The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1
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Title
The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1
Authors
Keywords
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Journal
Science Signaling
Volume 8, Issue 404, Pages ra120-ra120
Publisher
American Association for the Advancement of Science (AAAS)
Online
2015-11-25
DOI
10.1126/scisignal.aad0667
References
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- Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin
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- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
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- Cortactin
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- Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
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- Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo
- (2010) T. Suzuki et al. CANCER RESEARCH
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Increased cell migration and plasticity in Nrf2-deficient cancer cell lines
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- Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
- (2009) Christopher M. Mahaffey et al. FREE RADICAL BIOLOGY AND MEDICINE
- Localization of cortactin is associated with colorectal cancer development
- (2009) Hirakawa INTERNATIONAL JOURNAL OF ONCOLOGY
- Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression
- (2009) Xu-Zhi Xu et al. MODERN PATHOLOGY
- Cortactin in tumor invasiveness
- (2008) Alissa M. Weaver CANCER LETTERS
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- Deacetylation of cortactin by SIRT1 promotes cell migration
- (2008) Y Zhang et al. ONCOGENE
- The actin-binding domain of cortactin is dynamic and unstructured and affects lateral and longitudinal contacts in F-actin
- (2008) Alexander Shvetsov et al. CELL MOTILITY AND THE CYTOSKELETON
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