Article
Reproductive Biology
Yaoyun Duan, Juan Yu, Miaojuan Chen, Qinsheng Lu, Fen Ning, Xiaowen Gan, Hanbo Liu, Yixin Ye, Shenjiao Lu, Gendie E. Lash
Summary: HSP60 interacts with OXSM and maintains its stability. Knockdown of HSPD1 promotes the proliferation and migration of SKOV3 and OVCAR3 by lowering the protein level of OXSM and LA synthesis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Guangxu Xu, Weimin Kong, Ziwei Fang, Yali Fan, Yajie Yin, Stephanie A. Sullivan, Arthur-Quan Tran, Leslie H. Clark, Wenchuan Sun, Tianran Hao, Luyu Zhao, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: The natural product asparagus officinalis exhibits anti-tumorigenic and anti-metastatic effects on serous ovarian cancer cells by decreasing cell viability, inducing apoptosis, and reducing adhesion and invasion abilities. Additionally, it shows synergistic anti-proliferative activity when combined with paclitaxel, and inhibits tumor growth and reduces serum levels of VEGF in a mouse model of ovarian cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Summary: ONC201 shows promising anti-tumor potential in ovarian cancer by suppressing cell proliferation and inducing apoptosis through multiple pathways. It also inhibits adhesion and invasion in cancer cells. Additionally, it can suppress tumor growth and decrease serum VEGF production, which is accelerated by obesity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang
Summary: The study found a positive correlation between the high expression of PDLIM1 autoantibodies in OC patients and high expression of PDLIM1 in tissues, indicating the potential of autoantibodies against PDLIM1 as a novel serological biomarker for OC, serving as a complementary measure to CA125 and improving the accuracy of OC detection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seongchun Min, Ji Yeon Kim, Hyo Min Cho, Sujin Park, Ji Min Hwang, Hyejin You, Young Chan Chae, Won-Jae Lee, Woong Sun, Dongmin Kang, Sanghyuk Lee, Sang Won Kang
Summary: This study reveals a novel signaling pathway in which mitochondria communicate with the cytosol via the release of heat shock protein 60, leading to the activation of survival genes in the nucleus.
Article
Multidisciplinary Sciences
Deann Glassman, Mark S. Kim, Meredit Spradlin, Sunil Badal, Man Taki, Prati Bhattacharya, Prasant Dutta, Charles V. Kingsley, Katherine I. Foster, Olamid Animasahum, Jin Heon Jeon, Abhinav Achreja, Anusha Jayaraman, Praveen Kumar, Minal Nenwani, Fulei Wuchu, Emine Bayraktar, Yutuan Wu, Elaine Stur, Lingegowd Mangala, Sanghoo Lee, Timothy A. Yap, Shannon N. Westin, Livia S. Eberlin, Deepak Nagrath, Anil K. Sood
Summary: Despite modest clinical improvement with AVA therapy in ovarian cancer, adaptive resistance is a common problem and alternative options are limited. This study investigates the effectiveness of a GLS inhibitor (GLSi) in combination with AVA therapy, and found that it had significant cytotoxic effects and reduced tumor growth. Additionally, GLSi showed promising results in reducing metabolic conversion and had robust antitumor effects when administered after the emergence of resistance to AVA therapy.
Review
Pharmacology & Pharmacy
Bo Sun, Ganghui Li, Qing Yu, Dongchun Liu, Xing Tang
Summary: HSP60, a molecular chaperone, plays a crucial role in cancer research due to its potential as a diagnostic biomarker and therapeutic target. Its involvement in apoptosis, metastasis, drug resistance, and liquid biopsy make it a promising area of study, although further research is required to fully understand its mechanisms in various types of cancer.
JOURNAL OF DRUG TARGETING
(2022)
Article
Biochemistry & Molecular Biology
Yue Wang, Jingyi Han, Dongdong Wang, Menghua Cai, Yi Xu, Yu Hu, Hui Chen, Wei He, Jianmin Zhang
Summary: This study constructed novel armored gamma delta T cells capable of secreting humanized anti-PD-1 antibodies, referred to as Lv-PD1-gamma delta T cells. These cells showed improved proliferation and enhanced cytotoxicity against tumor cells, resulting in augmented therapeutic effects and survival benefits in ovarian tumor-bearing mice. The engineered cells demonstrated a prolonged in vivo survival without any potential for tumorigenicity, and exhibited excellent tolerance and safety in humanized mice.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jianyuan Zeng, Andrew J. Sanders, Lin Ye, Rachel Hargest, Fiona Ruge, Wen G. Jiang
Summary: This study investigates the role of EPLIN, a putative tumor suppressor, in colorectal cancer. The findings show that EPLIN is downregulated in colorectal cancer tissues compared to normal tissues and its reduced expression is associated with poor clinical outcomes. EPLIN inhibits cellular growth, adhesion, migration, and invasion. It also interacts with proteins such as HSP60 and Her2 and regulates their expression in colorectal cancer cells. Furthermore, the combination of EPLIN, HSP60, and Her2 can predict the clinical outcome of colorectal cancer patients. EPLIN also affects cellular response to chemotherapy and targeted therapeutic agents for EGFR/Her2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yaoxiang Tang, Ying Zhou, Songqing Fan, Qiuyuan Wen
Summary: This review article summarizes the importance of HSP60 in cancer, including its structure, functional cycle, regulatory mechanism, and its applications in diagnosis and therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Jiannan Chen, Jianhua Hu, Lili Gu, Feng Ji, Fan Zhang, Miaomiao Zhang, Jun Li, Zhengliang Chen, Longwei Jiang, Yan Zhang, Ruifang Shi, Lihua Ma, Shaochang Jia, Ying Zhang, Qi Zhang, Junqing Liang, Shunyu Yao, Zhigang Hu, Zhigang Guo
Summary: This study demonstrates the efficacy of anti-MSLN CAR-T treatment for ovarian cancer through the screening and design of antibodies and CAR-T cells, and successful clinical trials have been conducted to preliminarily evaluate the safety and effectiveness.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Chao Mei, Weijing Gong, Xu Wang, Yongning Lv, Yu Zhang, Sanlan Wu, Chunqi Zhu
Summary: Ovarian cancer is the most fatal disease among gynecologic malignant tumors. Tumor angiogenesis, regulated by multiple factors and pathways, plays a vital role in the development and progression of cancer. However, the efficacy of anti-angiogenic therapy is limited by low response rates and emerging drug resistance. This review focuses on the mechanisms, clinical trial outcomes, resistance mechanisms, biomarkers, and predictive models of anti-angiogenic therapy in ovarian cancer, providing insights into the prospect of precision medicine.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingyuan Wu, Tuoyu Zhou, Yinxue Wang, Yanbiao Jiang, Yiqing Wang
Summary: Ovarian cancer ranks seventh among female malignant tumors, threatening reproductive health with a high recurrence rate and poor prognosis. Botanical compounds show unique advantages in reducing tumor burden and improving treatment quality, potentially serving as an auxiliary option for managing ovarian cancer.
Article
Biochemistry & Molecular Biology
Shuang Ju, Yu Zhang, Xijun Guo, Qinghui Yan, Siyi Liu, Bokai Ma, Mei Zhang, Jiaolin Bao, Sulan Luo, Ying Fu
Summary: Conotoxins from marine cone snail venom are valuable drug resources and potential candidates for ovarian cancer treatment.
Article
Biochemistry & Molecular Biology
Yu Huang, Yali Fan, Ziyi Zhao, Xin Zhang, Katherine Tucker, Allison Staley, Hongyan Suo, Wenchuan Sun, Xiaochang Shen, Boer Deng, Stuart R. Pierce, Lindsay West, Yajie Yin, Michael J. Emanuele, Chunxiao Zhou, Victoria Bae-Jump
Summary: This study investigated the effect of CDK1 expression on the prognosis of ovarian cancer patients and the anti-tumorigenic effect of the CDK1 inhibitor, RO-3306. The results showed that the overexpression of CDK1 was associated with poor prognosis, and RO-3306 effectively reduced cell proliferation and tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Aleksandra Damasiewicz-Bodzek, Magdalena Szumska, Krystyna Tyrpien-Golder
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2020)
Article
Medicine, General & Internal
Apolonia Stefaniak, Robert Partyka, Sylwia Duda, Weronika Ostrega, Jacek Niedziela, Jolanta Nowak, Jolanta Malinowska-Borowska, Tomasz Rywik, Przemyslaw Leszek, Bartosz Hudzik, Barbara Zubelewicz-Szkodzinska, Piotr Rozentryt
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, Research & Experimental
Bozena Adamczyk, Robert Partyka, Monika Adamczyk-Sowa, Krzysztof Wierzbicki, Pawel Sowa, Danuta Kokocinska
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2020)
Article
Obstetrics & Gynecology
Piotr Bodzek, Bogdan Szymala, Aleksandra Damasiewicz-Bodzek, Iwona Janosz, Lukasz Witek, Anita Olejek
Summary: This study found that the concentration of anti-HSP27 antibody could be helpful in detecting cervical and endometrial cancer. There were differences in antibody concentrations among different cancer stages, but more large-scale studies are needed to determine the cut-off point. Anti-HSP27 and anti-HSP60 antibodies show potential as biomarkers in cervical and endometrial cancer.
GINEKOLOGIA POLSKA
(2021)
Article
Neurosciences
Aleksandra Damasiewicz-Bodzek, Beata Labuz-Roszak, Bartlomiej Kumaszka, Bartosz Tadeusiak, Krystyna Tyrpien-Golder
Summary: The study found that serum AGE concentration was higher and sRAGE concentration was lower in multiple sclerosis (MS) patients compared to healthy controls, but the differences were not statistically significant. In MS patients, serum AGE and sRAGE concentrations did not differ significantly based on disease duration and EDSS score.
Article
Cell Biology
Agnieszka Nowak, Brygida Przywara-Chowaniec, Aleksandra Damasiewicz-Bodzek, Dominika Blachut, Ewa Nowalany-Kozielska, Krystyna Tyrpien-Golder
Summary: Systemic lupus erythematosus (SLE) study found that SLE patients have higher concentrations of AGEs and lower concentrations of sRAGE in serum, which may pose a risk for exacerbating the disease course, but the compounds contributing to the increase of AGEs in blood are not clear at the moment.
Article
Health Care Sciences & Services
Katarzyna Smilowska, Marek Smilowski, Robert Partyka, Danuta Kokocinska, Przemyslaw Jalowiecki
Summary: The study found that serum suPAR levels in ischemic stroke patients increased over time, with higher suPAR and CRP concentrations in patients with hypertension, ischemic heart disease, and type 2 diabetes. A suPAR-3 concentration above 10.5ng/mL, NIHSS-1 score above 12 points, and CRP-3 concentration above 15.6mg/L significantly increased mortality risk in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Damasiewicz-Bodzek, Agnieszka Nowak
Summary: Psoriasis patients have significantly higher concentrations of CML, CEL, and sRAGE compared to healthy individuals, regardless of disease severity. Remission of the disease leads to a decrease in these concentrations but they remain higher than in the control group. The study suggests that intense glycoxidation process accompanies psoriasis, and elevated sRAGE levels reflect continuous RAGE overstimulation.
Article
Biochemistry & Molecular Biology
Mateusz Marcinek, Michal Tkocz, Kamil Marczewski, Robert Partyka, Leszek Kukulski, Krystyna Mlynarek-Sniezek, Bogumila Sedziak-Marcinek, Pawel Rajwa, Adam Berezowski, Danuta Kokocinska
Summary: The study aimed to determine SIRS markers and their association with postoperative complications in patients undergoing kidney tumor surgery. The results showed that BMI, ASA score, and intraoperative blood loss were associated with the development of SIRS, and obese patients had a higher likelihood of developing SIRS on the third postoperative day.
Article
Biochemistry & Molecular Biology
Aleksandra Waligora, Aleksandra Damasiewicz-Bodzek, Piotr Gorczyca, Slawomir Waligora, Krystyna Tyrpien-Golder
Summary: The study revealed significantly lower levels of biopterin in the urine samples of patients with ASD compared to healthy individuals, with no significant differences observed between mild, moderate, and severe ASD cases. This suggests that BH4 deficiency may play a role in the development of ASD.
Article
Cell Biology
Lukasz Witek, Tomasz Janikowski, Iwona Gabriel, Piotr Bodzek, Anita Olejek
Summary: Endometrial cancer, the most common malignancy of the female genital system in developed countries, is affected by the differential expression of five miRNAs that regulate tumor suppressor genes related to the cell cycle. Among these miRNAs, mir-874-3p shows promise for playing a key role in endometrial adenocarcinoma proliferation.