Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Getting TRAIL back on track for cancer therapy

(2014) J Lemke et al.   CELL DEATH AND DIFFERENTIATION

A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

(2014) Dominique Kranz et al.   EMBO JOURNAL

CoreFlow: A computational platform for integration, analysis and modeling of complex biological data

(2014) Adrian Pasculescu et al.   Journal of Proteomics

Evaluating DAPK as a therapeutic target

(2013) Yide Huang et al.   APOPTOSIS

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

Cell Death Triggered by Yersinia enterocolitica Identifies Processing of the Proinflammatory Signal Adapter MyD88 as a General Event in the Execution of Apoptosis

(2013) L. Novikova et al.   JOURNAL OF IMMUNOLOGY

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

(2013) Markku Varjosalo et al.   NATURE METHODS

Persistent Inhibition of ABL Tyrosine Kinase Causes Enhanced Apoptotic Response to TRAIL and Disrupts the Pro-Apoptotic Effect of Chloroquine

(2013) Priya Sridevi et al.   PLoS One

TRAIL on trial: preclinical advances in cancer therapy

(2013) Daniel W. Stuckey et al.   TRENDS IN MOLECULAR MEDICINE

The Protein Interaction Landscape of the Human CMGC Kinase Group

(2013) Markku Varjosalo et al.   Cell Reports

Cell Cycle Control by the CDC25 Phosphatases

(2012) Bernadette Aressy et al.   Anti-Cancer Agents in Medicinal Chemistry

Augmentation of Therapeutic Responses in Melanoma by Inhibition of IRAK-1,-4

(2012) R. Srivastava et al.   CANCER RESEARCH

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

Molecular signaling network complexity is correlated with cancer patient survivability

(2012) D. Breitkreutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

(2012) Maria R. Girotti et al.   Cancer Discovery

Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes

(2011) J. Fasolo et al.   GENES & DEVELOPMENT

High-throughput RNAi Screening Identifies a Role for TNK1 in Growth and Survival of Pancreatic Cancer Cells

(2011) M. C. Henderson et al.   MOLECULAR CANCER RESEARCH

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

(2011) Nicolas Bisson et al.   NATURE BIOTECHNOLOGY

OpenFreezer: a reagent information management software system

(2011) Marina Olhovsky et al.   NATURE METHODS

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

A Peptide-Based Target Screen Implicates the Protein Kinase CK2 in the Global Regulation of Caspase Signaling

(2011) J. S. Duncan et al.   Science Signaling

Exploring death receptor pathways as selective targets in cancer therapy

(2010) Maria Russo et al.   BIOCHEMICAL PHARMACOLOGY

TRAIL receptor signaling and therapeutics

(2010) Junaid Abdulghani et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity

(2010) Gernot Guderian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking

(2010) H. Takeuchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

ProHits: integrated software for mass spectrometry–based interaction proteomics

(2010) Guomin Liu et al.   NATURE BIOTECHNOLOGY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

Analysis of Kinase Gene Expression Patterns across 5681 Human Tissue Samples Reveals Functional Genomic Taxonomy of the Kinome

(2010) Sami Kilpinen et al.   PLoS One

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Global Protein Kinase and Phosphatase Interaction Network in Yeast

(2010) A. Breitkreutz et al.   SCIENCE

Associating Genes and Protein Complexes with Disease via Network Propagation

(2010) Oron Vanunu et al.   PLoS Computational Biology

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

(2009) Jasmine V. Abella et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance

(2009) Jae J. Song et al.   CELLULAR SIGNALLING

Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines

(2009) Yuko Akazawa et al.   GASTROENTEROLOGY

Caspase-mediated Cleavage of β-Catenin Precedes Drug-induced Apoptosis in Resistant Cancer Cells

(2009) Subramanian Senthivinayagam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma

(2009) Adam D. Durbin et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic modularity in protein interaction networks predicts breast cancer outcome

(2009) Ian W Taylor et al.   NATURE BIOTECHNOLOGY

Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells

(2009) C. Jorgensen et al.   SCIENCE

Information Flow Analysis of Interactome Networks

(2009) Patrycja Vasilyev Missiuro et al.   PLoS Computational Biology

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-  Is a Mechanism of Acute Resistance to TRAIL

(2008) S. Van Schaeybroeck et al.   CANCER RESEARCH

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling

(2008) Markku Varjosalo et al.   CELL

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Network medicine

(2008) Tony Pawson et al.   FEBS LETTERS

TRAIL-related neurotoxicity implies interaction with the Wnt pathway in human neuronal cells in vitro

(2008) Giuseppina Cantarella et al.   JOURNAL OF NEUROCHEMISTRY

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

(2008) Claudio P. Albuquerque et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Network-based global inference of human disease genes

(2008) Xuebing Wu et al.   Molecular Systems Biology

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

(2008) Avi Ashkenazi   NATURE REVIEWS DRUG DISCOVERY

A Test of Highly Optimized Tolerance Reveals Fragile Cell-Cycle Mechanisms Are Molecular Targets in Clinical Cancer Trials

(2008) Satyaprakash Nayak et al.   PLoS One

Linear Motif Atlas for Phosphorylation-Dependent Signaling

(2008) M. L. Miller et al.   Science Signaling

The COP9 signalosome: more than a protease

(2008) N WEI et al.   TRENDS IN BIOCHEMICAL SCIENCES

IRAK1: A critical signaling mediator of innate immunity

(2007) Sridevi Gottipati et al.   CELLULAR SIGNALLING

Activation of DNA-Dependent Protein Kinase May Play a Role in Apoptosis of Human Neuroblastoma Cells

(2003) Balu R Chakravarthy et al.   JOURNAL OF NEUROCHEMISTRY