Review
Biochemistry & Molecular Biology
Maria Alemany
Summary: Androgens are important steroid hormones with diverse functions including energy control, skeletal maintenance, brain development, and reproductive mechanism regulation. Testosterone plays a key role in maintaining metabolism and its insufficiency is associated with aging and metabolic disorders. T replacement therapy is effective in maintaining core metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Erica Sarchielli, Paolo Comeglio, Sandra Filippi, Ilaria Cellai, Giulia Guarnieri, Alessandra Marzoppi, Sarah Cipriani, Linda Vignozzi, Annamaria Morelli, Mario Maggi
Summary: This study showed that testosterone treatment has positive effects on a high-fat diet-induced animal model of Metabolic Syndrome, improving conditions such as hypertension, visceral adipose tissue accumulation, and glucose homeostasis derangements. The treatment also countered inflammation in the hypothalamus and reversed alterations in the expression of key regulators of energy and reproduction within the brain region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bato Korac, Andjelika Kalezic, Vanja Pekovic-Vaughan, Aleksandra Korac, Aleksandra Jankovic
Summary: Life is defined as an instantaneous encounter of circulating matter and flowing energy, and the relationship between redox biology and metabolism forms a dynamic balance in health, but disruption can lead to disease. The rising prevalence of metabolic diseases presents challenges in understanding, diagnosing, and treating them, emphasizing the need for research on novel redox-metabolic biomarkers.
Review
Biology
Ashutosh Tiwari, Priya Rathor, Prabodh Kumar Trivedi, Ratnasekhar Ch
Summary: Type 2 diabetes is a metabolic disorder characterized by dysregulated glucose metabolism. Circadian arrhythmia caused by irregular meal timing and sleep loss alters glucose metabolism and insulin production, leading to T2D. Understanding the dysregulated circadian metabolism using systems biology approaches may provide solutions to treat T2D.
Article
Endocrinology & Metabolism
Chia-Chu Liu, Shu-Pin Huang, Yung-Chin Lee, Cheng-Hsueh Lee, Tsung-Yi Huang, Jiun-Hung Geng, Che-Wei Chang, Chung-Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Tusty-Jiuan Hsieh
Summary: The study found an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and testosterone deficiency (TD) in aging Taiwanese men, particularly in those without metabolic syndrome (MetS). This suggests that MAFLD could serve as an early predictor of TD, facilitating the identification of high-risk individuals and enabling timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Shang-Rong Zhong, Han-Hsuan Yang, Cheng-Hsi Liao, Deng-Ho Yang, Shih-Kai Tu, Chia-Lien Hung, Chun-Cheng Liao
Summary: The study revealed a strong association between serum testosterone and metabolic syndrome in Taiwanese men, with the predictive value increasing with age.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Inass Hassan Ahmad, Eman Roshdy Mohamed Mostafa, Shymaa Abdelhafeez Mohammed, Walaa Shipl, Amany Ahmed Soliman, Marwa Said
Summary: This study demonstrates a positive correlation between serum testosterone and irisin levels, with lower irisin levels observed in patients with MetS. These findings highlight the impact of serum testosterone on irisin formation from skeletal muscle, suggesting potential benefits of testosterone supplementation in MetS treatment.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Giovanni Corona, Giulia Rastrelli, Linda Vignozzi, Arcangelo Barbonetti, Alessandra Sforza, Edoardo Mannucci, Mario Maggi
Summary: Data from preclinical and clinical studies suggest that testosterone administration can improve body composition and aspects of glucose metabolism by reducing fat mass. The effects of testosterone replacement therapy on sexual function in patients with metabolic derangements are inconsistent, with better results observed in preclinical conditions or in patients with newly diagnosed type 2 diabetes mellitus.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
S. M. Mahmudul Hasan, Mosiur Rahman, Keiko Nakamura, Yuri Tashiro, Ayano Miyashita, Kaoruko Seino
Summary: In addition to clinical determinants related to diabetes, self-care practices and oral hygiene practices must be considered for the prevention and control of periodontal disease in patients with diabetes.
Review
Biochemistry & Molecular Biology
Francesco Lotti, Sara Marchiani, Giovanni Corona, Mario Maggi
Summary: Metabolic syndrome and male infertility are prevalent issues globally, with some studies suggesting a negative association between MetS and testosterone levels, FSH levels, and semen parameters. However, larger prospective investigations are needed to further confirm these findings and explore the potential impact of MetS on male reproductive potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Marietta Rottenkolber, Christina Gar, Cornelia Then, Lorena Wanger, Vanessa Sacco, Friederike Banning, Anne L. Potzel, Stefanie Kern-Matschilles, Claudia Nevinny-Stickel-Hinzpeter, Harald Grallert, Nina Hesse, Jochen Seissler, Andreas Lechner
Summary: This study re-evaluated the prevailing hypothesis that metabolic syndrome components are central to all cases of T2DM. Results showed that a significant proportion of T2DM cases did not display any components of metabolic syndrome, indicating the existence of a second, unrelated pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Nutrition & Dietetics
Gabriele Piuri, Monica Zocchi, Matteo Della Porta, Valentina Ficara, Michele Manoni, Gian Vincenzo Zuccotti, Luciano Pinotti, Jeanette A. Maier, Roberta Cazzola
Summary: Magnesium (Mg2+) deficiency is often underestimated in Western countries, especially in obese individuals with type 2 diabetes and metabolic syndrome. Proper intake of Mg2+ can help improve metabolic syndrome by regulating gene expression, proteomic profile, and impacting intestinal microbiota and vitamin metabolism.
Article
Multidisciplinary Sciences
Min-Woo Lee, Jong-Wook Lee, Kook-Hyung Lee, Young-Hoon Lee, Jung-Yeul Kim
Summary: This study investigates the effects of various factors on diabetic retinal neurodegeneration (DRN) and microvascular impairment in type 2 diabetes (T2DM) patients without diabetic retinopathy. The ratio of RNFL thickness/vessel density (RNFL/VD) is used to identify these effects. The results show that microvascular impairment precedes DRN in T2DM, as indicated by a higher RNFL/VD ratio in T2DM patients compared to normal controls. Age and T2DM duration are negatively correlated with the RNFL/VD ratio, suggesting that inner retinal damage caused by DRN becomes more prominent over time than microvascular impairment in T2DM.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Jian Wang, Fang Liu, Rongzhen Kong, Xiuxia Han
Summary: This study found that globulin (GLB) was positively associated with the occurrence of diabetic nephropathy (DN) in patients with type2 diabetes mellitus. This finding is of great significance for controlling the occurrence of DN and improving the quality of life for patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lee-Ling Lim, Eric S. H. Lau, Johnny T. K. Cheung, Siew Pheng Chan, Linong Ji, Soo Lim, Sirinart Sirinvaravong, A. G. Unnikrishnan, Andrea O. Y. Luk, Viviana Cortese, Alexandra Durocher, Juliana C. N. Chan
Summary: This study explored the usage patterns of oral glucose-lowering drugs (OGLDs), particularly sulphonylureas (SUs), in Asian patients with type 2 diabetes (T2D). The findings showed that SUs, often combined with metformin, are a popular class of OGLDs in Asia. They are associated with good glycemic control and safety profiles.
DIABETES OBESITY & METABOLISM
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Letter
Dermatology
Mai Shi, Aimin Yang, Elaine Chow, Eric S. H. Lau, Claudia H. T. Tam, Alice P. S. Kong, Andrea O. Y. Luk, Ronald C. W. Ma, Christina M. T. Cheung, Juliana C. N. Chan, Agnes W. S. Chan
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anna Birukov, Ruijin Lu, Guoqi Yu, Yan Qiao, Mohammad Rahman, Qi Sun, Ronald C. Ma, Zhen Chen, Frank B. Hu, Cuilin Zhang
Review
Endocrinology & Metabolism
Calvin Ke, Emaad Mohammad, Juliana C. N. Chan, Alice P. S. Kong, Fok-Han Leung, Baiju R. R. Shah, Douglas Lee, Andrea O. O. Luk, Ronald C. W. Ma, Elaine Chow, Xiaolin Wei
Summary: This review compared the implementation of team-based diabetes care in Ontario, Canada and Hong Kong. The study found discrepancies in accessibility and referral procedures, follow-up processes, and financing models between the two jurisdictions. Adequate infrastructure, processes, and staff support are essential for team-based care. Policymakers and funders should invest in skilled health professionals, infrastructure, and processes to improve care quality.
CURRENT DIABETES REPORTS
(2023)
Article
Endocrinology & Metabolism
Claudia H. T. Tam, Cadmon K. P. Lim, Andrea O. Y. Luk, Mai Shi, Hoi Man Cheung, Alex C. W. Ng, Heung-man Lee, Eric S. H. Lau, Baoqi Fan, Guozhi Jiang, Alice P. S. Kong, Risa Ozaki, Elaine Y. K. Chow, Ka Fai Lee, Shing Chung Siu, Grace Hui, Chiu Chi Tsang, Kam Piu Lau, Jenny Y. Y. Leung, Elaine Y. N. Cheung, Man Wo Tsang, Grace Kam, Ip Tim Lau, June K. Y. Li, Vincent T. F. Yeung, Emmy Lau, Stanley Lo, Samuel Fung, Yuk Lun Cheng, Chun Chung Chow, Xiaodan Fan, Ting Fung Chan, Kevin Y. L. Yip, Si Lok, Weichuan Yu, Stephen K. W. Tsui, Hui-Yao Lan, Cheuk Chun Szeto, Nelson L. S. Tang, Brian Tomlinson, Yu Huang, Alicia J. Jenkins, Anthony Keech, Wing-Yee So, Juliana C. N. Chan, Ronald C. W. Ma
Summary: The objective of this study was to uncover genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. The study identified a novel variant associated with CHD and blood pressure (BP) in Chinese T2D patients, and found that this variant interacts with BP goal attainment to have divergent effects on CHD risk.
Article
Multidisciplinary Sciences
Kelly Yichen Li, Claudia Ha Ting Tam, Hongbo Liu, Samantha Day, Cadmon King Poo Lim, Wing Yee So, Chuiguo Huang, Guozhi Jiang, Mai Shi, Heung Man Lee, Hui-yao Lan, Cheuk-Chun L. Szeto, Robert L. G. Hanson, Robert G. Nelson, Katalin Susztak, Juliana C. N. Y. Chan, Kevin Y. Yip, Ronald C. W. Ma
Summary: In this study, the authors identified CpG sites associated with kidney function and subsequent decline, highlighting the potential of methylation markers in risk stratification of kidney disease in individuals with type 2 diabetes. The use of both single-site and multisite analysis proved to have functional significance in the kidney.
NATURE COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Helena J. Teede, Chau Thien Tay, Joop Laven, Anuja Dokras, Lisa J. Moran, Terhi T. Piltonen, Michael F. Costello, Jacky Boivin, Leanne M. Redman, Jacqueline A. Boyle, Robert. J. Norman, Aya Mousa, Anju E. Joham
Summary: The recommended assessment and management of polycystic ovary syndrome (PCOS) based on the best available evidence, clinical expertise, and consumer preference can improve the care and health outcomes for PCOS patients. The international evidence-based guidelines provide prioritized questions and outcomes, as well as 254 recommendations and practice points.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Hongjiang Wu, Aimin Yang, Eric S. H. Lau, Xinge Zhang, Baoqi Fan, Mai Shi, Chuiguo Huang, Ronald C. W. Ma, Alice P. S. Kong, Elaine Chow, Wing-Yee So, Juliana C. N. Chan, Andrea O. Y. Luk
Summary: The study analyzed data from 758,254 people with type 2 diabetes and 758,254 matched controls in Hong Kong. It found that type 2 diabetes was associated with increased risks of hospital bed-days for a wide range of medical conditions, and the association varied by age and sex. The study highlights the importance of considering age and sex differences in planning preventive and therapeutic strategies for type 2 diabetes, particularly focusing on mental health disorders.
Article
Health Care Sciences & Services
Xinge Zhang, Hongjiang Wu, Baoqi Fan, Mai Shi, Eric S. H. Lau, Aimin Yang, Elaine Chow, Alice P. S. Kong, Juliana C. N. Chan, Ronald C. W. Ma, Andrea O. Y. Luk
Summary: This study found that prediabetes is associated with an increased risk of cardiovascular disease and all-cause mortality, with a stronger relationship observed in younger individuals. The risk attenuates with increasing age.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Endocrinology & Metabolism
Juliana N. M. Lui, Eric S. H. Lau, Aimin Yang, Hongjiang Wu, Amy Fu, Vanessa Lau, Kitman Loo, Theresa Yeung, Rebecca Yue, Ronald C. W. Ma, Alice P. S. Kong, Risa Ozaki, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan
Summary: This study investigated the temporal impacts of diabetes-related complications on health-related quality of life (HRQoL) in a 12-year prospective cohort of Chinese patients with type 2 diabetes. The study found that hemorrhagic stroke had the largest decrement in HRQoL, followed by ischemic stroke, peripheral vascular disease, lower extremity amputation, and chronic kidney disease, among others. The impacts on HRQoL persisted for up to 2 years after the occurrence of congestive heart failure or ischemic stroke, and 1 year after hemorrhagic stroke or CKD G3-G4 without renal replacement therapy.
JOURNAL OF DIABETES
(2023)
Review
Medicine, Research & Experimental
Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks
Summary: This systematic review examines whether sociodemographic, clinical, behavioral, and molecular factors modify the effectiveness of dietary or lifestyle interventions to prevent type 2 diabetes. The evidence suggests that individual characteristics have a low to very low impact on intervention effectiveness.
COMMUNICATIONS MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims
Summary: This article provides an overview of T1D disease modifying therapies and features linked to treatment response through a systematic review of randomized-controlled trials. The quality of prevention and intervention trials is generally high, but the quality of precision analyses is low, and certain factors should be considered in future trial designs.
COMMUNICATIONS MEDICINE
(2023)
Review
Medicine, Research & Experimental
Laura M. Jacobsen, Jennifer L. Sherr, Elizabeth Considine, Angela Chen, Sarah M. Peeling, Margo Hulsmans, Sara Charleer, Marzhan Urazbayeva, Mustafa Tosur, Selma Alamarie, Maria J. Redondo, Korey K. Hood, Peter A. Gottlieb, Pieter Gillard, Jessie J. Wong, Irl B. Hirsch, Richard E. Pratley, Lori M. Laffel, Chantal Mathieu, I ADA EASD PMD
Summary: Jacobsen, Sherr et al. evaluate the utility of novel technologies in the treatment of type 1 diabetes. Their systematic review finds technologies such as continuous glucose monitoring, insulin pumps, and decision support tools improve important measures (e.g., HbA1c, time in range, quality of life) allowing precision-directed uptake of technology.
COMMUNICATIONS MEDICINE
(2023)