Acute DNase1 treatment improves left ventricular remodeling after myocardial infarction by disruption of free chromatin

Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition

(2014) Daniela Fraccarollo et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting MMP-2 to treat ischemic heart injury

(2014) Bryan G. Hughes et al.   BASIC RESEARCH IN CARDIOLOGY

Cardiac macrophages and their role in ischaemic heart disease

(2014) Stefan Frantz et al.   CARDIOVASCULAR RESEARCH

Cardiovascular remodelling in coronary artery disease and heart failure

(2014) Gerd Heusch et al.   LANCET

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

(2014) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

5-Lipoxygenase facilitates healing after myocardial infarction

(2013) Nadja Blömer et al.   BASIC RESEARCH IN CARDIOLOGY

How can we cure a heart “in flame”? A translational view on inflammation in heart failure

(2013) Ulrich Hofmann et al.   BASIC RESEARCH IN CARDIOLOGY

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

DNase I–hypersensitive exons colocalize with promoters and distal regulatory elements

(2013) Tim R Mercer et al.   NATURE GENETICS

Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

(2013) Martin Sillesen et al.   SURGERY

Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells

(2013) Femke Stephan et al.   Arthritis & Rheumatology

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Excess histone levels mediate cytotoxicity via multiple mechanisms

(2010) Rakesh Kumar Singh et al.   CELL CYCLE

Regulation of Cardiomyocyte Polyploidy and Multinucleation by CyclinG1

(2010) Zhipei Liu et al.   CIRCULATION RESEARCH

Histones interact with anionic phospholipids with high avidity; its relevance for the binding of histone-antihistone immune complexes

(2010) L. F. PEREIRA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysing cell-free plasma DNA and SLE disease activity

(2010) Johanna Atamaniuk et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Nuclease Expression by Staphylococcus aureus Facilitates Escape from Neutrophil Extracellular Traps

(2010) Evelien T.M. Berends et al.   Journal of Innate Immunity

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis

(2009) Guo Hua Li et al.   CIRCULATION RESEARCH

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

DNase I footprinting of the nucleosome in whole nuclei

(2008) D.Z. Staynov   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Murine serum deoxyribonuclease 1 (Dnase1) activity partly originates from the liver

(2008) Sebastian Ludwig et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY