Article
Immunology
Irina Maljkovic Berry, Melanie C. Melendrez, Simon Pollett, Katherine Figueroa, Darunee Buddhari, Chonticha Klungthong, Ananda Nisalak, Michael Panciera, Butsaya Thaisomboonsuk, Tao Li, Tyghe G. Vallard, Louis Macareo, In-Kyu Yoon, Stephen J. Thomas, Timothy Endy, Richard G. Jarman
Summary: Researchers used phylogenomic analysis to study household transmissions of dengue virus in Kamphaeng Phet, Thailand, finding that on average, dengue disperses 70 meters per day between households in the community. This approach provides a framework for public health tools to inform control approaches and track dengue transmissions accurately.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Jessica Navero-Castillejos, Rosa Benitez, Nuria Torner, Jose Munoz, Daniel Camprubi-Ferrer, Aida Peiro-Mestres, Elena Sulleiro, Aroa Silgado, Veronica Gonzalo, Teresa Falgueras, Izaskun Alejo-Cancho, Montserrat Roldan, Virginia Plasencia, Rosa Albarracin, Josefa Perez, Alexander Navarro, Ana Calderon, Rosa Rubio, Mireia Navarro, Miguel Mico, Jaume Llaberia, Maria Navarro, Josep Barrachina, Anna Vilamala, Carmina Marti, Maria Angeles Pulido, Maria Paz Sanchez-Seco, Ana Vazquez, Ana Martinez, Mireia Jane, Miguel Julian Martinez
Summary: This study conducted molecular characterization of 104 dengue cases detected in Catalonia, northeastern Spain, from 2013 to 2018, including imported infections and the first autochthonous case in the region. All four dengue serotypes were detected in travelers, reflecting global circulation in endemic areas. The primary travel-related case of the 2018 autochthonous transmission was not identified, but molecular analysis revealed the origin of the dengue virus strain.
Article
Virology
Hirawati Deval, Sthita P. Behera, Awdhesh Agrawal, Rajeev Singh, Brijranjan Misra, Vanka Janardhan, Gajanan Patil, Kamlesh Sah, Niraj Kumar, Ravishankar Singh, Vijay P. Bondre
Summary: During the dengue outbreaks in 2015 to 2016 in Uttar Pradesh and Bihar, only DEN-2 serotype was prevalent, with DV-2 being the main circulating serotype. Genetic analysis revealed the presence of lineages I and III of DV-2 cosmopolitan genotype in 2015, and lineage II in 2016, based on full-length envelope (E) protein sequence derived from patient's sera and DV isolates. The phylogenetic analysis showed a genetic relationship between these DV-2 strains and recent DV-2 genotypes reported in DEN outbreaks in north India, indicating the circulation of cosmopolitan genotype of DV-2 in eastern Uttar Pradesh and western Bihar.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Entomology
Caroline Stephenson, Eric Coker, Samantha Wisely, Song Liang, Rhoel R. Dinglasan, John A. Lednicky
Summary: This study investigated the incidence of dengue fever in Florida and found that average temperature, minimum temperature, and maximum temperature were associated with the risk of local dengue virus transmission. Additionally, moderate rainfall and increasing numbers of travel-related cases were also associated with local transmission. The study provides a parsimonious predictive model for dengue fever incidence in Florida and highlights the importance of travel-related cases and environmental conditions in dengue virus transmission.
Editorial Material
Multidisciplinary Sciences
Younjung Kim, Guillaume Fournie, Raphalle Metras, Daesub Song, Christl A. Donnelly, Dirk U. Pfeiffer, Pierre Nouvellet
Summary: This article discusses recent outbreaks of highly pathogenic avian influenza in two cat shelters in South Korea and emphasizes the need to enhance surveillance for cross-species viral transmission from a One Health perspective.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
K. Alagarasu, J. A. Patil, M. B. Kakade, A. M. More, B. Yogesh, P. Newase, S. M. Jadhav, D. Parashar, H. Kaur, N. Gupta, N. Vijay, J. Narayan, P. S. Shah
Summary: A retrospective study in 2018 investigated the circulating dengue virus (DENV) serotypes and genotypes in India, revealing regional differences with DENV-2 as the most common serotype in many states. Molecular surveillance may play a crucial role in predicting large-scale dengue outbreaks by detecting regional shifts in circulating serotypes and genotypes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Orsolya Nagy, Anna Nagy, Anita Koroknai, Nikolett Csonka, Maria Takacs
Summary: Whole-genome sequencing was performed to isolate and characterize imported dengue strains in Hungary. The isolated strains belonged to various serotypes and were associated with severe cases. Analyzing these strains helps in estimating the risk of local transmission in Hungary.
Editorial Material
Immunology
Widaliz Vega-Rodriguez, Hinh Ly
Summary: Recent outbreaks of viral hemorrhagic fever (VHF) diseases caused by Ebola virus (EBOV) and Marburg virus (MARV) in West Africa are concerning. This editorial aims to highlight the known information about these viruses and their outbreaks in Africa and raise awareness about Lassa virus (LASV), which causes recurrent outbreaks and endemic infections in West Africa.
Article
Public, Environmental & Occupational Health
Catherine Machalaba, Marcela Uhart, Marie-Pierre Ryser-Degiorgis, William B. Karesh
Summary: The importance of wildlife and environmental factors in pandemic prevention is underestimated in health security priorities and plans, with many countries lacking functional wildlife health surveillance programs. Strengthening wildlife health capacity and operations is crucial for monitoring and mitigating disease risks, and should be emphasized in One Health efforts.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2021)
Article
Multidisciplinary Sciences
Mary E. Petrone, Rebecca Earnest, Jose Lourenco, Moritz U. G. Kraemer, Robert Paulino-Ramirez, Nathan D. Grubaugh, Leandro Tapia
Summary: This study analyzed the temporal and spatial patterns of chikungunya, Zika, and dengue outbreaks reported in the Dominican Republic between 2012 and 2018. The research found that emerging disease outbreaks were robust to the climatological and spatio-temporal constraints defining seasonal dengue outbreak dynamics, indicating the need for constant surveillance to prevent future health crises.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nidhi Chaudhary, Shikha Srivastava, Sunny Gupta, Manoj B. Menon, Ashok Kumar Patel
Summary: This study reveals the role of HMGB1 in regulating the cellular autophagy process during DENV-2 infection. Inhibition of autophagy or silencing of HMGB1 reduces DENV-2 replication, while induction of HMGB1 enhances autophagy and promotes viral replication. The HMGB1 inhibitor glycyrrhizic acid also suppresses autophagy and DENV-2 replication. Overall, HMGB1 induces BECN1 dependent autophagy to facilitate DENV-2 replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
N. Veena Rani, Neera Kapoor, Anuja Krishnan
Summary: This study explores the importance of utilizing viral-like particles (VLPs) for diagnostics, drug delivery, and vaccine production, as well as their role as a model system for studying virus assembly and fusion processes. By replacing certain regions of the E protein of Dengue virus (DENV) with corresponding regions of the G protein of Vesicular Stomatitis virus (VSV), chimeric VLPs were generated that showed higher levels of VLP production compared to the wild type. These chimeric VLPs also demonstrated effective recognition by dengue-infected patient sera, suggesting their potential for vaccine production and serodiagnosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Virology
Thanyaporn Dechtawewat, Sittiruk Roytrakul, Yodying Yingchutrakul, Sawanya Charoenlappanit, Bunpote Siridechadilok, Thawornchai Limjindaporn, Arunothai Mangkang, Tanapan Prommool, Chunya Puttikhunt, Pucharee Songprakhon, Kessiri Kongmanas, Nuttapong Kaewjew, Panisadee Avirutnan, Pa-thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran
Summary: This study uncovered the phosphorylation modification of the dengue virus NS1 protein, with mutational analysis showing specific phosphorylation sites affecting DENV infectivity and the production of NS1 dimers post-infection.
Article
Biotechnology & Applied Microbiology
Vengala Rao Yenuganti, Sumbul Afroz, Rafiq Ahmad Khan, Chandrima Bharadwaj, Deepti Kailash Nabariya, Nagaraj Nayak, Madhuri Subbiah, Kumaraswami Chintala, Sharmistha Banerjee, Pallu Reddanna, Nooruddin Khan
Summary: This study demonstrates the antiviral properties of milk exosomes and opens new avenues for the development of exosome-based therapies to treat viral diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Microbiology
Mayra Diosa-Toro, Debbie R. Kennedy, Vanessa Chuo, Vsevolod L. Popov, Julien Pompon, Mariano A. Garcia-Blanco
Summary: Infection with dengue virus induces rearrangements of the endoplasmic reticulum, and a host RNA-binding protein YBX1 plays a crucial role in viral replication and assembly by interacting with the viral nucleocapsid and participating in assembly sites.
Article
Anesthesiology
Luis Filipe Malheiro, Rita Gaio, Manuel Vaz da Silva, Sandra Martins, Antonio Sarmento, Lurdes Santos
Summary: This study aimed to evaluate the impact of critical illness on reactive hyperaemia measured by peripheral arterial tonometry (RH-PAT) and its correlation with outcomes. The results showed that RH-PAT is associated with disease severity, early mortality, cardiovascular and renal dysfunctions. RH-PAT variation can predict late mortality.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Medicine, General & Internal
Claudia Conceicao, Marcia Medeiros, Nelia Pereira, Luzia Goncalves, Abilio Antunes, Ellen Blonde, Rosa Teodosio, Carlos Araujo, Filomena Pereira
Summary: The study found that 39.3% of travelers experienced health problems during or after their trips, with diarrhea being the most common issue. However, many travelers did not follow recommendations for preventive measures or seek medical help when symptoms occurred, highlighting the need for further research on the reasons behind these behaviors.
ACTA MEDICA PORTUGUESA
(2021)
Article
Microbiology
Nicole Pedro, Claudio N. Silva, Ana C. Magalhaes, Bruno Cavadas, Ana M. Rocha, Ana C. Moreira, Maria Salome Gomes, Diogo Silva, Joana Sobrinho-Simoes, Angelica Ramos, Maria J. Cardoso, Rita Filipe, Pedro Palma, Filipa Ceia, Susana Silva, Joao T. Guimaraes, Antonio Sarmento, Veronica Fernandes, Luisa Pereira, Margarida Tavares
Summary: This study reports a case of reinfection of SARS-CoV-2 in a 17-year-old Portuguese female, showing co-infection by two different lineages of the virus, which may have contributed to the severity of the disease and prolonged shedding of the virus.
Editorial Material
Gastroenterology & Hepatology
T. Kucharzik, P. Ellul, T. Greuter, J. F. Rahier, B. Verstockt, C. Abreu, A. Albuquerque, M. Allocca, M. Esteve, F. A. Farraye, H. Gordon, K. Karmiris, U. Kopylov, J. Kirchgesner, E. MacMahon, F. Magro, C. Maaser, L. de Ridder, C. Taxonera, M. Toruner, L. Tremblay, M. Scharl, N. Viget, Y. Zabana, S. Vavricka
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Fisheries
Andreia Filipa-Silva, Ricardo Parreira, Monica Nunes, Maria Teresa Barreto Crespo
Summary: Global demand for seafood is increasing, making aquaculture production of capital importance in terms of fish resources sustainability. Fish disease outbreaks are a significant constraint to fisheries trade and aquaculture production, affecting economic development worldwide. Virological screening in wild and farmed fish populations can identify potential hosts and help prevent major economic losses in the fish industry due to viral infections.
Article
Virology
Paulo Morais, Nidia S. Trovao, Ana B. Abecasis, Ricardo Parreira
Summary: Research on the Mesoniviridae family, an RNA genome insect-specific viruses, has been steadily increasing in the past decade. This study analyzed nucleotide and protein sequences of mesoniviruses using various molecular tools and proposed a taxonomic revision for the family. The findings highlight the need for caution in classifying new mesoniviruses sequences, especially those found in organisms other than mosquitos.
Review
Public, Environmental & Occupational Health
Yusuf Ozbel, Seray Toz, Clara Munoz, Maria Ortuno, Zarima Jumakanova, Pedro Perez-Cutillas, Carla Maia, Claudia Conceicao, Gad Baneth, Andre Pereira, Yves Van der Stede, Celine M. Gossner, Eduardo Berriatua
Summary: This study analyzed the epidemiology of leishmaniasis in Turkey, Azerbaijan, and Georgia from 2005 to 2020 and evaluated the risk of disease emergence in European countries. The study found that leishmaniasis incidence varied spatially and temporally in these countries and posed a challenge to human and animal health.
ZOONOSES AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Regina Becker Reifschneider Loesch, Rafaela M. Ribeiro, Claudia Conceicao
Summary: This scoping review aimed to explore the situation of TB contact investigation in African Portuguese-speaking countries. The results showed that recommended processes for TB contact investigation were only identified in Cape Verde and Mozambique, while adopted processes were mentioned in research studies from Angola, Guinea-Bissau, and Mozambique. Therefore, the current study highlights the scarcity of references on TB contact investigation in PALOP and the importance of an information system to assess the impact of interventions on controlling the disease in these countries.
Article
Public, Environmental & Occupational Health
Aducabe Bancessi, Rosa Teodosio, Elizabeth Duarte, Aladje Balde, Luis Catarino, Teresa Nazareth
Summary: This study explored the perceptions of a group of women in Guinea-Bissau regarding household water purification strategies. The findings revealed a general underestimation of the risk of waterborne diseases and a strong belief in the efficacy of moringa-teabags for water purification. However, there is also a need for more information on water treatment and safety.
Article
Biodiversity Conservation
Eddyson Montalvo-Sabino, Ana Paula Abilio, Milehna Mara Guarido, Vera Valadas, Maria Teresa Novo, Ayubo Kampango, Carla Alexandra Sousa, Jose Fafetine, Marietjie Venter, Peter N. Thompson, Leo Braack, Anthony John Cornel, Ricardo Parreira, Antonio Paulo Gouveia de Almeida
Summary: This study focused on the characterization and genetic analysis of Culicine mosquitoes from South Africa, Mozambique, and Angola, providing new records of mosquito species and contributing to the genetic library of Afro-tropical mosquitoes.
Article
Microbiology
Joana Cavadas, Ricardo Parreira, Ines Leonardo, Maria Teresa Barreto Crespo, Monica Nunes
Summary: In this study, the molecular diversity of human adenoviruses (HAdV) in waste and environmental waters in the Lisbon Metropolitan Area (LMA) was evaluated. The analysis revealed a range of HAdV types, along with the presence of murine adenovirus (MAdV-2) and fecal contamination in environmental waters. These results provide valuable information on the distribution and detection of important virus types in the study area.
Article
Microbiology
Marta Falcao, Margarida Barros, Margarida D. Duarte, Fabio Abade dos Santos, Teresa Fagulha, Margarida Henriques, Fernanda Ramos, Ana Duarte, Tiago Luis, Ricardo Parreira, Silvia C. Barros
Summary: In September 2021, Bagaza virus (BAGV), a member of the Ntaya group from the Flavivirus genus, was detected for the first time in Portugal. The genomic characterization of the BAGV strain from Portugal showed a close relationship with BAGV strains previously detected in Spain, suggesting a common ancestor that arrived in the Iberia Peninsula in the late 1990s to early 2000s. This study also supported the classification of BAGV and Israel turkey meningoencephalitis virus (ITV) as the same viral species.
Article
Entomology
Daniel Bravo-Barriga, Mikel Alexander Gonzalez, Ricardo Parreira, Eva Frontera, Heron Huerta, Pedro Maria Alarcon-Elbal
Summary: This study examined the taxonomic status of two Culicoides species, C. jamaicensis and C. paolae, which are currently found in the Neotropical and Palearctic areas, respectively. Previous research suggested that these species may be synonyms. However, our comprehensive approach using genetic markers and morphological analysis revealed that C. paolae and C. jamaicensis belong to the same species.
JOURNAL OF MEDICAL ENTOMOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Candida Abreu
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Immunology
Candida Abreu, Antonio Martins, Fernando Silva, Gabriela Canelas, Lucia Ribeiro, Stefano Pinto, Antonio Sarmento, Fernando Magro
Summary: Patients with immune-mediated inflammatory diseases treated with immunomodulatory therapy are at higher risk of infections, but adherence to vaccination is suboptimal. In this study, less than 5% of patients had all their vaccines up-to-date, and a majority did not fully adhere to the recommended vaccination schedule.