-cause death, total heart failure hospitalizations, and MACE in the entire spectrum of heart failure, with sustained benefits over time. Full implementation of dapagliflozin in clinical practice leads to a substantial reduction in hospitalizations for heart failure and death in real-life populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Li Shen, Pardeep Singh Jhund, Kieran Francis Docherty, Muthiah Vaduganathan, Mark Colquhoun Petrie, Akshay Suvas Desai, Lars Kober, Morten Schou, Milton Packer, Scott David Solomon, Xingwei Zhang, John Joseph Valentine McMurray
Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yumiko Kawakubo Ichihara, Yasuyuki Shiraishi, Shun Kohsaka, Shintaro Nakano, Yuji Nagatomo, Tomohiko Ono, Makoto Takei, Munehisa Sakamoto, Atsushi Mizuno, Mitsunobu Kitamura, Nozomi Niimi, Takashi Kohno, Tsutomu Yoshikawa
Summary: This study found that patients with behavioral precipitant factors (PFs) had a higher risk of heart failure rehospitalization, despite having a lower risk of in-hospital death.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Joan Weston, Andrew L. Clark
Summary: This prospective cohort study aimed to compare the short-term prognostic value of 9 commonly used malnutrition tools in patients with chronic heart failure. The study found that most tools were independently associated with worse morbidity and mortality in patients with CHF, with serum albumin providing comparable prognostic information to simple or multidimensional malnutrition tools.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Vanessa Blumer, Robert J. Mentz, Jie-Lena Sun, Javed Butler, Marco Metra, Adriaan A. Voors, Adrian F. Hernandez, Christopher M. O'Connor, Stephen J. Greene
Summary: The study found that prior hospitalization for heart failure was not associated with 180-day mortality after accounting for patient characteristics measured during the index patient visit. Clinical confounders measured at the point-of-care may explain previously observed associations.
CIRCULATION-HEART FAILURE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Andrew J. S. Coats, Stephane Heymans, Dimitrios Farmakis, Stefan D. Anker, Johannes Backs, Johann Bauersachs, Rudolf A. de Boer, Jelena Celutkiene, John G. F. Cleland, Dobromir Dobrev, Isabelle C. van Gelder, Stephan von Haehling, Gerhard Hindricks, Ewa Jankowska, Dipak Kotecha, Linda W. van Laake, Mitja Lainscak, Lars H. Lund, Ida Gjervold Lunde, Alexander R. Lyon, Aristomenis Manouras, Davor Milicic, Christian Mueller, Marija Polovina, Piotr Ponikowski, Giuseppe Rosano, Petar M. Seferovic, Carsten Tschope, Rolf Wachter, Frank Ruschitzka
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Frank L. J. Visseren, Francois Mach, Yvo M. Smulders, David Carballo, Konstantinos C. Koskinas, Maria Back, Athanase Benetos, Alessandro Biffi, Jose-Manuel Boavida, Davide Capodanno, Bernard Cosyns, Carolyn Crawford, Constantinos H. Davos, Ileana Desormais, Emanuele Di Angelantonio, Oscar H. Franco, Sigrun Halvorsen, F. D. Richard Hobbs, Monika Hollander, Ewa A. Jankowska, Matthias Michal, Simona Sacco, Naveed Sattar, Lale Tokgozoglu, Serena Tonstad, Konstantinos P. Tsioufis, Ineke van Dis, Isabelle C. van Gelder, Christoph Wanner, Bryan Williams, Guy De Backer, Vera Regitz-Zagrosek, Anne Hege Aamodt, Magdy Abdelhamid, Victor Aboyans, Christian Albus, Riccardo Asteggiano, Magnus Back, Michael A. Borger, Carlos Brotons, Jelena Celutkiene, Renata Cifkova, Maja Cikes, Francesco Cosentino, Nikolaos Dagres, Tine De Backer, Dirk De Bacquer, Victoria Delgado, Hester Den Ruijter, Paul Dendale, Heinz Drexel, Volkmar Falk, Laurent Fauchier, Brian A. Ference, Jean Ferrieres, Marc Ferrini, Miles Fisher, Danilo Fliser, Zlatko Fras, Dan Gaita, Simona Giampaoli, Stephan Gielen, Ian Graham, Catriona Jennings, Torben Jorgensen, Alexandra Kautzky-Willer, Maryam Kavousi, Wolfgang Koenig, Aleksandra Konradi, Dipak Kotecha, Ulf Landmesser, Madalena Lettino, Basil S. Lewis, Ales Linhart, Maja-Lisa Lochen, Konstantinos Makrilakis, Giuseppe Mancia, Pedro Marques-Vidal, John William McEvoy, Paul McGreavy, Bela Merkely, Lis Neubeck, Jens Cosedis Nielsen, Joep Perk, Steffen E. Petersen, Anna Sonia Petronio, Massimo Piepoli, Nana Goar Pogosova, Eva Irene Bossano Prescott, Kausik K. Ray, Zeljko Reiner, Dimitrios J. Richter, Lars Ryden, Evgeny Shlyakhto, Marta Sitges, Miguel Sousa-Uva, Isabella Sudano, Monica Tiberi, Rhian M. Touyz, Andrea Ungar, W. M. Monique Verschuren, Olov Wiklund, David Wood, Jose Luis Zamorano
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Carly Adamson, Kieran F. Docherty, Hiddo J. L. Heerspink, Rudolf A. de Boer, Kevin Damman, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Mark C. Petrie, Piotr Ponikowski, Marc S. Sabatine, Morten Schou, Scott D. Solomon, Subodh Verma, Olof Bengtsson, Anna Maria Langkilde, Mikaela Sjostrand, Muthiah Vaduganathan, Pardeep S. Jhund, John J. McMurray
Summary: In heart failure patients with reduced ejection fraction, the early decline in eGFR after dapagliflozin initiation is associated with better clinical outcomes, and large declines in eGFR are rare.
Article
Biochemistry & Molecular Biology
Mateusz Guzik, Mateusz Sokolski, Magdalena Hurkacz, Agata Zdanowicz, Gracjan Iwanek, Dominik Marciniak, Robert Zymlinski, Piotr Ponikowski, Jan Biegus
Summary: Neurohormone activation is important in the pathophysiology of Acute Heart Failure (AHF), and serum osmolarity can affect this activation. The relationship between serum osmolarity, vasopressin concentration, and clinical parameters, in-hospital course, and outcomes in AHF patients was evaluated. The study found an association between serum osmolarity and clinical status, as well as in-hospital and out-of-hospital outcomes. There was also a linear dependence between vasopressin concentration and serum osmolarity, driven mainly by patients with de novo AHF.
Article
Medicine, Research & Experimental
Michal Kosowski, Katarzyna Swoboda, Jan Chmura, Dorota Kustrzycka-Kratochwil, John A. Todd, Ewa A. Jankowska, Krzysztof Reczuch, Piotr Ponikowski
Summary: This study aimed to evaluate the effects of running a marathon on inflammatory biomarkers and cardiovascular function. The results showed a sharp rise of inflammatory and cardiovascular stress biomarkers after the race, but no correlation was found between immune activation and cardiac biomarker release. Cardiovascular imaging also did not show any myocardial damage due to ischemia or inflammation.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Economics
Phil McEwan, Piotr Ponikowski, Tinevimbo Shiri, Giuseppe M. C. Rosano, Andrew J. S. Coats, Fabio Dorigotti, Antonio Ramirez de Arellano, Ewa A. Jankowska
Summary: This study evaluates the financial implications of introducing ferric carboxymaltose (FCM) for treating acute heart failure patients in the UK, Switzerland, and Italy. The findings suggest that FCM could lead to cost savings in the healthcare systems of these countries.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Review
Cardiac & Cardiovascular Systems
Marta Wleklik, Quin Denfeld, Michal Czapla, Ewa A. Jankowska, Massimo Francesco Piepoli, Izabella Uchmanowicz
Summary: Frailty syndrome has a significant impact on clinical features, diagnosis, management, adverse medical outcomes, and costs in patients with heart failure. Individualized approaches are necessary for patients with heart failure burdened with multimorbidity and frailty in therapeutic decisions.
CARDIOLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Iain C. Macdougall, Piotr Ponikowski, Austin G. Stack, David C. Wheeler, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Udo-Michael Goehring, Bridget-Anne Kirwan, Vasuki Kumpeson, Marco Metra, Giuseppe Rosano, Frank Ruschitzka, Peter van der Meer, Sandra Waechter, Ewa A. Jankowska
Summary: The study found that the treatment of ferric carboxymaltose in patients with acute heart failure and coexisting kidney impairment has the same safety and efficacy.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Theresa A. McDonagh, Marco Metra, Marianna Adamo, Roy S. Gardner, Andreas Baumbach, Michael Boehm, Haran Burri, Javed Butler, Jelena Celutkiene, Ovidiu Chioncel, John G. F. Cleland, Maria Generosa Crespo-Leiro, Dimitrios Farmakis, Martine Gilard, Stephane Heymans, Arno W. Hoes, Tiny Jaarsma, Ewa A. Jankowska, Mitja Lainscak, Carolyn S. P. Lam, Alexander R. Lyon, John J. V. McMurray, Alexandre Mebazaa, Richard Mindham, Claudio Muneretto, Massimo Francesco Piepoli, Susanna Price, Giuseppe M. C. Rosano, Frank Ruschitzka, Anne Kathrine Skibelund
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Agnieszka Matera-Witkiewicz, Magdalena Krupinska, Adrian Doroszko, Malgorzata Trocha, Katarzyna Giniewicz, Krzysztof Kujawa, Maciej Rabczynski, Marta Obremska, Edwin Kuznik, Pawel Lubieniecki, Barbara Adamik, Krzysztof Kaliszewski, Katarzyna Kilis-Pstrusinska, Michal Pomorski, Marcin Protasiewicz, Marcin Madziarski, Janusz Sokolowski, Ewa A. Jankowska, Katarzyna Madziarska
Summary: Advanced age is a predictor for COVID-19 severity. The VACO index, along with past medical records, can be used to predict short-term mortality and disease progression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Sokolski, Marta Kaluzna-Oleksy, Agnieszka Tycinska, Ewa A. Jankowska
Summary: Studies have found that patients with heart failure (HF) and COVID-19 have a higher risk of complications and mortality. The pandemic has disrupted access to standard procedures, leading to increased mortality in HF patients and the need for reorganisation of healthcare systems. New technologies, such as telemedicine and remote monitoring, have shown promise in addressing the challenges faced by HF patients during the pandemic and are likely to be further developed in the future.
Article
Cardiac & Cardiovascular Systems
Jacek Grzybowski, Piotr Podolec, Katarzyna Holcman, Monika Gawor-Prokopczyk, Ewa Jankowska, Magdalena Kostkiewicz, Alicja Dabrowska-Kugacka, Marta Lipowska, Lukasz Mazurkiewicz, Renata Rajtar-Salwa, Pawel Rubis, Ewa Straburzynska-Migaj, Justyna Szczygiel, Przemyslaw Mitkowski, Zbigniew Gasior, Przemyslaw Leszek
Summary: Considering the low prevalence of ATTR-CM in Poland, this article addresses the challenges faced by patients in terms of diagnosis and treatment. It presents recommended diagnostic algorithms involving laboratory workup, imaging tests, and genetic tests. Additionally, it discusses distinguishing ATTR-CM from light chain amyloidosis, neurological manifestations, therapeutic options, and nonpharmacological treatment recommendations. The need for accessing causative treatment with tafamidis is emphasized.
KARDIOLOGIA POLSKA
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Guzik, P. Gajewski, M. Garus, R. Zymlinski, P. Ponikowski, J. Biegus
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Kulej-Lyko, P. Niewinski, S. Tubek, P. Ponikowski
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Michelle A. Keske, Monika Przewlocka-Kosmala, Anna K. Woznicka, Andrzej Mysiak, Ewa A. Jankowska, Piotr Ponikowski, Wojciech Kosmala
Summary: Reducing dietary sodium intake in overweight/obese individuals with insulin resistance can improve cardiac function, potentially through improvements in skeletal muscle perfusion and insulin resistance.