Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy

Complement 5a Receptor Mediates Angiotensin II–Induced Cardiac Inflammation and Remodeling

(2014) Congcong Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury

(2014) Vince C. De Hoog et al.   CARDIOVASCULAR RESEARCH

Arrhythmogenic right ventricular cardiomyopathy — An update

(2014) S. Peters   INTERNATIONAL JOURNAL OF CARDIOLOGY

How can we cure a heart “in flame”? A translational view on inflammation in heart failure

(2013) Ulrich Hofmann et al.   BASIC RESEARCH IN CARDIOLOGY

The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death

(2013) Andreas Brodehl et al.   Circulation-Cardiovascular Genetics

The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration

(2013) Martin Mueller et al.   IMMUNOBIOLOGY

Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans

(2013) H. Unnewehr et al.   JOURNAL OF IMMUNOLOGY

A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis

(2013) Kai Hoehlig et al.   MOLECULAR THERAPY

Mutations with pathogenic potential in proteins located in or at the composite junctions of the intercalated disk connecting mammalian cardiomyocytes: a reference thesaurus for arrhythmogenic cardiomyopathies and for Naxos and Carvajal diseases

(2012) Steffen Rickelt et al.   CELL AND TISSUE RESEARCH

Arrhythmogenic cardiomyopathy: A biventricular disease in search of a cure

(2012) Gaetano Thiene et al.   HEART RHYTHM

Desmoglein 2 mutant mice develop cardiac fibrosis and dilation

(2011) Claudia A. Krusche et al.   BASIC RESEARCH IN CARDIOLOGY

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Angeliki Asimaki et al.   Circulation-Arrhythmia and Electrophysiology

Arrhythmogenic Cardiomyopathy

(2011) Kalliopi Pilichou et al.   Circulation-Cardiovascular Genetics

Regulation of adverse remodelling by osteopontin in a genetic heart failure model

(2011) Stelios Psarras et al.   EUROPEAN HEART JOURNAL

Complement dependency of cardiomyocyte release of mediators during sepsis

(2011) Gelareh Atefi et al.   FASEB JOURNAL

Validation of Noninvasive Measurements of Cardiac Output in Mice Using Echocardiography

(2011) François Tournoux et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

(2010) Jesper van der Pals et al.   BMC Cardiovascular Disorders

Cardiac desmosomal (dys)function and myocyte viability

(2010) Carol Ann Remme et al.   CELL CYCLE

Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

(2010) Frank I. Marcus et al.   CIRCULATION

Desmin-related myopathy

(2010) KY van Spaendonck-Zwarts et al.   CLINICAL GENETICS

Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia

(2010) Maria E. Campian et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Arrhythmogenic Right Ventricular Cardiomyopathy and Desmin: Another gene fits the shoe

(2010) Karen Maass   HEART RHYTHM

Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks

(2010) Ellen Otten et al.   HEART RHYTHM

De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy

(2010) Baerbel Klauke et al.   HUMAN MOLECULAR GENETICS

Complement-Mediated Ischemia-Reperfusion Injury

(2009) Gwendolyn M. P. Diepenhorst et al.   ANNALS OF SURGERY

Myocardial inflammation and non-ischaemic heart failure: is there a role for C-reactive protein?

(2009) Oliver Zimmermann et al.   BASIC RESEARCH IN CARDIOLOGY

Animal models of arrhythmogenic cardiomyopathy

(2009) M. D. McCauley et al.   Disease Models & Mechanisms

Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene

(2009) J. Peter van Tintelen et al.   HEART RHYTHM

Myocyte necrosis underlies progressive myocardial dystrophy in mousedsg2-related arrhythmogenic right ventricular cardiomyopathy

(2009) Kalliopi Pilichou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The sepsis seesaw: seeking a heart salve

(2009) Peter A Ward   NATURE MEDICINE

A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization

(2008) Manolis Mavroidis et al.   FASEB JOURNAL

Desmin mediates TNF-α–induced aggregate formation and intercalated disk reorganization in heart failure

(2008) Panagiota Panagopoulou et al.   JOURNAL OF CELL BIOLOGY