Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Stuart T. Hamilton, Friedrich Hahn, Eric Sonntag, Manfred Marschall, William D. Rawlinson
Summary: Congenital infection by human cytomegalovirus is a major cause of fetal malformation in developed countries. The miRNA miR-517a-3p from the chromosome 19 miRNA cluster has been shown to inhibit HCMV replication, offering potential for antiviral therapeutic strategies during pregnancy.
Article
Biochemistry & Molecular Biology
Xiaole Pan, Saki Noguchi, Misuzu Ando, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study found that overexpression of miR-126 can inhibit the invasive ability of JEG-3 cells by targeting LIN28A, without affecting proliferation and migration. In addition, miR-126-mediated downregulation of LIN28A may contribute to the onset/deterioration of preeclampsia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Environmental Sciences
Esther lvarez-Silvares, Tania Fernandez-Cruz, Monica Bermudez-Gonzalez, Paula Rubio-Cid, Agostinho Almeida, Edgar Pinto, Teresa Seoane-Pillado, Elena Martinez-Carballo
Summary: Placental development plays a crucial role in the progression of pregnancy, and exposure to environmental toxicants, including metals, can have an impact on placenta and subsequently affect pregnancy outcomes. This study investigates the correlation between placental levels of 14 essential and non-essential elements and neonatal weight. The findings suggest that certain metal concentrations in the placenta may influence fetal growth, with cobalt and strontium associated with higher newborn weight, while lithium, molybdenum, and selenium associated with lower newborn weight.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Developmental Biology
Andreanna Burman, Rolando Garcia-Milian, Madeleine Wood, Natalie A. DeWitt, Vasilis Vasiliou, Seth Guller, Vikki M. Abrahams, Shannon Whirledge
Summary: The use of acetaminophen may interfere with critical trophoblast functions, potentially impacting fetal development.
Article
Cell Biology
Violeta Stojanovska, Susanne Arnold, Mario Bauer, Hermann Voss, Stefan Fest, Ana Claudia Zenclussen
Summary: This study characterized three different 3D cultures derived from trophoblast cell lines and compared them to primary fetal trophoblasts and placental tissue. The results showed that these 3D cell culture models exhibit similar functionality and gene expression profiles to primary placental tissue, making them ideal models for studying the placenta.
Review
Endocrinology & Metabolism
Yongdan Ma, Yongyan Hu, Jingmei Ma
Summary: Placenta accreta spectrum disorder (PAS) is a disease characterized by abnormal invasion of the placenta into the myometrium and uterus. The understanding of its mechanisms and signaling pathways is limited due to the lack of suitable animal models. Mouse models, particularly those induced by uterine surgery, have been used to simulate different phenotypes of PAS and investigate its pathogenesis. This review summarizes the approaches of PAS modeling in mice and provides insight into the strengths, limitations, and future perspectives of each strategy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Danai Georgiadou, Souad Boussata, Remco Keijser, Dianta A. M. Janssen, Gijs B. Afink, Marie van Dijk
Summary: Mutations in the LINC-HELLP non-coding RNA (HELLPAR) are associated with familial forms of the pregnancy-specific HELLP syndrome, impacting EVT differentiation and the binding of RNA splicing complex proteins PCBP1, PCBP2, and YBX1 to LINC-HELLP. Knockdown of PCBP2, and to a lesser extent YBX1 and PCBP1, leads to failure of EVTs to differentiate towards an invasive phenotype. PCBP2 silencing alters splicing for genes related to cellular assembly, organization, function, maintenance, growth, proliferation, and the cell cycle, indicating its crucial role in EVT differentiation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Juan F. Mejia, Parker Hall, Kelsey M. Hirschi, Paul R. Reynolds, Juan A. Arroyo
Summary: The PKM2 protein is associated with IUGR in placenta, and its activation can protect placental and fetal weights from decreasing. The expression and localization of PKM2 in trophoblast cells change under different oxygen levels.
Article
Environmental Sciences
Samantha M. Hall, Sharon Zhang, Kate Hoffman, Marie Lynn Miranda, Heather M. Stapleton
Summary: There are associations between placental PFAS concentrations and birth outcomes, suggesting potential effects of PFAS on fetal health.
Article
Environmental Sciences
Maimaitiminjiang Wulayin, Zhenghong Zhu, Huailin Wang, Xin Chen, Xiaoxin Zhang, Tarik Benmarhnia, Jiajun Luo, Qianhong Liang, Weiyi Chen, Hualiang Lin, Yuewei Liu, Chunxiang Shi, Ruijun Xu, Cunrui Huang, Qiong Wang
Summary: Studies have shown that exposure to low and high temperatures during pregnancy has negative effects on fetal development. The placenta, which plays a crucial role in fetal development, may also be affected by suboptimal temperatures. However, it is unclear whether the placenta mediates the association between suboptimal temperature and birth weight.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Khondoker M. M. Akram, Neha S. S. Kulkarni, Abbey Brook, Matthew D. D. Wyles, Dilly O. C. Anumba
Summary: This study identified key genes and signaling pathways associated with the pathogenesis of spontaneous preterm birth by analyzing gene expression and signaling pathways in placental tissue. The findings provide new molecular insights for developing predictive biomarkers and therapeutics for preterm birth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Orsolya Oravecz, Andrea Balogh, Roberto Romero, Yi Xu, Kata Juhasz, Zsolt Gelencser, Zhonghui Xu, Gaurav Bhatti, Roger Pique-Regi, Balint Peterfia, Petronella Hupuczi, Ilona Kovalszky, Padma Murthi, Adi L. Tarca, Zoltan Papp, Janos Matko, Nandor Gabor Than
Summary: Proteoglycan macromolecules, specifically syndecan-1, play crucial roles in various physiological processes during placenta development and healthy pregnancy. Dysregulated expression of proteoglycans, including syndecan-1, has been observed in pregnancy complications such as pre-eclampsia and fetal growth restriction. Further research is needed to explore the potential diagnostic and therapeutic applications of proteoglycans in complicated pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Zhirui Chen, Mengying Wu, Haixia Huang, Hui Tao, Li Zou, Qingqing Luo
Summary: The expression of miR-199a-5p is significantly increased in plasma exosomes and placenta tissue from patients with severe preeclampsia (sPE). Exosomal miR-199a-5p impairs endothelial cell function by targeting SIRT1, contributing to the development of preeclampsia.
REPRODUCTIVE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Dan Wang, Quan Na, Guiyu Song, Ying Wang, Yang Wang
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Obstetrics & Gynecology
Song Guiyu, Na Quan, Wang Ruochen, Wang Dan, Chen Bingnan, Li Yuanyua, Bian Yue, Jin Feng, Qiao Chong, Wang Leilei
Summary: The study revealed a significant inverse correlation between miR-517a and lncRNA-SNX17 expression in the placenta of diabetic macrosomia. It was suggested that lncRNA-SNX17 might promote trophoblast proliferation through the miR-517a/IGF-1 pathway, playing a role in the placentation of diabetic macrosomia.
REPRODUCTIVE SCIENCES
(2022)
Article
Health Care Sciences & Services
Leilei Wang, Sishi Liu, Guiyu Song, Man Gao, Tong Liu
Summary: This study aimed to evaluate the effects of misoprostol on induction of labour in hypertensive disorders of pregnancy (HDP) patients. The meta-analysis results showed that misoprostol had a significantly higher effective rate of induction of labour and reduced postpartum hemorrhage compared to oxytocin. This provides meaningful guidance for clinicians.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Environmental Sciences
Dan Wang, Hongbo Guan, Ying Wang, Guiyu Song, Yajun Xia
Summary: This study explores the mechanism of m6A-modified circSETD2 in trophoblast biological behaviors and finds that m6A modification suppresses miR-181a-5p and increases MCL1 transcription, thus regulating trophoblasts. The findings suggest the important role of m6A modification in the development of PE.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Shaoxun Wang, Guiyu Song, Mahsa Nouri Barkestani, Zuzana Tobiasova, Qianxun Wang, Quan Jiang, Roberto Lopez, Yasmin Adelekan-Kamara, Matthew Fan, Jordan S. Pober, George Tellides, Dan Jane-wit
Summary: This study identifies functional heterogeneity within the Ptch(Hi) T-cell population implicated in IRI, and demonstrates that Hh-mediated costimulation can induce clonal expansion within this population.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
G. Y. Song, Q. Na, D. Wang, C. Qiao
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
