Review
Endocrinology & Metabolism
Akihisa Imagawa, Toshiaki Hanafusa
Summary: Fulminant type 1 diabetes is a subtype of type 1 diabetes characterized by rapid destruction of beta cells. It is common in East Asian countries, but rare in Western countries. Factors such as human leukocyte antigen and environmental factors, including viruses and drug-induced hypersensitivity syndrome, may contribute to its development. Further research is needed to understand its etiology and clinical characteristics. Prompt diagnosis and appropriate treatment are crucial due to its life-threatening nature.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Linlu Bai, Yuan Zhang, Pan Wang, Xiaojun Zhu, Jing-Wei Xiong, Liyan Cui
Summary: This study used an artificial neural network to improve the diagnosis of rheumatoid arthritis (RA) and found that anti-CCP antibodies have the greatest impact on RA diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woojun Kim, Hyeong-Geol Shin, Hyebin Lee, Dohoon Park, Junghwa Kang, Yoonho Nam, Jongho Lee, Jinhee Jang
Summary: This study evaluated the characteristics of brain lesions in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using chi-separation imaging. The findings showed that MS lesions exhibited a higher proportion of hypodiamagnetic lesions compared to NMOSD lesions, suggesting that this feature can be used to differentiate between the two diseases.
Review
Medicine, General & Internal
Serena Bergamo
Summary: Adamantiades-Behcet's disease is a chronic-relapsing multisystemic inflammatory disease with unknown etiology. Diagnosis is based on clinical judgment using specific signs and symptoms, and there are diagnostic and classification criteria available for reference.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Zhongyun Chen, Yu Kong, Jing Zhang, Min Chu, Li Liu, Kexin Xie, Yue Cui, Hong Ye, Junjie Li, Lin Wang, Liyong Wu
Summary: The study aimed to assess the proportion of MM2-type sCJD and describe the clinical features of MM2C and MM2T-type sCJD in a Chinese cohort. Among the 209 patients with sCJD, 24.4% were diagnosed with MM2-type sCJD, with 44 cases of MM2C-type and 7 cases of MM2T-type. The absence of typical sCJD symptoms within 6 months was found in 61.3% of MM2C-type sCJD patients on admission, but all had cortical hyperintensity on DWI. MM2C-type sCJD was associated with slower disease progression and the absence of typical clinical features, while MM2T-type had distinct characteristics such as higher male proportion, earlier age of onset, longer disease duration, and higher incidence of bilateral thalamic hypometabolism/hypoperfusion.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Richard Taubert, Bastian Engel, Jana Diestelhorst, Katharina L. Hupa-Breier, Patrick Behrendt, Niklas T. Baerlecken, Kurt-Wolfram Suehs, Maciej K. Janik, Kalliopi Zachou, Marcial Sebode, Christoph Schramm, Maria-Carlota Londono, Sarah Habes, Ye H. Oo, Claudine Lalanne, Simon Pape, Maren Schubert, Michael Hust, Stefan Duebel, Mario Thevis, Danny Jonigk, Julia Beimdiek, Falk F. R. Buettner, Joost P. H. Drenth, Luigi Muratori, David H. Adams, Jessica K. Dyson, Amedee Renand, Isabel Graupera, Ansgar W. Lohse, George N. Dalekos, Piotr Milkiewicz, Martin Stangel, Benjamin Maasoumy, Torsten Witte, Heiner Wedemeyer, Michael P. Manns, Elmar Jaeckel
Summary: This study identified more accurate autoantibodies for diagnosing autoimmune hepatitis (AIH) using a protein macroarray, which showed higher specificity and sensitivity compared to conventional autoantibodies. These antibodies could be used as promising markers to improve the diagnostic workup of liver diseases, particularly in cases of seronegative AIH.
Article
Gastroenterology & Hepatology
James Buxbaum, Bashar Qumseya, Sachin Wani
Summary: Despite the lack of consensus criteria for the diagnosis of cholangitis, the BILE criteria appears to be a promising approach in identifying high-risk patients. Further validation studies are needed to confirm its diagnostic performance and ability to prevent unnecessary ERCP.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Multidisciplinary Sciences
Jonathan Kennedy, Natasha Kennedy, Roxanne Cooksey, Ernest Choy, Stefan Siebert, Muhammad Rahman, Sinead Brophy
Summary: This study used machine learning to develop a profile of individuals who are likely to be diagnosed with ankylosing spondylitis (AS) in the future. The models showed that lower back pain, uveitis, and NSAID use under age 20 are associated with AS development in men, while women tend to have an older age of symptom presentation, along with back pain and multiple pain relief medications. However, when applied to a general population with low prevalence rates, the positive predictive value of these models would be very low.
Article
Dermatology
O. Reiter, E. Chousakos, N. Kurtansky, J. K. Nanda, S. W. Dusza, M. A. Marchetti, N. Jaimes, A. Moraes, A. A. Marghoob
Summary: This study found that melanocytic lesions with atypical or asymmetrically distributed peripheral globules, especially when located on the extremities, are more likely to be melanoma; on the contrary, lesions with typical and symmetrically distributed peripheral globules, and with no other concerning dermoscopic features, are unlikely to be malignant.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Biology
Fadi Hassan, Helana Jeries, Mohammad E. Naffaa
Summary: Behcet's disease is a chronic inflammatory disorder characterized by oral and genital ulcers, skin lesions, and uveitis. The diagnosis is solely based on clinical features as there is no specific laboratory test. International diagnostic criteria were introduced in 1990, but they have limitations in diagnosing atypical presentations. In 2013, new criteria were introduced to improve sensitivity with minimal compromise on specificity. Efforts should continue to enhance the currently accepted international classification criteria, possibly by incorporating genetic testing and ethnicity-specific features.
Article
Medicine, General & Internal
Duaa Fahs, Dima Salloum, Mona Nasrallah, Ghina Ghazeeri
Summary: Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder that affects women in the reproductive age group. It has features of both reproductive and metabolic disorders. The most widely used criteria for diagnosis are the 2003 Rotterdam criteria, which require the presence of two out of three criteria. Artificial intelligence, specifically machine learning, is being explored as a promising tool for PCOS diagnosis and prediction. This review focuses on the pathophysiology, clinical features, and diagnostic challenges of PCOS in females.
Article
Clinical Neurology
Tuan Van Nguyen, Tuan Anh Tran, Hinh Thi Vu
Summary: The study evaluated the role of electromyography and Awaji criteria for the early diagnosis of ALS, finding that Awaji criteria have higher sensitivity for early diagnosis of ALS.
NEUROLOGICAL SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
F. Ouyang, Q. Wu, B. Duan, X. Yuan, B. Wang, Y. Chen, M. Yin, X. Zeng
Summary: The study identified specific indicators, including cauda equina disorder (CED) and perimedullary flow voids (PFV), for the diagnosis of spinal dural arteriovenous fistulas (SDAVFs). The diagnostic model constructed using PFV and CED signs showed good diagnostic performance. The 3D-T2-SPACE and CE-MRA sequences had good localization values for SDAVF and combining them improved diagnostic accuracy compared to digital subtraction angiography (DSA).
CLINICAL RADIOLOGY
(2023)
Article
Ophthalmology
Michael Stormly Hansen, Lene Terslev, Mads Radmer Jensen, Jane Maestri Brittain, Uffe Moller Dohn, Carsten Faber, Steffen Heegaard, Oliver Niels Klefter, Elisabeth Bay Konig, Yousif Subhi, Anne Katrine Wiencke, Steffen Hamann
Summary: This study assesses the diagnostic performance of temporal artery ultrasound and biopsy in the diagnosis of giant cell arteritis (GCA). The results show that both ultrasound and biopsy have relatively high sensitivity and specificity, although the overall diagnostic accuracy of ultrasound is slightly lower than that of biopsy.
Article
Clinical Neurology
Vincenzo Donadio, Zerui Wang, Alex Incensi, Giovanni Rizzo, Enrico Fileccia, Veria Vacchiano, Sabina Capellari, Martina Magnani, Cesa Scaglione, Michelangelo Stanzani Maserati, Patrizia Avoni, Rocco Liguori, Wenquan Zou
Summary: The study demonstrates that both immunofluorescence and RT-QuIC have high diagnostic accuracy in distinguishing synucleinopathies from non-synucleinopathies, with immunofluorescence showing higher diagnostic accuracy and a good level of agreement with RT-QuIC in both skin and CSF.
Article
Nutrition & Dietetics
Takujiro Iuchi, Toshio Hosaka, Masahiro Shiroishi, Hiraku Ono, Kouichi Inukai, Takashi Sumita, Gouta Sakai, Shigehiro Katayama, Takuya Awata
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Medicine, General & Internal
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
Article
Multidisciplinary Sciences
Junichi Yasui, Eiji Kawasaki, Shoichiro Tanaka, Takuya Awata, Hiroshi Ikegami, Akihisa Imagawa, Yasuko Uchigata, Haruhiko Osawa, Hiroshi Kajio, Yumiko Kawabata, Akira Shimada, Kazuma Takahashi, Kazuki Yasuda, Hisafumi Yasuda, Toshiaki Hanafusa, Tetsuro Kobayashi
Article
Multidisciplinary Sciences
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi
Article
Endocrinology & Metabolism
Gota Sakai, Ikuo Inoue, Tokuko Suzuki, Takashi Sumita, Kouichi Inukai, Shigehiro Katayama, Takuya Awata, Tetsuya Yamada, Tomoichiro Asano, Hideki Katagiri, Mitsuhiko Noda, Akira Shimada, Hiraku Ono
Article
Multidisciplinary Sciences
Kenji Yamashiro, Keisuke Mori, Shigeru Honda, Mariko Kano, Yasuo Yanagi, Akira Obana, Yoichi Sakurada, Taku Sato, Yoshimi Nagai, Taiichi Hikichi, Yasushi Kataoka, Chikako Hara, Yasurou Koyama, Hideki Koizumi, Munemitsu Yoshikawa, Masahiro Miyake, Isao Nakata, Takashi Tsuchihashi, Kuniko Horie-Inoue, Wataru Matsumiya, Masashi Ogasawara, Ryo Obata, Seigo Yoneyama, Hidetaka Matsumoto, Masayuki Ohnaka, Hirokuni Kitamei, Kaori Sayanagi, Sotaro Ooto, Hiroshi Tamura, Akio Oishi, Sho Kabasawa, Kazuhiro Ueyama, Akiko Miki, Naoshi Kondo, Hiroaki Bessho, Masaaki Saito, Hidenori Takahashi, Xue Tan, Keiko Azuma, Wataru Kikushima, Ryo Mukai, Akihiro Ohira, Fumi Gomi, Kazunori Miyata, Kanji Takahashi, Shoji Kishi, Hiroyuki Iijima, Tetsuju Sekiryu, Tomohiro Iida, Takuya Awata, Satoshi Inoue, Ryo Yamada, Fumihiko Matsuda, Akitaka Tsujikawa, Akira Negi, Shin Yoneya, Takeshi Iwata, Nagahisa Yoshimura
SCIENTIFIC REPORTS
(2017)
Article
Endocrinology & Metabolism
Takuya Awata, Akira Shimada, Taro Maruyama, Yoichi Oikawa, Nobuyuki Yasukawa, Susumu Kurihara, Yumi Miyashita, Masako Hatano, Yuichi Ikegami, Masafumi Matsuda, Masataka Niwa, Youichiro Kazama, Shoichiro Tanaka, Tetsuro Kobayashi
Article
Endocrinology & Metabolism
Takuya Awata, Akira Shimada, Taro Maruyama, Yoichi Oikawa, Nobuyuki Yasukawa, Susumu Kurihara, Yumi Miyashita, Masako Hatano, Yuichi Ikegami, Masafumi Matsuda, Masataka Niwa, Youichiro Kazama, Shoichiro Tanaka, Tetsuro Kobayashi
Article
Endocrinology & Metabolism
Eiji Kawasaki, Akira Shimada, Akihisa Imagawa, Norio Abiru, Takuya Awata, Yoichi Oikawa, Haruhiko Osawa, Yumiko Kawabata, Junji Kozawa, Tetsuro Kobayashi, Kazuma Takahashi, Daisuke Chujo, Tomoyasu Fukui, Junnosuke Miura, Kazuki Yasuda, Hisafumi Yasuda, Hiroshi Kajio, Toshiaki Hanafusa, Hiroshi Ikegami
Summary: This study investigated the clinical significance and antigen specificity of autoantibodies to insulinoma-associated antigen-2 (IA-2A) in Japanese patients with type 1 diabetes. The results showed that IA-2A-ELISA is a reliable marker for the diagnosis of type 1 diabetes and the prediction of future insulin dependency.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Correction
Endocrinology & Metabolism
Yoshitaka Akiyama, Tomoko Morita-Ohkubo, Natsuko Oshitani, Yuko Ohno, Yoshimasa Aso, Toshihiko Inukai, Masafumi Kakei, Masanobu Kawakami, Takuya Awata, Shigehiro Katayama, Masafumi Matsuda
DIABETOLOGY INTERNATIONAL
(2017)
Article
Endocrinology & Metabolism
Yoichi Oikawa, Akira Shimada, Takuya Awata, Tomoyasu Fukui, Hiroshi Ikegami, Akihisa Imagawa, Hiroshi Kajio, Yumiko Kawabata, Eiji Kawasaki, Junnosuke Miura, Haruhiko Osawa, Kazuma Takahashi, Shoichiro Tanaka, Yasuko Uchigata, Hisafumi Yasuda, Kazuki Yasuda, Toshiaki Hanafusa, Tetsuro Kobayashi
DIABETOLOGY INTERNATIONAL
(2017)
Article
Endocrinology & Metabolism
Yoshitaka Akiyama, Tomoko Morita-Ohkubo, Natsuko Oshitani, Yuko Ohno, Yoshimasa Aso, Toshihiko Inukai, Masafumi Kakei, Masanobu Kawakami, Takuya Awata, Shigehiro Katayama, Masafumi Matsuda
DIABETOLOGY INTERNATIONAL
(2016)
Article
Endocrinology & Metabolism
Megu Yamaguchi Baden, Akihisa Imagawa, Hiromi Iwahashi, Iichiro Shimomura, Takuya Awata, Hiroshi Ikegami, Yasuko Uchigata, Haruhiko Osawa, Hiroshi Kajio, Eiji Kawasaki, Yumiko Kawabata, Akira Shimada, Kazuma Takahashi, Shoichiro Tanaka, Kazuki Yasuda, Hisafumi Yasuda, Tetsuro Kobayashi, Toshiaki Hanafusa
DIABETOLOGY INTERNATIONAL
(2016)
Correction
Endocrinology & Metabolism
Shoichiro Tanaka, Masayuki Ohmori, Takuya Awata, Akira Shimada, Satoshi Murao, Taro Maruyama, Kyuzi Kamoi, Eiji Kawasaki, Koji Nakanishi, Masao Nagata, Sumie Fujii, Hiroshi Ikegami, Akihisa Imagawa, Yasuko Uchigata, Minoru Okubo, Haruhiko Osawa, Hiroshi Kajio, Akio Kawaguchi, Yumiko Kawabata, Jo Satoh, Ikki Shimizu, Kazuma Takahashi, Hideichi Makino, Hiromi Iwahashi, Junnosuke Miura, Kazuki Yasuda, Toshiaki Hanafusa, Tetsuro Kobayashi
DIABETOLOGY INTERNATIONAL
(2015)
Article
Endocrinology & Metabolism
Shoichiro Tanaka, Masayuki Ohmori, Takuya Awata, Akira Shimada, Satoshi Murao, Taro Maruyama, Kyuzi Kamoi, Eiji Kawasaki, Koji Nakanishi, Masao Nagata, Sumie Fujii, Horoshi Ikegami, Akihisa Imagawa, Yasuko Uchigata, Minoru Okubo, Haruhiko Osawa, Horishi Kajio, Akio Kawaguchi, Yumiko Kawabata, Jo Satoh, Ikki Shimizu, Kazuma Takahashi, Hideichi Makino, Hiromi Iwahashi, Junnosuke Miura, Kazuki Yasuda, Toshiaki Hanafusa, Tetsuro Kobayashi
DIABETOLOGY INTERNATIONAL
(2015)
