Article
Polymer Science
Won Lee, Nark-Kyoung Rho, Eun-Jung Yang
Summary: Although the mode of action of hyaluronic acid (HA) filler injections remains unclear, it is associated with various non-vascular inflammatory complications. Impurities in hyaluronic acid fillers may lead to an immune response. This study aimed to identify any impurities in hyaluronic acid fillers available on the market, and found contaminant particles such as silicon and aluminum isotopes.
Review
Dermatology
Daniel Cassuto, Gilberto Bellia, Chiara Schiraldi
Summary: Hyaluronic acid (HA)-based injectable filling agents are leading the demand for noninvasive dermatological procedures, and this review critically evaluates the differences in rheological nature and clinical application of currently available HA-based products. The performance of crosslinked fillers depends on various factors such as HA concentration, degree of crosslinking, elastic modulus, cohesivity, and type of crosslinking agent employed.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
Article
Surgery
Shirin Hamed-Azzam, Cat Burkat, Abed Mukari, Daniel Briscoe, Narish Joshi, Richard Scawn, Eran Alon, Morris Hartstein
Summary: This study reports a series of cases where dermal filler injected into the face migrated to the orbit, leading to orbital complications. Treatment methods and possible mechanisms of this complication are discussed. Patients may present with orbital symptoms, but the distance between the injection site and the complication site could lead to delays in diagnosis.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Dermatology
Yasamin Kalantari, Zeinab Aryanian, Seyed-Mohamad-Sadegh Mirahmadi, Sanam Alilou, Parvaneh Hatami, Azadeh Goodarzi
Summary: This study analyzed the characteristics of patients experiencing filler reactions after COVID-19 vaccination and addressed considerations for medical practice. The study found that patients who developed delayed-type reactions were middle-aged women without known allergies. All patients had received hyaluronic acid fillers in the head and neck area and experienced symptoms such as swelling within a few days after vaccination. Lisinopril, hyaluronidase, and corticosteroids showed promising results in managing the reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Giorgia Salvia, Nicola Zerbinati, Flavia Manzo Margiotta, Alessandra Michelucci, Giammarco Granieri, Cristian Fidanzi, Riccardo Morganti, Marco Romanelli, Valentina Dini
Summary: This study evaluated the use of ultra-high-frequency ultrasound (UHFUS) for assessing dermal hyaluronic acid (HA) fillers. The results demonstrated the efficacy of UHFUS in evaluating nasolabial fold correction.
Article
Biochemistry & Molecular Biology
Jae Yoon An, Wooram Um, Dong Gil You, Yeari Song, Jeongjin Lee, Nguyen Van Quy, Hyeyeon Joo, Jueun Jeon, Jae Hyung Park
Summary: A novel hyaluronic acid hydrogel-based depot with ultrasound-triggered thermal elevation and on-demand cargo release for cancer therapy was reported in this study. The results demonstrated that the hydrogel significantly increased temperature and released cargo under ultrasound, showing potential for in vivo applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Shancheng Si, Linying Lai, Xue Ding, Wei Su, Guiwen Zhou, Qihua Wang, Lei Wang, Yicong Ji, Anming Chen, Youtao Yu, Minliang Chen, Yuntao Hu
Summary: A new injury severity scale has been proposed to evaluate the prognosis of different ocular complications following cosmetic filler injection. This scale can help inform injured patients about the possibility of certain complications and the extent of improvement.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Pharmacology & Pharmacy
Sabrina Sciabica, Giovanni Tafuro, Alessandra Semenzato, Daniela Traini, Dina M. Silva, Larissa Gomes Dos Reis, Luisa Canilli, Massimo Terno, Elisa Durini, Silvia Vertuani, Anna Baldisserotto, Stefano Manfredini
Summary: By modifying native HA through cross-linking reactions with Ornithine, the half-life and performance of the new product (HA-Orn) were improved. The gel-like profile of HA-Orn showed improved resistance against enzymatic digestion, and in vitro cytotoxicity studies demonstrated no cytotoxicity on lung cell lines.
Article
Surgery
Lei Zhang, Ye Zhao, Qinghao Gu, Xiao Feng, Jingyu Li, Fangyuan Lai, Lei Pan, Yi Sun, Sufan Wu
Summary: This study provides comprehensive anatomical information for facial contouring injections, including the topography of injection points, penetration depth, filler location, and the vascular anatomical structure in high-risk facial zones. The study suggests the use of static periosteum injections with effective aspiration for maximum safety during filler injections. The findings contribute to a better understanding of facial anatomy and injection techniques for clinicians.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Dermatology
Pantea Shekarriz, Farid Hosseini, Pardis Shojaee
Summary: This study investigated the vascular pattern of the common zones of non-surgical filler-based rhinoplasty (NSR) using Doppler ultrasound. The results showed that the common method of NSR was relatively safe in the radix but carried an increased risk of vascular events in the nasal tip.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Tom S. Decates, Faryha Sayghani, Jani A. Van Loghem, Peter J. Velthuis
Summary: This study aimed to analyze the factors contributing to the increased number of adverse events associated with hyaluronic acid fillers and evaluate the impact of new European regulations on the approval process. The study found that Hyacorp-1000 and Hyacorp H-S (H-800) fillers had a higher incidence of adverse events compared to other hyaluronic acid fillers, possibly due to their longer duration in the body.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Awika Rongthong, Rungsima Wanitphakdeedecha, Mart Maiprasert, Kathryn Anne Guico Cembrano, Nataya Voravutinon, Sarawalai Rakchart, Kanchana Sermswan, Pongsiri Koonngam
Summary: This study evaluated the efficacy and safety of hyaluronic acid (HA) fillers for the treatment of horizontal neck lines using a blunt cannula injection technique. The results showed that the HA filler injection improved the appearance of neck lines, with peak improvement at 1 month and sustained rejuvenation effects up to 6 months after treatment.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Ophthalmology
Anna Ginter, Terry Lee, Julie Woodward
Summary: The study aimed to compare the contributions of intrinsic filler fluid dynamics and delivery systems to ease of injection by measuring extrusion force variability across different syringes and needles. Six different fillers were tested using both the provided injection apparatus and a standardized syringe with varying needle sizes. The results showed that the delivery apparatus had the greatest impact on extrusion force, and standardization of the syringe reduced the force required for injection.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dermatology
Natthachat Jurairattanaporn, Watinee Amornpetkul, Suthinee Rutnin, Vasanop Vachiramon
Summary: This study evaluated the effects of radiofrequency (RF) treatment at different time points on the degradation of hyaluronic acid (HA) filler in vivo. The results showed that RF treatment may affect the integrity of the HA filler, especially if performed on the same day after injection.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Mohamed Tharwat, Abdulla Al-Hawas
Summary: This study in Saudi Arabia during the 4th King Abdulaziz Camel Festival aimed to describe the locations and ultrasound features of injected cosmetic fillers in camels. Out of 11,626 camels examined, 58 were found to have been injected with fillers, mainly in the upper lip. The study found that ultrasound was useful in detecting the presence of injected fillers and monitoring complications.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2021)
Review
Dermatology
Leonie W. Schelke, Daniel Cassuto, Peter Velthuis, Ximena Wortsman
JOURNAL OF COSMETIC DERMATOLOGY
(2020)
Article
Dermatology
Tom S. Decates, Peter J. Velthuis, Leonie W. Schelke, Neubury Lardy, Eduard Palou, Simo Schwartz, Yara Bachour, Frank B. Niessen, Tamar Nijsten, Jaume Alijotas-Reig
Summary: This study found that genetic polymorphisms such as HLA combinations, particularly the combination of HLA subtype-B*08 and HLA subtype-DRB1*03, may be associated with late-onset inflammatory adverse events related to dermal fillers. This specific combination was linked to almost a 4-fold increase in the odds of developing immune mediated adverse events.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Helga van den Elzen, Leonie Schelke, Peter Velthuis
Summary: This study aimed to investigate compromised blood flow after filler injection, and the results suggest that the issue is not due to intra-arterial occlusion, but rather external compression of the artery, which may lead to clinical symptoms.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Letter
Dermatology
Stella Desyatnikova, Leonie Schelke
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Leonie Schelke, Tamar Schoonen, Peter J. Velthuis
Summary: In recent years, the pre-auricular area has been increasingly used for filler injections. This study examined ultrasonographic data and a video to assess the depth of subcutaneous fat and the process of filler injection. The results showed that filler injections may easily enter the parotid gland without being noticed by the injector and client. The discussion and literature data confirmed that filler injections in the pre-auricular area may end up inside or near the parotid gland, leading to an inflammatory response. It is recommended to be cautious and perform sonographic assessment of subcutaneous depth prior to filler injections in this area.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
L. Schelke, O. Liplavk, S. Cotofana, S. Shah-Desai, P. Velthuis
Summary: This study evaluated patients with malar edema after hyaluronic acid filler treatment and found that filler material was mainly located inside the SMAS. With duplex-ultrasound guided filler removal, clinical improvement of malar edema was observed minutes after treatment.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Leonie Schelke, Steve Harris, Hugues Cartier, Michael Alfertshofer, Marwah Doestzada, Sebastian Cotofana, Peter J. Velthuis
Summary: This study demonstrates the identification, evaluation, and treatment of facial overfilled syndrome using facial ultrasound and simultaneous hyaluronidase injections. Targeted hyaluronidase injections have shown to restore a natural smile, reduce excess midfacial volume, and decrease the severity of lateral canthal lines.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
